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| 1 | Effect of oxidization on enrichment behavior of TiO_2 in titanium-bearing slag显示文摘Due to the dispersed distribution of the titanium component in various mineral phases and very fine grain size, it is difficult to recover the titanium component from the slag. In order to utilize titanium resources, selective enriching and selective growing of the titanium component from the molten slag is expected. In this paper, the selection of the best tita- nium enrichment phase and the effect of oxidization on the enrichment of titanium by blowing air into the molten slag were studied. The results showed that through oxidizing the slag, the content of the perovskite phase increases while that of the other titanium-bearing mineral phases decreases until they disappear. Most titania resources were enriched into the perovskite phase and increase in size. The process of enrichment and growth is easily carried out. | WANG Mingyu LI Liaosha ZHANG Li ZHANG Linnan TU Ganfeng SUI Zhitong | 2006 | Rare Metals2006，25，2： | 23 |
| 2 | IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis显示文摘Macrophages acquire distinct phenotypes during tissue stress and inflammatory responses.Macrophages are roughly categorized into two different subsets named inflammatory M1 and anti-inflammatory M2 macrophages.We herein identified a unique pathogenic macrophage subpopulation driven by IL-23 with a distinct gene expression profile including defined types of cytokines.The freshly isolated resting mouse peritoneal macrophages were stimulated with different cytokines in vitro,the expression of cytokines and chemokines were detected by microarray,real-time PCR,ELISA and multiple colors flow cytometry.Adoptive transfer of macrophages and imiquimod-induced psoriasis mice were used.In contrast to M1-and M2-polarized macrophages,IL-23-treated macrophages produce large amounts of IL-17A,IL-22and IFN-γ.Biochemical and molecular studies showed that IL-23 induces IL-17A expression in macrophages through the signal transducer and activator of transcription 3(STAT3)-retinoid related orphan receptor-γ T (RORyT)pathway.T-bet mediates the IFN-γ production in IL-23-treated macrophages.Importantly,IL-23-treated macrophages signifi- cantly promote the dermatitis pathogenesis in a psoriasis-like mouse model.IL-23-treated resting macrophages express a distinctive gene expression prolife compared with M1 and M2 macrophages.The identification of IL-23-induced macrophage polarization may help us to understand the contribution of macrophage subpopulation in Th17-cytokines-related pathogenesis. | Yuzhu Hou Linnan Zhu Hongling Tian Hai-Xi Sun Ruoyu Wang Lianfeng Zhang Yong Zhao | 2018 | Protein & Cell2018，9，12： | 16 |
| 3 | Fluid Inclusion and H-O Isotope Geochemistry of the Phapon Gold Deposit, NW Laos: Implications for Fluid Source and Ore Genesis显示文摘The Phapon gold deposit, located in northern Laos, is a unique large-scale gold deposit in Luang Prabang-Loei metallogenic belt. It is hosted in the Lower Permian limestone and controlled by a NE-trending ductile-brittle fault system. There are three types of primary ore including auriferous calcite vein type, disseminated type, and breccia type, and the first two are important in the Phapon gold deposit. Based on fluid inclusion petrography and microthermometry, three types of primary fluid inclusions including type 1 liquid-rich aqueous, type 2 vapor-rich aqueous and type 3 daughter mineralbearing aqueous were identified in hydrothermal calcite grains. The ore-forming fluids are normally homogeneous, as indicated by the widespread type 1 inclusions with identical composition. The coexistence of type 1 and type 2 inclusions, showing similar final homogenization temperature but different compositions, indicate that fluid immiscibility did locally take place in both two types of ores. The results of microthermometry and H-O isotopes geochemistry indicate that there are little differences on ore-fluid geochemistry between the auriferous calcite vein-type and disseminated type ores. The oreforming fluids are characterized by medium-low temperatures(157–268 oC) and low salinity(1.6 wt.%–9.9 wt.% NaCl eq.). It is likely to have a metamorphic-dominant mixed source, which could be associated with dehydration and decarbonisation of Lower Permian limestone and Middle–Upper Triassic sandstones during the dynamic metamorphism. The fluid-wallrock interaction played a major role, and the locally occurred fluid-immiscible processes played a subordinate role in gold precipitation. Combined with the regional and ore deposit geology, and ore-fluid geochemistry, we suggest that the Phapon gold deposit is best considered to be a member of the epizonal orogenic deposit class. | Linnan Guo Shusheng Liu Lin Hou Jieting Wang Meifeng Shi Qiming Zhang Fei Nie Yongfei Yang Zhimin Peng | 2019 | Journal of Earth Science2019，30，1： | 11 |
