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| 1 | Additive manufacturing of high-strength CrMnFeCoNi high-entropy alloys-based composites with WC addition显示文摘Laser melting deposition with WC addition has been developed to fabricate high-strength CrMnFeCoNibased high-entropy alloys-based composites.By this technique,a microstructure of compact refined equiaxed grains can be achieved,and the tensile strength can be remarkably improved.The sample with 5 wt%WC addition shows a promising mechanical performance with a tensile strength of 800 MPa and an elongation of 37%.The improvement in mechanical property may be attributed to the formation of Cr(23)C6 reinforcement precipitates,which could promote the heterogeneous nucleation of grains and hinder the propagation of slip bands. | Jinfeng Li Shuo Xiang Hengwei Luan Abdukadir Amar Xue Liu Siyuan Lu Yangyang Zeng Guomin Le Xiaoying Wang Fengsheng Qu Chunli Jiang Guannan Yang | 2019 | Journal of Materials Science & Technology2019，35，11： | 13 |
| 2 | Specific targeting of nasopharyngeal carcinoma cell line CNE1 by C225-conjugated ultrasmall superparamagnetic iron oxide particles with magnetic resonance imaging显示文摘临床的目标体积(CTV ) 的一个精确定义为在鼻咽的癌(NPC ) 的放射疗法的应用程序是必要的处理。指向对比代理人(C225-USPIO ) 的新奇表皮的生长因素受体(EGFR ) 被结合 ultrasmall superparamagnetic 设计有 cetuximab (C225 ) 的氧化铁(USPIO ) nanoparticles, non-invasively 定义肿瘤的 CTV。到 NPC 房间线 CNE1 的 C225-USPIO 的 immunobinding 活动被流动 cytometry 和 immunofluorescence 证实。在 CNE1 房间的 C225-USPIO 的时间依赖者累积用普鲁士的蓝染色被评估。指向的成为主观和 C225-USPIO 的 subcellular 本地化被传播电子显微镜证实。结果显示了明确地在 CNE1 房间的表面上绑在 EGFR 的那 C225-USPIO 并且被收起进房间。由 CNE1 房间的 C225-USPIO 的举起与时间显著地增加了,当时与人的 IgG-USPIO 相比。另外, 4.7 T 磁性的回声成像(MRI ) 随着时间的过去表明 C225-USPIO 有一个能力在 CNE1 房间积累,与在 MRI T2 加权的信号紧张的结果的显著减少。这些调查结果当一个 MRI 对比代理人和罐头被采用 non-invasively 与 EGFR overexpression 检测早阶段的 NPC,暗示 C225-USPIO 有潜力。这为与混合物在 vivo 实验开始提供足够的理论基础。 | Dongbo Liu Chunli Chen Guangyuan Hu Qi Mei Hong Qiu Guoxian Long Guoqing Hu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 10 |
| 3 | Crosstalk Complexities between Auxin, Cytokinin, and Ethylene in Arabidopsis Root Development: From Experiments to Systems Modeling, and Back Again显示文摘理解荷尔蒙和基因怎么交往在变化环境协调植物生长是在植物的主要挑战发展生物学。植物生长素,细胞激动素,和乙烯是调整植物开发的许多方面的三重要荷尔蒙。这评论极其在 Arabidopsis 根开发评估在三荷尔蒙之间的串音。我们把许多试验性的数据集成到一个串音网络,它在植物生长素,细胞激动素,和乙烯串音揭示复杂性的多重层。特别地,数据集成揭示在乙烯和细胞激动素小径之间的一个另外的、大部分俯看的连接,它通过 phosphorelay 机制行动。这个建议连接探讨乙烯申请是否支持或禁止乙烯受体的受体 kinase 活动的突出的问题。阐明在植物生长素,细胞激动素,和乙烯串音的复杂性要求一联合试验性并且系统建模途径。我们为证实在植物生长素,细胞激动素,和乙烯之间的串音怎么在根开发调整 patterning 评估重要当模特儿的努力。我们讨论反复地把实验与为分析建模的系统相结合的新奇方法论怎么为阐明是必要的在在根开发的植物生长素,细胞激动素,和乙烯的串音的复杂性。最后,我们讨论未来挑战从一联合试验性、建模的观点。 | Junli Liu Simon Moore Chunli Chen Keith Lindsey | 2017 | Molecular Plant2017，10，12： | 8 |
| 4 | Research on the Mechanism of Penetration Increase by Flux in A-TIG Welding显示文摘The mechanism of penetration depth increased by activating flux in activating tungsten inert gas (A-TIG) weldingwas studied by measuring the distribution of trace element Bi in the weld and monitoring the change of arc voltageduring A-TIG welding of stainless steel 0Crl8Ni9 with fluxes SiO2 and TiO2. The results show that the mechanismof penetration depth in A-TIG welding depends on the sort of flux used. The weld pool convection after coating theflux SiO2 and flux TiO2 is changed inversely compared with convectional TIG welding without flux. The arc voltageis increased by flux SiO2 whilst flux TiO2 does not have effect on the arc voltage. The reason of penetration depthincrease for SiO2 is due to the constriction of arc plasma and the change of surface tension gradient. The increaseof weld penetration depth with TiO2 only ascribes to the change of surface tension gradient. | Chunli YANG Sanbao LIN Fengyao LIU Lin WU Qingtao ZHANG | 2003 | Journal of Materials Science & Technology2003，19，z1： | 8 |
