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| 1 | Performance evaluation of deep learning-based post-processing and diagnostic reporting system for coronary CT angiography: a clinical comparative study显示文摘To the Editor:Coronary computed tomography angiography(CCTA)has been increasingly,widely performed for diagnosing coronary artery,disease,lAnatomical diagnosis,that is,stenosis grading,is stillthe main diagnostic index provided'by most CCTA tests.Post-processing and interpretation of stenosis are 2 essential'steps that need to be performed bycardiovascular imaging professionals from scan completion to diagnosis conclusion,which is repetitive and time-consuming,taking an average of 30 minutes each case in China and becoming the bottleneck and gradually creating an imbalance between supply and demand.In ine with the rapid development of artificial intelligence(Al)technology in recent years,it has been expected to solve these specific problems.We developed an AI system for automating post-processing and diagnostic reporting of CCTA data using deep learning algorithms to establishanew1-clickworkflowforeverydayuse,namely,CCTA-AI(Figure 1).To further assess its capabilities,this study intends to answer 2 following questions:To what extent can it improve the efficiency of post-processing?To what extent can CCTA-AI detect and calculate coronary artery stenosis due to each atherosclerotic plaque? | Nan Luo Yi He Jitao Fan Ning Guo Guang Yang Yuanyuan Kong Jianyong Wei Tao Bi Jie Zhou Jiaxin Cao Xianjun Han Fang Li Shiyu Zhang Rujing Sun Zhaozhao Wang Tian Ma Lixue Xu Hui Chen Hongwei Li Zhenchang Wang Zhenghan Yang | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 2 | Use of angiotensin-converting enzyme inhibitors and angiotensin Ⅱ receptor blockers in context of COVID-19 outbreak:a retrospective analysis显示文摘The possible effects of angiotensin-converting enzyme inhibitors(ACEIs)or angiotensin Ⅱ receptor blockers(ARBs)on COVID-19 disease severity have generated considerable debate.We performed a single-center,retrospective analysis of hospitalized adult COVID-19 patients in Wuhan,China,who had definite clinical outcome(dead or discharged)by February 15,2020.Patients on anti-hypertensive treatment with or without ACEI/ARB were compared on their clinical characteristics and outcomes.The medical records from 702 patients were screened.Among the 101 patients with a history of hypertension and taking at least one anti-hypertensive medication,40 patients were receiving ACEI/ARB as part of their regimen,and 61 patients were on antihypertensive medication other than ACEI/ARB.We observed no statistically significant differences in percentages of in-hospital mortality(28%vs.34%,P=0.46),ICU admission(20%vs.28%,P=0.37)or invasive mechanical ventilation(18%vs.26%,P=0.31)between patients with or without ACEI/ARB treatment.Further multivariable adjustment of age and gender did not provide evidence for a significant association between ACEI/ARB treatment and severe COVID-19 outcomes.Our findings confirm the lack of an association between chronic receipt of reninangiotensin system antagonists and severe outcomes of COVID-19.Patients should continue previous antihypertensive therapy until further evidence is available. | Jiuyang Xu Chaolin Huang Guohui Fan Zhibo Liu Lianhan Shang Fei Zhou Yeming Wang Jiapei Yu Luning Yang Ke Xie Zhisheng Huang Lixue Huang Xiaoying Gu Hui Li Yi Zhang Yimin Wang Frederick G.Hayden Peter W.Horby Bin Cao Chen Wang | 2020 | Frontiers of Medicine2020，14，5： | 2 |
| 3 | Direct growth of FePO 4 /graphene and LiFePO 4 /graphene hybrids for high rate Li-ion batteries显示文摘 | Qi Fan Lixu Lei Xingyu Xu Gui Yin Yueming Sun | 2014 | Journal of Power Sources2014，，： | 1 |