| 4 | Characterization and allergic role of IL-33-induced neutrophil polarization显示文摘Neutrophils are involved in the pathogenesis of allergy.However,the contribution of the different functionally polarized neutrophils in allergy needs to be clarified.We sought to define the characteristics of interleukin(IL)-33-induced neutrophils and the involvement of this subset of polarized neutrophils in allergic pathogenesis.Freshly isolated neutrophils were treated with different cytokines and the cytokine expression levels were detected by realtime PCR.The gene expression profile of IL-33-induced neutrophils was determined by microarray assay.Adoptive transfer assay was used to investigate the function of IL-33-induced neutrophils in an ovalbumin(OVA)-induced allergic asthma model.IL-33-treated neutrophils selectively produced IL-4,IL-5,IL-9 and IL-13(referred as to N(IL-33)cells)and displayed a distinctive gene expression profile in sharp contrast to resting and lipopolysaccharide(LPS)-treated neutrophils.IL-33-induced neutrophils expressed high Levels of IL-1R2 on cell surface,whereas resting and LPS-treated neutrophils did not,indicating IL-1R2 might be used as a biomarker for N(IL-33)cells.Importantly,N(IL-33)neutrophils exist in the lungs of OVA-induced allergic asthma mice.Adoptive transfer of N(IL-33)neutrophils significantly promotes the severity of the lung pathogenesis in this model.IL-33 induces neutrophil polarization through c-Jun N-terminal kinase-and nuclear factor-κB-dependent pathways.A previously unappreciated neutrophil polarization driven by IL-33 with unique cell surface markers and cytokine/chemokineproducing gene profile was defined.The newly identified N(IL-33)subpopulation may have significant contribution to IL-33-related pathogenesis. | Bo Sun Linnan Zhu Yaling Tao Hai-Xi Sun Yang Li Peng Wang Yuzhu Hou Yang Zhao Xiaodong Zhang Lianfeng Zhang Ning Na Yong Zhao | 2018 | Cellular & Molecular Immunology2018，15，8： | 9 |
| 5 | The Formation of the Jiaodong Gold Province显示文摘Gold deposits in Jiaodong,termed Jiaodong-type,are tectonically located in the southeastern margin of the North China Craton.Their major features are reviewed in this paper to highlight the differences between Jiaodong deposits and other genetic types of gold deposits.The mineralization was synchronized with asthenosphere upwelling indicated by synore OIB-like mafic dike and large-scale crustal thinning suggested by decrease of Sr/Y from pre-ore to syn-ore granites.Asthenosphere upwelling induced by the roll-back of Paleo-Pacific Plate drove partial melting of lithospheric mantle and devolatilization,which induced the release of the ore-forming fluids.In concomitant with magmatic records,mineralization migrated from the western Jiaobei terrane(133–127 Ma)to the eastern Sulu orogenic belt(114–108 Ma),corresponding to the eastward roll-back of Paleo-Pacific Plate.Gold mineralization in Jiaodong formed in the transitions of ductile to brittle deformation,rapid to slow crustal uplift,and regional compression to extension.In the regional-scale,the gold deposits in the Jiaobei terrane are mostly situated at intersections between NE-trending faults and EW-trending basement faults,and gold orebodies dominantly controlled by the lithologic contacts between Precambrian metamorphic rocks and Mesozoic granites.The mineralization was dominated by the disseminated-veinlet ores related to quartz–sericite alteration in strong cataclasite-breccia zone,with subsidiary thick quartz-sulfide veins developed in secondary fault zones.The ore-forming fluids belong to a H_(2)O–CO_(2)–NaCl±CH_(4)system and show minor variations in salinity among different types of ore.Structure-fluid feedback involving fluid-rock reaction and hydrofracturing triggered the fluid phase separation and resultant gold deposition.The Jiaodong gold deposits are distinct from orogenic and intrusion-related gold deposits in terms of tectonic setting,origin of ore-forming fluids,and mechanism of gold deposition. | DENG Jun WANG Qingfei LIU Xuefei ZHANG Liang YANG Liqiang YANG Lin QIU Kunfeng GUO Linnan LIANG Yayun MA Yao | 2022 | Acta Geologica Sinica(English Edition)2022，96，6： | 7 |
