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| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | Negative association of time in range and urinary albumin excretion rate in patients with type 2 diabetes mellitus:a retrospective study of inpatients显示文摘Background:Time in range(TIR)refers to the time an individual spends within their target glucose range,which now has been popularized as an important metric to classify glycemic management and also recognized as an important outcome of current diabetes therapies.This study aimed to investigate the association between TIR and the severity of the urinary albumin excretion rate(UAER)in patients with type 2 diabetes mellitus(T2DM).Methods:We retrospectively analyzed the data of 1014 inpatients with T2DM at the Department of Endocrinology and Metabolism of Peking University International Hospital,China.TIR was defined as the percentage of blood glucose within the target range of 3.90-10.00 mmol/L.Urine samples for assessment of UAER were collected for 3 consecutive days from the start of hospitalization.Results:The TIR values for patients with normal urine levels of albumin,microalbuminuria,and macroalbuminuria were 70%±20%,50%±20%,and 30%±20%,respectively(allP<0.001).The patients were stratified according to quartiles of TIR as follows:quartile(Q)1,<55%;Q2,55%-72%;Q3,73%-83%;and Q4,>83%.The incidences of microalbuminuria in Q1,Q2,Q3,and Q4 were 41.1%,21.6%,7.1%,and 5.5%(allP<0.001),respectively.The respective incidences of macroalbuminuria were 24.2%,1.1%,1.4%,and 0%(allP<0.001).In multinomial logistic regression analyses,TIR was significantly correlated with microalbuminuria(odds ratio[OR]0.58,95%confidence interval[CI]:0.52-0.65,P<0.001)and macroalbuminuria(OR 0.26,95%CI:0.18-0.38,P<0.001)after adjusting for age,sex,body mass index,diabetes duration,systolic blood pressure,and levels of triglycerides,glycosylated hemoglobin A1c,and creatinine.Conclusion:The proportion of blood glucose in TIR is closely related to the severity of UAER in patients with T2DM. | Sanbao Chai Shanshan Wu Sixu Xin Ning Yuan Jianbin Sun Xiaomei Zhang Linong Ji | 2022 | Chinese Medical Journal2022，，9： | 3 |
| 3 | Cardiovascular safety and glycemic control of glucagon-like peptide-1 receptor agonists for type 2 diabetes mellitus: A pairwise and network meta-analysis显示文摘 | Feng Sun Kai Yu Shanshan Wu Yuan Zhang Zhirong Yang Luwen Shi Linong Ji Siyan Zhan | 2012 | Diabetes Research and Clinical Practice2012，，3： | 1 |
| 4 | Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study): A Nationwide, Multicenter, Clinic-Based Cross-Sectional Study显示文摘 | Zhou Zhiguang Xiang Yufei Ji Linong Jia Weiping Ning Guang Huang Gan Yang Lin Lin Jian Liu Zhenqi Hagopian William A Leslie R David | 2013 | Diabetes2013，，2： | 1 |
| 5 | First in- sulinization with basal insulin in patients with Type 2 di- abetes in a real-world setting in Aisa显示文摘 | Shih-Tzer TSAI Faruque PATHAN Linong JI | 2011 | J Diabetes2011，3，： | 1 |
| 6 | Prevalence of diabetes among menand women in China显示文摘 | Yang Wenying Lu Juming Weng Jianping Jia Weiping Ji Linong Xiao Jianzhong Shan Zhongyan Liu Jie Tian Ha- oming Ji Qiuhe Zhu Dalong Ge Jiapu Lin Lixiang Chen Li Guo Xiaohui Zhao Zhigang Li Qiang Zhou Zhiguang Shan Guangliang He Jiang | 2010 | N Engl J Med2010，362，： | 1 |
| 7 | Prevalence and associated factors of obstructive sleep apnea in hospitalized patients with type 2 diabetes in B eijing, C hina 对中国北京住院2型糖尿病患者的阻塞性睡眠呼吸暂停患病率的调查与相关因素分析显示文摘 | Rui Zhang Xiaohui Guo Lixin Guo Juming Lu Xianghai Zhou Linong Ji | 2015 | Journal of Diabetes2015，，： | 1 |