| 4 | Impact of corticosteroids on initiation and half-year durability of humoral response in COVID-19 survivors显示文摘Background:The impact of corticosteroids on humoral responses in coronavirus disease 2019(COVID-19)sur-vivors during the acute phase and subsequent 6-month period remains unknown.This study aimed to determine how the use of corticosteroids influences the initiation and duration of humoral responses in COVID-19 survivors 6 months after infection onset.Methods:We used kinetic antibody data from the lopinavir-ritonavir trial conducted at Jin Yin-Tan Hospital in January 2020,which involved adults hospitalized with severe COVID-19(LOTUS,ChiCTR2000029308).Anti-body samples were collected from 192 patients during hospitalization,and kinetic antibodies were monitored at all available time points after recruitment.Additionally,plasma samples were collected from 101 COVID-19 survivors for comprehensive humoral immune measurement at the half-year follow-up visit.The main focus was comparing the humoral responses between patients treated with systemic corticosteroid therapy and the non-corticosteroid group.Results:From illness onset to day 30,the median antibody titre areas under the receiver operating characteristic curve(AUCs)of nucleoprotein(N),spike protein(S),and receptor-binding domain(RBD)immunoglobulin G(IgG)were significantly lower in the corticosteroids group.The AUCs of N-,S-,and RBD-IgM as well as neutralizing antibodies(NAbs)were numerically lower in the corticosteroids group compared with the non-corticosteroid group.However,peak titres of N,S,RBD-IgM and-IgG and NAbs were not influenced by corticosteroids.During 6-month follow-up,we observed a delayed decline for most binding antibodies,except N-IgM(��−0.05,95%CI[−0.10,0.00])in the corticosteroids group,though not reaching statistical significance.No significant difference was observed for NAbs.However,for the half-year seropositive rate,corticosteroids significantly accelerated the decay of IgA and IgM but made no difference to N-,S-,and RBD-IgG or NAbs.Additionally,corticosteroids group showed a trend towards delayed viral clearance compared with the non-corticosteroid group,but the results were not statistically significant(adjusted hazard ratio 0.71,95%CI 0.50-1.00;P=0.0508).Conclusion:Our findings suggested that corticosteroid therapy was associated with impaired initiation of the antibody response but this did not compromise the peak titres of binding and neutralizing antibodies.Throughout the decay phase,from the acute phase to the half-year follow-up visit,short-term and low-dose corticosteroids did not significantly affect humoral responses,except for accelerating the waning of short-lived antibodies. | Yeming Wang Li Guo Guohui Fan Yang Han Qiao Zhang Lili Ren Hui Zhang Geng Wang Xueyang Zhang Tingxuan Huang Weiyang Wang Lan Chen Lixue Huang Xiaoying Gu Xinming Wang Jingchuan Zhong Ying Wang Hui Li Jiapei Yu Zhibo Liu Chaolin Huang Bin Cao Jianwei Wang | 2024 | Chinese Medical Journal Pulmonary and Critical Care Medicine2024，2，1： | 0 |
| 5 | Characters and structures of the nucleobase-ascorbate transporters(NAT)family genes in Gossypium hirsutum and their roles in responding to salt and drought stresses显示文摘Background: Nucleobase-ascorbate transporters(NAT), synonymously called nucleobase-cation symporter 2(NCS2) proteins, were earlier reported to be involved in plant growth, development and resistance to stress. Previous studies concluded that s a polymorphic SNP associated with NAT12 was significant di erent between salt-tolerant and salt-sensitive materials of upland cotton. In current study, a comprehensive analysis of NAT family genes was conducted for the first time in cotton.Results: In this study, we discovered 32, 32, 18, and 16 NAT genes in Gossypium hirsutum, G. barbadense, G. raimondii and G. arboreum, respectively, which were classified into four groups(groups I–IV) based on the multiple sequence analysis. These GhNAT genes were unevenly distributed on At and Dt sub-genome in G. hirsutum. Most GhNAT members in the same group had similar gene structure characteristics and motif composition. The collinearity analysis revealed segmental duplication as well as tandem duplication contributing to the expansion of the GhNATs. The analysis of cis-acting regulatory elements of GhNATs showed that the function of GhNAT