| 6 | TSC1 controls IL-1β expression in macrophages via mTORCl-dependent C/EBPβ pathway显示文摘 | Tao Yang Linnan Zhu Yanhua Zhai Qingjie Zhao Jianxia Peng Hongbing Zhang Zhongzhou Yang Lianfeng Zhang Wenjun Ding Yong Zhao | 2016 | Cellular & Molecular Immunology2016，13，5： | 3 |
| 7 | Characterization and biological significance of IL-23-induced neutrophil polarization显示文摘Neutrophils are heterogeneous with distinct subsets,and can switch phenotypes to exert regulatory functions on immunity.We herein demonstrate that IL-23-treated neutrophils selectively produce IL-17A,IL-17F and IL-22,and display a distinct gene expression profile in contrast to resting and lipopolysaccharide-treated neutrophils.IL-17+neutrophils are present in the colons of mice with dextran sulfate sodium-induced colitis.Adoptive transfer of IL-23-treated neutrophils significantly promotes pathogenesis in this model.IL-23 induces neutrophil polarization through STAT3-dependent RORγt and BATF pathways.Thus,IL-23-induced neutrophil polarization expresses a unique cytokine-producing profile,which may contribute to IL-23-mediated inflammatory diseases. | Yang Li Linnan Zhu Zhulang Chu Tao Yang Hai-Xi Sun Fan Yang Wei Wang Yuzhu Hou Peng Wang Qingjie Zhao Yaling Tao Lianfeng Zhang Xiaodong Zhang Yong Zhao | 2018 | Cellular & Molecular Immunology2018，15，5： | 3 |
| 8 | FT5a interferes with the Dt1-AP1 feedback loop to control flowering time and shoot determinacy in soybean显示文摘Flowering time and stem growth habit determine inflorescence architecture in soybean, which in turn influences seed yield. Dt1, a homolog of Arabidopsis TERMINAL FLOWER 1(TFL1), is a major controller of stem growth habit, but its underlying molecular mechanisms remain unclear.Here, we demonstrate that Dt1 affects node number and plant height, as well as flowering time,in soybean under long-day conditions. The b ZIP transcription factor FDc1 physically interacts with Dt1, and the FDc1-Dt1 complex directly represses the expression of APETALA1(AP1). We propose that FT5 a inhibits Dt1 activity via a competitive interaction with FDc1 and directly upregulates AP1. Moreover, AP1 represses Dt1 expression by directly binding to the Dt1 promoter, suggesting that AP1 and Dt1 form a suppressive regulatory feedback loop to determine the fate of the shoot apical meristem. These findings provide novel insights into the roles of Dt1 and FT5 a in controlling the stem growth habit and flowering time in soybean, which determine the adaptability and grain yield of this important crop. | Lin Yue Xiaoming Li Chao Fang Liyu Chen Hui Yang Jie Yang Zhonghui Chen Haiyang Nan Linnan Chen Yuhang Zhang Haiyang Li Xingliang Hou Zhicheng Dong James LWeller Jun Abe Baohui Liu Fanjiang Kong | 2021 | Journal of Integrative Plant Biology2021，63，6： | 3 |
| 9 | Mechanism of combination membrane and electro-winning process on treatment and remediation of Cu^(2+) polluted water body显示文摘Mechanism of treatment and remediation of synthetic Cu2+ polluted water body by membrane and electro-winning combination process was investigated.The influences of electrolysis voltage,pH,and electrolysis time on the metal recovery effciencies were studied.Relationship between trans-membrane pressure drop(△P),additions ratio,initial Cu2+ concentration on operating effciency,stability of membrane and the possibility of water reuse were also investigated.The morphology of membrane and electrodes were observed using scanning electron microscopy(SEM),the composition of surface deposits was ascertained using combined energy dispersive X-ray spectroscopy(EDX) and atomic absorption spectrophotometer.The results showed that using low pressure reverse osmosis(LPRO),Cu2+ concentration could increase from 20 to 100 mg/L or even higher in concentrated solutions and permeate water conductivity could be less than 20 μS/cm.The addition of sodium dodecy/sulfate sodium dodecyl sulfate improved Cu2+ removal effciency,while EDTA had little side influence.In electro-reduction process,using plante electrode cell,Cu2+ concentration could be further reduced to 5 mg/L,and the average current effciency ranged from 9% to 40%.Using 3D electrolysis treatment,Cu2+ concentration could be reduced to 0.5 mg/L with a current effciency range 60%-70%. | ZHANG Linnan WU Yanjun QU Xiaoyan LI Zhenshan NI Jinren | 2009 | Journal of Environmental Sciences2009，21，6： | 3 |
