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| 1 | Recent advances in gastric cancer early diagnosis显示文摘Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC. | Laura Necula Lilia Matei Denisa Dragu Ana I Neagu Cristina Mambet Saviana Nedeianu Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2019 | World Journal of Gastroenterology2019，25，17： | 70 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | BjussuSP-I:a new thrombin-like enzyme isolated from Bothropsjararacussu snake ven- om 显示文摘 | Sant' Ana C D Tic|i F K Oliveira L L | 2008 | Comp Biochem Physiol A Mol Integr Physiol2008，151，3： | 1 |
| 4 | Pyrroline-5-carboxylate synthase and proline biosynthesis :from osmotoleranee to rare met- abolic disease 显示文摘 | Isabel P A Francisco C A Ana I M | 2010 | Protein Sci2010，19，： | 1 |
| 5 | Mitochondrial-targeted protective properties of isolated diterpenoids from sideritis spp, in response to the deleterious changes induced by H2O2 显示文摘 | Elena G B Ana I D Maria E C | 2013 | Nat Prod2013，76，5： | 1 |
| 6 | Antimicrobial susceptibility of clinical strains of Streptococcus suis isolated from pigs in Spain 显示文摘 | ANA I V MIGUEL A M JOSE A C | 2005 | Veterinary Microbiology2005，105，2： | 1 |
| 7 | Influence of temperature, pH and ionic strength on the production of isoflavone - rich soy protein isolates 显示文摘 | ANA C L B FRANCO M L MARIA I G | 2006 | Food Chemistry2006，98，： | 1 |
| 8 | Regulation of tau RNA maturation by thyroid hormone is ediated by the neural RNA-binding protein Musashi1显示文摘 | Ana C Luis F Takao I | 2002 | Mol Cell Neurosci2002，20，2： | 1 |
| 9 | Studies on the interaction of emeraldine base polyaniline with Cu(Ⅱ), Fe(Ⅲ), and Zn(Ⅱ) ions in solutions and films显示文摘 | Celly M S I Ana M D C F Vera R L C | 2007 | Macromolecules2007，40，： | 1 |
| 10 | Glutathione-mediated cadmium sequestration in Rhizobium leguminosarum显示文摘 | Ana I G L Sofia C C Etelvina M A P F | 2006 | Enzyme and Microbial Technology2006，39，4： | 1 |
| 11 | Constituents of Prunus spinosa显示文摘 | ANA C I MARGARITA F F ANTONIO G G | 1992 | Journal of Natural Products1992，55，4： | 1 |
| 12 | Effect of salinity on the quantity and quality of carotenoids accumulated by Dunaliella salina(strain CONC-007) and Dunaliella bardawil(strain ATCC 30861) Chlorophyta显示文摘 | Patricia I G Alejandra B Ana S C | 2003 | Biol Res2003，36，： | 1 |
| 13 | Regulation of tau RNA maturation by thyroid hormone is mediated by the neural RNA-binding protein Musashi-1 显示文摘 | Luis F Takao I | 2002 | Mol Cell Neurosci2002，20，2： | 1 |
| 14 | Antimicrobial susceptibility of clinical strains of Streptococcus suis isolated from pigs in Spain显示文摘 | Ana I V Miguel A M Jose A C | 2005 | Veterinary Microbiology2005，2，105： | 1 |
| 15 | Contribution of Spartina maritima to the reduction of eutrophication in estuarine systems 显示文摘 | ANA I S ANA I L ISABEL C | 2008 | Environmental Pollution2008，156，： | 1 |
| 16 | Glutathione-mediated cadmium sequestration in Rhizobium leguminosarum显示文摘 | Ana I G L Sofia C C Etelvina M A P F | 2006 | Enzyme and Microbial Technology2006，39，4： | 1 |
| 17 | Xylose Isomerization toXylulose and its Dehydration to Furfural in AqueousMedia显示文摘 | Vinit C Ana B P Stanley I | 2011 | ACS Catalysis2011，1，： | 1 |
| 18 | Reduced P3 amplitudes by negative fa- cial emotional photographs in chizophrenia 显示文摘 | I Ana S Lee S Lee C | 2009 | Schizophr Res2009，35，： | 1 |
| 19 | Characterization of the most odor-active compounds of Iberian ham headspace显示文摘 | Ana I C Jesus V Carmen G | 2002 | J Agric Food Chem2002，50，： | 1 |
| 20 | Oxidative stability and fatty acid composition of pig muscles as affected by rearing system,crossbreeding and metabolic type of muscle fibre显示文摘 | Andres A I Ramon C Ana I M | 2001 | Meat Science2001，59，1： | 1 |
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