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109篇 您的检索式:作者名="Long You"
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1Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein显示文摘AIM To compare the therapeutic effect andsignificances of multimodality treatment forhepatocellular carcinoma (HCC) with tumorthrombi in portal vein (PVTT).METHODS HCC patients (n = 147) with tumortrombi in the main portal vein or the first branchof portal vein were divided into four groups bythe several therapeutic methods. There wereconservative treatment group in 18 out ofpatients (group A); and hepatic artery ligation(HAL) and/or hepatic artery infusion (HAl)group in 18 patients (group B), in whompostoberative chemoembolization was doneperiodically; group of removal of HCC with PVTTin 79 (group C) and group of transcatheterhepatic arterial chemoembolization (TACE) orHAl and/or portal vein infusion (PVI) afteroperation in 32 (group D).RESULTS The median survival period was 12months in our series and the 1-, 3-, and 5-yearsurvival rates were 44.3%, 24.5% and 15.2%,respectively. The median survival times were 2,5, 12 and 16 months in group A, B, C and D,respectively. The 1-, 3- and 5-year survival rateswere 5.6%, 0% and 0% in group A; 22.2%,5.6% and 0% in group B; 53.9%, 26.9% and16.6% in group C; 79.3%, 38.9% and 26.8% ingroup D, respectively. Significant differenceappeared in the survival rates among the groups(P<0.05).CONCLUSION Hepatic resection with removalof tumor thrombi and HCC should increase thecurative effects and be encouraged for theprolongation of life span and quality of life forHCC patients with PVTT, whereas the besttherapeutic method for HCC with PVTT is withregional hepatic chemotherapy orchemoemblization after hepatic resection withremoval of tumor thrombi.Jia Fan Zhi Quan Wu Zhao You Tang Jian Zhou Shuang Jian Qiu Zeng Chen Ma Xin Da Zhou Sheng Long Ye Liver Cancer Institute, Zhongshan Hospital, Fudan University Medical Center (Former Shanghai University), 136 Yixueyuan Road, Shanghai 200032, China 2001World Journal of Gastroenterology2001,7,1:80
2Relationship between expression of α-fetoprotein messenger RNA and some clinical parameters of human hepatocelular carcinoma显示文摘METHODWedetectedtheexpressionofAFPinmRNAlevelintissuesamplesfrom52patientssuferingfromHCCbyRTPCRmethod.RESULTSThepositiverat...HE Ping, TANG Zhao You, YE Sheng Long and LIU Bin Bin 1999World Journal of Gastroenterology1999,5,2:23
3mm Wave communications for 5G: implementation challenges and advances显示文摘The requirement of the fifth generation(5 G) wireless communication for high throughput motivates the wireless industry to use the mm Wave(millimeter wave) communications for its wide bandwidth advantage. To compensate the heavy path loss and increase the communications capacity, phased array beamforming and massive multiple-input multiple-output(MIMO) techniques are employed at both the user equipment(UE) and base stations(BS). Considering the commercial requirements, 5 G mm Wave large array systems should be implemented in an energy-and cost-efficient way with a small form factor. To address above issues and realize a reliable communications link, taking into account the particular characteristics of5 G mm Wave systems, this paper firstly examines the design challenges and trade-offs in system implementations, then some of the design strategies are summarized. At last, recent advance in RF front-end circuits and receiver sub-systems is then highlighted.Lianming LI Dongming WANG Xiaokang NIU Yuan CHAI Linhui CHEN Long HE Xu WU Fuchun ZHENG Tiejun CUI Xiaohu YOU 2018Science China(Information Sciences)2018,61,2:19
