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| 1 | Discovery of phosphatized gastrula fossils from the Dou-shantuo Formation,Weng'an,Guizhou Province,China显示文摘Globular fossils from Doushantuo phosphorites at the Weng’an area are for the first time identified as a gas-trulation stage of phosphatized embryos. They are got from the fossiliferous remains after acetic acid maceration. The fossils are found together with formerly reported animal resting eggs and embryos of the earlier cleavage stage. The oblate-shaped fossils with the same size as those reported embryos and invaginate at the middle part into the embryos, show the characteristics of the late blastula to the early gas-trula stage of the embryo development. This discovery convinces the existence of animal embryos at Doushantuo age and offers new facts for the studying of the affinity of related fossils, which are still controversial at present. | Yin Chongyu Yue Zhao Gao Linzhi | 2001 | Chinese Science Bulletin2001，46，20： | 16 |
| 2 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 3 | Seasonal bioconcentration of heavy metals in Onchidium struma(Gastropoda:Pulmonata)from Chongming Island,the Yangtze Estuary,China显示文摘The seasonal concentration changes of selected heavy metal Cd,Cr,Cu,Fe,Mn,Pb,and Zn in five tissues of marine gastropod Onchidium struma were studied in the Chongming Island,the Yangtze Estuary in April 2007,July 2006,September 2006,and November 2006,respectively.The results demonstrated that the bioconcentration factor of Cu(biomass/water) in all selected tissues was about 104 magnitudes,Fe and Cd were 103,Zn was 102,and Mn,Pb,and Cr were 101.Hepatopancreas was proven to be the dominant storage tissue of Cr,Cu,Mn,and Zn,whereas Fe and Pb were mainly stored in muscle and digenetic gland,and Cd was stored in vitelline gland and albumen gland.Additionally,it was found that Cu,Fe,Mn,and Zn were concentrated significantly by O.struma(whole-body) in summer or autumn,and Cd,Cr,and Pb increased slightly in spring and winter.Furthermore,the bioconcentration of Cr was nearly 2-fold higher and Zn was 1.6-fold higher in the water compared with the Water Quality Standard for Fisheries.With view of excessive amount of Pb,Cd,and Cu according to seafood standard,the consumption of O.struma might have the risk of health hazard. | LI Xiaobo JIA Linzhi ZHAO Yunlong WANG Qun CHENG Yongxu | 2009 | Journal of Environmental Sciences2009，21，2： | 7 |
| 4 | Report on 3.4 Ga SHRIMP Zircon Age from the Yuntaishan Geopark in Jiaozuo, Henan Province显示文摘Using the reported new U-Pb age with the Sensitive High-Resolution Ion Microprobe (SHRIMP II), zircon U-Pb ages were obtained from two samples of K-feldspar felsic paragneiss and K-feldspar gneissoid trondhjemite on the southern margin of the Taihang Mountains in the North China Craton. The protolith of the K-feldspar felsic paragneiss is argillaceous-sandy clastic sedimentary rock, probably deposited in the Neoarchean. Most of the detritus zircons show heavy loss of Pb. Five spots of zircons near the upper point, yield a weighted mean 207Pb/206Pb age of 3399±8 Ma, representing an age of the sedimentary source. Two groups of zircons from the K-feldspar gneissoid trondhjemite give weighted mean 207Pb/206Pb ages of 2511±13 Ma and 2735±16 Ma respectively. The former represents the emplacement time of the pluton, while the latter is interpreted as the age of the inherited zircons. The new data support that the Archean geological body in the central zone has an affinity with those from the eastern block of the North China Craton. | GAO Linzhi ZHAO Ting WAN Yusheng ZHAO Xun MA Yinsheng YANG Shouzheng | 2006 | Acta Geologica Sinica(English Edition)2006，80，1： | 4 |
