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| 1 | High salt primes a specific activation state of macrophages, M(Na)显示文摘 | Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan | 2015 | Cell Research2015，25，8： | 15 |
| 2 | Preparation of folate-conjugated starch nanoparticles and its application to tumor-targeted drug delivery vector显示文摘Anion starch nanoparticles (StNP) were prepared in water-in-oil microemulsion. Folate modi-fied with PEG was conjugated to the surface of StNP to obtain the folate-conjugated starch nanoparticles (FA-PEG/StNP). The average diameter of FA-PEG/ StNP determined by AFM and Zeta-Sizer apparatus was about 130 nm. Doxorubicin (DOX)-loaded FA- PEG/StNP was obtained via infiltrating combination. The result of UV spectrophotometer showed that the saturation concentration of DOX-loaded FA-PEG/ StNP was 28 μg/mg, which was effective for the con-trolled release of anticancer drug DOX. The cell ex-periments showed that the Lc50 of DOX-loaded FA-PEG/StNP and DOX-loaded StNP was higher than that of DOX, which indicates that FA-PEG/StNP and StNP can decrease the toxicity of DOX; while the lethal rate of DOX-loaded FA-PEG/StNP was 3 times that of DOX-loaded StNP with the same quantity of DOX, which indicates that FA in FA-PEG/StNP is ef-fective for improving the targeting function of nanoparticles, thus enhancing the inhibition effect of anticancer drug to cancer cell. This work demon-strates that the FA-PEG/StNP system is a potentially useful system for the targeted delivery of anticancer drug DOX. | XlAO Suyao TONG Chunyi LIU Xuanming YU Danmi LIU Qiaoling XUE Changgang TANG Dongyin ZHAO Lijian | 2006 | Chinese Science Bulletin2006，51，14： | 12 |
| 3 | Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame显示文摘导致的 pluripotent 的产生从体的细胞的茎(iPS ) 细胞被定义 reprogramming 抄写因素(TF ) 的同时的病毒的 transduction 成功地完成了。然而,这个过程为基因交货要求多重病毒的向量。作为结果,产生了 iPS 房间港口在他们的染色体的众多的病毒的集成地点。这能增加基因 mutagenesis 和 genomic 不稳定性的概率,并且介绍重要障碍给研究和 iPS 房间的临床的申请研究。在这篇论文,我们在场定义因素是的一个简单 lentivirus reprogramming 在系统经由自我劈开的 2A 序列熔化了在里面框架进一个单个开的读物框架(ORF ) 。一个 GFP 标记下游地被放 transgene 启用 transgene 表示追踪。我们证明这个 polycistronic 表示系统高效地产生 iPS 房间。产生 iPS 房间有正常 karyotypes 并且类似于鼠标在形态学和基因表示的胚胎的干细胞。而且,他们能在 vitro 并且在 vivo 试金在两个区分进三胚胎的细菌层的房间类型。显著地,大多数这些 iPS 房间仅仅怀有病毒的向量的一个单个拷贝。这个系统提供一个珍贵工具因为 iPS 房间的产生,和我们的数据建议在每个房间的 transduced reprogramming TF 的表示的平衡为 reprogramming 进程是必要的。更重要地,当由非集成的基因交货系统交付了时,这重新设计的单个 ORF 将没有基因修正便于人的 iPS 房间的有效产生。 | Lijian Shao Wei Feng Yan Sun Hao Bai Jun Liu Caroline Currie Jaejung Kim Rafael Gama Zack Wang Zhijian Qian Lucy Liaw Wen-Shu Wu | 2009 | Cell Research2009，19，3： | 12 |
| 4 | Degree of Brine Evaporation and Origin of the Mengyejing Potash Deposit:Evidence from Fluid Inclusions in Halite显示文摘The Mengyejing potash deposit is located in the southern port of the Simao Basin, Yunnan Province, and is hosted in mid-Cretaceous strata. The chemical compositions of fluid inclusions in halite crystals, collected from the level-610 adit in the deposit, were analysed by laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS). The results show that the brine is of the Na-K-Mg-Ca-Cl type and has K concentrations that are distinctly higher than those of Mg and Ca, unlike normal brines associated with Cretaceous halite. The high K concentrations indicate that the degree of evaporation of the ancient Mengyejing saline lake was very high, reaching the sylvite deposition stage but rarely reaching the carnallite deposition stage. The trajectory of the H and O isotopic compositions of the brines in the halite-hosted fluid inclusions corresponds to intense evaporation, indicating that the net