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| 1 | Virus profile in children with acute respiratory infections with various severities in Beijing, China显示文摘 | Zhu Runan Song Qinwei Qian Yuan Zhao Linqing Deng Jie Wang Fang Sun Yu | 2014 | Chinese Medical Journal2014，，21： | 10 |
| 2 | Human rhinovirus C infection is associated with asthma in children determined by x TAG respiratory viral panel FAST显示文摘Dear Editor,Cumulative evidence supports the role of early-life viral infections,especially respiratory syncytial virus(RSV)and human rhinovirus(HRV),as major antecedents of childhood asthma(Lemanske,2002;Jackson et al.,2008).In this study,the x TAG respiratory viral panel FAST(RVP FAST)assay,a multiplex polymerase chain reaction(PCR)-based method(Arens et al.,2010;BaladaLlasat et al.,2011;Gharabaghi et al.,2011;Selvaraju,2012),was used to investigate the association of infec- | Dongmei Chen Qinwei Song Runan Zhu Yuan Qian Yu Sun Jie Deng Fang Wang Yaxin Ding Run Tian Chuanhe Liu Wenjing Zhu Linqing Zhao | 2017 | Virologica Sinica2017，32，2： | 5 |
| 3 | Application of Human Adenovirus Genotyping by Phylogenetic Analysis in an Outbreak to Identify Nosocomial Infection显示文摘Nosocomial infections are common in pediatric patients and can be fatal in infants and immunocompromised patients. In September 2018, a high positive rate of human adenovirus HAdV was occurred among hospitalized children in the Children's Hospital Affiliated to the Capital Institute of Paediatrics in Beijing. To investigate whether this outbreak of HAdV was related to nosocomial infections or the result of community infections, we collected respiratory specimens from patients with acute respiratory infections in a respiratory ward during June to December 2018, and screened for respiratory viruses. Among 1,840 cases included, 95(5.2%, 95/1840) were positive for HAdV and 81 were genotyped based on phylogenetic analysis, including seven as HAdV-1(8.6%), 30 HAdV-3(37.0%), two HAdV-6(2.5%), and 42 HAdV-7(51.9%). More HAdV-positive samples were collected in August(4.7%, 12/255), September(15.0%, 41/274) and October(6.9%, 17/247), with a peak in September 2018. By combining the results of HAdV phylogenetic analysis with clinical data of patients, there were 77 cases(4.2%, 77/1840;81.1%, 77/95) excluded from nosocomial infections, eight cases representing possible infections transmitted by visitors or attending parents, three cases without sequences that might have been due to infection transmitted by roommates positive for HAdV, one case of a roommate without an HAdV sequence, and six cases that shared highly homologous sequences with those of their roommates, for which nosocomial infections might be considered. In conclusion, genotyping of HAdVs based on phylogenetic analysis combined with clinical information provides a powerful method to distinguish nosocomial infections from community acquired infection, especially when tracing the origins of nosocomial infections. | Chuanyu Yang Chunmei Zhu Yuan Qian Jie Deng Baoyuan Zhang Runan Zhu Fang Wang Yu Sun Dongmei Chen Qi Guo Yutong Zhou Lei Yu Ling Cao Linqing Zhao | 2021 | Virologica Sinica2021，36，3： | 3 |
| 4 | Prevalence analysis of different human bocavirus genotypes in pediatric patients revealed intra-genotype recombination显示文摘 | Min Zhao Runan Zhu Yuan Qian Jie Deng Fang Wang Yu Sun Huijin Dong Liying Liu Liping Jia Linqing Zhao | 2014 | Infection, Genetics and Evolution2014，，： | 1 |
| 5 | Variant rs8400 enhances ALKBH5 expression through disrupting miR-186 binding and promotes neuroblastoma progression显示文摘Objective:AlkB homolog 5(ALKBH5)has been proven to be closely related to tumors.However,the role and molecular mechanism of ALKBH5 in neuroblastomas have rarely been reported.Methods:The potential functional single-nucleotide polymorphisms(SNPs)in ALKBH5 were identified by National Center for Biotechnology Information(NCBI)dbSNP screening and SNPinfo software.TaqMan probes were used for genotyping.A multiple logistic regression model was used to evaluate the effects of different SNP