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| 1 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 2 | Breeding and molecular cytogenetic identification of wheat-Thinopyrum intermedium addition lines resistant to powdery mildew显示文摘Wheat-related species Th. intermedium was used to cross with common wheat Yannong 15. In the self progenies of the hybrid, two addition lines, II -1-7-1 and II -3-3-2, stable in cytology, were developed by cytology and powdery mildew resistance identification. Their chromosome number were 2n = 44 and formed 22 bivalents at PMC MI. In F1 of the two addition lines crossing with Yannong 15, there appeared about one univalent at PMC MI, respectively. Resistance identification in greenhouse and field using the No. 15 and mixed strains of E. gramnis f. sp. tritici showed that they were immune to powdery mildew. Chromosome number and resistance identification using the F2 single plants of the addition line crossing with Yannong 15 indicated that the resistant gene was located on the alien chromosomes. In situ hybridization using St and E genomic DNA as probe showed that the added chromosome in the two addition lines probably came from the E genome of Th. intermedium, which indicated that a pair of E genome | Shubing Liu Honggang Wang | 2002 | Chinese Science Bulletin2002，47，22： | 7 |
| 3 | Geochemical Characteristics of Eolian Deposits in the Chengdu Plain of Sichuan Province and the Implications for Provenance显示文摘In this study Chengdu Red Earth(CRE)from the Chengdu Plain(CP),Sichuan province,was analyzed for its elemental(major and trace elements)and isotopic(Sm-Nd)geochemistry and compared with Pleistocene loess and paleosol samples from the Chinese Loess Plateau(CLP)in Northern China.The geochemical composition of CRE is similar to north China loess,and also resembles the average UCC.This indicates that CRE,as loess deposits in Northern China,was derived from well-mixed sedimentary protoliths that have undergone numerous upper crustal recycling processes.However,obvious differences in the geochemical characteristics of CRE and the north China loess are also revealed in our results.For chemically stable elements,CRE has higher Ti,Zr,Hf and lowerΣREE,Ba contents in comparison with loess samples from the CLP.Further analysis shows that CRE has higher TiO2/Al2O3,SiO2/Al2O3,Ba/Rb and lower Ce/Yb,Eu/Yb,LaN/YbN andΣLREE/ΣHREE ratios.In Sm-Nd isotopic geochemistry,Sm and Nd content and theεNd(0)value in CRE are significantly higher than those in north China loess.The higher TiO2content in CRE coincided with a high background concentration of Ti in the Sichuan Basin and the surrounding regions.The lowerΣREE and higher Sm,Nd,εNd(0)values are related to the wide distribution of basalt in the southwest Sichuan Basin.The elemental and isotopic geochemistry of CRE indicates that eolian materials in the CP predominantly come from the Sichuan Basin and the surrounding regions,which differs from loess deposits in the CLP. | TAN Yuanlong QIAO Yansong ZHAO Zhizhong WANG Yan QI Lin FU Jianli LIU Zongxiu YAO Haitao WANG Shubing JIANG Fuchu | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 3 |
| 4 | Quantitative trait loci for resistance to pre-harvest sprouting in US hard white winter wheat Rio Blanco显示文摘 | Liu Shubing Cai Shibin Robert Graybosch | 2008 | Theor Appl Genet2008，117，5： | 1 |
| 5 | Virus-like particle vaccine by intranasal vaccination elicits protective immunity against respiratory syncytial viral infection in mice显示文摘呼吸 syncytial 病毒(RSV ) 是在婴儿和孩子的更低的呼吸感染的一个领先的原因,但是仍然没有可得到的准许的疫苗。在这份报告,我们基于 Bac-to-Bac baculovirus 表达式系统开发了像病毒的粒子(VLP ) 疫苗,由一个流行性感冒病毒矩阵(M1 ) 组成蛋白质和 RSV 熔化蛋白质(F) 或 glycoprotein (G) 。这些 RSV VLP 被西方的污点分析和电子显微镜学识别。有 RSV-F VLP, RSV-G VLP,或两个的 intranasally 使免疫的女 BALB/c 老鼠(i.n ) 对 RSV 显示出病毒特定的抗体回答。全部的 IgG, IgG1, IgG2a,和 mucosal IgA 与 RSV-F 正 RSV-G VLP 在老鼠被检测,揭示细胞的有势力和 mucosal 免疫者回答。而且,我们发现这些混合 RSV VLP 对实时 RSV 挑战授与提高的保护,在病毒的复制和组织病理学说的变化的明显的变细与病毒的感染联系了的肺的出现重要减少。这些结果证明由 intranasal 种痘的 RSV-F 正 RSV-G VLP 是保证使用棉花老鼠和首领模型的进一步的评估的一个有希望的疫苗的候选人。 | Mengying Cai Cheng Wang Yufeng Li Hongjing Gu Sujing Sun Yueqiang Duan Chengcai Lai Keyu Wang Xiaolan Yang Li Xing Peirui Zhang Zhaohai Wang Shaogeng Zhang Xiaodong Guo Shubing Liu Yigang Tong Xiliang Wang Penghui Yang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 1 |
| 6 | InP/InGaAs Heterojunction Bipolar Transistor with Base μ Bridge and Emitter Air Bridge显示文摘 | Yu Jinyong Liu Xinyu Su Shubing | 2007 | Chinese Journal of Semiconductors2007，，2： | 1 |