| 8 | Epigenetic Disorder Plays a Fundamental Role in the Etiology of Type 2 Diabetes显示文摘Type 2 diabetes (T2D) is now considered a pandemic noncommunicable disease, and the prevalence is still increasing steadily worldwide. Several lines of evidence, including T2D, is an aging-related disease, and the phenomenon of the metabolic memory and developmental origins of adult diabetes argues that epigenetic disorder plays critical roles in the development of T2D. Environmental factors can affect epigenetics during early fetal life until adulthood. Altered epigenetics can be maintained during mitosis and meiosis, so that the subsequent response to environmental cue in later life has also been altered. Epigenetic aberra-tions affect miRNA expression and functions, and altered miRNA expression can also affect expression of many genes including those relevant to epigenetics. Thus, the development of T2D is an accumulative process that may involve complex interactions between altered transcription factors, miRNA functions, and increased epigenetics disorder in response to environmental stimuli during different stages of life. | ZHANG Junlong XIAO Xinhua JI Linong | 2013 | Wuhan University Journal of Natural Sciences2013，18，1： | 1 |
| 9 | Serum Lipids and Lipoproteins in Chinese Men and Women显示文摘 | Wenying Yang Jianzhong Xiao Zhaojun Yang Linong Ji Weiping Jia Jianping Weng Juming Lu Zhongyan Shan Jie Liu Haoming Tian Qiuhe Ji Dalong Zhu Jiapu Ge Lixiang Lin Li Chen Xiaohui Guo Zhigang Zhao Qiang Li Zhiguang Zhou Guangliang Shan Jiang He | 2012 | Circulation2012，，18： | 1 |
| 10 | Dapagliflozin as Monotherapy in Drug-Naive Asian Patients With Type 2 Diabetes Mellitus: A Randomized, Blinded, Prospective Phase III Study显示文摘 | Linong Ji Jianhua Ma Hongmei Li Traci A. Mansfield Caroline L. T’joen Nayyar Iqbal Agata Ptaszynska James F. List | 2013 | Clinical Therapeutics2013，，： | 1 |
| 11 | Understanding the standard of care in the treatment of type 2 diabetes in China: results from a national survey显示文摘 | Ji Linong Julliana Newman Lu Juming Cai Xiaoling | 2014 | Chinese Medical Journal2014，，20： | 1 |
| 12 | Estimation of atherosclerotic cardiovascular disease risk in type 2 diabetes显示文摘To the Editor:The global prevalence of diabetes is increasing dramatically.[1]To prevent and treat diabetes and its cardiovascular complications,clinical practice guidelines recommend to assess the prevalent nonmodifiable risk factors in people with diabetes.The prediction for atherosclerotic cardiovascular disease(ASCVD)risk in China(China-PAR)model was specifically developed to predict the 10-year risk for ASCVD in China. | Xiaoling Cai Chu Lin Linong Ji | 2022 | Chinese Medical Journal2022，135，21： | 1 |
| 13 | P38 Plays an Important Role in Glucolipotoxicity-Induced Apoptosis in INS-1 Cells显示文摘 | Lingli Zhou Xiaoling Cai Xueyao Han Linong Ji Yanbing Li | 2014 | Journal of Diabetes Research2014，，： | 1 |
| 14 | Cardiovascular risk profile and clinical characteristics of diabetic patients:a cross-sectional study in China显示文摘Background:Cardiovascular(CV)disease is the leading cause of morbidity and mortality in adults with type 2 diabetes(T2D).The aim of this study was to determine the CV risk in Chinese patients with T2D based on the 2019 European Society of Cardiology(ESC)and the European Association for the Study of Diabetes(EASD)guidelines on diabetes,pre-diabetes,and CV diseases.Methods:A total of 25,411 patients with T2D,who participated in the study of China Cardiometabolic Registries 3B study,were included in our analysis.We assessed the proportions of patients in each CV risk category according to 2019 ESC/EASD guidelines.Results:Based on the 2019 ESC/EASD guidelines,16,663(65.6%),1895(7.5%),and 152(0.6%)of patients were included in'very high risk,''high risk,'and'moderate risk'categories,respectively.The proportions of patients in each category varied based on age,sex,body mass index,and duration.While 58.7%(9786/16,663)of elderly patients were classified to'very high risk'group,89.6%(3732/4165)of patients with obesity were divided into'very high risk'group.Almost all patients with a duration of diabetes>10 years had'very high risk'or'high risk.'However,6701(26.4%)of Chinese T2D patients,who had shorter duration,and one or two risk factors,could not be included in any category(the'unclear risk'category).Conclusions:In China,most patients with T2D have'very high'or'high'CV risk based on 2019 ESC/EASD guidelines.However,the risk of patients in'unclear risk'group needs to be further classified. | Fang Lyu Xiaoling Cai Chu Lin Tianpei Hong Xiaomei Zhang Juming Lu Xiaohui Guo Zhufeng Wang Huifang Xing Guizhi Zong Linong Ji | 2022 | Chinese Medical Journal2022，，3： | 0 |