| 5 | Chemical speciation code CHEMSPEC and its applications显示文摘The adsorption and migration behavior of a radionuclide in geological media heavily depends on its chemical forms in a given chemical environment.In order to predict the temporal and spatial distribution of radionuclides around a disposal site when its canister is damaged,it is necessary to develop coupled chemical speciation-solute transport models and relevant software.For that reason,we wrote a new chemical speciation program CHEMSPEC.In this paper,the principles and structure of CHEMSPEC are briefly described,and the strategy and algorithms that were used in this code are interpreted in some detail,such as the measures adopted to prevent divergence in iteratively solving the mass balance equations,the 'predictor-corrector' algorithm for calculation of the number and quantities of solid species formed,and the alternate use of 'freezing' and 'defreezing' oxidation states in handling of co-existent redox and precipitation equilibria.Four examples are given to illustrate CHEMSPEC's features and capabilities. | WANG XiangYun CHEN Tao LIU ChunLi | 2009 | Science China Chemistry2009，52，11： | 5 |
| 6 | Employee quality,monitoring environment and internal control显示文摘We investigate the effect of internal control employees(ICEs) on internal control quality. Using special survey data from Chinese listed firms, we find that ICE quality has a significant positive influence on internal control quality.We examine the effect of monitoring on this result and find that the effect is more pronounced for firms with strict monitoring environments, especially when the firms implement the Chinese internal control regulation system(CSOX), have higher institutional ownership or attach greater importance to internal control. Our findings suggest that ICEs play an important role in the design and implementation of internal control systems. Our study should be of interest to both top managers who wish to improve corporate internal control quality and regulators who wish to understand the mechanisms of internal control monitoring. | Chunli Liu Bin Lin Wei Shu | 2017 | China Journal of Accounting Research2017，，1： | 5 |
| 7 | Application of red mud as a basic catalyst for biodiesel production显示文摘Red mud was investigated in triglyceride transesterification with a view to determine its viability as a basic catalyst for use in biodiesel synthesis.The effect of calcination temperature on the structure and activity of red mud catalysts was investigated.It was found that highly active catalyst was obtained by simply drying red mud at 200°C.Utilization of red mud as a catalyst for biodiesel production not only provides a cost-effective and environmentally friendly way of recycling this solid red mud waste,significantly reducing its environmental effects,but also reduces the price of biodiesel to make biodiesel competitive with petroleum diesel. | Qiang Liu Ruirui Xin Chengcheng Li Chunli Xu Jun Yang | 2013 | Journal of Environmental Sciences2013，25，4： | 5 |
| 8 | In situ U-Pb dating of xenotime by laser ablation (LA)-ICP-MS显示文摘Xenotime is an ideal mineral for U-Th-Pb isotopic dating because of its relatively high U and Th contents, but typically low concentration of common Pb. These characteristics, and the fact that it is widespread throughout various types of rocks, suggest that the U-Th-Pb dating of xenotime has broad applications. Studies of U-Pb dating on xenotime by ion microprobe (such as SHRIMP) have increased in recent years, whereas studies by laser ablation (LA)-ICP-MS are still rare. In this study, we developed a technique for U-Pb dating of xenotime using the 193 nm ArF laser-ablation system and Agilent 7500a Q-ICP-MS. To evaluate the reliability of our method, a xenotime standard, BS-1, was analyzed and calibrated against another xenotime standard, MG-1. The weighted mean 206 Pb/ 238 U ages of 510.1 ± 5.2 Ma (2 n = 21), 509.8 ± 4.3 Ma (2 n = 21) and 510.0 ± 4.6 Ma (2 n = 21) were obtained using beam diameters of 16, 24 and 32 m, respectively. These ages are identical to those determined by ID-TIMS method (weighted mean 206 Pb/ 238 U age of 508.8 ± 1.4 Ma), which supports the reliability of our LA-ICP-MS method. We also analyzed xenotimes in leucogranites from South Tibet and granites from Xihuashan in southern China, and obtained accurate and precise ages. Nevertheless, we observed systematic differences in Pb/U fractionation among xenotime, monazite and zircon. The matrix-effect resulted in either under-correction or over-correction of fractionation, and thus led to inaccurate ages. Thus, a matrix-matched material is required for U-Pb dating of xenotime by LA-ICP-MS. | LIU ZhiChao WU FuYuan GUO ChunLi ZHAO ZiFu YANG JinHui SUN JinFeng | 2011 | Chinese Science Bulletin2011，56，27： | 5 |
