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| 1 | Reprogramming of ovine adult fibroblasts to pluripotency via drug-inducible expression of defined factors显示文摘在 enucleated 鸡蛋的体的房间的 Reprogramming 做了多丽,绵羊,在 1996 的第一个成功地克隆的哺乳动物。然而,绵羊的机制体的房间 reprogramming 还没被探讨了。而且,绵羊胚胎的茎(ES ) 细胞仍然不是可得到的,它限制精确修改基因的绵羊的产生。在这研究,我们报导体的房间能是的那只绵羊直接 reprogrammed 到导致的 pluripotent 用定义因素(Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, SV40 大 T 和 hTERT ) 的茎(iPS ) 房间。我们的观察显示从绵羊的体的细胞比从另外的种,在 iPS,细胞被报导了的体的细胞对改编更困难。我们证明绵羊 iPS 房间表示 ES 房间标记,包括碱的磷酸酶, Oct4, Nanog, Sox2, Rex1,阶段特定的胚胎的 antigen-1, TRA-1-60, TRA-1-81 和 E-cadherin。绵羊 iPS 房间展出了正常 karyotypes 并且能在 vitro 并且在 teratomas 区分进所有三细菌层。我们的学习可以帮助在绵羊揭示体的房间 reprogramming 的机制并且提供一个平台为绵羊 ES 房间探索文化条件。而且,绵羊 iPS 房间可以直接被用来产生精确修改基因的绵羊。 | Lei Bao Lixiazi He Jijun Chen Zhao Wu Jing Liao Lmgdun Rao Jiangtao Ren Hui Li Hui Zhu Lei Qian Yijun Gu Huimin Dai Xun Xu Jinqiu Zhou Wen Wang Chun Cui Lei Xiao | 2011 | Cell Research2011，21，4： | 32 |
| 2 | Generation of hircine-induced pluripotent stem cells by somatic cell reprogramming显示文摘 | Jiangtao Ren Yongjun Pak Lixiazi He Lei Qian Yijun Gu Hui Li Lingjun Rao Jing Liao Chun Cui Xun Xu Jinqiu Zhou Hakchol Ri Lei Xiao | 2011 | Cell Research2011，21，5： | 10 |
| 3 | Hepatopancreatoduodenectomy for advanced biliary malignancies显示文摘Background:Hepatopancreatoduodenectomy(HPD)has been considered the only curative treatment for metastatic cholangiocarcinoma and some locally advanced gallbladder cancers(GBCs).However,HPD has not yet been included in treatment guidelines as a standard surgical procedure in consideration of its morbidity and mortality rates.The aim of this study was to evaluate the safety and effectiveness of HPD in treating biliary malignancies.Methods:The medical records of 57 patients with advanced biliary cancer undergoing HPD from January 2009 to December 2019 were retrospectively retrieved.A case-control analysis was conducted at our department.Patients with advanced GBC who underwent HPD(HPD-GBC group)were compared with a control group(None-HPD-GBC group).Baseline characteristics,preoperative treatments,tumor pathologic features,operative results,and prognosis were assessed.Results:Thirteen patients with cholangiocarcinoma and 44 patients with GBC underwent HPD at our department.Significant postoperative complications(grade III or greater)and postoperative pancreatic fistula were observed in 24(42.1%)and 15(26.3%)patients,respectively.One postoperative death occurred in the present study.Overall survival(OS)was longer in patients with advanced cholangiocarcinoma than in those with GBC(median survival time[MST],31 months vs.11 months;P<0.001).In the subgroup analysis of patients with advanced GBC,multivariate analysis demonstrated that T4 stage tumors(P=0.012),N2 tumors(P=0.001),and positive margin status(P=0.004)were independently associated with poorer OS.Patients with either one or more prognostic factors exhibited a shorter MST than patients without those prognostic factors(P<0.001).Conclusion:HPD could be performed with a relatively low mortality rate and an acceptable morbidity rate in an experienced highvolume center.For patients with advanced GBC without an N2 or T4 tumor,HPD can be a preferable treatment option. | Xiangsong Wu Maolan Li Wenguang Wu Xu’an Wang Huaifeng Li Runfa Bao Yijun Shu Jun Shen Jun Gu Xuefeng Wang Wei Gong Shuyou Peng Yingbin Liu | 2022 | Chinese Medical Journal2022，135，23： | 3 |
| 4 | Quantitative trait locus mapping of resistance to Aspergillus flavus infection using a recombinant inbred line population in maize显示文摘 | Zhitong Yin Yanqiu Wang Feifei Wu Xiao Gu Yunlong Bian Yijun Wang Dexiang Deng | 2014 | Molecular Breeding2014，，1： | 1 |
