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| 1 | Frequent Mutation of rs13281615 and Its Association with PVT1 Expression and Cell Proliferation in Breast Cancer显示文摘The q24 band of chromosome 8(8q24)is frequently amplified in human cancers including breast cancer,and several SNPs(single nucleotide polymorphisms)at 8q24,including rs13281615,have been identified for their association with cancer risks.These SNPs are in a'gene desert'region,and their functions in cancer development remain to be illustrated,although several of the SNPs appear to influence the genes in the'desert'in a long-range manner,including the v-myc avian myelocytomatosis viral oncogene homolog(MYC)and the nonprotein coding plasmacytoma variant translocation 1(PVT1),both of which have been implicated in human cancers.In the current study,we examined rs13281615 for its potential role in breast cancer using normal and cancer tissues from 121 Chinese women with breast cancer.In addition to confirming the association of the GG genotype of rs13281615 with breast cancer risk,we found that germline GG genotype was significantly associated with estrogen receptor(ER)positivity,higher tumor grade and higher proliferation index.We also found frequent somatic mutations(22/121 or 18.2%)of this SNP in breast cancer.Interestingly,the majority of the mutations(17/22 or 77%)involved a G/A change,resulting in a decrease in the number of cancers with the GG risk genotype and subsequent loss of GG association with higher tumor grade and proliferation index in cancers.Furthermore,PVT1 expression was increased in cancers,and the increase was associated with the GG genotype of rs13281615.These results suggest that the GG genotype of SNP rs13281615 plays a role in breast cancer likely by influencing PVT1 expression,and that during oncogenesis,'protective'mutations could occur. | Zhiqian Zhang Zhengmao Zhu Baotong Zhang Weidong Li Xin Li Xiao Wu Lijuan Wang Liya Fu Li Fu Jin-Tang Dong | 2014 | Journal of Genetics and Genomics2014，41，4： | 12 |
| 2 | Ubiquitinome Profiling Reveals the Landscape of Ubiquitination Regulation in Rice Young Panicles显示文摘Ubiquitination,an essential post-transcriptional modification(PTM),plays a vital role in nearly every biological process,including development and growth.Despite its functions in plant reproductive development,its targets in rice panicles remain unclear.In this study,we used proteome-wide profiling of lysine ubiquitination in rice(O.sativa ssp.indica)young panicles.We created the largest ubiquitinome dataset in rice to date,identifying 1638 lysine ubiquitination sites on916 unique proteins.We detected three conserved ubiquitination motifs,noting that acidic glutamic acid(E)and aspartic acid(D)were most frequently present around ubiquitinated lysine.Enrichment analysis of Gene Ontology(GO)annotations and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways of these ubiquitinated proteins revealed that ubiquitination plays an important role in fundamental cellular processes in rice young panicles.Interestingly,enrichment analysis of protein domains indicated that ubiquitination was enriched on a variety of receptorlike kinases and cytoplasmic tyrosine and serine-threonine kinases.Furthermore,we analyzed the crosstalk between ubiquitination,acetylation,and succinylation,and constructed a potential protein interaction network within our rice ubiquitinome.Moreover,we identified ubiquitinated proteins related to pollen and grain development,indicating that ubiquitination may play a critical role in the physiological functions in young panicles.Taken together,we reported the most comprehensive lysine ubiquitinome in rice so far,and used it to reveal the functional role of lysine ubiquitination in rice young panicles. | Liya Zhu Han Cheng Guoqing Peng Shuansuo Wang Zhiguo Zhang Erdong Ni Xiangdong Fu Chuxiong Zhuang Zexian Liu Hai Zhou | 2020 | Genomics, Proteomics & Bioinformatics2020，18，3： | 2 |
| 3 | Trends of visibility on sunny days in China in the recent 50 years显示文摘 | Jian Wu Chuanbo Fu Liya Zhang Jianping Tang | 2012 | Atmospheric Environment2012，，： | 1 |
