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| 1 | Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210显示文摘Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events. | Xuelian Chen Lanying Ma Xi Wang Hongnan Mo Dawei Wu Bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu | 2019 | Cancer Biology & Medicine2019，16，1： | 53 |
| 2 | Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios. | Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，5： | 32 |
| 3 | Anti-fibrotic role and mechanism of Periplaneta americana extracts in CCl4-induced hepatic fibrosis in rats显示文摘 | Dingchun Li Wu Li Yihui Chen Lihui Liu Dehong Ma Hongtu Wang Lu Zhang Shenjun Zhao Qin Peng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 14 |
| 4 | Plasmacytoid Transitional Cell Carcinoma of Bladder: A Clinico-pathological Study and Review of Literatures显示文摘客观:学习血浆的病理学的特征,并且分析诊断特征,为鉴别诊断的标准和肿瘤的临床的意义膀胱的似细胞的过渡房间癌。方法:膀胱 plasmacytoidtransitional 房间癌的二个盒子被学习。平淡的石蜡节与他染色,由 S-P 方法的奶头油迹 andimmunohistochemistry 在一台轻显微镜下面被观察。病理学、临床的数据被比较在文学与早报导的案例分析。结果:这个肿瘤的 Acharacteristic 特征具有在薄板 propria 或 muscularispropria 的深侵略,除了在粘膜的原位癌的部件,当肿瘤被诊断时。组织学的模式和 cytological 特征显示出类似到 plasmacytoidtumor。肿瘤房间为 AE1/AE3, CEA 和 CK18 是强烈积极的。预后看起来比平常的过渡房间癌更坏。结论:血浆膀胱的似细胞的过渡房间癌是稀罕的,但是有典型病理学,免疫组织学、临床的特征。病理学家们应该知道膀胱的这种原发性瘤。 | FENG Xiaoli ZHANG Hongtu SUN Yuntian LIU Xiuyun | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，4： | 3 |
| 5 | Carbon and nitrogen pools in different aggregates of a Chinese Mollisol as influenced by long-term fertilization显示文摘 | Ying Chen Xudong Zhang Hongbo He Hongtu Xie Ying Yan Ping Zhu Jun Ren Lichun Wang | 2010 | Journal of Soils and Sediments2010，，6： | 3 |
| 6 | Synthesis of thermoresponsive polystyrene-based comb-type grafted poly(N-isopropylacrylamide)显示文摘Narrowly distributed polystyrene-g-p(N-isopropylacrylamide) (PSt-g-PNIPAM) was prepared by atom transfer radical polymerization (ATRP) of N-isopropylacrylamide using the brominated polystyrene as macroinitiator and CuCl combined with hexamethyltriethylenetetramine as catalyst. Fourier transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy confirmed the structure of PSt-g-PNIPAM. The gel permeation chromatography (GPC) showed that the graft copoly- mer had a single distribution peak with molecular weight, Mn (g/mol) of 19815 g/mol (using polystyrene as the standard). Differential scanning calorimetry (DSC) revealed that due to both effects of hydro- phobic isopropyl groups and hydrogen bonds in the amide group, the glass transition temperature (Tg) of PSt-g-PNIPAM enhanced 16.0 ℃ compared to the Tg of the polystyrene. | XU YaXin LI HongTu ZHANG Kai ZHANG Bao AI Peng WANG JingYuan | 2007 | Science China Chemistry2007，50，5： | 2 |
| 7 | Synchronous primary cancers of the endometrium and ovary: review of 43 cases显示文摘目的将调查子宫内膜和卵巢的同步原发癌的临床、病理学的特征,治疗方法,和预后。有子宫内膜和卵巢的同步原发癌的 43 个病人的临床的数据回顾地被考察的方法。幸存被 Kaplan-Meier 方法计算并且比较了使用木头等级测试。结果在诊断的病人的中部的年龄是 49 年(范围, 28 73 年) 。最普通的症状是反常阴道流血(69.8%) 并且腹或骨盆的疼痛(44.2%) 。骨盆的群众在 39.5% 病人被发现并且在药品检查在 27.9% 扩大了宫体,当骨盆的群众在 43 个病人(29 个案例) 中的 67.4% 个被发现并且变厚时或在 23.3% 的反常子宫内膜(10 个案例) 在超声检查期间。CT/MRI 检查的 25 个病人,骨盆的群众在 13 种情况中被发现并且在 11 种情况中扩大了子宫。经历了子宫内膜的活体检视的所有 15 个病人被证明有子宫内膜样癌。浆液 CA125 水平被发现与中部的价值在 34 个检验盒子(64.7%) 中的 22 个中被提高 500 U/mL (范围, 39 3439 U/mL ) 。子宫内膜的癌的 FIGO 阶段:IA 18 盒子, IB 20 盒子, IC 2 盒子,和 IIA 3 盒子;卵巢的癌的阶段:IA 19 大小写, IB 4 盒子, IC 7 盒子, II 4 盒子,和 IIIC 9 盒子。24 个病人(55.8%) 在舞台我子宫内膜、卵巢的癌。同时, 31 个病人与网膜切除术和阑尾切除术加双边的输卵管卵巢切除术经历了全部的子宫切除 12 个病人有骨盆的淋巴节点解剖。43 个病人(88.4%) 中的 38 个有一病理地证明的子宫内膜的腺癌。占优势的卵巢的组织学与子宫内膜样部件是子宫内膜样或混合瘤(30/43, 69.8%) 。手术后地, 26 个病人(60.5%) 独自收到了辅助化疗,加放射疗法的 12 有的化疗,仅仅一个病人有独自一个的放射并且留下 4 个盒子没收到辅佐疗法。这个组的 3 年、 5 年的幸存率分别地是 87.4% 和 71.1% 。有子宫内膜样癌在的病人的 3 年、 5 年的幸存率子宫内膜、卵巢比有 non-endometrioid 的那些的高或混合了 histologic 子类型(93.8% , 82% 对 79.7% , 69%) 。有早阶段疾病的病人的 3 年、 5 年的幸存率比另外的病人的那些好(93.3% , 93.3% 对 69.7% , 36.7%) 。复发在 15 个病人(34.9%) 发展了。它被降低加放射疗法的化疗显著地并且断然影响了的 CA125 水平,早 FIGO 阶段,和助手的 univariate 分析显示出 5 年的幸存评价,当加放射疗法的仅仅早的 FIGO 舞台和化疗被揭示由时多变量分析同样独立的预示的因素。子宫内膜和卵巢的结论同步原发癌与也不同主要子宫内膜或卵巢的癌症,当通常它能与好预后在早舞台被检测时。进一步的预后需要上的 CA125 水平的影响学习了。外科治疗可能独自为早阶段病人是足够的。化疗正放射疗法可能为先进病人是必要的。 | Shaokang Ma Hongtu Zhang Yangchun Sun Lingying Wu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，2： | 2 |