| 9 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 10 | Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway显示文摘Consumption of kava(Piper methysticum Forst) has been linked to reduced cancer risk in the South Pacific Islands.Kavalactones are major bioactive components in kava root extracts, which have recently demonstrated anti-cancer activities. However, molecular mechanisms of kavalactones' anti-cancer action remain largely unknown. We have identified two kavalactones, yangonin and 5' 6'-dehydrokawain, as potent inducers of autophagic cell death in bladder cancer cells. The effect of yangonin inducing autophagy is associated with increased expression of beclin and ATG5.In addition, yangonin increases the expression of LKB1 and decreases the phosphorylation of Akt, PRAS40, rpS6,p70S6 K and 4E-BP1, leading to increased binding of 4E-BP1 to m7 GTP. The growth inhibitory effects of yangonin were attenuated in TSC1 or LKB1 knockout mouse embryonic fibroblasts, suggesting that TSC1 and LKB1 expression may contribute to optimal growth inhibition by yangonin. Furthermore, yangonin reduces the viability of bladder cancer cell lines derived from different stages of human bladder cancer, and acts synergistically with apoptosis-inducing agents such as docetaxel and flavokawain A. Our results support a novel anti-bladder cancer mechanism by yangonin and further studies are needed to assess the potential use of yangonin for bladder cancer prevention and | Zhongbo Liu U-Syn Ha Ke Yu Chunli Wu Noriko Yokoyama Xiaolin Zi | 2017 | The Journal of Biomedical Research2017，31，5： | 4 |
| 11 | Separation process of butanol-butyl acetate-methyl isobutyl ketone system by the analysis to residual curve and the double effect pressure-swing distillation显示文摘The separation of ternary mixture of butanol, butyl acetate, and methyl isobutyl ketone(MIBK) was initially analyzed by the residual curve. In this process, MIBK was chosen as the azeotropic agent during the first step of separation. The optimum mass ratio of extra MIBK was 1.6 in the modified feed stream according to the residual curve. Thus on this condition the top product was butanol-MIBK azeotrope while the bottom product was butyl acetate in the preliminary separation of the mixture. Then the butanol and MIBK azeotrope was separated by the double effect pressureswing distillation with the low pressure column performing at 30 kPa and the atmospheric pressure column at 101 kPa. The optimal operating conditions were then obtained by using Aspen Plus to simulate and optimize the process. The results showed that the mass purities of butanol, butyl acetate, and MIBK were all more than 99% and reached the design requirements. Additionally, compared with the traditional distillation with outside heating, the double effect pressure swing distillation saved the reboiler duty by 48.6% and the condenser duty by 44.6%. | Chunli Li Yuanyuan Song Jing Fang Yang Liu Weiyi Su Yuqi Hu | 2017 | Chinese Journal of Chemical Engineering2017，25，3： | 4 |
| 12 | Kinetics of FeSe_2 oxidation by ferric iron and its reactivity compared with FeS_2显示文摘The mobility and bioavailability of selenium is a major health and environmental issue and a main concern for geological disposal of high-level radioactive waste. Chemically and/or microbially mediated oxidation of insoluble Se-bearing particulate, such as iron selenides, to dissolved and mobile phases controls the transport and distribution of Se in the environment. The oxidation of ferroselite(FeSe2) by ferric iron was investigated in anoxic conditions. The redox reaction can be represented by: FeSe2 + 2Fe3+ = 2Se0 + 3Fe2+. Kinetic studies indicated that the reaction can be described by second-order rate law, with rate constants of 0.49±0.01, 0.85±0.02, 1.84±0.04, and 3.29±0.13 L mol-1 s-1 at pH 1.62, 1.87, 2.23, and 2.49, respectively. The positive correlation between reaction rate and pH implies that diffusion of Fe3+ oxidant to the mineral surface is the rate-determining step. The strong reactivity of FeSe2 towards Fe3+ suggests that ferric iron may play a significant role in FeSe2 oxidation