| 7 | Pm23: a new allele of Pm4 located on chromosome 2AL in wheat显示文摘 | Yuanfeng Hao Aifeng Liu Yuhai Wang Deshun Feng Jurong Gao Xingfeng Li Shubing Liu Honggang Wang | 2008 | Theoretical and Applied Genetics2008，，8： | 1 |
| 8 | Visfatin stimulates production of monocyte chemotactic protein-1 and interleukin-6 in human vein umbilical endothelial cells显示文摘 | LIU Shuwen QIAO Shubing YUAN Jiansong | 2009 | Horm Metab Res2009，41，4： | 1 |
| 9 | Association of plasma visfatin levels with inflammation, atherosclerosis and acute coronary syndromes (ACS) in humans 显示文摘 | LIU Shuwen QIAO Shubing YUAN Jiansong | 2009 | Clin Endocrinol ( Oxf)2009，71，2： | 1 |
| 10 | Allelic impacts on pre-harvest sprouting resistance and favorable haplotypes in Ta PHS1 of Chinese wheat accessions显示文摘Pre-harvest sprouting(PHS)influences yield and end-use quality of bread wheat.Developing varieties with PHS resistance is the most effective way to reduce this problem.In this study,a panel of 725 Chinese wheat accessions were evaluated for PHS resistance in three environments.There was abundant variation in PHS resistance and 63 accessions showing high resistance had germination rates of less than 10%across three experiments.The distribution of three causal single nucleotide polymorphisms in Ta PHS1 at bases-222,+646,and+666 were assessed and frequencies were determined.Favorable alleles conferring PHS resistance were identified for each locus.Haplotype analysis showed that bases C,G,and A at each of the three loci comprised the best haplotype for PHS resistance,whereas TAT showed the highest sprouting rate.Accessions with the superior Ta PHS1 haplotypes proved to be resistant to PHS providing a basis to develop varieties with PHS resistance through marker assisted breeding. | Danfeng Wang Yunlong Pang Lei Dong Anfei Li Lingrang Kong Shubing Liu | 2020 | The Crop Journal2020，8，4： | 1 |
| 11 | Late Cenozoic Geology and Paleo-environment Change in the Eastern Edge of Qinghai-Xizang Plateau显示文摘在 Qinghai-Xizang 高原的东方边有迟了的新生代湖的存款和黄土和红泥土和冰碛。各种各样的基因沉积在迟了的新生代 paleo 环境变化上记录了富有的信息。Xigeda 湖在在那里的 4.2 妈 B.P.-2.6 妈 B.P 期间形成了是 9 周期的温暖寒冷的引申。在西方的四川的 Eolian 免职在黄土土壤序列连续地记录了的 1.15 妈 B.P 开始了 14 个 paleo 季风气候周期。自从在那里的 1.13 妈 B.P 是在东方 Qinghai-Xizang 高原的 4.3 妈 B.P 的一个旧冰川的时期,在 Chengdu 平原的红土记录了 paleoclimatic 阶段的 5 个阶段。在期间第四级,有与 5 冻结成冰相应的 5 个极端 paleoclimatic 事件。 | ZHAO Zhizhong QIAO Yansong WANG Shubing YAO Haitao WANG Yan LI Chaozhu FU Jianli LIU Zongxiu LI Mingze MIAO Qi JIANG Fuchu | 2008 | Acta Geologica Sinica(English Edition)2008，82，5： | 0 |
| 12 | Histone Deacetylase Inhibitor SAHA Induces Expression of Fatty Acid-Binding Protein 4 and Inhibits Replication of Human Cytomegalovirus显示文摘Suberoylanilide hydroxamic acid(SAHA) is a histone deacetylase inhibitor that shows marked efficacy against many types of cancers and is approved to treat severe metastatic cutaneous T-cell lymphomas. In addition to its anticancer activity,SAHA has significant effects on the growth of many viruses. The effect of SAHA on replication of human cytomegalovirus(HCMV) has not, however, been investigated. Here, we showed that the replication of HCMV was significantly suppressed by treatment with SAHA at concentrations that did not show appreciable cytotoxicity. SAHA reduced transcription and protein levels of HCMV immediate early genes, showing that SAHA acts at an early stage in the viral life-cycle. RNAsequencing data mining showed that numerous pathways and molecules were affected by SAHA. Interferon-mediated immunity was one of the most relevant pathways in the RNA-sequencing data, and we confirmed that SAHA inhibits HCMV-induced IFN-mediated immune responses using quantitative Real-time PCR(qRT-PCR). Fatty acid-binding protein 4(FABP4), which plays a role in lipid metabolism, was identified by RNA-sequencing. We found that FABP4 expression was reduced by HCMV infection but increased by treatment with SAHA. We then showed that knockdown of FABP4 partially rescued the effect of SAHA on HCMV replication. Our data suggest that FABP4 contributes to the inhibitory effect of SAHA on HCMV replication. | Zhongshun Liu Baoqin Xuan Shubing Tang Zhikang Qian | 2021 | Virologica Sinica2021，36，6： | 0 |