| 8 | Quantitative analysis of the tribological properties of phosphate glass at the nano- and macro-scales显示文摘Processing(grinding,polishing)of phosphate laser(PL)glass involves material removal at two vastly different(spatial)scales.In this study,the nano‐and macro‐tribological properties of PL glass are investigated by rubbing the glass against a SiO_(2) counter‐surface in both dry and humid conditions.The results indicate that the friction of the PL glass/SiO_(2) pair has opposing trends at the nano‐and macroscales.At the nanoscale,the friction coefficient(COF)in humid air is much higher than in dry air,which is attributed to the capillary effect of the absorbed water‐film at the interface.At the macroscale,on the other hand,the COF in humid air is lower than in dry air,because the water‐related mechanochemical wear makes the worn surface less susceptible to cracking.Material removal for PL glass is better facilitated by humid air than by dry air at both scales,because the stress‐enhanced hydrolysis accelerates the material‐removal process in glass.Moreover,the material‐removal is more sensitive to contact pressure at the macroscale,because stronger mechanical‐interaction occurs during material removal at the macroscale with the multi asperity contact mode.At the macroscale,the material removal is more sensitive to contact pressure in humid air compared to dry air.Because almost all mechanical energy is used to remove material in humid air,and most of the mechanical energy is used to produce cracks in PL glass in dry air.The results of this study can help optimize the multi‐scale surface processing of optical glasses. | Huimin QI Wen HU Hongtu HE Yafeng ZHANG Chenfei SONG Jiaxin YU | 2021 | Friction2021，9，5： | 1 |
| 9 | Jingyuan Wang Synthesis and characterization of nanocomposites of silicon dioxide and polyurethane and epoxy resin interpenetrating network显示文摘 | Hongwen Zhang Bing Wang Hongtu Li | 2003 | Polymer International2003，52，9： | 1 |
| 10 | Synthesis and characterizationg of nanocomposites of silicon dioxide and polyurethane and epoxy resin interpenetrating network显示文摘 | Zhang Hongwen Wang Bing Li Hongtu | 2003 | Polymer International2003，52，9： | 1 |
| 11 | Temporal responses of soil microorganisms to substrate addition as indicated by amino sugar differentiation显示文摘 | Hongbo He Wei Zhang Xudong Zhang Hongtu Xie Jie Zhuang | 2011 | Soil Biology and Biochemistry2011，，6： | 1 |
| 12 | Relationships of soil physical and microbial properties with nitrous oxide emission affected by freeze-thaw event显示文摘 | Lianfeng Wang Xin Sun Yanjiang Cai Hongtu Xie Xudong Zhang | 2008 | Frontiers of Agriculture in China2008，，3： | 1 |
| 13 | Synthesis and characterization of nanocomposites of silicon dioxide and polyurethane and epoxy resin interpenetrating network显示文摘 | Zhang Hongwen Wang Bing Li Hongtu | 2003 | Polymer International2003，52，9： | 1 |
