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| 1 | Potential of soluble CD26 as a serum marker for colorectal cancer detection显示文摘Colorectal cancer is characterized by a low survival rate even though the basis for colon cancer development,which involves the evolution of adenomas to carcinoma,is known.Moreover,the mortality rates continue to rise in economically transitioning countries although there is the opportunity to intervene in the natural history of the adenoma–cancer sequence through risk factors,screening,and treatment.Screening in particular accounted for most of the decline in colorectal cancer mortality achieved in the USA during the period 1975-2000.Patients show a better prognosis when the neoplasm is diagnosed early.Among the variety of screening strategies,the methods range from invasive and costly procedures such as colonoscopy to more low-cost and non-invasive tests such as the fecal occult blood test(guaiac and immunochemical).As a non-invasive biological serum marker would be of great benefit because of the performance of the test,several biomarkers,including cytologic assays,DNA and mRNA,and soluble proteins,have been studied.We found that the soluble CD26(sCD26)concentration is diminished in serum of colorectal cancer patients compared to healthy donors,suggesting the potential utility of a sCD26 immunochemical detection test for early diagnosis.sCD26 originates from plasma membrane CD26 lacking its transmembrane and cytoplasmic domains.Some 90%–95%of sCD26 has been associated with serum dipeptidyl peptidase IV(DPPIV)activity.DPP-IV,assigned to the CD26 cluster,is a pleiotropic enzyme expressed mainly on epithelial cells and lymphocytes.Our studies intended to validate this test for population screening to detect colorectal cancer and advanced adenomas are reviewed here. | Oscar J Cordero Monica Imbernon Loretta De Chiara Vicenta S Martinez-Zorzano Daniel Ayude Maria Paez de la Cadena F Javier Rodriguez-Berrocal | 2011 | World Journal of Clinical Oncology2011，2，6： | 5 |
| 2 | Lunx is a superior molecular marker for detection of non-small lung cell cancer in peripheral blood 显示文摘 | Michael M Loretta H Gerard S | 2003 | J Mol Diagn2003，5，4： | 1 |
| 3 | Implementation of the VA MRSA Bundle at a 132Bed Acute Care VA Medical Center Shows Promise in Long-Range Rate Reductions for Healthcare-Associated MRSA Infection 显示文摘 | Maria C Patricia L Loretta S | 2009 | American Journal of Infection Control2009，37，5： | 1 |
| 4 | lunx is a superior molecular marker for detection of non small lung cell cancer in peripheral blood 显示文摘 | Michael M Loretta H Gerard S | 2003 | Mol Diaql2003，5，2： | 1 |
| 5 | Neuropathic Diabetic Foot Ulcers显示文摘 | Andrew JM Robert S Loretta V | 2004 | N Engl J Med2004，351，1： | 1 |
| 6 | Lunx is a superior molecular marker for detection of non-small lung cell cancer in peripheral blood显示文摘 | Michael M Loretta H Gerard S | 2003 | J Mol Diagn2003，5，4： | 1 |
| 7 | Lunx is a superior mo- lecular marker for detection of non-small lung cell cancer in peripheral blood显示文摘 | Michael M Loretta H Gerard S | 2003 | J Mol Diagn2003，5，4： | 1 |
| 8 | Implementation of the VA MRSA bundle at a 132 bed acute care va medical center shows promise in long - range rate reductions for healthcare - associated MRSA infection显示文摘 | llarla C Patr/cia L Loretta S | 2009 | Am J Infect Control2009，37，5： | 1 |
| 9 | Lunx is a superior molecular marker for detection of non-small lung cell cancer in peripheral blood显示文摘 | Michael M Loretta H Gerard S | 2003 | J Mol Diagn2003，5，4： | 1 |
| 10 | Enhancement of electrokinetic extraction from lead-spiked soils显示文摘 | RAYMOND S L LORETTA Y L | 2000 | Journal of Environmental Engineering2000，126，： | 1 |
| 11 | The role of cytochrome c in caspase activation in Dorosophia melamegaster cells显示文摘 | LORETTA D REED S D | 2002 | Cell Biology2002，156，： | 1 |