| 10 | Geology, Geochronology, and Hf Isotopic Composition of the Pha Lek Fe Deposit, Northern Laos: Implications for Early Permian Subduction-Related Skarn Fe Mineralization in the Truong Son Belt显示文摘The Truong Son metallogenic belt in central Laos and Vietnam is an important Fe-Cu-Sn-Au polymetallic ore district. The Pha Lek Fe deposit is closely related to Late Carboniferous– Early Permian I-type granitic magmatism, and contains >50 Mt @ 45% to 50% of Fe ore. Ore minerals occur mainly as magnetite and hematite in the skarn alteration zone between a granitic pluton and metamorphosed Middle–Upper Devonian carbonates. The granitic pluton comprises granodiorite and granite, with zircon U-Pb dating indicating synchronous emplacement at 288.2±1.3 and 284.9±1.2 Ma, respectively. Zircons from these granitoids have ε_(Hf)(t) values of 2.9–11.2 and relatively young TDM2 ages(<1.0 Ga), indicating an origin by partial melting of depleted mafic crust or magma mixing. Previous studies have shown that these granitoids have high Y, Yb, and K_2O contents, and low Sr and Na_2O contents, which are interpreted as the melting of mafic continental crust. Pyrite of the main mineralization stage yields an ^(187)Re/^(188)Os-^(187)Os/^(188)Os isochron age of 287±17 Ma, indicating that mineralization is associated with Pha Lek granitic magmatism. A Late Carboniferous–Early Permian subduction-related skarn-type Fe mineralization model is proposed for the Pha Lek deposit. More evidence is needed to verify a hypothesis of volcanic overprinting during Late Triassic post-collisional extension. | Lin Hou Shusheng Liu Linnan Guo Fuhao Xiong Chao Li Meifeng Shi Qiming Zhang Siwei Xu Songyang Wu | 2019 | Journal of Earth Science2019，30，1： | 2 |
| 11 | A multifunctional biomedical patch based on hyperbranched epoxy polymer and MXene显示文摘Biomedical patches play fundamental roles in various applications such as wound closure and tissue regeneration.The hybrid patches integrating versatile properties will prominently improve the therapeutic effects in clinical applications.Herein,an epoxy network loading curcumin and Ti3 C2 TxMXenes were developed as a hybrid biomedical patch.The hybrid patch was basically prepared through an epoxy/thiol curing chemistry,and its topological structure can be destructed and rearranged as a vitrimer does due to the active transesterification at high temperature.The resulted hybrid patch exhibits shape-morphing capability,multi-substrate adhesion,self-healing ability,and photothermal effects under 980 nm near infrared(NIR).Additionally,the asprepared hybrid patch possesses strong UV-shielding,excellent oxidation resistance(ROS scavenging efficiency was 89.3%in3 min),highly effective antibacterial vitality(more than 99%)against S.aureus and E.coli,and good cytocompatibility.As a proof of concept,the present multifunctional hybrid patch broadens the potential applications in the biomedical field. | ZOU Yang JIN Xin ZHANG XiaoPing KONG XiaoLing ZHANG Qian XIE XianHua LIU ChangJun KE LinNan LIU WenGuang WANG Wei | 2021 | Science China(Technological Sciences)2021，64，12： | 2 |
| 12 | Influence of nanometric CeO_2 coating on high temperature oxidation of Cr显示文摘铬和它的表面上应用的 nanometric CeO 2 样品的等温、周期的氧化行为在空中在 900 ° C 被学习。扫描电子显微镜学,(SEM ) ,传播电子显微镜学(TEM ) 和高分辨率电子显微镜学(HREM ) 被用来检验氧化物电影的形态学和微观结构。ceria 增加极大地在等温、周期的氧化实验两个都改进了 Cr 的反氧化能力,这被发现。声学的排放(AE ) 技术在裂开和氧化物的 spalling 拍摄的 situto 监视器被使用,并且 AE 信号根据相关氧化物破裂模型的意见在时间域和数字域被分析。激光拉曼分光计也被用来学习有或没有 ceria 在 Cr 上形成的氧化物电影的压力地位。为在铬的反氧化的改进的主要原因是 ceria 极大地减少了成长速度和 Cr 2 O 3 。这有细密纹理的 Cr 2 O 3 氧化物电影可能有更好高的温度粘性并且能借助于爬减轻压缩应力的部分,并且维持山脉特性和相对低的内部压力水平。同时, ceria 申请减少了尺寸和界面的缺点的数字,当显著地提高了时 Cr 2 在 Cr 上形成的 O 3 氧化物规模底层。 | Jin Huiming Zhang Linnan Liu Xiaojun | 2007 | Progress in Natural Science:Materials International2007，17，5： | 2 |
| 13 | Influence of Nanometric Ceria Coating on Oxidation Behavior of Chromium at 900 °C显示文摘 | Jin Huiming Liu Xiaojun Zhang Linnan | 2007 | Journal of Rare Earths2007，，1： | 1 |
