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| 1 | Novel CeO_2@TiO_2 core–shell nanostructure catalyst for selective catalytic reduction of NOx with NH_3显示文摘The CeO_2@TiO_2 core-shell nanostructure catalyst prepared by a two-step hydrothermal method was used for selective catalytic reduction(SCR) of NOx with NH_3 in this study.The catalyst presented the obvious core-shell structure,and the shell was amorphous TiO_2which could protect the active center from the SO_2 erosion.The catalyst showed high activity and stability,excellent N_2 selectivity and superior SO_2 resistance and H_2O tolerance.Characterizations such as TEM,HR-TEM,XRD,BET,XPS,NH_3-TPD,and H_2-TPR were carried out.The results indicated that the catalyst had large surface area and the active sites were well dispersed on the surface.The NH_3-TPD,H_2-TPR and XPS results implied that its increased SCR activity might be due to the enhancement of NH_3 chemisorption and the increase of active oxygen species,both of which were conductive to NH_3 activation.The excellent catalytic performance suggests that it is a promising candidate for SCR catalyst. | Bingjie Huang Danqing Yu Zhongyi Sheng Liu Yang | 2017 | Journal of Environmental Sciences2017，29，5： | 15 |
| 2 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy显示文摘 | Kefang Liu ShuguangTan Yan Chai Danqing Chen Hao Song Catherine Wei-Hong Zhang yi Shi Jun Liu Wenjie Tan Jianxin Lyu Shah Gao Jinghua Yan Jianxun Qi George F Gao | 2017 | Cell Research2017，27，1： | 11 |
| 3 | Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies显示文摘基于抗体的 PD-1/PD-L1 封锁治疗为癌症在免疫疗法拿了中心舞台,与多重临床的成功。发信号的 PD-1 在肿瘤驱动的 T 房间机能障碍起枢轴的作用。与优先的途径相对照产生或增加肿瘤特定的 T 房间回答,基于抗体的 PD-1/PD-L1 封锁指向导致肿瘤的 T 房间缺点并且恢复先存在调制 antitumor 免疫的 T 房间功能。在这评论,表达式规定和 PD-1 的禁止的函数和基于抗体的 PD-1/PD-L1 封锁治疗的现在的理解上的基本知识简短被总结。我们然后有关 PD-1/PD-Ls 相互作用的结构的基础集中于最近的突破工作并且怎么指向 PD-L1 的治疗学的抗体, pembrolizumab 指向 PD-1 和 avelumab,与 PD-1/PD-L1 的绑定竞争打断 PD-1/PD-L1 相互作用。我们相信这个结构的信息将有益于指向 PD-1 发信号的治疗学的抗体的设计和改进。 | ShuguangTan Danqing Chen Kefang Liu Mengnan He Hao Song Yi Shi Jun Liu Catherine W.-H. Zhang Jianxun Qi Jinghua Yan Shan Gao George F. Gao | 2016 | Protein & Cell2016，7，12： | 8 |
| 4 | Rupture process and aftershock focal mechanisms of the 2022 M6.8 Luding earthquake in Sichuan显示文摘According to the China Earthquake Networks Center,a strong earthquake of M6.8 occurred in Luding County,Ganzi Tibetan Autonomous Prefecture,Sichuan Province,China(102.08°E,29.59°N),on September 5,2022,with a focal depth of 16 km.Rapid determination of the source parameters of the earthquake sequence is vital for post-earthquake rescue,disaster assessment,and scientific research.Near-field seismic observations play a key role in the fast and reliable determination of earthquake source parameters.The numerous broadband seismic stations and strong-motion stations recently deployed by the National Earthquake Intensity Rapid Report and Early Warning project have provided valuable real-time near-field observation data.Using these near-field observations and conventional mid-and far-field seismic waveform records,we obtained the focal mechanism solutions of the mainshock and M≥3.0 aftershocks through the waveform fitting method.We were further able to rapidly invert the rupture process of the mainshock.Based on the evaluation of the focal mechanism solution of the mainshock and the regional tectonic setting,we speculate that the Xianshuihe fault formed the seismogenic structure of the M6.8 strong earthquake.The aftershocks formed three spatially separated clusters with distinctly different focal mechanisms,reflecting the segmented nature of the Xianshuihe fault.As more high-frequency information has been applied in this study,the absolute location of the fault rupture is better constrained by the near-field strong-motion data.The rupture process of the mainshock correlates well with the spatial distribution of aftershocks,i.e.,aftershock activities were relatively weak in the maximum slip area,and strong aftershock activities were distributed in the peripheral regions. | Zhigao Yang Danqing Dai Yong Zhang Xuemei Zhang Jie Liu | 2022 | Earthquake Science2022，35，6： | 5 |