| 12 | Implementation of the VAMRSA bundle at a 132 bed acute care medical center showspromise in long-range rate reductions for healthcare-associatedMRSA infection显示文摘 | Marla C Patricia L Loretta S et a1 | 2009 | Am J Infect Control2009，37，5： | 1 |
| 13 | Implementation of the VA MRSA bundle at a 132 bed acute care va medical center shows promise in long - range rate reductions for healthcare - associated MRSA infection显示文摘 | Maria C Patricia L Loretta S | 2009 | American Journal of Infection Control2009，37，5： | 1 |
| 14 | Lunx is a superior moleodar marker for detection of non-small lung cell cancer in peripheral blood显示文摘 | Michael M Loretta H Gerard S | 2003 | Mol Di agn2003，5，： | 1 |
| 15 | hmx is a superior molecular marker for detection of non-small lung cell cancer in peripheral blood显示文摘 | Michael M Loretta H Gerard S | 2003 | Mol Diagn2003，5，： | 1 |
| 16 | Physiological and isotopic aspects of photosynthesis in Peperomia显示文摘 | Irwin P T Loretta B Leonel O S | 1985 | Plant Physiology1985，78，： | 1 |
| 17 | Synthesis and Structural Characterization of MSU-type Silica tin Molecular Sieves:Post-synthesis Grafting of Tin Chlorides显示文摘 | Manuela C Elisa M Loretta S | 2006 | Micropor Mesopor Mater2006，91，： | 1 |
| 18 | The intersection of genetic and chemical genomic screens identifies GSK-3[alpha] as a target in human acute myeloid leukemia显示文摘 | Banerji Versha Frumm Stacey M Ross Kenneth N Li Loretta S Schinzel Anna C Hahn Cynthia K Kakoza Rose M Chow Kwan T Ross Linda Alexe Gabriela Tolliday Nicola Inguilizian Haig Galinsky Ilene Stone Richard M DeAngelo Daniel J Roti Giovanni As | 2012 | EN2012，，3： | 1 |
| 19 | Enhancement of electrokinetic ectraction from lead-spiked soil显示文摘 | LORETTA Y L | 2000 | Journal of Environmental Engineering2000，126，： | 1 |
| 20 | High prevalence of chronic viral hepatitis B and C in Minnesota Somalis contributes to rising hepatocellular carcinoma incidence显示文摘BACKGROUND Chronic hepatitis B virus(HBV)and hepatitis C virus(HCV)infections are known risk factors for liver disease,cirrhosis and hepatocellular carcinoma(HCC).There is substantial global variation in HBV and HCV prevalence resulting in variations in cirrhosis and HCC.We previously reported high prevalence of HBV and HCV infections in Somali immigrants seen at an academic medical center in Minnesota.AIM To determine the prevalence of chronic viral hepatitis in Somali immigrants in Minnesota through a community-based screening program.METHODS We conducted a prospective community-based participatory research study in the Somali community in Minnesota in partnership with community advisory boards,community clinics and local mosques between November 2010 and December 2015(data was analyzed in 2020).Serum was tested for hepatitis B surface antigen,hepatitis B core antibody,hepatitis B surface antibody and anti-HCV antibody.RESULTS Of 779 participants,15.4%tested positive for chronic HBV infection,50.2%for prior exposure to HBV and 7.6%for chronic HCV infection.Calculated age-adjusted frequencies in males and females for chronic HBV were 12.5%and 11.6%;for prior exposure to HBV were 44.8%and 41.3%;and for chronic HCV were 6.7%and 5.7%,respectively.Seven participants developed incident HCC during follow up.CONCLUSION Chronic HBV and HCV are major risk factors for liver disease and HCC among Somali immigrants,with prevalence of both infections substantially higher than in the general United States population.Community-based screening is essential for identifying and providing health education and linkage to care for diagnosed patients. | Essa A Mohamed Nasra H Giama Abubaker O Abdalla Hassan M Shaleh Abdul M Oseini Hamdi A Ali Fowsiyo Ahmed Wesam Taha Hager Ahmed Mohammed Jessica Cvinar Ibrahim A Waaeys Hawa Ali Loretta K Allotey Abdiwahab O Ali Safra A Mohamed William S Harmsen Eimad M Ahmmad Numra A Bajwa Mohamud D Afgarshe Abdirashid M Shire Joyce E Balls-Berry Lewis R Roberts | 2022 | World Journal of Gastroenterology2022，28，35： | 0 |
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