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| 1 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 2 | An ionic liquid as a solvent for headspace single drop microextraction of ehlorobenzenes from water samples显示文摘 | Lorena V Elefteria P Claudia E D | | 0，，01： | 1 |
| 3 | Short-term Effects of Experimental Fire for a Soil under Euca- lyptus Forest (SE Australia) 显示文摘 | Arturo J P Granged Antonio Jorddn Lorena M Zavala | 2011 | Geoderma2011，16，7168： | 1 |
| 4 | A review on the combination of binary classifiers in multiclass problems 显示文摘 | LORENA A C DE CARVALHO C P L F GAMA J M P | 2008 | Artificial Intelligence Review2008，30，1234： | 1 |
| 5 | Toughening by nanostructure 显示文摘 | LORENA R P ROYSTON G J FAIRCLOUGH J P A | 2008 | Polymer2008，49，21： | 1 |
| 6 | Protein cellular localization prediction with support vector machines and decision trees显示文摘 | Lorena A C Andre C P | 2007 | Computers in Biology and Medicine2007，37，2： | 1 |
| 7 | Grounding, semantic motivation, and conceptual interaction in indirect directive speech acts显示文摘 | Lorena Pérez Hernández Francisco José Ruiz de Mendoza | 2002 | Journal of Pragmatics2002，，3： | 1 |
| 8 | Expression of p53 during mouse embryogenesis显示文摘 | Schmid P Lorena A Hameister H | 1991 | Development1991，113，： | 1 |
| 9 | Hydrolysis of soybean isoflavones by Debaryomyces hansenii UFV-1 immobilised cells and free β-glucosidase显示文摘 | GABR1ELA P M A LORENA G D A L MAIRA A | 2014 | Food Chem2014，，146： | 1 |
| 10 | Breakthrough bacteremia due to clostridium tertium in a patient with neutropenic fever,and identification by MALDI-TOF mass spectrometry显示文摘 | Francisco S Lorena P Luisa D | 2013 | International Journal of Infectious Diseases2013，17，： | 1 |
| 11 | Response of SOUR and AUR to heavy metal contamination in activa- ted sludge显示文摘 | MADONI P DAVOLI D LORENA G | 1999 | Water Research1999，33，10： | 1 |
| 12 | Development of an impedimetric aptasensor for the determination of aflatoxin M_1 in milk显示文摘 | GEORGES I NATHALIE P LORENA Z | 2016 | Talanta2016，146，： | 1 |
| 13 | Development and valida- tion of an UPLC-PDA method to quantify daptomycin in human plasma and in dried plasma spots 显示文摘 | Lorena B Antonio DA Simone P | 2014 | Pharm Biomed Anal2014，88，： | 1 |
| 14 | Fluvastatin and tissue factor pathway inhibitor in type Ⅱa and Ⅱb and hyperlipidemia and in acute myocardial infarction显示文摘 | Lorena M Perolin S Cassazzaf P | 1997 | Thromb Res1997，87，4： | 1 |
| 15 | Board cutting from logs: Optimal and heuristic approaches for the problem of packing rectangles in a circle显示文摘 | Ignacio H Lorena P Víctor P | 2013 | International Journal of Production Economics2013，145，2： | 1 |
| 16 | Analysis of virgin oliveoil volatile compounds by headspace solid phase micro extractioncoupled to gas chromatography with mass spectrometric andflame ionization detection显示文摘 | Stefania V Ana I C Lorena P | 2003 | Journal of chromatography A2003，983，： | 1 |
| 17 | Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses显示文摘 | Hector Eloy Tamez Perez María Dolores Gómez de Ossio Dania Lizet Quintanilla Flores Mayra Ivonne Hernández Coria Alejandra Lorena Tamez Pe?a Gissén Jazmín Cuz Pérez Stephanie Lissette Proskauer Pe?a | 2012 | Revista da Associa??o Médica Brasileira2012，，1： | 1 |
| 18 | Smooth Muscle-specific sM22 protein is expressed in the adventitial cells of balloon-injured rabbit carotid artery显示文摘 | Elisabetta F Massimo P Lorena Z | 1999 | Arterioscler Thromb Vasc Biol1999，19，： | 1 |
| 19 | Fluvastatin and tissue factor pathway inhibitor in type IIa and IIb and hyperlipidemia and in acute myocardial infarction显示文摘 | Perolin S Cassazzaf P | 1997 | Thromb Res1997，87，： | 1 |
| 20 | Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation显示文摘 | LORENA A P JOHN C R | 2008 | Gene Dev2008，22，： | 1 |
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