| 4 | Precision Methylome and In Vivo Methylation Kinetics Characterization of Klebsiella pneumoniae显示文摘Klebsiella pneumoniae(K.pneumoniae)is an important pathogen that can cause severe hospital-and community-acquired infections.To systematically investigate its methylation features,we determined the whole-genome sequences of 14 K.pneumoniae strains covering varying serotypes,multilocus sequence types,clonal groups,viscosity/virulence,and drug resistance.Their methylomes were further characterized using Pacific Biosciences single-molecule real-time and bisulfite technologies.We identified 15 methylation motifs[13 N6-methyladenine(6mA)and two 5-methylcytosine(5mC)motifs],among which eight were novel.Their corresponding DNA methyltransferases were also validated.Additionally,we analyzed the genomic distribution of GATC and CCWGG methylation motifs shared by all strains,and identified differential distribution patterns of some hemi-/un-methylated GATC motifs,which tend to be located within intergenic regions(IGRs).Specifically,we characterized the in vivo methylation kinetics at single-base resolution on a genome-wide scale by simulating the dynamic processes of replication-mediated passive demethylation and MTase-catalyzed re-methylation.The slow methylation of the GATC motifs in the replication origin(oriC)regions and IGRs implicates the epigenetic regulation of replication initiation and transcription.Our findings illustrate the first comprehensive dynamic methylome map of K.pneumoniae at single-base resolution,and provide a useful reference to better understand epigenetic regulation in this and other bacterial species. | Jing Fu Ju Zhang Li Yang Nan Ding Liya Yue Xiangli Zhang Dandan Lu Xinmiao Jia Cuidan Li Chongye Guo Zhe Yin Xiaoyuan Jiang Yongliang Zhao Fei Chen Dongsheng Zhou | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 1 |
| 5 | Development, dilemma and potential strategies for the application of nanocatalysts in wastewater catalytic ozonation: A review显示文摘With the continuous development of nanomaterials in recent years,the application of nanocatalysts in catalytic ozone oxidation has attracted more and more researchers’attention due to their excellent catalytic properties.In this review,we systematically summarized the current research status of nanocatalysts mainly involving material categories,mechanisms and catalytic efficiency.Based on summary and analysis,we found most of the reported nanocatalysts were in the stage of laboratory research,which was caused by the nanocatalysts defects such as easy aggregation,difficult separation,and easy leakage.These defects might result in severe resource waste,economic loss and potentially adverse effects imposed on the ecosystem and human health.Aiming at solving these defects,we further analyzed the reasons and the existing reports,and revealed that coupling nano-catalyst and membrane,supported nanocatalysts and magnetic nanocatalysts had promising potential in solving these problems and promoting the actual application of nanocatalysts in wastewater treatment.Furthermore,the advantages,shortages and our perspectives of these methods are summarized and discussed. | Xiaoguang Jin Changyong Wu Liya Fu Xiangmiao Tian Panxin Wang Yuexi Zhou Jiane Zuo | 2023 | Journal of Environmental Sciences2023，，2： | 1 |
| 6 | A tailored and rapid approach for ozonation catalyst design显示文摘Catalytic ozonation is widely employed in advanced wastewater treatment owing to its high mineralization of refractory organics.The key to high mineralization is the compatibility between catalyst formulation and wastewater quality.Machine learning can greatly improve experimental efficiency,while fluorescence data can provide additional wastewater quality information on the composition and concentration of organics,which is conducive to optimizing catalyst formulation.In this study,machine learning combined with fluorescence spectroscopy was applied to develop ozonation catalysts(Mn/g-Al_(2)O_(3)catalyst was used as an example).Based on the data collected from 52 different catalysts,a machine-learning model was established to predict catalyst performance.The correlation coefficient between the experimental and model-predicted values was 0.9659,demonstrating the robustness and good generalization ability of the model.The range of the catalyst formulations was preliminarily screened by fluorescence spectroscopy.When the wastewater was dominated by tryptophan-like and soluble microbial products,the impregnation concentration and time of Mn(NO_(3))_(2) were less than 0.3 mol L^(-1)and 10 h,respectively.Furthermore,the optimized Mn/g-Al_(2)O_(3)formulation obtained by the model was impregnation with 0.155 mol L^(-1)Mn(NO_(3))_(2)solution for 8.5 h and calcination at 600℃ for 3.5 h.The model-predicted and experimental values for total organic carbon removal were 54.48% and 53.96%,respectively.Finally,the improved catalytic performance was attributed to the synergistic effect of oxidation(·OH and ^(1)O_(2))and the Mn/g-Al_(2)O_(3) catalyst.This study provides a rapid approach to catalyst design based on the characteristics of wastewater quality using machine learning combined with fluorescence spectroscopy. | Min Li Liya Fu Liyan Deng Yingming Hu Yue Yuan Changyong Wu | 2023 | Environmental Science and Ecotechnology2023，，3： | 0 |
