|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | One-step approach for full-thickness skin defect reconstruction in rats using minced split-thickness skin grafts with Pelnac overlay显示文摘Background:Split-thickness skin grafting is the current gold standard for the treatment of traumatic skin loss.However,for patients with extensive burns,split-thickness skin grafting is limited by donor skin availability.Grafting split-thickness skin minced into micrografts increases the expansion ratio but may reduce wound repair quality.Dermal substitutes such as Pelnac can enhance the healing of full-thickness skin wounds,but their application currently requires two surgeries.The present study investigated whether it is possible to repair full-thickness skin defects and improve wound healing quality in a single surgery using Pelnac as an overlay of minced split-thickness skin grafts in a rat model.Methods:A full-thickness skin defect model was established using male Sprague-Dawley rats of 10 weeks old.The animals were randomly divided into control and experimental groups in which Vaseline gauze and Pelnac,respectively,were overlaid on minced split-thickness skin grafts to repair the defects.Wound healing rate and quality were compared between the two groups.For better illustration of the quality of wound healing,some results were compared with those obtained for normal skin of rats.Results:We found that using Pelnac as an overlay for minced split-thickness skin grafts accelerated wound closure and stimulated cell proliferation and tissue angiogenesis.In addition,this approach enhanced collagen synthesis and increased the formation of basement membrane and dermis as well as the expression of growth factors related to wound healing while reducing scar formation.Conclusions:Using minced split-thickness skin grafts overlaid with Pelnac enables the reconstruction of fullthickness skin defects in a single step and can increase the healing rate while improving the quality of wound healing. | Tong Liu Chao Qiu Chi Ben Haihang Li Shihui Zhu | 2019 | Burns & Trauma2019，7，1： | 7 |
| 2 | Mass culture of Undaria gametophyte clones and their use in sporeling culture显示文摘 | Wu Chaoyuan Li Dapeng Liu Haihang | 2004 | Hydrobiologia2004，512，： | 1 |
| 3 | A numerical study on smoke behaviors in inclined tunnel fires under natural ventilation显示文摘To investigate the effect of tunnel slope on hot gas movement and smoke distribution in a slopping tunnel fire,a series of tunnel fire models are built by fire dynamics simulator(FDS),with a slope varies from 0 to 10%.Parameters such as ceiling temperature and airflow velocity are measured.The results indicate that the relationship between smoke back-layering length and tunnel slope can be described as an exponential function.The smoke temperature at the downstream exit first increased and then decreased with a higher slope.The airflow velocity at downstream outlet increased nonlinearity when tunnel slope was less than 8%.In the slope tunnel,the fire smoke spread process can be divided into three stages.Fire smoke spreads upstream to the peak distance,subsequently,the upstream smoke layer decreases gradually,the tunnel fire reaches a quasi-steady state.The backflow characteristics of smoke in sloped tunnels are coupled with the downstream length and outlet smoke temperature.In the initial stage of a slope tunnel fire,smoke spreads upstream for a long distance,endangering human health. | Jie Kong Wenjiao You Zhisheng Xu Hui Liu Haihang Li | 2022 | Journal of Safety Science and Resilience2022，3，2： | 1 |
| 4 | Post-transcriptional regulation of erythropoiesis显示文摘Erythropoiesis is a complex,precise,and lifelong process that is essential for maintaining normal body functions.Its strict regulation is necessary to prevent a variety of blood diseases.Normal erythropoiesis is precisely regulated by an intricate network that involves transcription levels,signal transduction,and various epigenetic modifications.In recent years,research on posttranscriptional levels in erythropoiesis has expanded significantly.The dynamic regulation of splicing transitions is responsible for changes in protein isoform expression that add new functions beneficial for erythropoiesis.RNA-binding proteins adapt the translation of transcripts to the protein requirements of the cell,yielding mRNA with dynamic translation efficiency.Noncoding RNAs,such as microRNAs and lncRNAs,are indispensable for changing the translational efficiency and/or stability of targeted mRNAs to maintain the normal expression of genes related to erythropoiesis.N6-methyladenosine-dependent