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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Molecular mechanisms of fluoroquinolone resist- ance 显示文摘 | Chen FJ Lo HJ | 2003 | J Microbiol Immunol Infect2003，36，1： | 1 |
| 3 | Uncaria rhynehophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epi- lepsy rats : A proteomie analysis 显示文摘 | Lo WY Tsai FJ Liu CH | 2010 | Am J Chin Med2010，38，4： | 1 |
| 4 | Study of ma- trix metalloproteinases and their inhibitors in breast cancer显示文摘 | Vizoso FJ Gonzfilez LO Corte MD | 2007 | Br J Cancer2007，96，6： | 1 |
| 5 | Molecular mechanisms of fluoroquinolone resistance显示文摘 | Chen FJ Lo HJ | | 0，，01： | 1 |
| 6 | Molecular mechanisms of fluoroquinolone resistance显示文摘 | Chen FJ Lo HJ | | 0，，01： | 1 |
| 7 | Crystal structure of a bacterial endospore coat component--A laccase with enhanced thermostability properties显示文摘 | Enguita FJ Martins LO Henriques AO | 2003 | Journal of Biological Chemistry2003，278，19： | 1 |
| 8 | Molecular mechanisms of fluoroquinolone resistance显示文摘 | Chen FJ Lo HJ | 2003 | J Microbiol Immunol Infect2003，36，1： | 1 |
| 9 | Molecular mechanisms of fluoroquinolone resistance 显示文摘 | Chen FJ Lo HJ | 2003 | J Microbiol Immunol Infect2003，36，1： | 1 |
| 10 | Crystal structure of a bacterial endospore coat component a laccase with enhanced thermostability properties 显示文摘 | Enguita FJ Martins LO Henriques AO | 2003 | J Biol Chem2003，278，19： | 1 |
| 11 | Study of matrix metallopr- oteinases and their inhibitors in breast cancer显示文摘 | Vizoso FJ Gonzalez LO Corte MD | 2007 | Br J Cancer2007，96，： | 1 |
| 12 | Molecular mechanisms of fluoroquinoione resistance显示文摘 | Chen FJ Lo HJ | 2003 | J Microbiol Immunol Infect2003，36，1： | 1 |
| 13 | Molecular mechanisms of fluoroquinolone resis- tance显示文摘 | Chen FJ Lo HJ | 2003 | J Microbiol Immunol Infect2003，36，1： | 1 |
| 14 | Study of matrix metalloproteinases and their inhibitors in breast cancer 显示文摘 | Vizoso FJ Gonzalez LO Corte MD | 2007 | Br J Canc er2007，96，： | 1 |
| 15 | Molecular mechanism of fluoroquinolone resist-ance显示文摘 | Chen FJ Lo HJ | 2003 | J Microbiol Immunol Infect2003，35，1： | 1 |
| 16 | Study of matrix metall oproteinases and their inhibitors in breast cancer显示文摘 | Vizoso FJ Gonzalez LO Corte MD | 2007 | Br J Cancer2007，96，6： | 1 |
| 17 | Study of matrix metalloproteinases and their inhibitors in breast cancer 显示文摘 | Vizoso FJ Gonzalez LO Corte MD Rodriguez JC | 2007 | Br J Cancer2007，96，： | 1 |
| 18 | Molecular mechanisms of fluoroquinolone resistance显示文摘 | Chen FJ Lo HJ | 2003 | J Microbiol Immunol Infect2003，36，1： | 1 |
| 19 | Study of matrix metalloproteinases and their inhibitors in breast cancer显示文摘 | Vizoso FJ González LO Corte MD Rodríguez JC Vázquez J Lamelas ML | 2007 | Br J Cancer2007，96，6： | 1 |
| 20 | Xanthine oxidase inhibitors from the leaves of Alsophila spinulosa (Hook) Tryon显示文摘 | Chiang HC Lo YJ Lu FJ | 1994 | J Enzyme Inhib1994，8，1： | 1 |
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