genes in cotton might be related to plant hormone and stress response. Under di erent conditions, the expression levels further suggested the GhNAT family genes were associated with plant response to various abiotic stresses. GhNAT12 was detected in the plasma membrane. And it was validated that the GhNAT12 gene played an important role in regulating cotton resistance to salt and drought stress through the virus-induced gene silencing(VIGS) analysis.Conclusions: A comprehensive analysis of NAT gene family was performed in cotton, including phylogenetic analysis, chromosomal location, collinearity analysis, motifs, gene structure and so on. Our results will further broaden the insight into the evolution and potential functions of NAT genes in cotton. Current findings could make significant contribution towards screening more candidate genes related to biotic and abiotic resistance for the improvement in cotton. | GUO Lixue ZHAO Lanjie LU Xuke CHEN Xiugui WANG Shuai WANG Junjuan WANG Delong YIN Zujun CHEN Chao FAN Yapeng ZHANG Yuexin YE Wuwei | 2022 | Journal of Cotton Research2022，5，2： | 0 |
| 6 | Functional structure analysis and genome‑wide identification of CNX gene family in cotton显示文摘Background:Under abiotic stress conditions,cotton growth is inhibited and yield losses are severe.Identification of calnexin family members and function analysis under abiotic stress laid the foundation for the screening of stressrelated candidate genes.Results:A total of 60 CNX family members have been identified in Gossypium hirsutum,G.barbadense,G.arboreum,and G.raimondii,and they were divided into two categories:CNX and CRT genes.Through the construction of a phylogenetic tree,they were subdivided into three classes.Further analysis of chromosome localization,conserved promoters,gene structure and selection under pressure showed that the family members were highly conserved in the evolution process.Analysis of cis-acting elements in the promoter regions showed that CNX family genes contain regulatory elements for growth and development,anaerobic,drought,defense and stress response,and plant hormones.Using RNA-seq data to study the expression pattern of GhCNX genes under cold,hot,salt stress and Polyethylene glycol,it was observed that the gene expression levels changed by different degrees under different stress conditions,indicating that GhCNX members were involved in the regulation of multiple biological stresses.Conclusion:This study provides an insight into the members of cotton CNX genes.The results of this study suggested that CNX family members play a role in defense against adversity and provide a foundation for the discovery of stress-related genes. | XU Nan ZHANG Hong ZHANG Yuexin FAN Yapeng WANG Jing MALIK Waqar Afzal RUI Cun HAN Mingge LU Xuke CHEN Xiugui WANG Junjuan WANG Delong WANG Shuai CHEN Chao GUO Lixue ZHAO Lanjie YE Wuwei | 2022 | Journal of Cotton Research2022，5，3： | 0 |
| 7 | The probiotic effects of host-associated Bacillus velezensis in diets for hybrid yellow catfish(Pelteobagrus fulvidraco♀×Pelteobagrus vachelli♂)显示文摘This study was to evaluate the potential of a host-associated Bacillus velezensis as a probiotic for hybrid yellow catfish(Pelteobagrus fulvidraco♀×Pelteobagrus vachelli♂).Diets(B0 to B5)containing 0,0.90×10^(8),0.80×109,0.85×10^(10),0.90×10^(11),0.83×10^(12)CFU/kg B.velezensis YFI-E109 were fed to the fish with initial weight(3.07±0.08 g)in a recirculating aquaculture system for six weeks with three replicates,respectively.Probiotic effects were analyzed based on growth,body composition,liver and gut morphology,gut microbiome,and liver metabolome.Analysis of the bacterial genome has shown that the most abundant genes in B.velezensis YFI-E109 were distributed in carbohydrate and amino acid metabolism.Fish in groups B3 and B4 had better growth performance,and higher intestinal amylase(AMS)and lipase(LPS)activities compared with other groups(P<0.05).Fish in groups B0 and B5 showed significant liver damage,while this status improved in group B3.The liver