process(e.g., by Se4+, O2, etc.) and Se0 should be the first reaction product. Also, it was shown that the reduction rate of Fe3+ or Se4+ by pyrite(FeS2) can be significantly increased in the presence of FeSe2, suggesting a stronger reactivity of FeSe2 compared with pyrite. The results obtained extend our knowledge about the subtle interaction between Se, pyrite and iron selenides in the environment, and give insight into the transfer of selenium from iron selenides to bio-available selenium(i.e., selenite and selenate) in the Se-rich environment. | MA Bin NIE Zhe LIU ChunLi KANG MingLiang BARDELLI Fabrizio CHEN FanRong CHARLET Laurent | 2014 | Science China Chemistry2014，57，9： | 3 |
| 13 | Osteoporosis affects both post-yield microdamage accumulation and plasticity degradation in vertebra of ovariectomized rats显示文摘Estrogen withdrawal in postmenopausal women increases bone loss and bone fragility in the vertebra. Bone loss with osteoporosis not only reduces bone mineral density(BMD), but actually alters bone quality, which can be comprehensively represented by bone post-yield behaviors. This study aimed to provide some information as to how osteoporosis induced by estrogen depletion could influence the evolution of post-yield microdamage accumulation and plastic deformation in vertebral bodies. This study also tried to reveal the part of the mechanisms of how estrogen deficiency-induced osteoporosis would increase the bone fracture risk. A rat bilateral ovariectomy(OVX)model was used to induce osteoporosis. Progressive cyclic compression loading was developed for vertebra testing to elucidate the post-yield behaviors. BMD, bone volume fraction, stiffness degradation, and plastic deformation evolution were compared among rats raised for 5 weeks(ovx5w and sham5 w groups) and 35 weeks(ovx35w and sham35 w groups) after sham surgery and OVX. The results showedthat a higher bone loss in vertebral bodies corresponded to lower stiffness and higher plastic deformation. Thus, osteoporosis could increase the vertebral fracture risk probably through microdamage accumulation and plastic deforming degradation. | Siwei Li Guodong Niu Neil X. Dong Xiaodu Wang Zhongjun Liu Chunli Song Huijie Leng | 2017 | Acta Mechanica Sinica2017，33，2： | 3 |
| 14 | Uranium sorption on oxyhydroxide minerals by surface complexation and precipitation显示文摘During the chemical weathering of the uranium mill tailings,released uranium could be immobilized by the newly formed secondary minerals such as oxyhydroxides.A deeper understanding of the interaction between uranium and common oxyhydroxides under environmental conditions is necessary.In this work,uranium sorption behaviors on Al-,Mn-and Fe-oxyhydroxide minerals(boehmite,manganite,goethite,and lepidocrocite)were investigated by batch experiments.Results showed that the uranium sorption on Al-oxyhydroxide behaved significantly differently from the other three minerals.The sorption edge of the Mn-and Fe-oxyhydroxides located around pH 5,while the sorption edge of boehmite shifted about 1.5 pH unit to near neutral.The sorption isotherms of uranium on manganite,goethite and lepidocrocite at pH 5.0 could be well fitted by the Langmuir model.Instead of surface complexation,sorption on boehmite happened mainly by uranium-bearing carbonates and hydroxides precipitation as illustrated by the characterization results.Both carbonate and phosphate strongly affected the uranium sorption behavior.The removal efficiency of uranium by boehmite exceeded 98%after three sorption-desorption cycles,indicating it may be a potential material for uranium removal and recovery. | Jingyi Wang Wanqiang Zhou Yanlin Shi Yao Li Dongfan Xian Ning Guo Chunli Liu | 2022 | Chinese Chemical Letters2022，33，7： | 3 |
