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| 1 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 2 | Kindlin-2 expression in adult tissues correlates with their embryonic origins显示文摘Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tissues originated.Kindlin-2 expression was examined in normal adult human organs and human cancer tissues by immunohistochemical analyses.Analysis of Kindlin-2 mRNA levels in adult human organs in the Oncomine dataset revealed Kindlin-2 is highly expressed in mesoderm-derived organs.However,Kindlin-2 was negative or weakly expressed in endoderm/ectoderm-derived organs.Interestingly,the abnormal expression of Kindlin-2 was observed in a variety of human cancers.In agreement with its expression profile in humans,Kindlin-2 was also highly expressed in mesoderm-derived organs in mouse embryos with the exception of strong Kindlin-2 expression in ectoderm-derived spinal cord and ganglia,tissues that are highly mobile during embryonic development.Importantly,we demonstrated the expression level of Kindlin-2 in adult organs correlated with their embryonic dermal origins and deregulation of Kindlin-2 in tissues is associated with tumor progression.This finding will help us understand the dual role of Kindlin-2 in the regulation of tumor progression and embryonic development. | ZHAN Jun YANG Mei CHI XiaoChun ZHANG Jing PEI XueLian REN CaiXia GUO YongQing LIU Wei ZHANG HongQuan | 2014 | Science China(Life Sciences)2014，57，7： | 8 |
| 3 | The application of three-dimensional seismic spectral decomposition and semblance attribute to characterizing the deepwater channel depositional elements in the Taranaki Basin of New Zealand显示文摘In the past few years, three-dimensional(3-D) seismogram has become an essential tool for the interpretation of subsurface stratigraphy and depositional systems. Seismic stratigraphy in conjunction with seismic geomorphology has elevated the degree to which seismic data can facilitate geological interpretation, especially in a deepwater environment. Technologies such as time slicing and interval attribute analysis can enhance geomorphological interpretations, and, when integrated with stratigraphic analyses, can yield insights regarding distribution of seal and reservoir facies. Multiple attributes corendering can further bring out features of geological interest that other technologies may overlook. This method involves corender spectral decomposition components(SDC) with semblance attributes to describe the distribution of deepwater channel elements and the boundaries of deepwater sinuous channel. Applying this technology to four elements is observed:(1) point-bars,(2) migration of channel meander loops,(3) channel erosion/cut, and(4) avulsion. The planview expression of the deepwater channel ranges from low sinuosity to high sinuosity. Furthermore, this technology has enabled interpreters to visualize details of complex depositional elements and can be used to predict net-to-gross ratio in channel systems, which can be incorporated into borehole planning for exploration as well as development needs to improve risk management significantly. The technology is applied to the study area in an effort to illustrate the variety of interpretation technologies available to the geoscientist. | LI Quan WU Wei YU Shui KANG Hongquan TONG Liqing CAO Xiangyang LIU Xiaolong | 2017 | Acta Oceanologica Sinica2017，36，9： | 3 |
| 4 | Identification of novel Lynch syndrome mutations in Chinese patients with endometriod endometrial cancer显示文摘Objective:Lynch syndrome(LS)predisposes patients to early onset endometrioid endometrial cancer(EEC).However,little is known about LS-related EEC in the Chinese population.The aim of this study was to investigate the prevalence of LS and to identify the specific variants of LS in Chinese patients with EEC.Methods:We applied universal immunohistochemistry screening to detect the expression of mismatch repair(MMR)proteins,which was followed by MLH1 methylation analysis to identify suspected LS cases,next-generation sequencing(NGS)to confirm LS,and microsatellite instability(MSI)analysis to verify LS.Results:We collected 211 samples with EEC.Twenty-seven(27/211,12.8%)EEC cases had a loss of MMR protein expression.After MLH1 methylation analysis,16 EEC cases were suggested to be associated with LS.Finally,through NGS and MSI analysis,we determined that 10 EEC(10/209,4.78%)cases were associated with LS.Among those cases,3 unreported mutations(1 frameshift and 2 nonsense)were identified.M SH6 c.597_597delC,found in 4 patients,is likely to be a founder mutation in China.Conclusions:We demonstrated the feasibility of a process for LS screening in Chinese patients with EEC,by using universal immunohistochemistry screening followed by MLH1 methylation analysis and confirmation through NGS and MSI analysis.The novel mutations identified in this study expand knowledge of LS. | Caixia Ren Yan Liu Yuxiang Wang Yan Tang Yawei Wei Congrong Liu Hongquan Zhang | 2020 | Cancer Biology & Medicine2020，17，2： | 3 |