| 5 | Late Cenozoic Geomorphology, Geochronology and Physiography of Yuntaishan in Southern Taihang Mountain, North China显示文摘在 Yuntaishan 世界 Geopark 的 Zhingfang 河集水的迟了的新生代似地球形状的特征和 geochronologic 数据被学习。几个 quarternary geochronologic 方法,包括的电子旋转回声(ESR ) ,光学地刺激的光(OSL ) ,热照明(TL ) 和 U 系列在这份报纸被介绍。结果建议有二均夷作用表面,作为是在渐新世或渐新世期间形成到早中间的中新世的时期的 Taihang 舞台的一个近似平原的 Taihang 表面说出,并且是 Tang-hien 舞台的一条成熟宽山谷的 Tang-hien 表面在晚中新世上新世或上新世早的更新世时期期间形成了并且可能基于 ESR 在 2.22.6 妈以前结束了标明日期。在 Tang-hien 阶段以后,河的切口和沉积分别地在河底部上面与 35 m, 812 m, 2224 m, 2838 m, 5062 m 和 8085 m 的高度形成了六个溪流平台。冲积层沉积的标明日期的结果建议这些平台在 Holocene, 2023 ka B.P, 110120 ka B.P, 200240 ka B.P, 8401200 ka B.P 或 450 ka 期间被形成 B.P 或 1100 ka B.P 分别地。这些结果显示河的阵发性的切口,在 Yuntaishan 世界 Geopark 控制风景的形成,被周期的干燥湿的气候变化主要在迟了的新生代山期间影响高举。 | WU Zhonghai ZHAO Xitao MA Yinsheng ZHAO Xun ZHAO Ting YANG Shouzheng GAO Linzhi | 2010 | Acta Geologica Sinica(English Edition)2010，84，1： | 3 |
| 6 | A intervarietal genetic map and QTL analysis for yield traits in wheat显示文摘 | Sishen Li Jizeng Jia Xianyun Wei Xiaocun Zhang Linzhi Li Haimei Chen Yuding Fan Haiyan Sun Xinhua Zhao Tiandong Lei Yunfong Xu Fangshan Jiang Honggang Wang Lihui Li | 2007 | Molecular Breeding2007，，2： | 3 |
| 7 | A intervarietal genetic map and QTL analysis for yield traits in wheat显示文摘 | Sishen Li Jizeng Jia Xianyun Wei Xiaocun Zhang Linzhi Li Haimei Chen Yuding Fan Haiyan Sun Xinhua Zhao Tiandong Lei Yunfong Xu Fangshan Jiang Honggang Wang Lihui Li | 2007 | Molecular Breeding2007，，2： | 1 |
| 8 | Numerical Simulation on Open Wellbore Shrinkage and Casing Equivalent Stress in Bedded Salt Rock Stratum 显示文摘 | Jianjun Liu Linzhi Zhang Jinzhou Zhao | 2013 | The Scientific World Journal2013，，10： | 1 |
| 9 | A intervarietal genetic map and QTL analysis for yield traits in wheat显示文摘 | Sishen Li Jizeng Jia Xianyun Wei Xiaocun Zhang Linzhi Li Haimei Chen Yuding Fan Haiyan Sun Xinhua Zhao Tiandong Lei Yunfong Xu Fangshan Jiang Honggang Wang Lihui Li | 2007 | Molecular Breeding2007，，2： | 1 |
| 10 | Evaluation of the safety and efficacy of glucocorticoid therapy for hyperbilirubinemia in patients with hepatocellular carcinoma who have undergone transcatheter arterial chemoembolization显示文摘Objective The aim of this study was to analyze the safety and efficacy of glucocorticoid treatment for hyperbilirubinemia in patients with hepatocellular carcinoma(HCC)who have undergone transcatheter arterial chemoembolization(TACE).Methods We conducted a retrospective analysis of the clinical data of 198 patients with HCC who were admitted to The Fifth Medical Center of PLA General Hospital from June 2014 to August 2019 and underwent TACE therapy.The patients were divided into glucocorticoid(GCC)treatment group and control group.Standard liver-protecting procedures were used in both groups.The treatment group also received intravenous injections of methylprednisolone sodium succinate for 3–5 days.Reduction in bilirubin concentration,mean duration of hospitalization,and complications were compared between the two groups to investigate the safety and efficacy of GCCs for treatment of hyperbilirubinemia after TACE treatment.Results Bilirubin concentrations were significantly lower in the treatment group than in control group on days 3 and 5 after GCC/conventional liver-protecting treatment(P<0.05).The treatment group had significantly shorter durations of total post-surgery hospitalization,and recovery time than the control group(14.5±4.6 days vs.17.5±6.6 days,P<0.001;9.2±3.3 days vs.11.8±5.4 days,P=0.001;7.0±3.3 days vs.9.3±4.6 days,P<0.001).No GCC-associated complications were detected in the treatment group.Conclusion Short-term use of GCCs to treat hyperbilirubinemia in patients with HCC who have undergone TACE is safe and associated with rapid decline in bilirubin concentration and shorter hospital stay compared with patients who did not receive GCCs. | Jingyan Wang Linzhi Zhang Xiaoming Peng Yun Zhao Lin Zhou | 2020 | Oncology and Translational Medicine2020，6，2： | 1 |