| 5 | Influence of electric field on the quenched-in vacancy and solute clustering during early stage ageing of Al-Cu alloy显示文摘The effects of electric field on the evolution of excess quenched-in vacancy as well as solute clustering in Al-4wt%Cu alloy, and on the vacancy migration and formation enthalpy of pure aluminum were investigated, using positron annihilation lifetime spectroscopy, high-angle annular dark-field scanning transmission electron microscopy, transmission electron microscopy, hardness measurement and four-probe electrical resistivity measurement. The results showed that the electric field improved age hardening response obviously and postponed the decay of excess vacancies for 30 min during the early stage ageing of Al-4wt%Cu alloy. A large number of 2–4 nm GP zones with dense distribution were observed after 1 min ageing with an electric field applied. The electric field-assisted-aged sample owned a lower coarsening rate of GP zone, which was about three fifths of that in the aged sample without an electric field, from 1 min to 120 min ageing. The electric field contributed 8% increase of the vacancy migration enthalpy(0.663 ± 0.021 e V) of pure Al, comparing with that(0.611 ± 0.023 e V) of pure Al without an electric field. The increase of vacancy migration enthalpy, induced by the electric field, was responsible for the difference on evolution of quenched-in vacancy, rapid solute clustering and age hardening improvement during the early stage ageing of Al-4wt%Cu alloy. | Shang Fu Ying Zhang Huiqun Liu Danqing Yi Bin Wang Yong Jiang Zhiquan Chen Ning Qi | 2018 | Journal of Materials Science & Technology2018，34，2： | 3 |
| 6 | Synthesis and biological evaluation of new 13-n-nonylprotoberberine derivatives as antitubercular agents显示文摘Tuberculosis is a serious threat to public health throughout the world.A series of new l3-n-nonylprotoberberine derivatives was designed,synthesized and evaluated for anti-mycobacterial activity against Mycobacterium tuberculosis strain H_(37)Rv.Several compounds(2,11a-c,11g,13d,15c)exhibited excellent anti-tubercular activity with an MIC below 1.0μg/mL.Notably,compound 13d showed potential antibacterial effect against both drug-susceptible and multidrug-resistant(MDR)M.tuberculosis with MIC ranges of 0.0625-1.0μg/mL.These results suggest a mode of action different from that of the current anti-mycobacterial drugs rifampicin and isoniazid.Hence,compound 13d is an attractive lead compound for the development of new antitubercular agents. | Yinghong Li Yanxin Liu Yanxiang Wang Sheng Tang Danqing Song | 2013 | Acta Pharmaceutica Sinica B2013，3，1： | 3 |
| 7 | Synthesis and biological evaluation of novel tricyclic matrinic derivatives as potential anti-filovirus agents显示文摘Twenty-six novel tricyclic sophoridinic and matrinic derivatives containing a common chlorinated benzene fragment were designed, synthesized and evaluated for their anti-ebolavirus(EBOV)activities. Structure–activity relationship analysis indicated:(i) 12 N-dichlorobenzyl motif was beneficial for the activity;(ii) the chiral configuration at C5 atom might not affect the activity much. Among the target compounds, compound 7d exhibited the most potent potency against EBOV with an IC_(50) value of 5.29 μmol/L and an SI value of over 37.8. Further in vivo anti-EBOV assay of 7d identified its high effectiveness, and in vivo anti-MARV assay of 7d suggested its inspiring broad-spectrum anti-filovirus activity. The results provided powerful information on further strategic optimization and development of this kind of compounds against filoviruses. | Xin Zhang Qiang Liu Qianqian Li Yinghong Li Zhandong Liu Hongbin Deng Sheng Tang Yanxiang Wang Youchun Wang Danqing Song | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 2 |
