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| 1 | HiQoS:An SDN-Based Multipath QoS Solution显示文摘Today's Internet architecture provides only 'best effort' services,thus it cannot guarantee quality of service(QoS) for applications.Software Defined Network(SDN)is a new approach to computer networking that separates control plane and forwarding planes,and has the advantage of centralized control and programmability.In this paper,we propose HiQoS that provides QoS guarantees using SDN.Moreover,HiQoS makes use of multiple paths between source and destination and queuing mechanisms to guarantee QoS for different types of traffic.Experimental results show that our HiQoS scheme can reduce delay and increase throughput to guarantee QoS.Very importantly,HiQoS recovers from link failure very quickly by rerouting traffic from failed path to other available path. | YAN Jinyao ZHANG Hailong SHUAI Qianjun LIU Bo GUO Xiao | 2015 | China Communications2015，12，5： | 19 |
| 2 | Ethanol and liver: Recent insights into the mechanisms of ethanol-induced fatty liver显示文摘Alcoholic fatty liver disease(AFLD),a potentially pathologic condition,can progress to steatohepatitis,fibrosis,and cirrhosis,leading to an increased probability of hepatic failure and death.Alcohol induces fatty liver by increasing the ratio of reduced form of nicotinamide adenine dinucleotide to oxidized form of nicotinamide adenine dinucleotide in hepatocytes;increasing hepatic sterol regulatory element-binding protein(SREBP)-1,plasminogen activator inhibitor(PAI)-1,and early growth response-1 activity;and decreasing hepatic peroxisome proliferator-activated receptor-αactivity.Alcohol activates the innate immune system and induces an imbalance of the immune response,which is followed by activated Kupffer cell-derived tumor necrosis factor(TNF)-αoverproduction,which is in turn responsible for the changes in the hepatic SREBP-1 and PAI-1 activity.Alcohol abuse promotes the migration of bone marrowderived cells(BMDCs)to the liver and then reprograms TNF-αexpression from BMDCs.Chronic alcohol intake triggers the sympathetic hyperactivity-activated hepatic stellate cell(HSC)feedback loop that in turn activates the HSCs,resulting in HSC-derived TNF-αoverproduction.Carvedilol may block this feedback loop by suppressing sympathetic activity,which attenuates the progression of AFLD.Clinical studies evaluating com-bination therapy of carvedilol with a TNF-αinhibitor to treat patients with AFLD are warranted to prevent the development of alcoholic liver disease. | Jinyao Liu | 2014 | World Journal of Gastroenterology2014，20，40： | 16 |
| 3 | Atomic-Scale Layer-by-Layer Deposition of Fe SiAl@ZnO@Al_(2)O_(3) Hybrid with Threshold Anti-Corrosion and Ultra-High Microwave Absorption Properties in Low-Frequency Bands显示文摘Developing highly efficient magnetic microwave absorb-ers(MAs)is crucial,and yet challenging for anti-corrosion properties in extremely humid and salt-induced foggy environments.Herein,a dual-oxide shell of ZnO/Al_(2)O_(3) as a robust barrier to FeSiAl core is introduced to mitigate corrosion resistance.The FeSiAl@ZnO@Al_(2)O_(3) layer by layer hybrid structure is realized with atomic-scale precision through the atomic layer deposition technique.Owing to the unique hybrid structure,the FeSiAl@ZnO@Al_(2)O_(3) exhibits record-high micro-wave absorbing performance in low-frequency bands covering L and S bands with a minimum reflection loss(RLmin)of-50.6 dB at 3.4 GHz.Compared with pure FeSiAl(RLmin of-13.5 dB,a bandwidth of 0.5 GHz),the RLmin value and effective bandwidth of this designed novel absorber increased up to~3.7 and~3 times,respectively.Fur-thermore,the inert ceramic dual-shells have improved 9.0 times the anti-corrosion property of FeSiAl core by multistage barriers towards corrosive medium and obstruction of the electric circuit.This is attributed to the large charge transfer resistance,increased impedance modulus|Z|0.01 Hz,and frequency time constant of FeSiAl@ZnO@Al_(2)O_(3).The research demonstrates a promising platform toward the design of next-generation MAs with improved anti-corrosion properties. | Wei Tian Jinyao Li Yifan Liu Rashad Ali Yang Guo Longjiang Deng Nasir Mahmood Xian Jian | 2021 | Nano-Micro Letters2021，13，10： | 6 |