| 11 | Combination of TACE and FOLFOX4 in the treatment of unresectable advanced hepatocellular carcinoma:a prospective cohort study显示文摘Objective The aim of the study was to assess the effectiveness and safety of a combined therapy with transcatheter arterial chemoembolization(TACE)and FOLFOX4,in patients with unresectable advanced hepatocellular carcinoma(HCC).Methods In this study,patients with advanced HCC,that received treatment between November 2015 and October 2017,were recruited.Among these,30 patients were treated with TACE only(TACE group);whereas 33 patients were treated with a combination of FOLFOX4 chemotherapy and TACE(combination group).Survival analyses,including overall survival(OS)and progression free survival(PFS)analysis,were performed for both groups.Following this,the responses of patients to treatment were evaluated every 3 months,and the toxic and adverse events were observed.Results The median follow-up time was 9.2 months(3-36 months).In the combination group,at 3 months,a disease control rate(DCR)of 60.6%,and a median OS of 9.1 months was obtained[95%confidence interval(CI)6.5-11.7].In the TACE group,the DCR and OS were 33.3%and 5.5 months(95%CI 4.3-6.7),respectively.On the other hand,the PFS in the combination and TACE groups were observed as 5.6 months(95%CI 3.6-7.6)and 2.6 months(95%CI 2.0-3.2),respectively.Both these findings indicate a statistically significant difference(P=0.01)between both the groups.Similar TACE associated adverse events were observed in both groups.In the combination group,frequently observed FOLFOX4 related adverse effects included nausea(90.9%),leukopenia(75.8%),thrombocytopenia(69.7%),and vomiting(69.7%).Most adverse reactions were between grades I-III and were alleviated after symptomatic treatments.Conclusion The combination of TACE with FOLFOX4 therapy has better effectivity and safety than TACE alone. | Jingyan Wang Linzhi Zhang Xiaoming Peng Yun Zhao Lin Zhou | 2020 | Oncology and Translational Medicine2020，6，5： | 1 |
| 12 | GCR-Net:3D Graph convolution-based residual network for robust reconstruction in cerenkov luminescence tomography显示文摘Cerenkov Luminescence Tomography(CLT)is a novel and potential imaging modality which can display the three-dimensional distribution of radioactive probes.However,due to severe ill-posed inverse problem,obtaining accurate reconstruction results is still a challenge for traditional model-based methods.The recently emerged deep learning-based methods can directly learn the mapping relation between the surface photon intensity and the distribution of the radioactive source,which effectively improves the performance of CLT reconstruction.However,the previously proposed deep learning-based methods cannot work well when the order of input is disarranged.In this paper,a novel 3D graph convolution-based residual network,GCR-Net,is proposed,which can obtain a robust and accurate reconstruction result from the photon intensity of the surface.Additionally,it is proved that the network is insensitive to the order of input.The performance of this method was evaluated with numerical simulations and in vivo experiments.The results demonstrated that compared with the existing methods,the proposed method can achieve efficient and accurate reconstruction in localization and shape recovery by utilizing threedimensional information. | Weitong Li Mengfei Du Yi Chen Haolin Wang Linzhi Su Huangjian Yi Fengjun Zhao Kang Li Lin Wang Xin Cao | 2023 | Journal of Innovative Optical Health Sciences2023，16，1： | 0 |