evaporation exceeded the net inflow of brines. These brine compositions in halite-hosted fluid inclusions were likely formed by the dissolution of previously deposited K-bearing minerals by fresh continental and/or seawater, forming a type of modified seawater, with deep hydrothermal fluids potentially supplying additional potassium. The basin likely experienced multiple seawater incursion, dissolution and redeposition events in a high-temperature environment with high evaporation rates. | SHEN Lijian LIU Chenglin WANG Licheng HU Yufei HU Mingyue FENG Yuexing | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 9 |
| 5 | Studies of poly-L-lysine-starch nanoparticle preparation and its application as gene carrier显示文摘Anion starch nanoparticle (StNP) with a diameter of 50 nm was prepared in wa- ter-in-oil microemulsion, with soluble starch as raw materials and POCl3 as crosslinking agent. PLL-StNP was prepared by linking poly-L-lysine (PLL) on the surface of StNP. At the same time, the size of PLL-StNP and its stability in aqueous solution were checked by AFM. The analysis of plasmid DNA binding, DNase I enzymatic degradation, toxicity and transfection were done. We discovered that PLL-StNP may be used as non-virus nanoparticle gene carrier. And we devel- oped the method of preparing PLL-StNP gene carrier and used it in cell transfection. As non-virus gene carrier, PLL-StNP has some advantages, such as large load of DNA, high transfection effi- ciency, low cell toxicity and biodegradability. | XIAO Suyao LIU Xuanming TONG Chunyi LIU Jun TANG Dongying ZHAO Lijian | 2005 | Science China Chemistry2005，48，2： | 7 |
| 6 | A Cretaceous Desert-Playa Sedimentary System Controlled the Potash Formation in the Simao Basin显示文摘Objective The Simao Basin in Yunnan Province has developed Cretaceous evaporite-bearing clastic deposits,including the Mangang and Mengyejing Formations which were originally interpreted as fluvial and lacustrine deposits.The Mangang Fm.composed of well-rounded quartz sandstones,were commonly considered as the bottom part of the Mengyejing salt series.During last decades,drilling projects targeting to prospect solid potash deposits in the Mengyejing salt series consequently ceased when encountering these sandstones.The poor understanding of sedimentary environments leads to no breakthrough of prospecting solid potash deposits in the Simao Basin. | WU Chihua LIU Chenglin SHEN Lijian WANG Jiuyi ZHANG Hua | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 6 |
| 7 | Transporter-Mediated Nuclear Entry of Jasmonoyl-lsoleucine Is Essential for Jasmonate Signaling显示文摘到由直接对荷尔蒙集中作出回应的控制基因表示,动物和植物房间利用了可比较的机制在原子核察觉到小分子的荷尔蒙。这些荷尔蒙的原子入口是否活跃地通常被搬运或消极地扩散了,,,要求了,通过原子毛孔建筑群,仍然保持神秘。这里,我们在 Arabidopsis thaliana 识别了并且描绘 jasmonate transporter, AtJAT1/AtABCG16,哪个展览在原子信封和血浆的意外双本地化膜。我们证明 AtJAT1/AtABCG16 由两个都调停控制 jasmonate 植物激素的细胞质、原子的分区 jasmonic 酸(JA ) 和 jasmonoyl 异白氨酸(JA-Ile ) 的原子流入的细胞的流出,并且为维持批评原子 JA-Ile 集中激活 JA 发信号是必要的。这些结果说明小荷尔蒙分子的那个调停运输的原子条目调整原子荷尔蒙的新机制正在发信号。我们的调查结果提供一条大街开发指向小分子的原子入口的药品的代理人。 | Qingqing Li Jian Zheng Shuaizhang Li Guanrong Huang Stephen J. Skilling Lijian Wang Ling Li Mengya Li Lixing Yuan Pei Liu | 2017 | Molecular Plant2017，10，5： | 6 |
