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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | A heart breaking case of rapidly developing severe hemophagocytic syndrome secondary to chronic active EBV infection; a case report and review of the literature 显示文摘 | Tawfik K Liron Y Ayman AR | 2015 | J Clin Virol2015，67，6： | 1 |
| 3 | Systemic Delivery of Bone Marrow–Derived Mesenchymal Stem Cells to the Infarcted Myocardium: Feasibility, Cell Migration, and Body Distribution显示文摘 | Israel M. Barbash Pierre Chouraqui Jack Baron Micha S. Feinberg Sharon Etzion Ariel Tessone Liron Miller Esther Guetta Dov Zipori Laurence H. Kedes Robert A. Kloner Jonathan Leor | 2003 | Circulation: Journal of the American Heart Association2003，，7： | 1 |
| 4 | Laminar flow in a pipe at low and moderate reynolds numbers 显示文摘 | Friedmann M Gillis J Liron N | 1968 | Applied Scientific Re- search1968，19，1： | 1 |
| 5 | Agri-Environmental Policy Measures in Israel: The Potential of Using Market-Ori- ented Instruments显示文摘 | Amdur Liron Bertke Elke Freese Jan | 2011 | Environmental Management2011，47，5： | 1 |
| 6 | mTORC1 senses ly- sosomal amino acids through an inside-out mechanism that re- quires the vacuolar H -F-ATPase 显示文摘 | ROBERTO Z LIRON B P ALEJO E | 2011 | Science2011，334，6056： | 1 |
| 7 | Timfiban in unstable comnsry disease 显示文摘 | Liron M | 1998 | N Engl J Med1998，339，16： | 1 |
| 8 | Cuprum-catalysed Oxidation of Hydroxy Compounds by tert-butyl Hydroperoxide under Phase -tranfer Conditions显示文摘 | Liron F Yoel S | 1994 | J Chem See1994，1807，： | 1 |
| 9 | Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation显示文摘 | Dorn G W Souroujon M C Liron T | 1999 | Proc Natl Acad Sci USA1999，96，12： | 1 |
| 10 | DNA typing in a cattle stealing case显示文摘 | Ripoli D Liron JP | 2001 | J Forensic Sci2001，46，6： | 1 |
| 11 | Evalua- tion of the clinical pathway for Iaparoscopic bariatric surgery显示文摘 | Campillo - Soto A Martin - Lorenzo JG Liron - Ruiz R | 2008 | Obes Surg2008，18，4： | 1 |
| 12 | Sustained in vivo cardiac protection by a rationally designed peptide that causes εproteinkinase C translocation 显示文摘 | Dom II GW Souroujon MC Liron T | 1999 | Proc Natl Acad Sci1999，96，12： | 1 |
| 13 | Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation显示文摘 | Dorn GW Souroujon MC Liron T | 1999 | Proc Nail Acad Sci USA1999，96，12： | 1 |
| 14 | Ultrahigh-resolution and 3-dimensional optical coherence tomography ex vivo imaging of the large and small intestines <ce:link locator='fx1'/>显示文摘 | Pei-Lin Hsiung Liron Pantanowitz Aaron D. Aguirre Yu Chen Darshan Phatak Tony H. Ko Stephane Bourquin Stuart J. Schnitt Sugrah Raza James L. Connolly Hiroshi Mashimo James G. Fujimoto | 2005 | Gastrointestinal Endoscopy2005，，4： | 1 |
| 15 | Sus-tained in vivo cardiac protection by a rationally de-signed peptide that causes epsilon protein kinase Ctranslocation 显示文摘 | Dorn GW Souroujon MC Liron T | 1999 | Proc Natl Acad Sci USA1999，96，12： | 1 |
| 16 | The path to 'single-component composites':An in situ X-ray study of melting and crystallization of extended-chain polyethylene fibers under pressure显示文摘 | LIRON S H DMITRY M R RAFAIL K | 2005 | Nucl Instrum Methods Phys Res B2005，238，： | 1 |
| 17 | Breast augmentation under general anesthesia versus monitored anesthesia care a retrospective comparative study显示文摘 | Liron E Avi W | 2008 | An- nals of Plastic Surgery2008，61，9： | 1 |
| 18 | Life-Threatening Events During Endurance Sports显示文摘 | Lior Yankelson Ben Sadeh Liron Gershovitz Julieta Werthein Karin Heller Pinchas Halpern Amir Halkin Arnon Adler Arie Steinvil Sami Viskin | 2014 | Journal of the American College of Cardiology2014，，5： | 1 |
| 19 | Laser autofocusing system for high-resolution cell biological imaging 显示文摘 | LIRON Y PARAN Y ZATORSKY NG | 2006 | Journal of Microscopy-Oxford (S0022- 2720)2006，221，2： | 1 |
| 20 | Scene based non-uniformity correction in thermal images using Kalman filter显示文摘 | AMIR Averbuch GABI Liron BEN Zion Bobrovsky | 2007 | Image and Vision Comouting2007，，25： | 1 |
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