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| 1 | Danggui Buxue Tang ameliorates bleomycin-induced pulmonary fibrosis in rats through inhibiting transforming growth factor-β1/Smad3/plasminogen activator inhibitor-1 signaling pathway显示文摘OBJECTIVE: To investigate the effect of Danggui Buxue Tang(DBT), a decoction from Traditional Chinese Medicine, on bleomycin-induced pulmonary fibrosis in rats, and to propose the possible underlying mechanism.METHODS: Forty male Sprague-Dawley rats were randomly divided into sham group, model group,prednisone group and DBT group. Pulmonary fibrosis rat model was established by intratracheal injection with bleomycin. Body weight and lung index were monitored. Histopathologic examination and collagen deposition were determined using Hematoxylin and eosin(HE) and Masson's trichrome staining. Immunohistochemistry staining was applied to observe the expression of alpha-smooth muscle actin(α-SMA). m RNA expression of α-SMA,collagen Ⅰ and collagen Ⅲ were measured by realtime fluorescence quantitative PCR(RT-q PCR). Inflammatory cytokines, including tumor necrosis factor alpha(TNF-α), interleukin-6(IL-6) and IL-1β in serum were detected by Enzyme-linked immunosorbent assay. Alkali hydrolysis method was conducted to investigate the content of hydroxyproline(HYP). Transforming growth factor-β1(TGF-β1),Smad3 and plasminogen activator inhibitor-1(PAI-1) protein level were examined by Western blot assay.RESULTS: DBT significantly reduced the severity of bleomycin-induced pulmonary fibrosis and inflammation as indicated by minimizing the lost of weight, and by lowering the levels of lung index, inflammation score, Ashcroft score, collagen volume fraction(%), HYP, α-SMA, collagen Ⅰ, collagen Ⅲ,TNF-α, IL-6, IL-1β, TGF-β1, Smad3 and PAI-1, consistent with the effect of prednisone.CONCLUSION: Our findings suggest that DBT is able to ameliorate the pulmonary fibrosis, the possible mechanism may involve inhibition of pulmonary inflammation and collagen deposition, possibly via suppressing TGF-β1/Smad3/PAI-1 signaling pathway. | Wang Jiepeng Fang Chaoyi Wang Shaoxian Fang Fang Chu Xinqiao Liu Na Lu Chenxi Wang Shuo Li Wei | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 5 |
| 2 | Seismic behavior of thin-walled circular and stiffened square steel tubed-reinforced-concrete columns显示文摘Steel tubed-reinforced-concrete(TRC) columns have been gradually used in the construction of high-rise buildings recently because of their high axial load-carrying capacities and excellent seismic behavior. Existing studies about their seismic behavior were focused on columns with relatively thick tubes, i.e., diameter-to-thickness/width-to-thickness(D/t) ratios were below 100,while little is known about thin-walled TRC columns, especially for square TRC columns. Considering the infilled concrete of square TRC columns is non-uniformly and non-effectively confined, accordingly, stiffened square TRC columns are usually adopted in practice. Thus, two thin-walled circular TRC columns(D/t=120) and two stiffened square ones with diagonal stiffeners in plastic hinge regions(D/t=106) were tested under a constant axial compression combined with cyclic lateral loading.Both the circular and stiffened square TRC columns had the same cross sectional area, tube thickness, reinforcing bar ratio and column height. Flexural failure occurred for all the four specimens. Test results showed the strengths of the stiffened square TRC columns were a little higher in comparison to their circular counterparts; the ductility and energy dissipation capacities were excellent for both the stiffened and circular TRC columns, indicating very good confinement was gained from the yielded steel tubes of the plastic hinge regions at the peak loads. And shear stresses(35–90 MPa) in the sheared plates showed their moderate contribution of carrying lateral loads. Finally, cross sectional capacity analysis results demonstrated the method for TRC columns is acceptable for the stiffened square TRC columns. | GAN Dan ZHOU XuHong LIU JiePeng LI Jiang | 2019 | Science China(Technological Sciences)2019，62，3： | 3 |
| 3 | Preparation and toxicity evaluation of a novel nattokinase-tauroursodeoxycholate complex显示文摘Nattokinase(NK), which has been identified as a potent fibrinolytic protease, has remarkable potential in treatment of thrombolysis, and even has the ability to ameliorate chronic vein thrombosis. To reduce the hemorrhagic risk from an intravenous injection of NK,nattokinase-tauroursodeoxycholate(NK-TUDCA) complex was prepared at different pH values and with different ratios of NK and TUDCA. When assessing survival time, survival state,tail injury, and the body weight of mice, it was found that the NK-TUDCA complex(NK: 10 k IU/ml; TUDCA: 10 mg/ml; pH 5.0) had a lower toxicity when administered at an NK dosage of 130 kIU/kg in the acute toxicity test and 13 kIU/kg in the repeated low-dose challenge. From the results of the in vitro thrombolytic test and characterization of NKTUDCA, we speculated that the delayed release of NK-TUDCA might be the main cause of toxicity reduction by the complex. This study described the preparation of an NK complex with low toxicity following intravenous administration, which could be utilized for further clinical study of NK. | Rui Feng Jing Li Jiepeng Chen Lili Duan XinRong Liu Donghua Di Yihui Deng Yanzhi Song | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，2： | 2 |