4Uptake of HIV Self-testing among Men Who have Sex with Men in Beijing, China: a Cross-sectional Study显示文摘Objective To examine HIV self-testing uptake and its determinates among men who have sex with men(MSM) in Beijing, China. Methods A cross-sectional online survey was conducted in Beijing, China in 2016. Participants were users of a popular Chinese gay networking application and had an unknown or negative HIV status. Univariate and multivariate logistic regression analyses were conducted to examine factors associated with HIV self-testing based on adjusted odds ratio(AOR) and 95% confidence interval(CI). Results Among the 5,996 MSM included in the study, 2,383(39.7%) reported to have used HIV self-testing kits. Willingness to use an HIV self-test kit in the future was expressed by 92% of the participants. High monthly income(AOR = 1.49; CI = 1.10-2.02; P = 0.010), large number of male sex partners(≥ 2: AOR = 1.24; CI = 1.09-1.43; P = 0.002), sexual activity with commercial male sex partners(≥ 2: AOR = 1.94; CI = 1.34-2.82; P = 0.001), long-term drug use(AOR = 1.42; CI = 1.23-1.62; P < 0.001), and long-term HIV voluntary counseling and testing(VCT) attendance(AOR = 3.62; CI = 3.11-4.22; P < 0.001) were all associated with increased odds of HIV self-testing uptake. Conclusion The nearly 40% rate of HIV self-testing uptake among MSM in our sample was high. In addition, an over 90% willingness to use kits in the future was encouraging. HIV self-testing could be an important solution to help China achieve the global target of having 90% of all people living with HIV diagnosed by 2020.REN Xian Long WU Zun You MI Guo Dong MCGOOGAN Jennifer ROU Ke Ming ZHAO Yan 2017Biomedical and Environmental Sciences2017,30,6:13
5Grey GM(1,1) Model with Function-Transfer Method for Wear Trend Prediction and its Application显示文摘Trend forecasting is an important aspect in fault diagnosis and work state supervision. The principle, where Grey theory is applied in fault forecasting, is that the forecast system is considered as a Grey system; the existing known information is used to infer the unknown information’s character, state and development trend in a fault pattern, and to make possible forecasting and decisions for future development. It involves the whitenization of a Grey process. But the traditional equal time interval Grey GM (1,1) model requires equal interval data and needs to bring about accumulating addition generation and reversion calculations. Its calculation is very complex. However, the non equal interval Grey GM (1,1) model decreases the condition of the primitive data when establishing a model, but its requirement is still higher and the data were pre processed. The abrasion primitive data of plant could not always satisfy these modeling requirements. Therefore, it establishes a division method suited for general data modeling and estimating parameters of GM (1,1), the standard error coefficient that was applied to judge accuracy height of the model was put forward; further, the function transform to forecast plant abrasion trend and assess GM (1,1) parameter was established. These two models need not pre process the primitive data. It is not only suited for equal interval data modeling, but also for non equal interval data modeling. Its calculation is simple and convenient to use. The oil spectrum analysis acted as an example. The two GM (1,1) models put forward in this paper and the new information model and its comprehensive usage were investigated. The example shows that the two models are simple and practical, and worth expanding and applying in plant fault diagnosis.LUO You xin 1 , PENG Zhu 2 , ZHANG Long ting 1 , GUO Hui xin 1 , CAI An hui 1 1Department of Mechanical Engineering, Changde Teachers University, Changde 415003, P.R. China 2 Engineering Technology Board, Changsha Cigare 2001International Journal of Plant Engineering and Management2001,6,4:11