| 5 | Effect of rich R-TiO2 on the rate and cycle properties of Li4Ti5O12 as anode for lithium ion batteries显示文摘Li4Ti5012 (LTO) with rich R-TiO2 (17.06, 23.69, and 34.42 wt%), namely, R-TiO2@Li4Ti5O12 composites, were synthesized using the hydrothermal method and tetrabutyl titanate (TBT) as the precursor. Rietveld refinement of X-ray diffraction (XRD) results show that the proportion of Li occupying 16d sites is extraordinary low and the lattice constants of LTO and R-TiO2 change with the ritanium dioxide content. EIS measurements showed that with in creasing R-TiO2 content, both its charge transfer impedance (Rct) and lithium ion diffusion coefficient (DLi) decreased. The changes of Rct and DLi caused by the increase of titanium dioxide content have synergic-antagonistic effects on the rate and cycle properties of Li4Ti5012. The rate performance is positively related to DLi, while the cycle property is negatively correlated with Rct, indicati ng that the rate performs nee is mainly related to DLi, while Rct more significantly affects the cycle performance. LTO-RT-17.06% exhibited excellent rate properties, especially under a high current density (5.0 C, 132.5 mAh/g) and LTO-RT-34.42% showed superior long-term cycle performance (0.012% capacity loss per cycle) compared to that of LTO-RT-17.06% and LTO-RT-23.69%. | Delai Qian Yijie Gu Shuainan Guo Hongquan Liu Yunbo Chen Juan Wang Guoxuan Ma Chuan Wu | 2019 | Journal of Energy Chemistry2019，28，5： | 3 |
| 6 | Video Scene Invariant Crowd Density Estimation Using Geographic Information Systems显示文摘Crowd density is an important factor of crowd stability.Previous crowd density estimation methods are highly dependent on the specific video scene.This paper presented a video scene invariant crowd density estimation method using Geographic Information Systems(GIS) to monitor crowd size for large areas.The proposed method mapped crowd images to GIS.Then we can estimate crowd density for each camera in GIS using an estimation model obtained by one camera.Test results show that one model obtained by one camera in GIS can be adaptively applied to other cameras in outdoor video scenes.A real-time monitoring system for crowd size in large areas based on scene invariant model has been successfully used in 'Jiangsu Qinhuai Lantern Festival,2012'.It can provide early warning information and scientific basis for safety and security decision making. | SONG Hongquan LIU Xuejun LU Guonian ZHANG Xingguo WANG Feng | 2014 | China Communications2014，11，11： | 2 |
| 7 | C1orf106, an innate immunity activator, is amplified in breast cancer and is required for basal-like/luminal progenitor fate decision显示文摘Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with other subtypes.However,genes that specifically promote basal-like breast cancer development remain largely unknown.Here,we report that a novel gene C1orf106 plays an important role in maintaining the feature of basal-like/luminal progenitors.C1orf106 is frequently amplified and overexpressed in basal-like breast cancer and is associated with a poor outcome in patients.In human TCGA database,C1orf106 expression was correlated with upregulation of ELF5 and downregulation of GATA3,two transcription factors that regulate mammary gland stem cell fate.Enhanced expression of C1orf106 promotes tumor progression and expression of basal-like/luminal progenitor marker ELF5;depletion of C1orf106 suppresses tumorigenesis and expression of basal-like/luminal progenitor marker GATA3.These findings suggest that C1orf106 maintains the basal-like/luminal progenitor character through balancing the expression of ELF5 and GATA3.Taken together,we demonstrated that C1orf106 is an important regulator for basal-like/luminal progenitors and targeting C1orf106 is of therapeutic value for breast cancer. | Ji Ma Cheng Liu Decao Yang Jiagui Song Jing Zhang Tianzhuo Wang Mengyuan Wang Weizhi Xu Xueying Li Shigang Ding Jun Zhan Hongquan Zhang | 2019 | Science China(Life Sciences)2019，62，9： | 2 |
| 8 | The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis显示文摘PH20 is a member of the human hyaluronidase family that degrades hyaluronan in the extracellular matrix and controls tumor progression.Inhibition of DNA methyltransferases(DNMTs)leads to elevated hyaluronan levels;however,whether DNMT inhibitors control PH20 remains unclear.Here,we report that the DNMT1 inhibitor,decitabine,suppresses PH20 expression by activating the long non-coding RNA PHACTR2-AS1(PAS1).PAS1 forms a tripartite complex with the RNA-binding protein vigilin and histone methyltransferase SUV39H1.The interaction between PAS1 and vigilin maintains the stability of PAS1.Meanwhile,PAS1 recruits SUV39H1 to trigger the H3K9 methylation of PH20,resulting in its silencing.Functionally,PAS1 inhibits breast cancer growth and metastasis,at least partially,by suppressing