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| 1 | Tuning the dual-active sites of ZIF-67 derived porous nanomaterials for boosting oxygen catalysis and rechargeable Zn-air batteries显示文摘The rational control of the active site of metal-organic frameworks(MOFs)derived nanomaterials is essential to build efficient bifunctional oxygen reduction/evolution reaction(ORR/OER)catalysts.Accordingly,through designing and constructing a Co_(3)O_(4)-Co heterostructure embedded in Co,N co-doped carbon polyhedra derived(Co_(3)O_(4)-Co@NC)from the in-situ compositions of ZIF-67 and cobalt nanocrystals synthesized by the strategy of in-situ NaBH4 reduction,the dual-active site(Co_(3)O_(4)-Co and Co-N_(x))is synchronously realized in a MOFs derived nanomaterials.The formed Co_(3)O_(4)-Co@NC shows excellent bifunctional electrocatalytic activity with ultra-small potential gap(ΔE=E_(j=10)(OER)–E_(1/2)(ORR))of 0.72 V,which surpasses the commercial Pt/C and RuO_(2) catalysts.The theory calculation results reveal that the excellent bifunctional electrocatalytic activity can be attributed to the charge redistribution of Co of Co-N_(x) induced by the synergistic effects of well-tuned active sites of Co_(3)O_(4)-Co nanoparticle and Co-N_(x),thus optimizing the rate-determining step of the desorption of O_(2)^(*)intermediate in ORR and OH^(*)intermediate in OER.The rechargeable Zn-air batteries with our bifunctional catalysts exhibit superior performance as well as high cycling stability.This simple-effective optimization strategy offers prospects for tuning the active site of MOF derived bifunctional catalyst in electrochemical energy devices. | Zeyi Zhang Yangyang Tan Tang Zeng Liyue Yu Runzhe Chen Niancai Cheng Shichun Mu Xueliang Sun | 2021 | Nano Research2021，14，7： | 3 |
| 2 | Virtual&augmented reality for biological microscope in experiment education显示文摘Background Mixed-reality technologies,including virtual reality(VR)and augmented reality(AR),are considered to be promising potential tools for science teaching and learning processes that could foster positive emotions,motivate autonomous learning,and improve learning outcomes.Methods In this study,a technology-aided biological microscope learning system based on VR/AR is presented.The structure of the microscope is described in a detailed three-dimensional(3D)model,each component being represented with their topological interrelationships and associations among them being established.The interactive behavior of the model was specified,and a standard operating guide was compiled.The motion control of components was simulated based on collision detection.Combined with immersive VR equipment and AR technology,we developed a virtual microscope subsystem and a mobile virtual microscope guidance system.Results The system consisted of a VR subsystem and an AR subsystem.The focus of the VR subsystem was to simulate operating the microscope and associated interactive behaviors that allowed users to observe and operate the components of the 3D microscope model by means of natural interactions in an immersive scenario.The AR subsystem allowed participants to use a mobile terminal that took a picture of a microscope from a textbook and then displayed the structure and functions of the instrument,as well as the relevant operating guidance.This flexibly allowed students to use the system before or after class without time and space constraints.The system allowed users to switch between the VR and AR subsystems.Conclusions The system is useful for helping learners(especially K-12 students)to recognize a microscope's structure and grasp the required operational skills by simulating operations using an interactive process.In the future,such technology-assisted education would be a successful learning platform in an open learning space. | Xiang ZHOU Liyu TANG Ding LIN Wei HAN | 2020 | Virtual Reality & Intelligent Hardware2020，2，4： | 1 |