| 4 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 5 | Bioreducible unimolecular micelles based on amphiphilic multiarm hyperbranched copolymers for triggered drug release显示文摘A novel type of bioreducible amphiphilic multiarm hyperbranched copolymer (H40-star-PLA-SS-PEG) based on Boltorn H40 core,poly(L-lactide) (PLA) inner-shell,and poly(ethylene glycol) (PEG) outer-shell with disulfide-linkages between the hydrophobic and hydrophilic moieties was developed as unimolecular micelles for controlled drug release triggered by reduction.The obtained H40-star-PLA-SS-PEG was characterized in detail by nuclear magnetic resonance (NMR),Fourier transform infrared (FTIR),gel permeation chromatography (GPC),differential scanning calorimeter (DSC),and thermal gravimetric analysis (TGA).Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analyses suggested that H40-star-PLA-SS-PEG formed stable unimolecular micelles in aqueous solution with an average diameter of 19 nm.Interestingly,these micelles aggregated into large particles rapidly in response to 10 mM dithiothreitol (DTT),most likely due to shedding of the hydrophilic PEG outer-shell through reductive cleavage of the disulfide bonds.As a hydrophobic anticancer model drug,doxorubicin (DOX) was encapsulated into these reductive unimolecular micelles.In vitro release studies revealed that under the reduction-stimulus,the detachment of PEG outer-shell in DOX-loaded micelles resulted in a rapid drug release.Flow cytometry and confocal laser scanning microscopy (CLSM) measurements indicated that these DOX-loaded micelles were easily internalized by living cells.Methyl tetrazolium (MTT) assay demonstrated a markedly enhanced drug efficacy of DOX-loaded H40-star-PLA-SS-PEG micelles as compared to free DOX.All of these results show that these bioreducible unimolecular micelles are promising carriers for the triggered intracellular delivery of hydrophobic anticancer drugs. | PANG Yan 1,LIU JinYao 1,SU Yue 1,ZHU BangShang 2,HUANG Wei 1,ZHOU YongFeng 1,ZHU XinYuan 1,2 & YAN DeYue 1 1 School of Chemistry and Chemical Engineering,State Key Laboratory of Metal Matrix Composites,Shanghai Jiao Tong University,Shanghai 200240,China 2 Instrumental Analysis Center,Shanghai Jiao Tong University,Shanghai 200240,China | 2010 | Science China Chemistry2010，53，12： | 3 |
| 6 | Carvedilol Attenuates the Progression of Alcohol Fatty Liver Disease in Rats显示文摘 | Jinyao Liu Izumi Takase Ayako Hakucho Nanako Okamura Tatsuya Fujimiya | 2012 | Alcohol Clin Exp Res2012，，9： | 2 |
| 7 | SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer显示文摘Alternative splicing is a critical process to generate protein diversity.However,whether and how alternative splicing regulates autophagy remains largely elusive.Here we systematically identify the splicing factor SRSF1 as an autophagy suppressor.Specifically,SRSF1 inhibits autophagosome formation by reducing the accumulation of LC3-ⅡI and numbers of autophagosomes in different cell lines.Mechanistically,SRSF1 promotes the splicing of the long isoform of Bcl-x that interacts with Beclinl,thereby dissociating the Beclin1-PIK3C3 complex.In addition,SRSF1 also directly interacts with PIK3C3 to disrupt the interaction between Beclinl and PIK3C3.Consequently,the decrease of SRSF1 stabilizes the Beclinl and PIK3C3 complex and activates autophagy.Interestingly,SRSF1 can be degraded by starvation-and oxidative stresses-induced autophagy through interacting with LC3-Ⅱ,whereas reduced SRSF1 further promotes autophagy.This positive feedback is critical to inhibiting Gefitinib-resistant cancer cell progression both in vitro and in vivo.Consistently,the expression level of SRSF1 is inversely correlated to LC3 level in clinical cancer samples.Our study not only provides mechanistic insights of alternative splicing in autophagy regulation but also discovers a new regulatory role of SRSF1 in tumorigenesis,thereby offering a novel avenue for potential cancer therapeutics. | Yuesheng Lv Wenjing Zhang Jinyao Zhao Bing Sun Yangfan Qi Haoyu Ji Chaoqun Chen Jinrui Zhang Junxiu Sheng Taishu Wang Daniel Dominguez Han Liu Quentin Liu Songshu Meng Xiaoling Li Yang Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 8 | Strain-regulated sensing properties of α-Fe_(2)O_(3) nano-cylinders with atomic carbon layers for ethanol detection显示文摘The sensitivity of ethanol sensor is of