| 8 | Capillary blood flow in patients with dysmenorrhea treated with acupuncture显示文摘OBJECTIVE: To observe capillary blood flow at acupoints during acupuncture treatment of primary dysmenorrhea and gain new insights into its analgesic mechanism. METHODS: Patients with primary dysmenorrhea were enrolled and randomly assigned to a treatment or control group. Subjects' symptoms were differentiated into variousTraditional Chinese Medicine(TCM) syndromes and treated for 10 sessions with puncturing acupuncture or self-pressing right-hand Hegu(LI 4), adding other acupoints based on syndrome. Laser speckle was used to compare the change in the vasomotor amplitude and perfusion of the capillaries in Hegu(LI 4) before and during the treatment. Each subject was required to finish the period pain symptoms observation form, verbal rating scales, numerical rating scale, pain rating index, face rating scale, Zung self-rating depression scale, Zung self-rating anxiety scale, and numerical rating scale before and after treatments. RESULTS: After 10 sessions, the symptom scores, pain index(PI), and visual analog scale(VAS) decreased significantly in treatment group. The volume of blood flow in Hegu(LI 4) declined slightly. No significant evidence supported that needling caused capillary contraction, but the capillary vasomotor amplitude at Hegu(LI 4) increased remarkably. CONCLUSION: Acupuncture can increase the capillary blood flow, thus promoting the flow of Qi and blood in terms of TCM theory, which facilitates pain relief. | Tao Huang Lijian Yang Shuyong Jia Xiang Mu Mozheng Wu Hang Ye Weizhe Liu Xinnong Cheng | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 5 |
| 9 | Approach to General Data Model of GIS Symbol Library and Symbol Library Data Exchange XML Schema显示文摘标志描绘是 GIS 的重要功能。在不同 GIS 平台分享符号的信息为 GIS 应用程序和用户是必要的。这篇论文讨论必要性,可能性和在不同 GIS 平台分享一个标志图书馆的答案技术。线路地图如下被设计:首先,为标志图书馆当模特儿建立一个一般数据,然后格式化设计标准交换,并且最后格式化号召 GIS 制造商为标准交换为他们的标志图书馆提供交换工具。这篇论文分析 GIS 符号的图书馆的一般特征,给一个标志图书馆模型和 XML 的一篇草稿标志图书馆交换格式的纲要。 | LI Qingyuan SU Deguo LI Hongsheng LIU Haochen SUN Lijian | 2009 | Geo-Spatial Information Science2009，12，4： | 4 |
| 10 | Importers Drive Leaf-to-Leaf Jasmonic Acid Transmission in Wound-Induced Systemic Immunity显示文摘The transmission of mobile wound signals along the phloem pathway is essential to the activation of wound-induced systemic response/resistance,which requires an upsurge of jasmonic acid(JA)in the distal undamaged leaves.Among these mobile signals,the electrical signal mediated by the glutamate-dependent activation of several clade three GLUTAMATE RECEPTOR-LIKE(GLR3)proteins is involved in the stimulation of JA production in distal leaves.However,whether JA acts as a mobile wound signal and,if so,how it is transmitted and interacts with the electrical signal remain unclear.Here,we show that JA was translocated from the local to distal leaves in Arabidopsis,and this process was predominantly regulated by two phloem-expressed and plasma membrane-localized jasmonate transporters,AtJAT3 and AtJAT4.In addition to the cooperation between AtJAT3/4 and GLR3.3 in the regulation of long-distance JA translocation,our findings indicate that importer-mediated cell-cell JA transport is important for driving the loading and translocation of JA in the phloem pathway in a self-propagating manner. | Mengya Li Feifei Wang Shuangzhang Li Guanghui Yu Lijian Wang Qingqing Li Xiangyu Zhu Zhen Li Lixing Yuan Pei Liu | 2020 | Molecular Plant2020，13，10： | 3 |
| 11 | Preventive and therapeutic effectiveness of Sanfu acupoint herbal patching for chronic obstructive pulmonary disease at stable stages:a systematic review and Meta-analysis显示文摘OBJECTIVE:To evaluate the preventive and therapeutic effects of Sanfu acupoint herbal patching(SAHP)in adjuvant treatment in patients with stable chronic obstructive pulmonary disease(COPD).METHODS:We had searched eight electronic databases and six major trial registries from their inception to July 2017 for randomized controlled trials(RCTs).We utilized RevMan 5.3 to