| 13 | A novel denoising framework for cerenkov luminescence imaging based on spatial information improved clustering and curvature-driven diffusion显示文摘With widely availed clinically used radionuclides,Cer enkov luminescence imaging(CLI)has become a potential tool in the field of optical molecular imaging.However,the impulse noises introduced by high-energy gamma rays that are generated during the decay of radionuclide reduce the image quality significantly,which affects the acauracy of quantitative analysis,as well as the three dimensional reconstruction.In this work,a novel denoising framework based on fuzzy dlustering and curvat ure driven difusion(CDD)is proposed to remove this kind of impulse noises.To improve the accuracy,the F u1zzy Local Information C-Means algorithm,where spatial information is evolved,is used.We evaluate the per formance of the proposed framework sys-tematically with a series of experiments,and the corresponding results demonstrate a better denoising effect than those from the commonly used median filter method.We hope this work may provide a useful data pre processing tool for CLI and its following studies. | Xin Cao Yi Sun Fei Kang Lin Wang Huangjian Yi Fengjun Zhao Linzhi Su Xiaowei He | 2018 | Journal of Innovative Optical Health Sciences2018，，4： | 0 |
| 14 | Application of Programmable Logic Controller in Hydraulic Spring Eye Machine显示文摘 | Yan Zhao Linzhi Cheng | 2006 | 通讯和计算机(中英文版)2006，3，1： | 0 |
| 15 | Storm Deposits of the Sinian Zhangqu Formation in Northern Anhui——An Upward Shallowing Carbonate Sequence显示文摘This paper studies. for the first time, the storm deposits of a carbonate sequence in the Sinian ZhangquFormation in northern Anhui. In the formation. a great number of calcareous trider sponge spicules were dis-covered in a distal storm turbidity sequence, which have provided further evidence for the correlation of theSinian Systems in North and South China from a view point of palaeontology. | Qiao Xiufu Xing Yusheng Gao Linzhi Yin Chongyu Yue Zhao Liu Guizhi Institute of Geology, Chinese Academy of Geological Sciences, Beijing Jia Zhongpeng Gao Linzhi | 1990 | Acta Geologica Sinica(English Edition)1990，64，2： | 0 |
| 16 | Correlation between boson peak and thermal expansion manifested by physical aging and high pressure显示文摘We investigate the effects of high pressure and physical aging on the boson peak and thermal expansion of a typical metallic glass. Specifically, the thermal expansion coefficient and boson peak intensity monotonically decrease during physical aging.With the increase of high pressure, the boson peak intensity and the thermal expansion coefficient coincidently experience an incipient decrease and then a subsequent increase. The boson peak intensity shows an approximately linear relationship with the thermal expansion coefficient. The thermal expansion can be affected by structural relaxation or rejuvenation, which can reflect the flow units variation and atomic packing of a metallic glass. Our results indicate a direct link between structural relaxation or rejuvenation and fast boson peak dynamics, providing insights into the boson peak behavior and structural heterogeneity of metallic glasses. | Rongjie Xue Linzhi Zhao Yunqi Cai Jiaojiao Yi Jinguang Cheng Ping Wen Weihua Wang Mingxiang Pan Haiyang Bai | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，4： | 0 |
| 17 | Microfossils from the Chert in the Lower Cambrian Shuijingtuo Formation at Miaohe, Zigui, Hubei Province显示文摘This paper reports for the first time on the microfossils discovered in the black cherts of the basal part of the Lower Cambrian Shuijingtuo Formation at Miaohe village, Zigui County, Hubei Province, all of which were observed in thin sections. Nine genera, 9 species and 3 indeterminate species (including a new species) are described. According to these microfossils, the conclusion is made that the microfossil zone may be equivalent to the small shelly fossil assemblage zones 2—3 of the Meishucun stage. They have provided another important line of evidence for the correlation of the Sinian-Cambrian boundary strata with those of the adjacent areas. | Yin Chongyu, Yue Zhao, Gao Linzhi Institute of Geology, CAGS, Beijing and Ding Qixiu Hubei Geological Institute, Hubei Bureau of Geology, Wuhan | 1993 | Acta Geologica Sinica(English Edition)1993，67，2： | 0 |
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