| 13 | Anisotropic exchange coupling interaction between hard-hard magnetic grains in sintered SrFe_(12)O_(19)ferrites显示文摘Exchange coupling interaction in sintered magnetic materials is generally isotropic.In this study,the anisotropic exchange coupling interaction was found in sintered oblate cylindrical SrFe_(12)O_(19)(SrM)specimens obtained by the SrM nanopowders synthesized via a hydrothermal method.According to Henkel plots,the exchange coupling interaction between hard-hard magnetic grains was found in both as-pressed and sintered specimens.However,the exchange coupling interaction can only be found in the in-plane direction but not in the out-of-plane direction for thel sintered specimens.By building a model of a grain configuration,this anisotropy of the exchange coupling interaction was ascribed to the vertically arranged plate-like SrM grains with micrometers in width but nanometers in thickness,which was confirmed by morphologies of cross sections in fractured specimens. | Shuang Zhang Chunxiang Cao Shubing Su Ailin Xia Huiyan Zhang Hailing Li Zhiyuan Liu Chuangui Jin | 2023 | Journal of Advanced Ceramics2023，12，4： | 0 |
| 14 | Immunostimulant nanomodulator boosts antitumor immune response in triple negative breast cancer by synergism of vessel normalization and photothermal therapy显示文摘Tumor vascular dysfunction and immune suppression predict poor outcomes of tumor therapy.Combination of photothermal therapy(PTT)and vessel normalization with tumor immunotherapy is promising to augment antitumor benefit.Herein,we develop a potential immunostimulatory nanomodulator for treatment of triple-negative breast cancer(TNBC)treatment via synergism of PTT,vessel normalization,and priming of tumoral suppressive immune microenvironment by blocking transforming growth factor-β(TGF-β)pathway.The nanomodulator,namely Vac@Apt@BPs,is developed by conjugation of TGF-βinhibitor Vactosertib(Vac)and nucleolin-recognizing aptamer(Apt)on the surface of black phosphorus nanoparticles(BPs).Vac@Apt@BPs show good accumulation in TNBC via aptamer-induced active targeting of TNBC.Via the blockade of TGF-βsignaling,Vac@Apt@BPs effectively inhibit the formation of tumor neovascular,and normalize the vessels to recover vascular integrity and alleviate the hypoxia stress.Together with the tumor eradication and immunogenic cell death via PTT,robust immune response was boosted by promoted maturation of dendritic cells,suppression of regulatory T cells,and stimulation of effective T cells.This synergistic therapeutic strategy potentially suppresses the growth of TNBC in mice. | Hao Jiang Yilang He Jia Zhao Ruimin Chang Hailun He Tan Li Xingyu Zhang Bo Shu Wenxuan Zhang Huaiyu Wang Jing Liu Shubing Zhang Yuetao Zhao | 2023 | Nano Research2023，16，8： | 0 |
| 15 | Study of MRPC technology for BESIII endcap-TOF upgrade显示文摘Purpose In order to improve the charged particle identi-fication capability,end-cap time-of-flight(ETOF)detector of the Beijing Spectrometer(BESIII)has been upgraded with multi-gap resistive plate chamber(MRPC)technology,aiming at an overall time resolution of 80 ps for minimum-ionization particles to extend the K/πseparation(2σ)momentum range to 1.4 GeV/c.Methods The previous version of ETOF in BESIII consisted of plastic scintillators.The multi-hit events distort both shape and amplitude of the output signals.MRPC technique was chosen for the BESIII ETOF upgrade as it provides high time resolution and high detection efficiency,is of relatively low cost and is insensitive to neutral particles.Most importantly,the fine segmentation of the MRPC readout stripes can suppress multi-hit events effectively.Results The final design of MRPC module for ETOF is characterized by double-stack(2×6)structure,dual-end readout mode and precision electronics.To batch-produce and test these MRPC modules,a series of tools and production procedures as well as related performance simulation and test methods were developed.Results showed that each MRPC module’s intrinsic time resolution(including the electronics contribution)is around 50 ps and the efficiency is better than 97%.The overall performance of the upgraded ETOF is better than the designed index.The new ETOF has been successfully installed at BESIII and run in 2016. | Xin Li Yongjie Sun Cheng Li Zhen Liu Yuekun Heng Ming Shao Xiaozhuang Wang Zhi Wu Ping Cao Mingming Chen Hongliang Dai Shubing Liu Xiaolan Luo Xiaoshan Jiang Shengsen Sun Zebo Tang Weijia Sun Siyu Wang Meihang Xu Rongxing Yang Kejun Zhu | 2017 | Radiation Detection Technology and Methods2017，1，2： | 0 |
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