| 4 | Seismic behavior and strength of tubed steel reinforced concrete (SRC) short columns显示文摘 | Xuhong Zhou Jiepeng Liu | 2010 | Journal of Constructional Steel Research2010，，7： | 2 |
| 5 | Axial load behavior and strength of tubed steel reinforced-concrete (SRC) stub columns 显示文摘 | Qi Hongtuo Guo Lanhui Liu Jiepeng | 2011 | Thin-Walled Structures2011，，49： | 1 |
| 6 | Seismic behavior and shearstrength of tubed RC short columns显示文摘 | Xuhong Zhou Jiepeng Liu | 2010 | Journal ofConstructional Steel Research2010，66，： | 1 |
| 7 | Seismic behavior and strength of square tube confined reinforced-concrete (STRC) columns 显示文摘 | Zhang Sumei Liu Jiepeng | 2007 | Journal of Constructional Steel Research2007，63，9： | 1 |
| 8 | Shear strength and behavior of tubed reinforced and steel reinforced concrete (TRC and TSRC) short columns显示文摘 | Jasim Ali Abdullah Zhang Sumei Liu Jiepeng | 2009 | Thin-Walled Structures2009，，3： | 1 |
| 9 | 双向弯矩作用下方钢管混凝土梁柱的抗震性能显示文摘对双向弯矩作用下方钢管混凝土梁柱的性能进行研究。进行了9个梁柱试验,加载为恒定轴向荷载和循环侧向荷载组合,加载范围由沿横截面轴线加载到对角线加载。为评估不同参数对结构整体反应、延性、耗能能力的影响,参数包括轴压比、宽厚比、混凝土抗压强度、长细比和弯矩强度计算中的荷载角。试验结果显示:双向加载的方钢管混凝土柱的延性和耗能能力会随着轴压比和混凝土抗压强度的增加而减小,但是延性几乎不受荷载角的影响。双向加载方钢管混凝土柱荷载角的增加会导致弯矩承载力的轻微减少。采用EC4和AIJ规范预测试验中的弯矩承载力都比较准确,其中根据AIJ算出的数值略为保守。另外,根据LRFD规范算出的数值极大地低估了其弯矩承载力。 | Jiepeng Liu, Xuhong Zhou and Sumei Zhang | 2009 | 钢结构2009，，1： | 1 |
| 10 | Be-havior and strength of circular tube confined reinforced-concrete (CTRC) columns 显示文摘 | Jiepeng Liu Sumei Zhang Xiaodong Zhang | 2009 | Journal of Construc-tional Steel Research2009，65，7： | 1 |
| 11 | Seismic behavior and moment strength of tubed steel reinforced-concrete (SRC) beam-columns 显示文摘 | GAN DAN GUO LANHUI LIU JIEPENG | 2011 | Journal of Constructional Steel Research2011，67，10： | 1 |
| 12 | Axial Load Behavior and Strength of Tubed Steel Reinforced-Concrete (SRC) Stub Col- umns显示文摘 | Qi Hongtuo Guo Lanhui Liu Jiepeng | 2011 | Thin-Walled Structures2011，49，： | 1 |
| 13 | Seismic behavior and moment strength of tubed steel reinforced-concrete (SRC) beam-columns显示文摘 | Dan Gan Lanhui Guo Jiepeng Liu Xuhong Zhou | 2011 | Journal of Constructional Steel Research2011，，10： | 1 |
| 14 | Axial load behavior and strength of tubed steel reinforced-concrete (SRC) stub columns显示文摘 | Hongtuo Qi Lanhui Guo Jiepeng Liu Dan Gan Sumei Zhang | 2011 | Thin-Walled Structures2011，，9： | 1 |
| 15 | Seismic behavior and strength of square tube confined reinforced-concrete (STRC) columns 显示文摘 | Zhang Sumei Liu Jiepeng | 2007 | Journal of Constructional Steel Research2007，63，9： | 1 |
| 16 | Hysteretic behavior and design of square tubed reinforced and steel reinforced concrete (STRC and/or STSRC) short columns显示文摘 | Jiepeng Liu Jasim Ali Abdullah Sumei Zhang | 2011 | Thin-Walled Structures2011，，7： | 1 |
| 17 | Seismic behavior and strength of square tube confined reinforced-concrete (STRC) columns 显示文摘 | ZHANG Sumei LIU Jiepeng | 2007 | Journal of Constructional Steel Research2007，63，9： | 1 |
| 18 | Behavior and strength of circular tube confined reinforced-concrete ( CTRC ) columns 显示文摘 | Liu Jiepeng Zhang Sumei Zhang Xiaodong Guo Lanhui | 2009 | Journal of Constructional Steel Research2009，65，7： | 1 |
| 19 | Seismic behavior and strength of square tube confined reinforced-concrete (STRC) columns 显示文摘 | Zhang Sumei Liu Jiepeng | 2007 | Journal of Constructional Steel Research2007，63，9： | 1 |
| 20 | Experimental and analytical studies on the vibration serviceability of long-span prestressed concrete floor显示文摘An extensive experimental and theoretical research study was undertaken to study the vibration serviceability of a long-span prestressed concrete floor system to be used in the lounge of a major airport.Specifically,jumping impact tests were carried out to obtain the floor’s modal parameters,followed by an analysis of the distribution of peak accelerations.Running tests were also performed to capture the acceleration responses.The prestressed concrete floor was found to have a low fundamental natural frequency(≈8.86 Hz)corresponding to the average modal damping ratio of≈2.17%.A coefficients plate with simply-supported edges.The calculated analytical results(natural frequencies and root-mean-square acceleration)agree well with the experimental ones.The analytical approach is thus validated. | Cao Liang Liu Jiepeng Li Jiang Zhang Ruizhi | 2018 | Earthquake Engineering and Engineering Vibration2018，17，2： | 1 |
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