regulation of mRNA translation plays an important role in maintaining the expression programs of erythroid-related genes and promoting erythroid lineage determination.This review aims to describe our current understanding of the role of post-transcriptional regulation in erythropoiesis and erythroid-associated diseases,and to shed light on the physiological and pathological implications of the post-transcriptional regulation machinery in erythropoiesis.These may help to further enrich our understanding of the regulatory network of erythropoiesis and provide new strategies for the diagnosis and treatment of erythroid-related diseases. | Yanan Li Haihang Zhang Bin Hu Pan Wang Wei Wang Jing Liu | 2023 | Blood Science2023，5，3： | 0 |
| 5 | Fast and efficient parallel breadth-first search with power-law graph transformation显示文摘1 Introduction Most real-world graphs are large-scale but unstructured and sparse.One of the most notable characteristics of real-world graphs is the skewed power law degree distribution[1]:most vertices have a few neighbors while a few own a large number of neighbors.These characteristics present challenges for efficient parallel graph processing,such as load imbalance,poor locality,and redundant computations.Apart from modifying the graph programming abstraction or changing the execution models on different architectures,reducing the irregularity of graph data also improves the performance of graph processing[2].For example,it is wellknown that BFS has a bad temporal locality,but it is possible to transform irregular graphs to more regular ones to improve spatial locality and gain more performance. | Zite JIANG Tao LIU Shuai ZHANG Mengting YUAN Haihang YOU | 2022 | Frontiers of Computer Science2022，16，5： | 0 |
| 6 | A hybrid-order local search algorithm for set k-cover problem in wireless sensor networks显示文摘1 Introduction The lifetime of wireless sensor networks(WSNs)is restricted by the limited energy of battery-powered sensor devices,making the lifetime extension a critical problem in real applications[1].Several aspects have been examined in previous works to extend the lifetime of WSNs,such as the deployment position,the network routing strategy and the sensing range adjustment.Given the fact that there are often many redundant sensors,a practical way to extend the lifetime of a WSN is to partition the sensors into subsets,each of which can cover all the targets[2].Then the sets are activated one by one,extending the lifetime of a WSN to times of the battery lifetime of a sensor.The problem of finding the maximal is abstracted as the set k-cover problem. | Boxiao LIU Mengting YUAN Haihang YOU | 2023 | Frontiers of Computer Science2023，17，3： | 0 |
| 7 | Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation显示文摘With the emergence of DNA nanotechnology in the 1980s, self-assembled DNA nanostructures have attracted considerable attention worldwide due to their inherent biocompatibility, unsurpassed programmability, and versatile functions. Especially promising nanostructures are tetrahedral framework nucleic acids(t FNAs), first proposed by Turberfield with the use of a one-step annealing approach. Benefiting from their various merits, such as simple synthesis, high reproducibility, structural stability, cellular internalization, tissue permeability, and editable functionality, t FNAs have been widely applied in the biomedical field as threedimensional DNA nanomaterials. Surprisingly, t FNAs exhibit positive effects on cellular biological behaviors and tissue regeneration,which may be used to treat inflammatory and degenerative diseases. According to their intended application and carrying capacity,t FNAs could carry functional nucleic acids or therapeutic molecules through extended sequences, sticky-end hybridization,intercalation, and encapsulation based on the Watson and Crick principle. Additionally, dynamic t FNAs also have potential applications in controlled and targeted therapies. This review summarized the latest progress in pure/modified/dynamic t FNAs and demonstrated their regenerative medicine applications. These applications include promoting the regeneration of the bone,cartilage, nerve, skin, vasculature, or muscle and treating diseases such as bone defects, neurological disorders, joint-related inflammatory diseases, periodontitis, and immune diseases. | Yunfeng Lin Qian Li Lihua Wang Quanyi Guo Shuyun Liu Shihui Zhu Yu Sun Yujiang Fan Yong Sun Haihang Li Xudong Tian Delun Luo Sirong Shi | 2022 | International Journal of Oral Science2022，14，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员