| 14 | Interactive effects of elevated CO2 and nitrogen fertilization levels on photosynthesized carbon allocation in a temperate spring wheat and soil system显示文摘Increasing atmospheric CO2 concentration impacts the terrestrial carbon(C) cycle by affecting plant photosynthesis, the flow of photosynthetically fixed C belowground, and soil C pool turnover. For managed agroecosystems, how and to what extent the interactions between elevated CO2 and N fertilization levels influence the accumulation of photosynthesized C in crops and the incorporation of photosynthesized C into arable soil are in urgent need of exploration.We conducted an experiment simulating elevated CO2 with spring wheat(Triticum aestivum L.) planted in growth chambers.13C-enriched CO2 with an identical 13C abundance was continuously supplied at ambient and elevated CO2 concentrations(350 and 600 μmol mol-1, respectively) until wheat harvest.Three levels of N fertilizer application(equivalent to 80, 120, and 180 kg N ha-1 soil) were supplied for wheat growth at both CO2 concentrations. During the continuous 62-d 13CO2 labeling period, elevated CO2 and increased N fertilizer application increased photosynthesized C accumulation in wheat by 14%–24% and 11%–20%, respectively, as indicated by increased biomass production, whereas the C/N ratio in the roots increased under elevated CO2 but declined with increasing N fertilizer application levels. Wheat root deposition induced 1%–2.5% renewal of soil C after 62 d of 13CO2 labeling. Compared to ambient CO2, elevated CO2 increased the amount of photosynthesized C incorporated into soil by 20%–44%. However, higher application rates of N fertilizer reduced the net input of root-derived C in soil by approximately 8% under elevated CO2. For the wheat-soil system, elevated CO2 and increased N fertilizer application levels synergistically increased the amount of photosynthesized C. The pivotal role of plants in photosynthesized C accumulation under elevated CO2 was thereby enhanced in the short term by the increased N application. Therefore, robust N management could mediate C cycling and sequestration by influencing the interactions between plants and soil in agroecosystems under elevated CO2. | Yu ZHAO Chao LIANG Shuai SHAO Jie LI Hongtu XIE Wei ZHANG Fusheng CHEN Hongbo HEI Xudong ZHANG | 2021 | Pedosphere2021，31，1： | 1 |
| 15 | Synthesis and characterization of nanocomposites of silicon dioxide and polyurethane and epoxy resin interpenetrating network显示文摘 | Hongwen Zhang Bing Wang Hongtu Li | | 0，，： | 1 |
| 16 | Dynamics of fertilizer-derived organic nitrogen fractions in an arable soil during a growing season显示文摘 | Huijie Lü Hongbo He Jinsong Zhao Wei Zhang Hongtu Xie Guoqing Hu Xiao Liu Yeye Wu Xudong Zhang | 2013 | 2013 (1-2)2013，，1： | 1 |
| 17 | 乳腺癌前哨淋巴结微小转移的检测(英文)显示文摘Objective: To study the best examination method of micrometastases in sentinel lymph node (SLN) of breast cancer and study the related factors with micrometastases. Methods: By step serial sectioning technique and immunohisto- chemistry, 121 SLNs and 44 tumors of 59 cases were examined. Results: Micrometastases was found in 17 SLNs (14%) of 14 (24%) cases. The more sections or examination methods, the more micrometastases were found. Micrometastases was related with the tumor size and the expression of c-erbB2, MMP-2 and VEGF. Conclusion: The best examination method is making sections at two levels with 100 μm interval and combination of HE staining and muc1 immunohistochemistry. We can get the excellent detection/cost by this method. Micrometastases is a bad prognostic factor. | Tao Zhang Baoning Zhang Baoping Chen Xiliang Wei Hongtu Zhang Yuntian Sun | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，6： | 1 |