6Formation Mechanism of the Changxing Formation Gas Reservoir in the Yuanba Gas Field,Sichuan Basin,China显示文摘在很轻轻的站台边缘 paleogeographic 环境,站台边缘礁石公寓使碳酸盐水库岩石褪色在 Yuanba 的 Changxing 形成被开发地。后来弱的结构的进化和 diagenetic 进化引起了 Changxing 形成形成 lithologic 陷井,与象溶解 bioclastic dolostone 那样的好水库并且溶解了毛孔 dolostone。Changxing 形成煤气的水库是伪 layered 在压力弄空开车下面的多孔的 lithologic 气体水库,与高 H2S 和中等 CO2 内容。为 Changxing 形成煤气的水库的进行的系统可能在内在的形成在 Changxing 形成水库, Changxing 形成的最高的 erosional 表面,以及 micropores 和 microfractures 由毛孔和 microfractures 组成的这纸 predictes。Changxing 形成水库经历了控告阶段的 3 烃。这份报纸建议那散开是为这座煤气的水库的主要形成机制。在中间、迟了的 Yanshanian, Yuanba 区域进入了主要煤气的收费阶段。气体从来源岩石和另外的含有石油的阶层在小差错和 microfractures 主要通过散开并且与渗出物流动的帮助移居了到 Changxing 形成碳酸盐水库岩石,形成 lithologic 气体水池。在喜玛拉雅的时代,没有强壮的修正, lithologic 陷井总体上被高举或重叠,并且为气体是有利的保藏。LONG Shengxian HUANG Renchun LI Hongtao YOU Yuchun LIU Guoping BAI Zhenrui 2011Acta Geologica Sinica(English Edition)2011,85,1:9
7HPLC and LC-MS analysis of sinomenine and its application in pharmacokinetic studies in rats显示文摘Li-hong LONG Peng-fei WU Xiang-Iong CHEN Zui ZHANG Yu CHEN Yi-yong LI You JIN Jian-guo CHEN Fang WANG 2010Acta Pharmacologica Sinica2010,31,11:8
8Grey System Judgment on Reliability of Mechanical Equipment显示文摘The Grey system theory was applied in reliability analysis of mechanical equipment.It is a new theory and method in reliability engineering of mechanical engineering of mechanical equipment. Through the Grey forecast of reliability parameters and the reliability forecast of parts and systems, decisions were made in the real operative state of equipment in real time. It replaced the old method that required mathematics and physical statistics in a large base of test data to obtain a pre check, and it was used in a practical problem. Because of applying the data of practical operation state in real time, it could much more approach the real condition of equipment; it was applied to guide the procedure and had rather considerable economic and social benefits.LUO You xin, GUO Hui xin, ZHANG Long ting, CAI An hui, PENG Zhu Department of Mechanical Engineering,Changde Teachers University, Changde 415003, P.R.China 2001International Journal of Plant Engineering and Management2001,6,3:7
9Effects of uniconazole rate on agronomic traits and physiological indexes of rapeseed blanket seedling显示文摘Mechanized transplanting of rapeseed(Brassica napus L.)blanket seedling is an innovative cultivation technology.Cultivating high quality blanket seedling to ensure high survival rate of seedling after transplanting is the key of the technology.The effects of different uniconazole rates of 0,0.5,1.0,1.5 and 2.0 mg/tray,spraying at one leaf and one heart stage,on selected agronomic traits,physiological indexes and survival rate of two rapeseed cultivars(‘Qinyou 100 and’Yangyou 90)were investigated in 2018 and 2019.Our results showed that the plant height decreased significantly with the increase of uniconazole rate.However,the collar diameter increased significantly with the increase of uniconazole rate up to 1.5 mg/tray,and the leaf area,dry weights of root and shoot increased with increased uniconazole rate up to 1.0 mg/tray.The root to shoot ratios,N concentrations of root and shoot with the uniconazole rates of 1.0 and 1.5 mg/tray were higher than those with other treatments.As uniconazole rate increasing,gibberellin(GA)and auxin(IAA)concentrations of root and shoot decreased,while abscisic acid(ABA)concentrations increased,and cytokinin(CTK)concentrations topped at uniconazole rate of 1.0 mg/tray and decreased thereafter.The seedling survival rates with 1.0 and 1.5 mg/tray were greatly higher than those in other treatments.Regression analysis suggested plant survival rate was positively related to CTK concentrations and negatively to GA concentrations of root and shoot.To achieve high survival rate after mechanized transplanting,our study revealed that the uniconazole applied at a rate of 1.0 mg/tray was recommended as the best,followed by 1.5 mg/tray.The findings would help to enhance qualities of rapeseed blanket seedling and to promote popularization of mechanized transplanting of rapeseed production.Qingsong Zuo Long Wang Jingdong Zheng Jingjing You Guang Yang Suohu Leng Jingyi Liu 2020Oil Crop Science2020,5,4:5