| 14 | Comparison of different quantitative PCR procedures in the analysis of the 4977-bp deletion in human mitochondrial DNA显示文摘 | Zhang C F Peters L E Linnane A W | 1996 | Biochem Biophy Res Commun1996，233，： | 1 |
| 15 | The improved blood–brain barrier permeability of endomorphin-1 using the cell-penetrating peptide synB3 with three different linkages显示文摘 | Hui Liu Wei Zhang Linnan Ma Linlan Fan Feiyun Gao Jingman Ni Rui Wang | 2014 | International Journal of Pharmaceutics . 2014 (1-2)2014，，： | 1 |
| 16 | Human aging and global function of coenzyme Q10 显示文摘 | Linnane AW Zhang CF Yarovaya N | 2002 | Ann NY Acad Sci2002，959，： | 1 |
| 17 | Occurrence of a parti-cular base substution (3243A to G)in mitochondrial DNA of tissues of ageing in humans显示文摘 | Linnane AW Nagley P | 1993 | Biochem Biophys Res Commun1993，195，： | 1 |
| 18 | Enhanced bone regenerative properties of calcium phosphate ceramic granules in rabbit posterolateral spinal fusion through a reduction of grain size显示文摘Osteoinductivity is a crucial factor to determine the success and efficiency of posterolateral spinal fusion(PLF)by employing calcium phosphate(Ca-P)bioceramics.In this study,three kinds of Ca-P ceramics with microscale to nanoscale gain size(BCP-control,BCP-micro and BCP-nano)were prepared and their physicochemical properties were characterized.BCP-nano had the spherical shape and nanoscale gain size,BCP-micro had the spherical shape and microscale gain size,and BCP-control(BAM®)had the irregular shape and microscale gain size.The obtained BCP-nano with specific nanotopography could well regulate in vitro protein adsorption and osteogenic differentiation of MC3T3 cells.In vivo rabbit PLF procedures further confirmed that nanotopography of BCP-nano might be responsible for the stronger bone regenerative ability comparing with BCP-micro and BCP-control.Collectedly,due to nanocrystal similarity with natural bone apatite,BCP-nano has excellent efficacy in guiding bone regeneration of PLF,and holds great potentials to become an alternative to standard bone grafts for future clinical applications. | Xiangfeng Li Quan Zhou Yonghao Wu Cong Feng Xi Yang Linnan Wang Yumei Xiao Kai Zhang Xiangdong Zhu Limin Liu Yueming Song Xingdong Zhang | 2022 | Bioactive Materials2022，7，5： | 0 |
| 19 | Characterization of dendritic cell subtypes in human cord blood by single-cell sequencing显示文摘Dendritic cells(DCs)are professional antigen-presenting cells(APCs).The key functions of DCs include engulfing,processing and presenting antigens to T cells and regulating the activation of T cells.There are two major DC subtypes in human blood:plasmacytoid DCs(pDCs)and conventional DCs.To define the differences between the adult and infant immune systems,especially in terms of DC const让ution,we enriched DCs from human cord blood and generated single-cell RNA sequencing data from about 7000 cells using the lOx Genomics Single Cell 3'Solution.After incorporating the differential expression analysis method in our clustering process,we identified all the known dendritic cell subsets.Interestingly,we also found a group of DCs with gene expression that was a mix of megakaryocytes and pDCs.Further;we verified the expression of selected genes at both the RNA level by PCR and the protein level by flow cytometry.This study further demonstrates the power of single-cell RNA sequencing in dendritic cell research. | Xiaoyang Jin Lingyuan Meng Zhao Yin Haisheng Yu Linnan Zhang Weifeng Liang Shouli Wang Guanyuan Liu Liguo Zhang | 2019 | Biophysics Reports2019，5，4： | 0 |
| 20 | Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients显示文摘Rapidly spreading coronavirus disease 2019(COVID-19)is currently affecting the world.Specifically,cytokine storms are a key feature in a substantial num ber of COVID-19 patients,1 and studies from our group and others suggest that the IL-6/IL-6R cascade plays a dom inant role in symptom-correlated cytokine storms. | Penghui Yang Yingze Zhao Jie Li Chuanyu Liu Linnan Zhu Jie Zhang Yeya Yu Wen-Jing Wang Guanglin Lei Jin Yan Fang Sun Chengrong Bian Fanping Meng Zhe Xu Changqing Bai Beiwei Ye Yuanyuan Guo Liumei Shu Xiaoju Yuan Ning Zhang Yuhai Bi Yi Shi Guizhen Wu Shaogeng Zhang George F.Gao Longqi Liu William J.Liu Hai-Xi Sun | 2021 | Cellular & Molecular Immunology2021，18，4： | 0 |
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