| 5 | MiR-196a2 rs11614913 T<ce:hsp sp='0.25'/>><ce:hsp sp='0.25'/>C polymorphism and risk of esophageal cancer in a Chinese population<!-- miRNA polymorphism and esophageal cancer risk -->显示文摘 | Jishu Wei Liang Zheng Shenghua Liu Jun Yin Liming Wang Xu Wang Yijun Shi Aizhong Shao Weifeng Tang Guowen Ding Chao Liu Suocheng Chen Haiyong Gu | 2013 | Human Immunology2013，，： | 1 |
| 6 | Infrared transmission and reflection absorption spectroscopy study on molecular orientation of long-chain n-Alkane amide and 2-n-alkylimidazole multilayer on silver and KRS-5 surfaces显示文摘 | Yijun Gu Zhenming Shi Chong-shi Nie | 1998 | Applied Spectroscopy1998，52，6： | 1 |
| 7 | Functional analysis of cyclin D2 and p27(KIP1) in cyclin D2 transgenic mouse mammary gland during development显示文摘 | Steven S Chua Yi Yijun | 2002 | Oncogene2002，21，47： | 1 |
| 8 | Structural insights into the CRISPR-Cas-associated ribonuclease activity of Staphylococcus epidermidis Csm3 and Csm6显示文摘The Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)-CRISPR-associated(Cas) system is an adaptive immune system in bacteria and archaea that resists exogenous invasion through nucleic acid-mediated cleavage. In the type III-A system, the Csm complex contains five effectors and a CRISPR RNA, which edits both single stranded RNA and double stranded DNA. It has recently been demonstrated that cyclic oligoadenylates(cOAs), which are synthesized by the Csm complex, act as second messengers that bind and activate Csm6. Here, we report the crystal structures of Staphylococcus epidermidis Csm3(SeCsm3) and an N-terminally truncated Csm6(SeCsm6 AN) at 2.26 and 2.0 , respectively. The structure of SeCsm3 highly resembled previously reported Csm3 structures from other species; however, it provided novel observations allowing further enzyme characterization. The homodimeric SeCsm6 AN folds into a compact structure. The dimerization of the HEPN domain leads to the formation of the ribonuclease active site, which is consistent with the reported Csm6 structures. Altogether, our studies provide a structural view of the ribonuclease activity mediated by Csm3 and Csm6 of the type Ⅲ-A CRISPR-Cas system. | Yanqun Zhao Jinjing Wang Qiu Sun Chao Dou Yijun Gu Chunlai Nie Xiaofeng Zhu Yuquan Wei Wei Cheng | 2018 | Science Bulletin2018，63，11： | 1 |
| 9 | Prediction of Airfoil Noise Induced by Low Mach Nunlber Flow 显示文摘 | MAO Yijun QI Datong GU Yuanyuan | 2012 | Pro- ceedings of the Institution of Mechical Engineers Part G Journal of Aerospace Engineering2012，226，5： | 1 |
| 10 | Theoretical andexperimental studies on the noise control of centrifugal fanscombining absorbing liner and inclined tongue 显示文摘 | Gu Yuanyuan Qi Datong Mao Yijun | 2011 | Proceedings of the Institution of Mechanical Engineers PartA: Journal of Power and Energy2011，225，6： | 1 |
| 11 | Heterophilic Graph Neural Network Based on Spatial and Frequency Domain Adaptive Embedding Mechanism显示文摘Graph Neural Networks(GNNs)play a significant role in tasks related to homophilic graphs.Traditional GNNs,based on the assumption of homophily,employ low-pass filters for neighboring nodes to achieve information aggregation and embedding.However,in heterophilic graphs,nodes from different categories often establish connections,while nodes of the same category are located further apart in the graph topology.This characteristic poses challenges to traditional GNNs,leading to issues of“distant node modeling deficiency”and“failure of the homophily assumption”.In response,this paper introduces the Spatial-Frequency domain Adaptive Heterophilic Graph Neural Networks(SFA-HGNN),which integrates adaptive embedding mechanisms for both spatial and frequency domains to address the aforementioned issues.Specifically,for the first problem,we propose the“Distant Spatial Embedding Module”,aiming to select and aggregate distant nodes through high-order