10Anti-inflammatory role of microRNA let-7c in LPS treated alveolar macrophages by targeting STAT3显示文摘Objective:To explore the expression of microRNA(miRNA) let-7c and its function in chronic obstructive pulmonary disease(COPD) and alveolar macrophage cells.Methods:Real time PCR was performed to detect the expression of miRNA let-7c in the lung tissue of COPD patients and COPD model in mice.MiRNA let-7c was overexpresscd in alveolar macrophages isolated from mice and its effect was measured by the production of pro-inflammation cytokines and the protein level of signal transducer and activator of transcription 3(STAT3) as well as phosphorylation level of STAT3 after LPS stimulation.Luciferase assay was used to detect the binding of miRNA let-7c and 3'UTR of STAT3.Results:MiRNA let-7c expression was significantly lower in patients with COPD compared with control group,and the similar result was found in COPD mice and LPS stimulated alveolar macrophages.Overexpression of miRNA lct-7c in alveolar macrophages inhibited LPS-induced increasing of tumor necrosis factor alpha,interleukin-6 and interleukin-1β.Luciferase assay showed STAT3 was a targeting of miRNA lct-7c in alveolar macrophages.Conclusions:MiRNA lct-7c low expression in COPD can regulate inflammatory responses by targeting STAT3 in alveolar macrophage,which may provide a new target for COPD treatment strategies.Ji-Hui Yu Li Long Zhi-Xiao Luo Lin-Man Li Jie-Ru You 2016Asian Pacific Journal of Tropical Medicine2016,9,1:4
11Dynamic blood single-cell immune responses in patients with COVID-19显示文摘The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health emergency.However,the virus'pathogenesis remains unclear,and there is no cure for the disease.We investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5'gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell resolution.We obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic studies.In addition,we used three control samples.We found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical condition.The type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions improved.Consistent with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 controls.The concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of COVID-19.TCR and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 antigens.Our study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic potentials in treating COVID-19.Lulin Huang Yi Shi Bo Gong Li Jiang Zhixin Zhang Xiaoqi Liu Jialiang Yang Yongquan He Zhilin Jiang Ling Zhong Juan Tang Chunfang You Qi Jiang Bo Long Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Shuqiang Wang Xingxiang Yang Zhenglin Yang 2021Signal Transduction and Targeted Therapy2021,6,4:4
12Effect of montmorillonite on kinetics of polyurethane preparation reaction显示文摘prepolymerization 和 polyurethane/montmorillonite 的治好的反应动力学分别地与端基分析和 FTIR 被学习了。prepolymerization 和治好的反应跟随了第二顺序动力学,这被发现。但是在 montmorillonite 以后从 42.7 kJ/mol 增加到 56.5 kJ/mol 的 prepolymerization 的激活精力在治好反应的反应系统,和激活精力被增加从 64.4 kJ/mol 减少了到 17.5 kJ/mol。You Cao Yu Jiang Shu Lu Zhao Xiao Jun Cai Mei Long Hu Bing Liao 2008Chinese Chemical Letters2008,19,1:4
13Research status and prospects of melt refining and purification technology of magnesium alloys显示文摘Refining and purification is a significant way to obtain pure and high-quality magnesium alloy melts.This paper summarizes the flux refining methods and non-flux purification methods(blowing purification,filtration purification,electromagnetic purification and ultrasonic purification).It also introduces the composite refining technologies that have been widely researched and applied in recent years,including low-voltage pulse electromagnetic technology,ultrasonic argon purification,self-purification technology and non-flux continuous purification technology.Among them,the non-flux continuous purification technology integrates a variety of purification methods,which can produce high-quality magnesium alloy continuously and steadily,realize environmental protection production,and achieve remarkable technical and economic benefits.Hanxue Cao Mengtao Huang Chengcheng Wang Siyuan Long Jili Zha Guoqiang You 2019Journal of Magnesium and Alloys2019,7,3:4