| 18 | Dynamics of fertilizer-derived organic nitrogen fractions in an arable soil during a growing season显示文摘 | Huijie Lü Hongbo He Jinsong Zhao Wei Zhang Hongtu Xie Guoqing Hu Xiao Liu Yeye Wu Xudong Zhang | 2013 | Plant and Soil (-)2013，，1： | 1 |
| 19 | 探讨粒细胞肉瘤的诊断与鉴别诊断(英文)显示文摘Objective:To discuss the diagnosis and differential diagnosis of granulocytic sarcoma(GS).Methods:Six cases were reported in this paper.They were assessed by pathologists.Immunohistochemistry(IHC) stain and routine hematoxylin and eosin(H&E) stain were applied.Results:All patients involved in different anatomic sites respectively including skin,lymph node,soft tissue,breast,cervix and penis.All cases were previously error diagnoses.Three of them were initially diagnosed as non-Hodgkin lymphoma(NHL).One case of cervical lymph node lesion was first considered as metastasized carcinoma by clinician.One biopsied skin sample was initially reported as Karposi's sarcoma.And one breast case was suspicious of the lobular carcinoma with the frozen samples without antecedent clinical history information.GS was accompanied with acute myeloid leukemia(AML) in one case and with acute lymphocytic leukemia(ALL) in one case.Histopathologically,blastic,immature and differentiated variants were found in four,one and one,respectively.Immunohistochemistry(IHC) showed that myeloperoxidase(MPO) and lysozyme were both found to be positive in all cases,CD43 was found in 5 of 6 cases.Three of six cases were CD68,CD15 and LCA positive.CD34 and CD117 were positive in 1/5 and 1/6 cases,respectively.However,CD20 and CD3 were negative in all cases.Conclusion:GS was uncommon and it may be misdiagnosed easily in routine practice.Each area had its own character,but they had the common features too.It can be correctly diagnosed by combination of H&E stain,IHC stain,peripheral blood and bone marrow.MPO and Lysozyme were necessary for the nature of granulocytes.In addition,CD43,CD68 and CD15 were very helpful. | Xiaoli Feng Jianming Ying C. Cameron Yin Ling Li Susheng Shi Hongtu Zhang Yuntian Sun | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，10： | 0 |
| 20 | CD10,Bcl-6,CD138,Bcl-2,MUM1在136例弥漫大B细胞淋巴瘤中的表达及预后意义(英文)显示文摘Objective: We evaluated the value of using a panel of GC B-cell (CD10 and Bcl-6) and activation (MUM1, CD138 and Bcl-2) markers by immunohistochemistry to define prognosis in patients with diffuse large B-cell lymphoma (DLBCL). Methods: Two different models (Hans’ and modified Chang’s model) were applied on 136 de novo DLBCL patients. Median follow-up in all patients was 39 months (range 5–80 months). Results: According to Hans’ model, patients with GCB had much better overall survival (5-year OS, 75%) than those with non-GCB (5-year OS, 52%) (Kaplan-Meier survival analysis, P < 0.05, log rank test). According to modified Chang’s model, patients with group 1 had much better overall survival (5-year OS, 78%) than those with group 3 (5-year OS, 44%) while group 2 had no significant value compared with group 1 and group 3 in prognosis (Kaplan-Meier survival analysis, P < 0.05, log-rank test). Using multivariate Cox proportional hazards regression analysis, the international prognostic index scores (IPI), expression of CD138 and the expression pattern of modified Chang’s model were independent prognostic indicators. Conclusion: Our results suggest that the expression patterns of the panel of GCB-cell and activation markers by immunohistochemistry correlate with prognosis of patients with DLBCL and both models can be used well in ordinary work. | Yan Song Zhi Cao Qin Su Ling Li Hongtu Zhang Yuankai Shi Xun Zhang | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，10： | 0 |
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