randomwalk transition probabilities to enhance modeling capabilities.For the second issue,we design the“Proximal Frequency Domain Embedding Module”,constructing adaptive filters to separate high and low-frequency signals of nodes,and introduce frequency-domain guided attention mechanisms to fuse the relevant information,thereby reducing the noise introduced by the failure of the homophily assumption.We deploy the SFA-HGNN on six publicly available heterophilic networks,achieving state-of-the-art results in four of them.Furthermore,we elaborate on the hyperparameter selection mechanism and validate the performance of each module through experimentation,demonstrating a positive correlation between“node structural similarity”,“node attribute vector similarity”,and“node homophily”in heterophilic networks. | Lanze Zhang Yijun Gu Jingjie Peng | 2024 | Computer Modeling in Engineering & Sciences2024，139，5： | 0 |
| 12 | A 5′tRNA-Ala-derived small RNA regulates anti-fungal defense in plants显示文摘Apart from their primordial role in protein synthesis,t RNAs can be cleaved to produce t RNA-derived small RNAs(ts RNAs).The biological functions of ts RNAs in plants remain largely unknown.In this study,we developed Rtc B ligation-based small RNA(s RNA)sequencing,a method that captures and distinguishes between 3′-2′,3′-cyclic-phosphate(c P)/phosphate(P)-terminated s RNAs and 3′-OH-terminated s RNAs,and profiled 5′ts RNAs and 5′t RNA halves in Arabidopsis thaliana.We found that Arabidopsis 5′ts RNAs and 5′t RNA halves predominantly contain a c P at the 3′end and require S-like RNase 1(RNS1)and RNS3 for their production.One of the most abundant 5′ts RNAs,5′ts R-Ala,by associating with AGO1,negatively regulates Cytochrome P45071 A13(CYP71 A13)expression and camalexin biosynthesis to repress anti-fungal defense.Interestingly,5′ts R-Ala is downregulated upon fungal infection.Our study provides a global view of 5′ts RNAs and 5′t RNA halves in Arabidopsis and unravels an important role of a 5′ts RNA in regulating anti-fungal defense. | Hanqing Gu Bi Lian Yuxiang Yuan Ci Kong Yan Li Chang Liu Yijun Qi | 2022 | Science China(Life Sciences)2022，65，1： | 0 |
| 13 | Improvement of Stochastic Competitive Learning for Social Network显示文摘As an unsupervised learning method,stochastic competitive learning is commonly used for community detection in social network analysis.Compared with the traditional community detection algorithms,it has the advantage of realizing the time-series community detection by simulating the community formation process.In order to improve the accuracy and solve the problem that several parameters in stochastic competitive learning need to be pre-set,the author improves the algorithms and realizes improved stochastic competitive learning by particle position initialization,parameter optimization and particle domination ability self-adaptive.The experiment result shows that each improved method improves the accuracy of the algorithm,and the F1 score of the improved algorithm is 9.07%higher than that of original algorithm. | Wenzheng Li Yijun Gu | 2020 | Computers, Materials & Continua2020，，5： | 0 |
| 14 | A speckle noise suppression method based on surface waves investigation and monitoring data显示文摘The internal energy distribution of waves can be described using ocean-wave spectra.In many ways,obtaining wave spectra on a global scale is critical.Surface waves investigation and monitoring onboard the Chinese-French oceanography satellite is the first space-borne instrument for detecting wave spectra specially,which was launched on October 29,2018.It can avoid the shortage of synthetic aperture radar detection results while still having some problems,especially with the effects of speckle noise.In this study,a method to suppress the speckle