loci on the risk of neuroblastoma.The expression of ALKBH5 in neuroblastoma was evaluated by Western blotting and immunohistochemistry(IHC).Cell counting kit-8(CCK-8),plate colony formation and 5-ethynyl-2'-deoxyuridine(EdU)incorporation assays were used to evaluate cell proliferation.Wound healing and Transwell assays were used to compare cell migration and invasion.Thermodynamic modelling was performed to predict the ability of miRNAs to bind to ALKBH5 with the rs8400 G/A polymorphism.RNA sequencing,N6-methyladenosine(mA)sequencing,mA methylated RNA immunoprecipitation(MeRIP)and a luciferase assay were used to identify the targeting effect of ALKBH5 on SPP1.Results:ALKBH5 was highly expressed in neuroblastoma.Knocking down ALKBH5 inhibited the proliferation,migration and invasion of cancer cells.miR-186-3p negatively regulates the expression of ALKBH5,and this ability is affected by the rs8400 polymorphism.When the G nucleotide was mutated to A,the ability of miR-186-3p to bind to the 3'-UTR of ALKBH5 decreased,resulting in upregulation of ALKBH5.SPPI is the downstream target gene of the ALKBH5 oncogene.Knocking down SPP1 partially restored the inhibitory effect of ALKBH5 downregulation on neuroblastoma.Downregulation of ALKBH5 can improve the therapeutic efficacy of carboplatin and etoposide in neuroblastoma.Conclusions:We first found that the rs8400 G>A polymorphism in the m6A demethylase-encoding gene ALKBH5 increases neuroblastoma susceptibility and determines the related mechanisms.The aberrant regulation of ALKBH5 by miR-186-3p caused by this genetic variation in ALKBH5 promotes the occurrence and development of neuroblastoma through the ALKBH5-SPP1 axis. | Qian Guan Huiran Lin Wenfeng Hua Lei Lin Jiabin Liu Linqing Deng Jiao Zhang Jiwen Cheng Zhonghua Yang Yong Li Jun Bian Haixia Zhou Suhong Li Li Li Lei Miao Huimin Xia Jing He Zhenjian Zhuo | 2023 | Chinese Journal of Cancer Research2023，35，2： | 0 |
| 6 | Interfacial Characteristics and Formation Mechanisms of Copper–steel Multimaterial Structures Fabricated via Laser Powder Bed Fusion Using Different Building Strategies显示文摘Laser powder bed fusion(LPBF)is an innovative method for manufacturing multimaterial components with high geometrical resolution.The LPBF-printing sequences of materials may be diverse in the actual design and application of multimaterial components.In this study,multimaterial copper(CuSn10)–steel(316 L)structures are printed using different building strategies(printing 316 L on CuSn10 and printing CuSn10 on 316 L)via LPBF,and the characteristics of two interfaces(the 316 L/CuSn10 or“L/C”and CuSn10/316 L or“C/L”interfaces)are investigated.Subsequently,the interfacial melting mode and formation mechanisms are discussed.At the L/C interface,the keyhole melting mode induced by the high volumetric energy density(EL/C=319.4 J/mm3)results in a large penetration depth in the pre-solidified layer and enhances laser energy absorption,thus promoting the extensive migration of materials and intense intermixing of elements to form a wide diffusion zone(∼400μm).At the C/L interface,the conduction mode induced by the low volumetric energy density(EC/L=74.1 J/mm3)results in a narrow diffusion zone(∼160μm).The interfacial defects observed are primarily cracks and pores.More cracks appeared at the C/L interface,which is attributable to the weak bonding strength of the narrow diffusion zone.This study provides guidance and reference for the design and manufacturing of multimaterial components via LPBF using different building strategies. | Linqing Liu Di Wang Guowei Deng Yongqiang Yang Jie Chen Jinrong Tang Yonggang Wang Yang Liu Xusheng Yang Yicha Zhang | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，3： | 0 |
| 7 | Effect of human rhinovirus infection in pediatric patients with influenza-like illness on the 2009 pandemic influenza A(H1N1) virus显示文摘 | Sun Yu Zhu Ru'nan Zhao Linqing Deng Jie Wang Fang Ding Yaxin Yuan Yi Qu Dong Qian Yuan | 2014 | Chinese Medical Journal2014，，9： | 0 |
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