| 8 | Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects显示文摘Using chemoproteomic techniques,we first identified EIF2AK2,eEF1A1,PRDX3 and VPS4B as direct targets of berberine(BBR)for its synergistically anti-inflammatory effects.Of them,BBR has the strongest affinity with EIF2AK2 via two ionic bonds,and regulates several key inflammatory pathways through EIF2AK2,indicating the dominant role of EIF2AK2.Also,BBR could subtly inhibit the dimerization of EIF2AK2,rather than its enzyme activity,to selectively modulate its downstream pathways including JNK,NF-κB,AKT and NLRP3,with an advantage of good safety profile.In EIF2AK2 gene knockdown mice,the inhibitory IL-1β,IL-6,IL-18 and TNF-a secretion of BBR was obviously attenuated,confirming an EIF2AK2-dependent anti-inflammatory efficacy.The results highlight the BBR's network mechanism on anti-inflammatory effects in which EIF2AK2 is a key target,and inhibition of EIF2AK2 dimerization has a potential to be a therapeutic strategy against inflammationrelated disorders. | Wei Wei Qingxuan Zeng Yan Wang Xixi Guo Tianyun Fan Yinghong Li Hongbin Deng Liping Zhao Xintong Zhang Yonghua Liu Yulong Shi Jingyang Zhu Xican Ma Yanxiang Wang Jiandong Jiang Danqing Song | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 2 |
| 9 | Optimization of Extraction Process and Antioxidant Activity of Polysaccharide in Embelia parviflora Wall.by RSM显示文摘[Objectives]To optimize the extraction process of polysaccharide in Embelia parviflora Wall.by response surface methodology,and to study the antioxidant activity in vitro of polysaccharide in E.parviflora,so as to provide a basis for the further development and utilization of E.parviflora.[Methods]The solid-to-liquid ratio,extraction temperature,extraction time and extraction times were used as single factors to investigate the effects.On this basis,the response surface methodology(RSM)was used to optimize the extraction process of polysaccharide in E.parviflora.DPPH and ABTS free radicals were used to investigate the antioxidant capacity of polysaccharide in E.parviflora.[Results]The optimal solid-to-liquid ratio for extraction of polysaccharide from E.parviflora was 32∶1(mL/g),extraction temperature was 77℃,and extraction time was 36 min.The IC50 values of DPPH and ABTS were 0.04 and 0.03 mg/mL,respectively.[Conclusions]The optimized extraction process of polysaccharide in E.parviflora is stable,the extraction rate is high,and has strong antioxidant activity.It is expected to provide a reference for the industrial extraction of polysaccharide from E.parviflora. | Wenli LI Xianxian LIU Xiaolian LIANG Yong CHEN Danqing PANG Zhouyan HUANG Qian HAN Wenjun LIU Liangni CHEN | 2020 | Medicinal Plant2020，11，3： | 2 |
| 10 | Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration显示文摘 | Yujing Zhang Danqing Liu Xi Chen Jing Li Limin Li Zhen Bian Fei Sun Jiuwei Lu Yuan Yin Xing Cai Qi Sun Kehui Wang Yi Ba Qiang Wang Dongjin Wang Junwei Yang Pingsheng Liu Tao Xu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Molecular Cell2010，，1： | 2 |