noise is proposed.First,the empirical formula for background speckle noise is established.Second,many spatio-temporal representative fluctuation spectra are classified and averaged.Third,rational transfer function filtering is used to obtain speckle noise close to the along-track direction.Finally,a signal-to-noise ratio threshold is used to suppress the abnormal speckle noise.This method solves the problems existing in previous denoising methods,such as excessive denoising in the along-track direction and the inability of some abnormal noises to be denoised in the two-dimensional directional wave spectra. | Jingwei Gu Xiuzhong Li Yijun He | 2023 | Acta Oceanologica Sinica2023，42，1： | 0 |
| 15 | Modulation of Excitonic Confinement of TiO_(2)in Molten Salts for Overall CO_(2)Photoreduction显示文摘Excitonic confinement greatly determines the charge carrier transport of photocatalysts.A molten salt modulation of excitonic con-finement is herein demonstrated as formation of ultrafine carbon-doped anatase TiO_(2)with grafted graphitic carbon nitride,which is rationalized as an excellent catalyst for overall CO_(2)photoreduction.Compared with bulk TiO_(2),the carbon-doped TiO_(2)(M-TiO_(2))pos-sesses a weaker excitonic confinement to decrease exciton binding energy from 99 to 58 meV,consequently enhancing free-charge-carrier generation and transportation.Effective Z-scheme electron transfer from M-TiO_(2)to C_(3)N_(4) is built,enhancing the CO_(2)conversion via the synchronous optimization of redox ability,CO_(2)activation,and^(*)COOH generation.This work highlights the unique chemistry of excitonic dissociation on facilitating separation of electron and hole,and also extends the scope of molten salt-mediated modulation of photocatalysis materials. | Jing Wang Ren Sheng Dong Gu Yuhao Peng Juanxiu Xiao Yijun Shen Wei Xiao | 2023 | Chinese Journal of Chemistry2023，41，10： | 0 |
| 16 | Cooperative Multi-Agent Reinforcement Learning with Constraint-Reduced DCOP显示文摘Cooperative multi-agent reinforcement learning( MARL) is an important topic in the field of artificial intelligence,in which distributed constraint optimization( DCOP) algorithms have been widely used to coordinate the actions of multiple agents. However,dense communication among agents affects the practicability of DCOP algorithms. In this paper,we propose a novel DCOP algorithm dealing with the previous DCOP algorithms' communication problem by reducing constraints.The contributions of this paper are primarily threefold:(1) It is proved that removing constraints can effectively reduce the communication burden of DCOP algorithms.(2) An criterion is provided to identify insignificant constraints whose elimination doesn't have a great impact on the performance of the whole system.(3) A constraint-reduced DCOP algorithm is proposed by adopting a variant of spectral clustering algorithm to detect and eliminate the insignificant constraints. Our algorithm reduces the communication burdern of the benchmark DCOP algorithm while keeping its overall performance unaffected. The performance of constraint-reduced DCOP algorithm is evaluated on four configurations of cooperative sensor networks. The effectiveness of communication reduction is also verified by comparisons between the constraint-reduced DCOP and the benchmark DCOP. | Yi Xie Zhongyi Liu Zhao Liu Yijun Gu | 2017 | Journal of Beijing Institute of Technology2017，26，4： | 0 |
