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1篇 您的检索式：作者名="Longsen Han"

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		题名	作者	年代	出处	被引量
	1	Increased mtDNA mutation frequency in oocytes causes epigenetic alterations and embryonic defects显示文摘Mitochondria are essential for female reproductive processes,yet the function of mitochondrial DNA(mtDNA)mutation in oocytes remains elusive.By employing an mtDNA mutator(Polgm)mouse model,we found the fetal growth retardation and placental dysfunction in post-implantation embryos derived from Polgm oocytes.Remarkably,Polgm oocytes displayed the global loss of DNA methylation;following fertilization,zygotic genome experienced insufficient demethylation,along with dysregulation of gene expression.Spindle–chromosome exchange experiment revealed that cytoplasmic factors in Polgm oocytes are responsible for such a deficient epigenetic remodeling.Moreover,metabolomic profiling identified a significant reduction in the α-ketoglutarate(αKG)level in oocytes from Polgm mice.Importantly,αKG supplement restored both DNA methylation state and transcriptional activity in Polgm embryos,consequently preventing the developmental defects.Our findings uncover the important role of oocyte mtDNA mutation in controlling epigenetic reprogramming and gene expression during embryogenesis.αKG deserves further evaluation as a potential drug for treating mitochondrial dysfunction-related fertility decline.	Longsen Han Yujia Chen Ling Li Chao Ren Haichao Wang Xinghan Wu Juan Ge Wenjie Shu Minjian Chen Qiang Wang	2022	National Science Review2022，9，10：	0

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