| 15 | Creep behaviour and constitutive model of coal filled with gas显示文摘Coal exhibits different creep behaviours when filled with different amounts of gas. Creep tests of coal filled with 0 and 0.5 MPa gas were performed, and strain under different axial stress was compared.The three creep constitutive models which were analysed using the method fitting experimental data for determining which creep model can reflect the creep process of the test best. The results show that the deformation of coal filled with 0.5 MPa gas is more higher than that of coal filled with 0 MPa gas under the same axial stress. Gas plays a positive effect on the deformation of coal process and will accelerate creep process. And gas will reduce coal intensity and change coal creep properties.Compared with Nishihara Model and Extensional Nishihara Model, Burgers Model can reflect the three stages of creep process of coal filled with gas better. The research results can contribute to reveal coal and gas outburst mechanism. | Li Xiangchun Yang Chunli Ren Ting Nie Baisheng Zhao Caihong Liu Shuiwen Jiang Tao | 2017 | International Journal of Mining Science and Technology2017，27，5： | 3 |
| 16 | Construction of TiO_(2)-covalent organic framework Z-Scheme hybrid through coordination bond for photocatalytic CO_(2) conversion显示文摘In this work,a covalent organic framework(COF),which is constructed by the building blocks of[5,10,15,20-tetrakis(4-aminophenyl)porphinato]copper(Ⅱ)(CuTAPP)and p-benzaldehyde,is employed to integrate with TiO_(2) for the purpose of establishing a Z-scheme hybrid.Within the system,isonicotinic acid performs the role of a bridge that connects the two components through a coordination bond.Further photocatalytic application reveals the hybrid framework is able to catalyze CO_(2) conversion under simulated solar light,resulting in CO production rate of 50.5 μmol g^(-1)·h^(-1),about 9.9 and 24.5 times that of COF and pristine TiO_(2),respectively.The ameliorated catalytic performance owes much to the por-phyrin block acting as photosensitizer that augments the light absorbance,and the establishment of Z-scheme system between the inorganic and orga nic comp on ents that enhances the separati on of the carriers.In addition,the chemical bridge also ensures a steady usage and stable charge delivery in the catalysis.Our study sheds light on the development of versatile approaches to covalently in corporate COFs with inorga nic semic on ductors. | Lei Wang Guofang Huang Liang Zhang Rui Lian Jingwei Huang Houde She Chunli Liu Qizhao Wang | 2022 | Journal of Energy Chemistry2022，31，1： | 3 |
| 17 | Location and size regulation of manganese oxides within mesoporous silica for enhanced antibiotic degradation显示文摘Refractory antibiotics in domestic wastewater are hard to be completely eliminated by conventional methods,and then lead to severe environmental contamination and adverse effects on public health.In present work,advanced oxidation processes(AOPs)are adopted to remove the antibiotic of sul-fachloropyridazine(SCP).Nanosized Mn_(2)O_(3) was fabricated on the SBA-15 material to catalytically acti-vate potassium peroxydisulfate(PDS)to generate reactive oxygen radicals of.OH and SO_(4).for SCP degradation.The effects of location and size of Mn_(2)O_(3) were explored through choosing either the as-made or template free SBA-15 as the precursor of substrate.Great influences from the site and size of Mn_(2)O_(3) on the oxidation activity were discovered.It was found that Mn_(2)O_(3) with a large size at the exterior of SBA-15(Mn-tfSBA)was slightly easier to degrade SCP at a low manganese loading of 1.0-2.0 mmol.g;however,complete SCP removal could only be achieved on the catalyst of Mn_(2)O_(3) with a refined size at the interior of SBA-15(Mn-asSBA).Moreover,the SO_(4).species were revealed to be the decisive radicals in the SCP degradation processes.Exploring the as-made mesoporous silica as a support provides a new idea for the further development of environmentally friendly catalysts. | Min Lu Mengxuan Liu Chunli Xu Yu Yin Lei Shi Hong Wu Aihua Yuan Xiao-Ming Ren Shaobin Wang Hongqi Sun | 2022 | Chinese Journal of Chemical Engineering2022，35，8： | 3 |
| 18 | Formation of domain structure of erythrocyte membrane in Wistar rat fed with CeCl_3per os显示文摘To explore the possibility of absorption of lanthanides via digestive duct and their effects on one membrane structure and permeability of erythrocytes, the fine structure of erythrocyte membrane from Wistar rats, fed for 70 days of daily administration per os with 20 mg CeCl3/kg weight, was imaged by means of atomic force microscopy and FT-IR deconvolution spectra. The results show that, although the erythrocytes maintain the intact shape, the change OT secondary structure, aggregation and crosslinking of the protein particles of membrane surface and the enlarged lipid regions lead to the domain structure formation. This structure might be responsible for the increasing permeability of erythrocyte membrane. | CHENG Yi, LIU Maozi, LI You, LI Rongchang, BAI Chunli & WANG Kui National Research Laboratories of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, China Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Wang Kui | 2000 | Chinese Science Bulletin2000，45，5： | 3 |