| 11 | Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration显示文摘 | Yujing Zhang Danqing Liu Xi Chen Jing Li Limin Li Zhen Bian Fei Sun Jiuwei Lu Yuan Yin Xing Cai Qi Sun Kehui Wang Yi Ba Qiang Wang Dongjin Wang Junwei Yang Pingsheng Liu Tao Xu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Molecular Cell2010，，1： | 1 |
| 12 | Microstructures and properties of silver-based contact material fabricated by hot extrusion of internal oxidized Ag–Sn–Sb alloy powders显示文摘 | Canhui Xu Danqing Yi Chunping Wu Huiqun Liu Weizhou Li | 2012 | Materials Science & Engineering A2012，，： | 1 |
| 13 | Genetic variations within a collection of anthuriums unraveled by morphological traits and AFLP markers显示文摘 | Yaying Ge Fei Zhang Xiaolan Shen Yongming Yu Xiaoyun Pan Xiaojing Liu Jianxin Liu Gangmin Pan Danqing Tian | 2012 | Biochemical Systematics and Ecology2012，，： | 1 |
| 14 | The tissue distribution in mice and pharmac okinetics in rabbits of oxaliplatin liposome 显示文摘 | Xiaoping Liu Danqing Geng Haixing Xu | 2009 | Journal of Liposome Research2009，19，4： | 1 |
| 15 | Morphology structure and formation mechanism of silicide coating by pack cementation process 显示文摘 | Xiao Lairong Cai Zhigang Yi Danqing Ying Lei Liu Huiqun Huang Daoyuan | 2006 | Transactions of Nonferrous Metals Society of China2006，16，5： | 1 |
| 16 | Thyra Bolton Increased Matrix Metalloproteinase 9 Predicts Poor Wound Healing in Diabetic Foot Ulcers显示文摘 | Yu Liu Danqing Min Thyra Bohon | 2009 | Diabetes Care January2009，32，1： | 1 |
| 17 | Microstructures and properties of silver-based contact material fabricated by hot extrusion of internal oxidized Ag–Sn–Sb alloy powders显示文摘 | Canhui Xu Danqing Yi Chunping Wu Huiqun Liu Weizhou Li | 2012 | Materials Science & Engineering A2012，，： | 1 |
| 18 | Chongmingfangyandezhishici崇明方言的指示词[ThedemonstrativesofChongmingDialect]显示文摘 | Liu Danqing(刘丹青) &HaiyanLiu(刘海燕) | 2005 | 方言2005，2，： | 1 |
| 19 | Focus and background, topic and liansentence in Chinese显示文摘 | Xu Liejiong Liu Danqing | 1998 | Chinese Language1998，，4： | 1 |
| 20 | Reactive Transport Modeling of Long-Term CO2 Sequestration Mechanisms at the Shenhua CCS Demonstration Project,China显示文摘Carbon dioxide injection into deep saline aquifers results in a variety of strongly coupled physical and chemical processes. In this study, reactive transport simulations using a 2-D radial model were performed to investigate the fate of the injected CO_2, the effect of CO_2-water-rock interactions on mineral alteration, and the long-term CO_2 sequestration mechanisms of the Liujiagou Formation sandstone at the Shenhua CCS(carbon capture and storage) pilot site of China. Carbon dioxide was injected at a constant rate of 0.1 Mt/year for 30 years, and the fluid flow and geochemical transport simulation was run for a period of 10 000 years by the TOUGHREACT code according to the underground conditions of the Liujiagou Formation. The results show that different trapping phases of CO_2 vary with time. Sensitivity analyses indicate that plagioclase composition and chlorite presence are the most significant determinants of stable carbonate minerals and CO_2 mineral trapping capacity. For arkosic arenite in the Liujiagou Formation, CO_2 can be immobilized by precipitation of ankerite, magnesite, siderite, dawsonite, and calcite for different mineral compositions, with Ca^(2+), Mg^(2+), Fe^(2+) and Na^+ provided by dissolution of calcite, albite(or oligoclase) and chlorite. This study can provide useful insights into the geochemistry of CO_2 storage in other arkosic arenite(feldspar rich sandstone) formations at other pilots or target sites. | Guodong Yang Yilian Li Aleks Atrens Danqing Liu Yongsheng Wang Li Jia Yu Lu | 2017 | Journal of Earth Science2017，28，3： | 1 |
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