14Peginterferon Alfa-2a Plus Ribavirin for the Treatment of Dual Chronic Infection With Hepatitis B and C Viruses显示文摘Chun–Jen Liu Wan–Long Chuang Chuan–Mo Lee Ming–Lung Yu Sheng–Nan Lu Shun–Sheng Wu Li–Ying Liao Chi–Ling Chen Hsing–Tao Kuo You–Chen Chao Shui–Yi Tung Sien–Sing Yang Jia–Horng Kao Chen–Hua Liu Wei–Wen Su Chih–Lin Lin Yung–Ming Jeng Pei–Jer Chen Ding–Shinn 2009Gastroenterology2009,,2:3
15Nitric Oxide Inducing Function and Intracellular Movement of Chicken Interleukin-18 in Cultured Cells显示文摘To evaluate the characteristics of chicken interleukin-18 (ChIL-18) in different forms in vitro,the ChIL-18 full-length gene (ChIL-18-F) and the ChIL-18 presumed mature protein gene (ChIL-18-M) werecloned and inserted into the eukaryotic expression vector pCI,to construct recombinant pCI-ChIL-18-Fand pCI-ChIL-18-M.The recombinant plasmids were then transferred into chicken splenic lymphocytes(CSLs).Western blot showed that ChIL-18-F,with a molecular weight of 23.0 kDa,was produced in CSLstransfected by pCI-ChlL-18-F;ChIL-18-M,with a molecular weight of 19.5 kDa,was produced in CSLstransfected by pCI-ChIL-18-M.The nitric oxide (NO) level in the transfected CSLs and the culture mediumat different time points was further examined under confocal microscopy using 4.5-diaminofluoresceinstaining.The results showed that both pCI-ChIL-18-F and pCI-ChIL-18-M groups showed significantincrease in intracellular and extracellular NO production compared with pCI transfected control cells.Theseresults suggest that both ChIL-18-F and ChIL-18-M could stimulate NO secretion in CSLs.To characterizethe intracellular distribution of ChIL-18,ChIL-18-F and ChIL-18-M were each fused to the enhanced greenfluorescent protein gene,and expressed in Vero cells.The results showed that the ChIL-18-F tended to themembranous region in Vero cells,while ChIL-18-M did not.This indicates that the N-terminal 27 amino acidpeptide helped ChIL-18 target to Veto cell membranes.Jian XU Tong-Le DENG Long LI Zhen-Qiang YOU Wang-Jun WAN Lian YU 2005Acta Biochimica et Biophysica Sinica2005,37,10:3
16Relationship between magnetic resonance imaging and molecular pathology in patients with glioblastoma multiforme显示文摘背景 Glioblastoma multiforme ( GBM )是在 adults.Magnetic 回声成像( MRI )的最普通、致命的主要大脑肿瘤习惯性地在诊断被使用,描述和 GBM.The 诊断的临床的管理和 GBM 的治疗被试图识别在磁性的回声特征和 43 个 glioblastoma 病人的 GBM.Methods MRI 图象的分子的病理之间的关系的组织病理学说和 immunohistochemistry.This 学习大部分指导是 collected.Four 成像特征,LI Wen-bin TANG Kai ZHANG Wei YAN Wei YOU Gang LI Shao-wu ZHANG Long HUANG Yan-jie JIANG Tao 2011Chinese Medical Journal2011,,17:3
17Preparation of multihollow P(St-MAA) particles by sequence soap-free/soap emulsion polymerization and followed by stepwise alkali/acid posttreatment显示文摘The effects of ionic emulsifier, sodium dodecylbenzene sulfate (SDBS), on the formation of the multihollow structures in sub-micron sized polymer particles produced by alkali/acid posttreatment were investigated. The original latex particles with narrow size distribution were synthesized by a new sequence emulsifier-free/emulsifier emulsion copolymerization of styrene (St) and methacrylic acid (MAA). Results indicated that the pore size decreased and the pore number increased with the increase of SDBS amount, and the morphology of the posttreated latex particles was also significantly influenced by the introducing time of SDBS in the preparation of the original latex particles, and a suitable introducing time was 3 h of polymerization.Rong Long Li Cheng You Kan Ze Ping Li Yi Du Yan Nan Cui 2007Chinese Chemical Letters2007,18,6:3