malondialdehyde(MDA)content in group B3 was lower than that in other groups(P<0.05).The abundance of Mycoplasma,Ralstonia and Acinetobacter was significantly reduced in B3 and B5 compared to B0.The amino acid and carbohydrate metabolism pathways were enriched in group B3 compared with group B0.In conclusion,dietary B.velezensis YFI-E109 supplementation has the potential to improve growth,liver metabolism,and liver and gut health,and reshape the gut microbiome of hybrid yellow catfish.Excessive B.velezensis YFI-E109 reduced the prebiotic effects.The recommended dietary supplementation of B.velezensis YFI-E109 is 0.31×10^(10) to 0.77×10^(11)CFU/kg for hybrid yellow catfish according to the quadratic regression method by plotting specific growth rate(SGR),feed conversion ratio(FCR),MDA and activities of AMS against dietary B.velezensis YFI-E109 levels. | Zhehui Ji Xing Lu Mingyang Xue Yuding Fan Juan Tian Lixue Dong Chuanzhong Zhu Hua Wen Ming Jiang | 2023 | Animal Nutrition2023，，4： | 0 |
| 8 | Light-up lipid droplets for the visualization of lipophagy and atherosclerosis by coumarin-derived bioprobe显示文摘Lipid droplets(LDs) are intracellular lipid-metabolism organelles that involved in many physiological processes,metabolic disorders as well as diseases such as atherosclerosis.However,the specific probes that can visually locate abnormal LDs-rich tissues and track LDs-associated behavior to the naked eye with adequate biosafety still are rare.Herein,we develop a new design strategy of LDs-targeted probe based on the solvatochromism of coumarin derivatives.The results revealed that the emission wavelength of coumarin fluorophores gradually red shift in different solvents with increasing polarity,while absorption wavelength almost unchanged.As a result,the enlarged stokes shift of coumarin was emerged from oil to water.Furthermore,properly reducing water solubility and adding electronic donor at the structure of coumarins can enlarge this type of solvatochromism.This discovery was utilized to develop suitable probe for the image of LDs and LDs-rich tissues with high resolution and biosafety.Therefore,LDs-associated behavior was visible to the naked eye during the process of lipophagy and atherosclerosis.We deem that the developed probe here offers a new possibility to accurately diagnosis and analyse LDs-related diseases in clinic and preclinical study. | Jinrong Zheng Shuheng Qin Lijuan Gui Hua Li Lixue Fan Yifei Yang Haiyan Chen Hui Xu Zhenwei Yuan | 2021 | Chinese Chemical Letters2021，32，8： | 0 |
| 9 | Identification of potential interdisciplinary cooperative topics based on co-word network:Taking LIS and computer science as an example显示文摘[Purpose/significance]Interdisciplinary knowledge fusion plays a key role in promoting the development of interdisciplinary integration and providing new ideas for interdisciplinary cooperative research.This study sets out to identify potential interdisciplinary cooperative topics between Library and Information Science(LIS)and Computer Science.[Method/Process]We built an interdisciplinary co-word network to identify potential interdisciplinary cooperative topics by closed and opened irrelevant knowledge discovery methods.We also constructed the topic interdisciplinary cooperation potential index(TICPI)to calculate the interdisciplinary cooperation potential of the topic and found the best contact path of the cooperation topic by constructing the practicable value(PV)of the contact patch.[Result/Conclusion]The experimental data suggested that both methods can identify the same potential interdisciplinary cooperative topics,such as knowledge service&matrix decomposition,online comments&social media processing,academic text&generative adversarial network,network public opinion&smart home.Exploiting the cooperation potential of these topics can help the knowledge fusion between disciplines. | Changling Li Guoyang Rong Kun Luan Xinxin Wang Lixu Shen Qingqing Fan | 2022 | Data Science and Informetrics2022，2，3： | 0 |
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