evaluate the methodological quality and to perform data analyses.RESULTS:A total of 28 RCTs involving 1615 records were included in the descriptive analysis,and 25 RCTs were performed for Meta-analysis.Lung function such as forced vital capacity rate of one second FEV1/predicted%,forced vital capacity(FVC)%found no significant difference.The results of Meta-analysis showed that SAHP plus conventional therapy(CT)in the treatment of stable COPD were better than CT,in second sessions'data of FEV1,in third sessions'data of FEV1/FVC,in three sessions'data of SGRQ,in third session's data of Modified Medical Research Council and 6MWT.The symptoms of SAHP's adverse reactions seem to be mild and the incidence of that seems to be low.Descriptive analysis shows that SAHP with CT seems to improve clinical effective rate and had a certain preventive effect on acute exacerbation of COPD,which the curative effect may be better with the increase of treatment course.CONCLUSION:SAHP with CT appears to be more effective than CT or CT plus placebo only on improving the quality of life,but the effect on lung function is not obvious.Improve clinical effective rate and preventive effect is uncertainty.SAHP with CT may be used in any Grade to safely treat patients with stable COPD.The more exactly clinical effect still needs to be proved by more high-quality,large sampling,multilingual RCTs. | Pang Lijian Zhang Haoyang Lu Xiaodong Liu Jianping Liu Chuang Lu Ling | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 3 |
| 12 | A Novel TiNi/AlSi Composite with High Strength and High Damping Capacity显示文摘A novel TiNi/AlSi composite with high compressive strength and high damping capacity was obtained by infiltrating Al-12%Si alloy into porous TiNi alloy.It had been found that the high compressive strength (440 MPa) of TiNi/AlSi composite is due to the increase of effective carrying area after infiltrating Al-12%Si alloy,while the high damping capacity is contributed to TiNi carcass,Al-12%Si filling material and micro- slipping at the interface. | Shuwei LIU Xiuyan LI Desheng YAN Haichang JIANG Lijian RONG | 2008 | Journal of Materials Science & Technology2008，24，6： | 3 |
| 13 | Effects of free-air CO_2 enrichment on adventitious root development of rice under low and normal soil nitrogen levels显示文摘Free air CO2 enrichment(FACE) and nitrogen(N) have marked effects on rice root growth,and numerical simulation can explain these effects. To further define the effects of FACE on root growth of rice, an experiment was performed, using the hybrid indica cultivar Xianyou63. The effects of increasing atmospheric CO2 concentration [CO2], 200 μmol mol-1higher than ambient, on the growth of rice adventitious roots were evaluated, with two levels of N: low(LN, 125 kg ha-1) and normal(NN, 250 kg ha-1). The results showed a significant increase in both adventitious root number(ARN) and adventitious root length(ARL) under FACE treatment. The application of nitrogen also increased ARN and ARL, but these increases were smaller than that under FACE treatment. On the basis of the FACE experiment, numerical models for rice adventitious root number and length were constructed with time as the driving factor. The models illustrated the dynamic development of rice adventitious root number and length after transplanting, regulated either by atmospheric [CO2] or by N application.The simulation result was supported by statistical tests comparing experimental data from different years, and the model yields realistic predictions of root growth. These results suggest that the models have strong predictive potential under conditions of atmospheric [CO2] rises in the future. | Chengming Sun Lijian Wang Tao Liu Doudou Guo Yingying Chen Wei Wu Yulong Wang Jianguo Zhu | 2014 | The Crop Journal2014，2，4： | 2 |