paramount importance in a variety of areas,including chemical production with ethanol,alcohol testing for driving safety,etc.Herein,α-Fe_(2)O_(3) nano-cylinders with atomic carbon layers are synthesized,for the first time,through in-situ catalytic chemical vapor deposition combined with hydrothermal techniques for the detection of ethanol.The reported α-Fe_(2)O_(3)@C nano-cylinders with double surficial strain effects deliver an ethanol detection sensitivity of 8 times as compared with α-Fe_(2)O_(3) nano-cylinders,10 times higher as compared with its detection sensitivity to ammonia,para-xylene,methanol and benzene.The sensor also exhibits over-14-day operation stability and the minimum detection limit of 10 ppm.To our best knowledge,the performances surpass those of previously reported α-Fe_(2)O_(3).Such attractive performances are attributed to the enhanced charge transfer in α-Fe_(2)O_(3) owing to the double surficial strain effects of α-Fe_(2)O_(3)@C nano-cylinders and the efficient adsorption of ethanol with atomic carbon layers. | Huajing Xiong Jianan Fu Jinyao Li Rashad Ali Hong Wang Yifan Liu Hua Su Yuanxun Li Woon-Ming Lau Nasir Mahmood Chunhong Mu Xian Jian | 2021 | Journal of Materials Science & Technology2021，，9： | 2 |
| 9 | Surface active structure of ultra-fine Cu/ZrO2 catalysts used for the CO2+H2 to methanol reaction显示文摘 | Liu Jinyao Shi Jiangliu He Dehua | 2001 | Applied Catalysis2001，1218，： | 1 |
| 10 | Can Transthoracic Doppler Echocardiography Predict the Discrepancy Between Left Ventrieular End-Diastolic Pressure and Mean Pulmonary Capillary Wedge Pressure in Patients With Heart Failure 显示文摘 | Asuyuki Hadano Kazuya Murata Jinyao Liu | 2005 | Circ J2005，69，： | 1 |
| 11 | Condensation of formaldehyde and methyl formate to methyl glycolate and methyl methoxy acetate using heteropolyacids and their salts显示文摘 | He Dehua Huang Weiguo Liu Jinyao | | Catalysis Today0，，： | 1 |
| 12 | Catalytic condensation of formal dehyde and methyl formate over 12-tungstosilicic compounds显示文摘 | Huang Weiguo He Dehua Liu Jinyao | | Applied Catalysis A:General0，，： | 1 |
| 13 | Phase Morphology and Rheological Properties of Metallocene-catalyzed Linear Lowdensity Polyethylene with a Small Amount of Diatomite/ Oligomer Hybrids显示文摘 | Xiaolong Liu Jinyao CHela Huilin Li | 2006 | Journal of Polymer Science: Part B: Polymer Physics2006，44，： | 1 |
| 14 | Effects of Ammonium Salts as Additives in Rh-Ph3PO Catalytic System on Hydro- formylation of Mixed Octenes显示文摘 | He Dehua Liu Jinyao Liu Ye | 2001 | CatalLett2001，73，24： | 1 |
| 15 | Bioreducible micelles self-assembled from amphiphilic hyperbranched multiarm copolymer for glutathione-mediated intracellular drug delivery显示文摘 | Liu Jinyao Pang Yan Huang Wei | 2011 | Biomacromolecules2011，12，： | 1 |
| 16 | Surface active structure of ultrafine Cu/ZrO2 catalysts used for the CO2 + H2 to methanol reaction显示文摘 | Liu Jinyao Shi Jiangliu | 2001 | Applied Catalysis A: General2001，218，： | 1 |
| 17 | Molecular cloning, expression, and characterization of a Sophora alopecuroides lectin from Escherichia coli显示文摘Sophora alopecuroides lectin (柳安) 从种子被孤立并且证实了有抗真菌并且 antitumor 活动,并且一会儿自然 lectin 的准备是拖累的,费时间,并且收益为进一步的分析是相对低的。在这研究, lectin,修正地点,和第二等的结构的信号肽被分析,并且柳安的三维的结构被建模。柳安的基因被反向的抄写聚合酶链反应放大,并且克隆进 pET-30a 向量并且由 isopropyl-beta-d-thiogalactopyranoside 的正式就职在 Escherichia coli BL21 (DE3 ) 表示了。完全, recombinant 柳安(rSAL ) 的 400 mg 通过 Ni-NTA agarose 列从细菌的文化的 1 l 被净化,纯净到达了 95% 。recombinant 蛋白质被西方的污点进一步用 rSAL 特定的抗体证实。生物活动分析结果显示出只绑在 d 半乳糖并且举办了通用 hemagglutinating 活动到人的 A, B, O,和 AB 的那 rSAL,并且兔子和老鼠红血球。rSAL 也禁止了真菌,癌症细胞的增长,和 HIV-I 反向的 transcriptase 活动的生长。在结论,这研究显示 rSAL 能在原核生物的表示系统在大数量被生产, recombinant 蛋白质仍然保留各种各样的生物活动,它将以可能的戏剧性地减少的成本做柳安 recombinant 蛋白质的大规模生产。 | Yang Li Tingting Li Jinyao Li Dongliang Liu Jie Yang Jianhua Yang Fuchun Zhang Surong Sun | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 0 |