| 3 | Vaccination of Goats with 31 kDa and 32 kDa Schistosoma japonicum Antigens by DNA Priming and Protein Boosting显示文摘Two Schistosoma japonicum vaccine candidate antigens Sj 31 and Sj 32, which have shown particular promise to induce protective immunity in mice, were used to immunize goats by using a DNA priming-protein boosting strategy in present work. DNA vaccine formulations of the two antigens (VRSj31 and VRSj32) were produced and injected intramuscularly twice at a 2-week interval and then recombinant proteins (rSj31 and rSj32) together with Freund Complete Adjuvant (FCA) were used to boost the goats. The experiment was repeated in different batche cercariae. A strong anamnestic antibody response was induced after boost. A significant reduction of liver egg counts and miracidial hatching was showed in both experiments. Significant protections against challenge infection were elicited with 31.6% of percentage reduction for worm recovery in the second experiment and 20.9% in the first experiment, respectively. | Lianfei Tang Zhijun Zhou Yuxiao Chen Yonghui Luo Linqian Wang Liyu Chen Fushen Huang Xianfang Zeng Xinyuan Yi | 2007 | Cellular & Molecular Immunology2007，4，2： | 1 |
| 4 | A virtual geographic environment for dynamic simulation and analysis of tailings dam failure显示文摘It is of great significance for disaster prevention and mitigation to carry out disaster simulations for dam failure accidents in advance,but at present,there are few professional systems for disaster simulations of tailings dams.In this paper,we focused on the construction of a virtual geographic environment(VGE)system that provides an effective tool for visualizing the dam-break process of a tailings pond.The dam-break numerical model of the tailings dam based on computational fluid dynamics(CFD)was integrated into the VGE system.The infrastructure of the VGE was supported by a 3-D geographic information system(GIS)with a user-friendly interface for the initiation,visualization,and analysis of the dynamic process of tailings dam failure.Key technologies,including the integration of numerical models,rendering of large-scale scenes,and optimizations of disaster simulation and visualization,were discussed in detail.In the prototype system,information on the run-out path,travel distance,etc.can be obtained to visually describe the flow motion released by two dam failure cases.The simulation results showed that the VGE can be used for the multidimensional,dynamic and interactive visualization of dam-break disasters,and can also be useful for assessing the risk associated with tailings dams. | Dayu Yu Liyu Tang Fan Ye Chongcheng Chen | 2021 | International Journal of Digital Earth2021，14，9： | 0 |
| 5 | Paradoxical effects of DNA tumor virus oncogenes on epithelium-derived tumor cell fate during tumor progression and chemotherapy response显示文摘Epstein-Barr virus(EBV)and human papillomavirus(HPV)infection is the risk factors for nasopharyngeal carcinoma and cervical carcinoma,respectively.However,clinical analyses demonstrate that EBV or HPV is associated with improved response of patients,although underlying mechanism remains unclear.Here,we reported that the oncoproteins of DNA viruses,such as LMP1 of EBV and E7 of HPV,inhibit PERK activity in cancer cells via the interaction of the viral oncoproteins with PERK through a conserved motif.Inhibition of PERK led to increased level of reactive oxygen species(ROS)that promoted tumor and enhanced the efficacy of chemotherapy in vivo.Consistently,disruption of viral oncoprotein-PERK interactions attenuated tumor growth and chemotherapy in both cancer cells and tumor-bearing mouse models.Our findings uncovered a paradoxical effect of DNA tumor virus oncoproteins on tumors and highlighted that targeting PERK might be an attractive strategy for the treatment of NPC and cervical carcinoma. | Jiang He Liyu Liu Feiyu Tang You Zhou Huan Liu Can Lu Deyun Feng Hong Zhu Yitao Mao Zhi Li Lu Zhang Yuemei Duan Zhi Xiao Musheng Zeng Liang Weng Lun-Quan Sun | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 0 |
| 6 | Design and Realization of 3D Management Information System for Ancient and Famous trees Based on Virtual Plant显示文摘The modernization and informatization management of ancient and famous trees’ management is an important standard with which the municipal public resource management level of a region or city can be measured.Design and development of ancient and famous trees’three-dimensional management information system was realized based on virtual plant by using integrated techniques of virtual plants and Geographic Information System.The system architecture design was developed on the basis of functional requirements,and the practical system was achieved in Visual Studio 2008 development tools and OpenGL graphics standards.The system has function of ancient trees archives management,three-dimensional reconstruction of the trees surrounding environment,individual tree information inquiry in three-dimensional scene,etc.Application and dissemination of this system will greatly promote the management and protection of ancient and famous trees standardization,informalization and | Wang Jingjing Tang Liyu Lin Ding Lin Yuxin | 2012 | Chinese Forestry Science and Technology2012，11，3： | 0 |