| 14 | Taking advantage of glass:capturing and retaining the helium gas on the moon显示文摘Helium-3(3He)is a noble gas that has critical applications in scientific research and promising application potential as clean fusion energy.It is thought that the lunar regolith contains large amounts of helium,but it is challenging to extract because most helium atoms are reserved in defects of crystals or as solid solutions.Here,we find large amounts of helium bubbles in the glassy surface layer of ilmenite particles that were brought back by the Chang’E-5 mission.The special disordered atomic packing structure of glasses should be the critical factor for capturing the noble helium gas.The reserves in bubbles do not require heating to high temperatures to be extracted.Mechanical methods at ambient temperatures can easily break the bubbles.Our results provide insights into the mechanism of helium gathering on the moon and offer guidance on future in situ extraction. | Ao Li Xiao Chen Lijian Song Guoxin Chen Wei Xu Juntao Huo Meng Gao Ming Li Lei Zhang Bingnan Yao Min Ji Yan Zhang Shaofan Zhao Wei Yao Yanhui Liu Jun-Qiang Wang Haiyang Bai Zhigang Zou Mengfei Yang Weihua Wang | 2022 | Materials Futures2022，1，3： | 2 |
| 15 | Effect of multiphase content on temperature-dependent electrical conductivity in silicone rubber composites显示文摘To investigate how the multiphase structures affect the electrical conductivity in semicrystalline polymer composites,herein,an accurate multiphase content calculation method is proposed and verified,which combines amorphous phase information in broadband dielectric spectroscopy and crystalline phase information in differential scanning calorimetry.Taken aluminium hydroxide(ATH)filled silicone rubber as an example,it is found that the rigid amorphous fraction(RAF)corresponding to the chains constrained by crystals(RAF_(cry))is not linearly increased with crystalline fraction(CF).Compared to non-isothermal crystallisation,RAF caused by ATH/silicone rubber interface(RAF_(int))after isothermal crystallisation at 213 K changes little,while mobile amorphous fraction and RAFcry is attenuated and CF is strengthened.Based on the calculated structures of ATH filled silicone rubber,activation energy of conductivities during cooling is dominated by the thermal transition for conductive ions and shortened distance among the conductive ions through shrunk volumes of the amorphous phase.Our findings deepen the understanding of multiphase content in semi-crystalline polymer composites and its relationship with electrical conductivity,which can be applied in manipulating electrical performance of semi-crystalline polymers by fillers. | Ying Lin Yuhao Liu Bin Cao Jianyi Xue Liming Wang Jianing Wang Lijian Ding | 2023 | High Voltage2023，8，2： | 2 |
| 16 | Damping behavior of Ti_(50.1)Ni_(49.9) alloy in reverse martensitic transformation region显示文摘Damping behavior of Ti50.1Ni49.9 shape memory alloy during reverse martensitic transformation has been investigated by dynamic mechanical analyzer in a dual-cantilever mode.With the increase of strain amplitude,internal friction(IF) of the alloy increases in martensite and austenite states while decreases in transformation region.Based on the regularity of IF attenuation in isothermal condition,IFTr and(IFPT+ IFI) are decomposed from the strain amplitude dependent IF in transformation region.For practical application of shape memory alloys as a damping material,it is significant to evaluate the damping capacity by eliminating the influence of IFTr and consider its time independent real IF(IFPT+ IFI). | ZENG JianMin JIANG HaiChang LIU ShuWei RONG LiJian | 2012 | Science China(Technological Sciences)2012，55，2： | 2 |