PH20.Combination therapy of decitabine and PAS1-30nt-RNA,which directly binds to SUV39H1,effectively blocked breast cancer growth and metastasis in mice.Taken together,DNMT1,PAS1,and PH20 comprise a regulatory axis to control breast cancer growth and metastasis.These findings reveal that the DNMT1-PAS1-PH20 axis is a potential therapeutic target for breast cancer. | Yenan Fu Xi Zhang Xiao Liu Peng Wang Wenhui Chu Wei Zhao Yunling Wang Guangbiao Zhou Yu Yu Hongquan Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 9 | Effect of K-doping on the Electrochemical Performance of Ca_3Co_4O_9 Anode for Li-ion Batteries显示文摘Ca3Co4O9 (CCO) and Ca2.95K0.05Co4O9 (CKCO) powders have been prepared by the polyacrylamide gel method. CKCO shows increased capacity and better cycling stability compared with CCO. After cycled for 50 cycles at 0.5 C, CKCO retains a capacity of 223 mAh·g-1, almost twice than CCO. The electrochemical impedance spectroscopy (EIS) tests shows the CKCO sample has a lower initial charge transfer resistance (Rct) and undergoes smaller Rct change during cycling than the CCO sample, indicating improved electrochemical performance by K-doping. | Jina Cao Hongquan Liu Jian Xie Caoshao Cao Xinbing Zhao | 2010 | Journal of Materials Science & Technology2010，26，7： | 2 |
| 10 | Development and Markets of China's Refractory Raw Materials显示文摘The distribution of refractory raw material resources,its throughput capacity , product vaneties and quality as well as market situation in China were investigated. | LIU Hongquan(China Industry Association of Non-metal Mine, Beijing 100026, China) | 2002 | China's Refractories2002，11，1： | 1 |
| 11 | Preparation,characterization,and some properties of ionomers from a sulfonated styrene-butadiene-styrene block copolymer without gelation显示文摘 | Xie Hongquan Liu Dagang Xie Dong | 2005 | J Appl Polym Sci2005，96，4： | 1 |
| 12 | Synthesis, characterization and properties of amphiphilic poly( ethyl acrylate) with uniform polyoxyethylene grafts 显示文摘 | Xie Hongquan Liu Yah | 2001 | J Appl Polym Sci2001，80，7： | 1 |
| 13 | Behavior of ionomers of sulfonated styrene-butadiene-styrene triblock copolymer in polymer blends with crystalline polyolefins and as compatibilizer显示文摘 | Xie Hongquan Liu Dagang Xie Dong | 2006 | J Appl Polym Sci2006，99，4： | 1 |
| 14 | An improved synthetic method for preparing polyoxyethylene macromers and a study of their eopolymerization with alkyl acrylates 显示文摘 | Xie Hongquan Liu Jin Li Hong | 1990 | J Maeromol Sci Chem1990，27，6： | 1 |
| 15 | Three kinds of graft eopolymers with uniform polyoxyethylene side chains 显示文摘 | Xie Hongquan Liu Jin Xie Dong | 1989 | Eur Polym J1989，25，12： | 1 |
| 16 | Modified apple polysaccharide prevents against tumorigenesis in a mouse model of colitis-associated colon cancer: role of galectin-3 and apoptosis in cancer prevention显示文摘 | Yuhua Li Li Liu Yinbo Niu Juan Feng Yang Sun Xianghe Kong Yongchun Chen Xiaoyan Chen Hongquan Gan Shousong Cao Qibing Mei | 2012 | European Journal of Nutrition2012，，1： | 1 |
| 17 | 4.1N suppresses hypoxia-induced epithelial-mesenchymal transition inepithelial ovarian cancer cells显示文摘 | Letian Zhang Ajin Hu Mengrui Li Hongquan Zhang Caixia Ren Xiuli An Congrong Liu | 2016 | Molecular Medicine Reports2016，，： | 1 |
| 18 | Progress on diagnostic and prognostic markers of pancreatic cancer显示文摘Pancreatic cancer is a malignant disease characterized by low survival and high recurrence rate,whose patients are mostly at the stage of locally advanced or metastatic disease when first diagnosed.Early diagnosis is particularly important because prognostic/predictive markers help guide optimal individualized treatment regimens.So far,CA19-9 is the only biomarker for pancreatic cancer approved by the FDA,but its effectiveness is limited by low sensitivity and specificity.With recent advances in genomics,proteomics,metabolomics,and other analytical and sequencing technologies,the rapid acquisition and screening of biomarkers is now possible.Liquid biopsy also occupies a significant place due to its unique advantages.In this review,we systematically describe and evaluate the available biomarkers that have the greatest potential as vital tools in diagnosing and treating pancreatic cancer. | HONG YANG WAN LI LIWEN REN YIHUI YANG YIZHI ZHANG BINBIN GE SHA LI XIANGJIN ZHENG JINYI LIU SEN ZHANG GUANHUA DU BO TANG HONGQUAN WANG JINHUA WANG | 2023 | Oncology Research2023，31，2： | 1 |
| 19 | Hydrogenation and neutralization of carboxylic styrene-butadiene latex to form thermoplastic elastomer with excellent thermooxidation resistance显示文摘 | Li Xiaodong Xie Hongquan Liu Xiangyao | 2002 | J Appl Polym Sci2002，83，： | 1 |
| 20 | Preparation, characterization and some properties of ionomers from a sulfonated styrene-butadiene-styrene triblock copolymer without gelation显示文摘 | Liu Dagang Xie Hongquan Guan Jianguo | 2005 | J Appl Polym Sci2005，96，： | 1 |
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