| 7 | CDK11 negatively regulates Wnt/β-catenin signaling in the endosomal compartment by affecting microtubule stability显示文摘Objectives:Improper activation of Wnt/β-catenin signaling has been implicated in human diseases.Beyond the well-studied glycogen synthase kinase 3p(GSK3p)and casein kinase 1(CK1),other kinases affecting Wnt/β-catenin signaling remain to be defined.Methods:To identify the kinases that modulate Wnt/β-catenin signaling,we applied a kinase small interfering RNA(siRNA)library screen approach.Luciferase assays,immunoblotting,and real-time polymerase chain reaction(PCR)were performed to confirm the regulation o f the Wnt/β-catenin signaling pathway by cyclin-dependent kinase 11(CDK11)and to investigate the underlying mechanism.Confocal immunofluorescence,coimmunoprecipitation(co-IP),and scratch wound assays were used to demonstrate colocalization,detect protein interactions,and explore the function of CDK11.Results:CDK11 was found to be a significant candidate kinase participating in the negative control of Wnt/P-catenin signaling.Down-regulation of CDK11 led to the accumulation of Wnt/β-catenin signaling receptor complexes,in a manner dependent on intact adenomatosis polyposis coli(APC)protein.Further analysis showed that CDK11 modulation of Wnt/P-catenin signaling engaged the endolysosomal machinery,and CDK11 knockdown enhanced the colocalization of Wnt/β-catenin signaling receptor complexes with early endosomes and decreased colocalization with lysosomes.Mechanistically,CDK11 was found to function in Wnt/β-catenin signaling by regulating microtubule stability.Depletion of CDK11 down-regulated acetyl-a-tubulin.Moreover,co-IP assays demonstrated that CDK11 interacts with the a-tubulin deacetylase SIRT2,whereas SIRT2 down-regulation in CDK11-depleted cells reversed the accumulation of Wnt/(3-catenin signaling receptor complexes.CDK11 was found to suppress cell migration through altered W nt/β-catenin signaling.Conclusions:CDK11 is a negative modulator of Wnt/β-catenin signaling that stabilizes microtubules,thus resulting in the dysregulation of receptor complex trafficking from early endosomes to lysosomes. | Danmin Ou Lin Chen Jiang He Zhuoxian Rong Jie Gao Liyu Liu Feiyu Tang Jiang Li Yuezhen Deng Lunquan Sun | 2020 | Cancer Biology & Medicine2020，17，2： | 0 |
| 8 | A ratiometric fluorescent probe for alkaline phosphatase with high sensitivity显示文摘Alkaline phosphatase(ALP)is one of essential biomarkers in mammalian tissue.Here we report a ratiometric probe for ALP,which is rationally designed and synthesized by employing ESIPT fluorophore N-(3-(benzo[d]thiazol-2-yl)-4-hydroxyphenyl)benzamide(BTHPB).The enzymatic dephosphorylation converts the probe to BTHPB,which exhibits a large spectral red-shift(120 nm),allowing extremely high sensitivity of ALP sensing at 0.004 mU/mL.The probe also shows excellent biocompatibility and has been applied for monitoring the endogenic ALP in living cells. | Yangyang Yang Chen Zhang Rizhao Pan Shiwei Zhang Shengtao Yao Yao Tang Weilong Zhu Liyue Wang Weiping Zhu Yufang Xu Xuhong Qian | 2020 | Chinese Chemical Letters2020，31，1： | 0 |
| 9 | Impact of minimalism on consumers’ low-carbon innovation behavior: Interactive role of quantitative behavior显示文摘Minimalism has become a new consumer trend that can guide low-carbon innovation behaviors.This study uses two experiments and one survey to explore the mechanisms underlying the relationships among minimalism,quantitative behavior,and low-carbon innovation behavior.The results show that(1)minimalism can positively influence consumers’low-carbon innovation behavior;(2)the interactive effect of minimalist and quantitative behavior on low-carbon innovation behavior is significant;and(3)meaning in life can play a significant mediating role in the relationship between minimalism and low-carbon innovation behavior.Finally,corresponding strategies for theory and management practices are proposed. | Jian Gao Liyu Tang Yang Lyuc | 2023 | Chinese Journal of Population,Resources and Environment2023，21，2： | 0 |
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