| 7 | Alterations in the Cytoskeleton and Biological Behavior in Human Lung Cancer Cell Line L9981 by Nm23-H1 gene Transfection显示文摘Objective and Methods The key cause of failure to cure and high mortality in lung cancer. At present, it has been known | Zhe WANG Junke FU Zhihao WU Hongyu LIU Jun CHEN Liya SUN Q inghua ZHOU | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 8 | Thermally Conductive Nanocomposites based on Epoxy Modified with Nano-Sic and POSS显示文摘OPAS/SiC/EP,SiC/EP,A151-SiC/EP composites were prepared and their impact properties,flexural properties,thermal conductivity and insulation,dielectric properties and thermal stability were investigated.The comparison of three different composites showed that OAPS/SiC/EP compositeshad best properties.Thermal conductivity of OAPS/ | Zong Peisong Shang Dapeng Chen Liya Ding Guojun Dong Xing Fu Jifang Shi Liyi | 2016 | 功能材料信息2016，13，2： | 0 |
| 9 | Estrogen-estrogen receptor signaling suppresses the transcription of ERRF in breast cancer cells显示文摘The estrogen receptor(ER)-related factor(ERRF)was previously reported as a novel modulator of breast cancer(Su et al.,2012).Its expression was upregulated in breast cancer,and increased ERRF expression was significantly associated with ER and/or progesterone receptor(PR)positivity and human epidermal growth factor receptor 2(HER2)negativity(Su et al.,2012).In addition,ERRF was necessary for ER-positive breast cancer cells to form tumors | Ang Luo Dan Su Xuan Zhang Leilei Qi Liya Fu Jin-Tang Dong | 2016 | Journal of Genetics and Genomics2016，43，9： | 0 |
| 10 | Selection and Breeding of Drought Resistant,Water-saving and High-yield Wheat Variety Cangmai 028显示文摘Cangmai 028 was selected and bred according to the climatic characteristic of the winter wheat in Heilonggang Basin taking 98(083)as the female parent and the Canghe 030 as the male parent by 'two-row parallel alternate selection' method.Cangmai 028 has characteristics of high resistance,water-saving,high and stable yield,and rich genetic background.This study elaborated selection and breeding background and methods,characteristics,quality,and yield of Cangmai 028. | Liang YU Liya NIU Jing FU Fengzhi WANG Songshan ZHAO Li LU Weiwei WANG | 2017 | Asian Agricultural Research2017，9，2： | 0 |
| 11 | Advances in Studies of Biological Nitrogen Saving Technology for Wheat显示文摘This paper first described the current status of wheat nitrogen fertilizers utilization rate. Then,from balanced fertilizer application,applying slow/controlled release fertilizer,deep application of nitrogen fertilizers and graded application,controlled application amount,selection of application time according to soil properties,diagnosed application of fertilizer with instrument,addition of synergist,and precise fertilizer application,it summarized biological nitrogen saving methods and introduced prospects of future biological nitrogen saving technology. | Liya NIU Liang YU Wei WANG Weiwei WANG Jing FU Fengzhi WANG Songshan ZHAO | 2018 | Asian Agricultural Research2018，10，2： | 0 |
| 12 | Zfhx3 is essential for progesterone/progesterone receptor signaling to drive ductal side-branching and alveologenesis in mouse mammary glands显示文摘Progesterone(Pg)/progesterone receptor(PR) signaling drives mammary gland side-branching and alveologenesis, but the mechanisms through which Pg/PR signaling functions remain to be clarified.Using in vitro and in vivo models and histological and molecular analyses, we determined the role of Zfhx3 transcription factor in mammary gland development driven by Pg/PR signaling. Postnatal deletion of Zfhx3 in mouse mammary epithelial cells attenuated side-branching morphogenesis and alveologenesis. These effects were undetectable in the absence of Pg/PR signaling. During the estrus cycle, Zfhx3 expression corresponded to that of Pg, being at the highest level at the diestrus stage; Zfhx3 deletion inhibited mammary gland branching more potently at diestrus than estrus stage. Loss of Zfhx3 not only attenuated the expansion of stem/progenitor cells driven by Pg/PR signaling, but also impaired the function of Pg/PR signaling in the transcriptional activation of multiple genes. In addition, Pg/PR signaling significantly expanded PR-and Zfhx3-positive epithelial cells, and induced the physical association of ZFHX3 with PR. These findings establish Zfhx3 as an integral transcription factor of Pg/PR signaling in driving side-branching and alveologenesis during mammary gland development. | Gui Ma Ang Gao Yinan Yang Yuan He Xi Zhang Baotong Zhang Zhiqian Zhang Mei Li Xing Fu Dan Zhao Rui Wu Leilei Qi Qingxia Hu Juan Li Liya Fu Zhengmao Zhu Jin-Tang Dong | 2019 | Journal of Genetics and Genomics2019，46，3： | 0 |
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