| 18 | A multipath routing algorithm for satellite networksbased on service demand and traffic awareness显示文摘With the reduction in manufacturing and launch costs of low Earth orbit satellites and the advantages of large coverage and high data transmission rates,satellites have become an important part of data transmission in air-ground networks.However,due to the factors such as geographical location and people’s living habits,the differences in user’demand for multimedia data will result in unbalanced network traffic,which may lead to network congestion and affect data transmission.In addition,in traditional satellite network transmission,the convergence of network information acquisition is slow and global network information cannot be collected in a fine-grained manner,which is not conducive to calculating optimal routes.The service quality requirements cannot be satisfied when multiple service requests are made.Based on the above,in this paper artificial intelligence technology is applied to the satellite network,and a software-defined network is used to obtain the global network information,perceive network traffic,develop comprehensive decisions online through reinforcement learning,and update the optimal routing strategy in real time.Simulation results show that the proposed reinforcement learning algorithm has good convergence performance and strong generalizability.Compared with traditional routing,the throughput is 8%higher,and the proposed method has load balancing characteristics. | Ziyang XING Hui QI Xiaoqiang DI Jinyao LIU Rui XU Jing CHEN Ligang CONG | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，6： | 0 |
| 19 | A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys显示文摘Retrograde adeno-associated viruses(AAVs)are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical and functional characterization of neural networks.However,few retro-grade AAV capsids have been shown to offer access to cor-tical projection neurons across different species and enable the manipulation of neural function in non-human primates(NHPs).Here,we report the development of a novel retro-grade AAV capsid,AAV-DJ8R,which efficiently labeled cortical projection neurons after local administration into the striatum of mice and macaques.In addition,intrastriatally injected AAV-DJ8R mediated opsin expression in the mouse motor cortex and induced robust behavioral alterations.Moreover,AAV-DJ8R markedly increased motor cortical neuron firing upon optogenetic light stimulation after viral delivery into the macaque putamen.These data demonstrate the usefulness of AAV-DJ8R as an efficient retrograde tracer for cortical projection neurons in rodents and NHPs and indicate its suitability for use in conducting functional interrogations. | Yefei Chen Jingyi Wang Jing Liu Jianbang Lin Yunping Lin Jinyao Nie Qi Yue Chunshan Deng Xiaofei Qi Yuantao Li Ji Dai Zhonghua Lu | 2024 | Neuroscience Bulletin2024，40，1： | 0 |
| 20 | Large-scale synthesis of fluorine-free carbonyl iron-organic silicon hydrophobic absorbers with long term corrosion protection property显示文摘Environmentally-friendly magnetic metallic absorbers with high-performing antioxidant property,thermal stability,and anticorrosion capability have attracted great attention in real-world applications.A surface modification technology of magnetic metallic absorbers with dense and inert materials has been an effective strategy to solve the aforesaid problem.Herein,fluorinefree core–shell carbonyl iron-organic silicon absorbers(CI@SiO_(2)/1,1,1,3,3,3-hexamethyl disilazane(HMDS))were fabricated via a facile one-pot synthesis using tetraethyl orthosilicate(TEOS)and HMDS as the precursor of protective layer(SiO_(2)/HMDS),and CI@SiO_(2)/HMDS hybrid reveals its long-term corrosion resistance and excellent microwave absorption performance with a minimum reflection loss value of−44.3 dB and an effective absorption bandwidth of 5.3 GHz at a thin thickness of 2.0 mm after immersion in 5.0 wt.%NaCl acidic solutions for 2,160 h.Meanwhile,CI@SiO_(2)/HMDS hybrid can still achieve the maximum radar cross-sectional(RCS)reduction values about 16.5 dB·m^(2) at the detectionθof 0°.The exceptional microwave absorption performance and structural stability are largely due to the extraordinary wave-transparent property and shielding ability against corrosive medium of SiO_(2)/HMDS hydrophobic protective layer with a contact angle of 132.5°.The research paves the way for the large-scale and batch production of high-performance magnetic metallic absorbers and increases their survivability and reliability in the harsh environments. | Wei Tian Jinyao Li Yifan Liu Longjiang Deng Yang Guo Xian Jian | 2022 | Nano Research2022，15，10： | 0 |
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