| 15 | Lipid control in adult Chinese patients with type 2 diabetes:a retrospective analysis of time trends and geographic regional differences显示文摘To the Editor:Patients with type 2 diabetes have a higher risk of cardiovascular diseases(CVD),relative to people without diabetes.Patients with diabetes always exhibit lipid abnormalities.Rapid economic development and accelerated urbanization have also led to lifestyle changes that may have an influence on the lipid parameters of Chinese patients with diabetes.Given the significant differences in socioeconomic status in China,geographical variations were also observed in the prevalence,awareness,treatment,and control of dyslipidemia among individuals who were≥45 years old in the general Chinese population.[1]There is a lack of large-scale studies regarding time trends and geographical variations in lipid concentrations and lipid control among Chinese adults with type 2 diabetes.Therefore,we conducted a study on time trends and geographical variations in lipid concentrations and lipid control in this population using the China National HbA1c Surveillance System(CNHSS)database of adult Chinese outpatients with type 2 diabetes during 2009 to 2013.The Ethics Committee of the Chinese People Liberation Army General Hospital approved the study protocol.Informed consent was obtained from all the patients before they were interviewed and data collected. | Yanping Yuan Xianghai Zhou Juming Lu Xiaohui Guo Linong Ji | 2022 | Chinese Medical Journal2022，，3： | 0 |
| 16 | Trends and regional differences in glycemic control of patients with type 2 diabetes in China, 2009–2013显示文摘To the Editor:According to the International Diabetes Federation,China has been ranked first worldwide in terms of the prevalence of diabetes among people aged 20 to 79 years.[1]As a cornerstone in the management of patients with type 2 diabetes mellitus(T2DM),the level of glycemic control has changed considerably over the past decades.A multicenter observational study in North China showed that 45.82%of patients with T2DM met the glycated hemoglobin(HbA1c)control standard in 2017.[2]With the largest population of residents with T2DM,China is also faced with significant regional discrepancies in the rates of adequate glycemic control(HbA1c<7%),ranging from 25.9%in Shaanxi province[3]to 56.1%in Jiangsu province.[4]Indeed,previous studies in China were conducted for short periods of time,in a limited number of areas,and with relatively small sample sizes.Based on the data of the China National HbA1c Surveillance System study(CNHSS),this analysis aimed to investigate temporal trends and regional variations in glycemic control in T2DM patients in China from 2009 to 2013. | Jiayu Cheng Xianghai Zhou Juming Lu Xiaohui Guo Linong Ji | 2022 | Chinese Medical Journal2022，，13： | 0 |
| 17 | 662 A/G gene variation in human tumor necrosis factor receptor superfamily,member 9(TNFRSF9)显示文摘The aim of this paper is to report a new coding variance of the TNFRSF9 gene,a candidate for auto-immune diseases.We found the variation in two families with type 2 diabetes mellitus by D-HPLC mutation screening method and confirmed our results by direct sequencing and PCR-RFLP.Although without changing the amino acid coding,the variance may have an effect on codon usage and play a role in disease development,such as type 2 diabetes mellitus.However,we cannot define the role of this variance because the frequency of the minor allele is low in the Chinese population and no homozygote of the variance was found.More research in multiple populations will be necessary to define the role of this variance. | Yanchun QU Ze YANG Liang SUN Linong JI | 2008 | Frontiers of Medicine2008，2，3： | 0 |
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