| 19 | CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage显示文摘Circular RNAs(circRNAs)are a novel class of endogenous noncoding RNAs that play important roles in gene expression regulation.This study aimed to evaluate the potential role of circRNAs in decidual tissue of patients with early recurrent miscarriage(RM).We constructed circRNA expression profiles in decidual tissue using microarray data.A total of 123 differentially expressed circRNAs,including 78 upregulated and 45 downregulated circRNAs were detected in the early RM group compared with the control group(P<0.05).Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis also revealed the enrichment of specific circRNAs.The verified circRNA-targeted miRNA-mRNA network was constructed,most of the circRNAs harbored miRNA binding sites.The network involved 3 circRNAs,27 microRNAs and 82 mRNAs.Hsa_circRNA_103092-miR-224-PRLR network was selected to verify by qRT-PCR.These results showed that circRNAs are aberrantly expressed in the decidual tissue in early RM patients and play potential roles in the development of early RM.It gives new insights into the mechanism of recurrent miscarriage. | Chunli Li Xuemei Chen Xueqing Liu Xiaoli Liu Junlin He Yubin Ding Chao Tong Chuan Peng Yingxiong Wang Rufei Gao | 2020 | Genes & Diseases2020，7，3： | 3 |
| 20 | Hierarchical Micropore/Nanorod Apatite Hybrids In-Situ Grown from 3-D Printed Macroporous Ti6Al4V Implants with Improved Bioactivity and Osseointegration显示文摘The advent of three-dimensional(3-D) printed technique provides great possibility in the fabrication of customized porous titanium(Ti) implant. However, the bioinert property of the printed Ti poses an outstanding problem. Hybrid micro-arc oxidation and hydrothermal(MAO–HT) treatment on porous metals is able to produce multi-scaled hierarchical orthopedic implant, showing great potential for surface modification of 3-D printed implant. In this study, cylindrical porous Ti6Al4V(Ti64) scaffolds with pore size of 640 μm, porosity of 73% were 3-D printed by electron beam melting process, and their surfaces were left untreated or treated by a combined MAO–HT procedure. In vitro bioactivity was tested by immersion in simulated body fluid for different time points. Then, 12 scaffolds in each group were implanted into the femoral condyles of New Zealand rabbit for 8 weeks. Osseointegration was evaluated by qualitative and quantitative histological analysis, and the bone ingrowth features were probed by sequential fluorescent labeling at 3 and 6 weeks post-surgery. Following the MAO–HT treatment, the porous Ti64 scaffold was endowed with multi-scaled micro/nano-topographies and high amounts of Ca P on its surface.The treated scaffold exhibited drastically enhanced apatite forming ability compared with the untreated one. In vivo test revealed significantly that a higher amount of bone ingrowth and bone implant contact at the treated scaffold. The 2 types of scaffolds had different patterns of bone ingrowth: the treated scaffold exhibited a pattern of contact osteogenesis, by which bone formed directly on the treated implant surface, whereas bone formed distal to the implant surface of the untreated scaffold. MAO–HT treatment can significantly enhance the in vitro apatite-inducing ability and in vivo osseointegration capacity of 3-D porous Ti64 scaffold and may provide as a viable approach for the fabrication of bioactive 3-D printed porous implant for orthopedic applications. | Peng Xiu Zhaojun Jia Jia Lv Chuan Yin Hong Cai Chunli Song Huijie Leng Yufeng Zheng Zhongjun Liu Yan Cheng | 2017 | Journal of Materials Science & Technology2017，33，2： | 2 |
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