18Thermotolerant and fireproof gel polymer electrolyte toward high-performance and safe lithium-ion battery显示文摘Poly(ethylene oxide)(PEO)and its derivatives based gel polymer electrolytes(GPEs)are severely limited in advanced and safe lithium-ion batteries(LIBs)owing to the intrinsically high flammability of liquid electrolytes and PEO.Directly adding flame retardants to the GPEs can suppress their flammability and thus improve the safety of LIBs,but results in deteriorative electrochemical performance.Herein,a novel GPE with chemically bonded flame retardant(i.e.diethyl vinylphosphonate)in cross-linked polyethylene glycol diacrylate matrix,featuring both high-safety and high-performance,is designed.This as-prepared GPE storing the commercial 1 mol L^(-1) LiPF6 electrolyte resists high temperature of 200℃and cannot be ignited as well as possesses a high ionic conductivity(0.60 m S cm^(-1))and good compatibility with lithium.Notably,the LiFePO_(4)/Li battery with this GPE delivers a satisfactory capacity of 142.2 m A h g^(-1) and a superior cycling performance with a capacity retention of 96.3%and a coulombic efficiency of close to 100%for 350 cycles at 0.2 C under ambient temperature.Furthermore,the battery can achieve steady charge–discharge for 100 cycles with a coulombic efficiency of 99.5%at 1 C under 80℃and run normally even at a high temperature of 150℃or under the exposure to butane flame.Differential scanning calorimetry manifests significantly improved battery safety compared to commercial battery systems.This work provides a new pathway for developing next-generation advanced LIBs with enhanced performance and high safety.Man-Cheng Long Ting Wang Ping-Hui Duan You Gao Xiu-Li Wang Gang Wu Yu-Zhong Wang 2022Journal of Energy Chemistry2022,31,2:3
19Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid显示文摘Through simplifying the complicated skeleton of the natural product gambogic acid, two series derivatives of chromone and xanthone were synthesized and examined for their antitumor activities against several cancer cells in vitro by MTT method. The results showed that appropriate introduction of prenyl group to the small molecular compounds could elevate their antitumor activities. The structure-activities relationship of synthesized compounds certified that the bridgecore in gambogic acid was very important for keeping its antitumor activities.Nian Guang Li Qi Dong You Xue Feng Huang Jin Xin Wang Qing Long Guo Xiao Guang Chen Yan Li Hong Yan Li 2007Chinese Chemical Letters2007,18,6:2
20Design of Pd{111}-TiO_2 interface for enhanced catalytic efficiency towards formic acid decomposition显示文摘Supports are commonly implemented in the industrial application of heterogeneous catalysts to improve the stability and recyclability of catalysts.The supported catalysts often show the enhanced activity and selectivity in various catalytic reactions.However,the specific contributions of electronic and steric effects to a catalytic system often remain elusive due to the lack of well-defined model systems.In this work,two types of uniform Pd nanocrystals covered by{111}facets in tetrahedral and octahedral shapes,respectively,are synthesized with identical chemical environment and loaded on Ti O_2supports to form hybrid structures(Pd{111}-Ti O_2)towards the application of formic acid decomposition.Our observation suggests that the polarization effect at the interface of Pd-Ti O_2enhances its activity in formic acid decomposition.Moreover,the Pd tetrahedrons-Ti O_2hybrid structure whose Pd{111}-Ti O_2interface possesses a larger angle shows higher catalytic activity,owing to the reduced steric effect as compared to Pd octahedrons-Ti O_2.This study reveals the nature of interface effects in formic acid decomposition,and provides a guidance for the related catalyst design.Yang You Hao Huang Song Xia Zijian Cai Panyiming Liu Chengming Wang Ran Long Li Song Yujie Xiong 2018Science China Chemistry2018,61,9:2
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