| 17 | An Aptamer-based Colorimetric Sensor for Streptomycin and Its Application in Food Inspection显示文摘 | LIU Zhongcheng ZHANG Yanfen XIE Yao SUN Ying BI Kewei CUI Zhe ZHAO Lijian FAN Wufang | 2017 | Chemical Research in Chinese Universities2017，33，5： | 2 |
| 18 | Health Status and Earnings of Migrant Workers from Rural China显示文摘进为雇用的城市的农村劳动者的迁居是中国在过去的三十年的经济生长的主要驱动力之一。基于中国的农业的部从 2003 ~ 2007 收集的数据集,这份报纸在从事要求好健康的身体上集中的工作的候鸟工人的收入上检验健康的影响。我们的调查结果显示那差的健康地位不仅削弱农村劳动者的刺激参予候鸟劳动力量而且显著地减少他们的收入。处于差的健康的一个候鸟工人仅仅挣一个健康工人做的中的 67% 个。在所有人的大写的特征和家庭经济因素之中,健康地位在为更少的教育工人的收入上是最有影响的。劳动生产率比一个人工作的天的年度数字在收入上有更大的影响。针对对农村劳动者可得到的保健服务的改进的进行中的保健改革被催促帮助在农村中国减少贫穷。 | Lijian Qin Chien-Ping Chen Xun Liu Chenggang Wang Zhongyi Jiang | 2015 | China & World Economy2015，23，2： | 2 |
| 19 | The Late Cretaceous source-to-sink system at the eastern margin of the Tibetan Plateau:Insights from the provenance of the Lanping Basin显示文摘The surface uplift of the Tibetan Plateau(TP)and its geomorphology evolution has triggered aridification of Asia's interior and drainage development at the eastern margin of the plateau.However,how the pre-Cenozoic early growth histories of the TP impact the drainage system and climate is poorly constrained.The Late Mesozoic Lacustrine evaporite-bearing basins on the eastern margin of the TP record significant information on the uplift of the source terranes,source-to-sink system development and climate change.In this study,we presented detrital zircon U-Pb ages from the Upper Cretaceous Yunlong Formation in the Lanping Basin,as well as Hf isotopic,petrographic,direct statistical,and multidimensional scaling analyses,and use them to characterize the provenance and reconstruct the drainage system.All of the samples have five major age peaks at 200-290 Ma,400-490 Ma,750-1000 Ma,1750-1950 Ma,and 2400-2600 Ma with mostly negativeε_(Hf)(t)values(81%).We infer the sediments are primarily derived from recycled sediments of the Songpan-Garze terrane,and partly from the Sichuan Basin and the Southern Qiangtang terrane,as well as the exposed magmatic rocks of the Yidun Arc and SongpanGarze terrane.The provenance features of the contemporaneous sediments from the Sichuan,Xichang,Chuxiong,and Simao basins indicate a complex hierarchical drainage pattern on the eastern margin of the TP during the Late Cretaceous.The hierarchical drainage system exhibits a complete gradational cycle of lake-basin types from overfilled freshwater Sichuan Basin through balanced fill saline Xichang Basin and underfilled hypersaline Chuxiong,Lanping,Simao,and Khorat Plateau basins from proximal to distal.The early growth of the TP primarily controlled the drainage and lake-basin evolution by not only causing the uplift and exhumation of the source areas and providing large amounts of clastic material to the proximal sub-drainage areas but also intensifying the aridity and deposition of evaporites. | Licheng Wang Lijian Shen Chenglin Liu Ke Chen Lin Ding Chengshan Wang | 2021 | Geoscience Frontiers2021，12，3： | 2 |
| 20 | Quantitative evaluation of heavy metals’ pollution hazards in liquefaction residues of sewage sludge显示文摘 | Huajun Huang Xingzhong Yuan Guangming Zeng Huina Zhu Hui Li Zhifeng Liu Hongwei Jiang Lijian Leng Wenkai Bi | 2011 | Bioresource Technology2011，，22： | 2 |
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