| 17 | The combined effects of biomass and temperature on maximum specific ammonia oxidation rate in domestic wastewater treatment显示文摘Measurement and predicted variations of ammonia oxidation rate(AOR)are critical for the optimization of biological nitrogen removal,however,it is difficult to predict accurate AOR based on current models.In this study,a modified model was developed to predict AOR based on laboratoryscale tests and verified through pilot-scale tests.In biological nitrogen removal reactors,the specific ammonia oxidation rate(SAOR)was affected by both mixed liquor volatile suspended solids(MLVSS)concentration and temperature.When MLVSS increased 1.6,4.2,and 7.1-fold(1.3‒8.9 g/L,at 20℃),the measured SAOR decreased by 21%,49%,and 56%,respectively.Thereby,the estimated SAOR was suggested to modify when MLVSS changed through a power equation fitting.In addition,temperature coefficient(θ)was modified based on MLVSS concentration.These results suggested that the prediction of variations ammonia oxidation rate in real wastewater treatment system could be more accurate when considering the effect of MLVSS variations on SAOR. | Yukun Zhang Shuying Wang Shengbo Gu Liang Zhang Yijun Dong Lei Jiang Wei Fan Yongzhen Peng | 2021 | Frontiers of Environmental Science & Engineering2021，15，6： | 0 |
| 18 | White-light-emitting diodes using GaN-excited CdSe/CdS/ZnS quantum dots显示文摘Fluorescence-based white-light-emitting diodes(WLEDs) were fabricated using blue GaN chips and green- and red-emitting CdSe/CdS/ZnS quantum dots(QDs).The coordinate and color temperature of the WLEDs could be varied because of the size-tunable emission of CdSe QDs from 510 to 620 nm.Warm and cold white emissions were confirmed with the color temperature ranging from 4000 to 9000 K.Color coordinates were analyzed at different bias.The fast enhancement of blue emission resulted in the shift of color coordinates to the cold side.The stability of white emission during operation was analyzed;stable spectra were achieved within 90 min. | Yijun Lin Yu Zhang Jia Zhao Pengfei Gu Ke Bi Qiuran Zhang Hairong Chu Tieqiang Zhang Tian Cui Yiding Wang Jun Zhao William W.Yu | 2014 | Particuology2014，12，4： | 0 |
| 19 | 结构和机理揭示巨型拟菌病毒具有独特的类似Cas4蛋白显示文摘文章简介细菌和古细菌利用CRISPR系统抵制外来噬菌体DNA和其他入侵DNA,进而阻止感染。巨型拟菌病毒(mimiviruses)也利用类似CRISPR系统Mimivirus Virophage Resistance Element System(MIMIVIRE)系统抵制外来入侵者。核酸酶R354是MIMIVIRE系统的重要组成部分,分析表明其极可能和Cas4具有类似功能。 | Chao Dou Mingjing Yu Yijun Gu Jinjing Wang Kun Yin Chunlai Nie Xiaofeng Zhu Shiqian Qi Yuquan Wei 程伟 | 2019 | 科学新闻2019，0，2： | 0 |
| 20 | Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme显示文摘S-adenosyl-1-methionine(SAM)-dependent enzymes regulate various disease-related behaviors in all organisms.Recently,the leporin biosynthesis enzyme LepI,a SAM-dependent enzyme,was reported to catalyze pericyclic reactions in leporin biosynthesis;however,the mechanisms underlying LepI activation and catalysis remain unclear.This study aimed to investigate the molecular mechanisms of LepI.Here,we reported crystal structures of LepI bound to SAM/5′-deoxy-5′-(methylthio)adenosine(MTA),S-adenosyl-homocysteine(SAH),and SAM/substrate states.Structural and biochemical analysis revealed that MTA or SAH inhibited the enzyme activities,whereas SAM activated the enzyme.The analysis of the substrate-bound structure of LepI demonstrated that this enzymatic retro-Claisen rearrangement was primarily driven by three critical polar residues His133,Arg197,Arg295 around the active site and assisted by SAM with unclear mechanism.The present studies indicate that the unique mechanisms underlying regulatory and catalysis of the unusual SAM-dependent enzyme LepI,not only strengthening current understanding of the fundamentally biochemical catalysis,but also providing novel insights into the design of SAM-dependent enzyme-specific small molecules. | Qiu Sun Yuehong Hu Yijun Gu Jiangkun Huang Jun He Lan Luo Yi Yang Shuo Yin Chao Dou Tianqi Wang Xianghui Fu Ling He Shiqian Qi Xiaofeng Zhu Shengyong Yang Xiawei Wei Wei Cheng | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 0 |
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