|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing in vitro Fertilization and Embryo Transfer: A Large Retrospective Cohort Study显示文摘Objective Prior pulmonary tuberculosis(PTB) on chest X-ray(CXR) was commonly found in infertile patients receiving examinations before in vitro fertilization and embryo transfer(IVF-ET). It was unclear whether untreated PTB would affect pregnancy outcomes after IVF-ET.Method We conducted a retrospective cohort study of 14,254 infertile patients who had received IVFET at Peking University Third Hospital in 2017. Prior PTB was defined as the presence of signs suggestive of old or inactive PTB on CXR, with or without a clinical TB history. Patients who had prior PTB on CXR but had not received a clinical diagnosis and anti-TB therapy were included for analysis. Live birth,clinical pregnancy, and miscarriage rates were compared between the untreated PTB and non-PTB groups.Results The untreated PTB group had significantly lower clinical pregnancy(31.7% vs. 38.1%) and live birth(23.8% vs. 30.6%) rates than the non-PTB group(both P < 0.001). Multivariate analysis revealed that untreated PTB was a risk factor for decreased live birth rate [odds ratio(OR), 0.80;95% confidence interval(CI), 0.66–0.98;P = 0.028] in all patients and for increased miscarriage(OR, 4.19;95% CI,1.69–10.39;P = 0.002) and decreased live birth(OR, 0.45;95% CI, 0.24–0.83;P = 0.011) rates in patients with unexplained infertility.Conclusions Untreated PTB was associated with adverse pregnancy outcomes after IVF-ET, especially in patients with unexplained infertility, highlighting the clinical significance of PTB in this specific patient population. | GAI Xiao Yan CHI Hong Bin ZENG Lin CAO Wen Li CHEN Li Xue ZHANG Chen LU Ming NING Lan Ding CHANG Chun ZHANG Wei Xia LIU Ping LI Rong SUN Yong Chang QIAO Jie | 2021 | Biomedical and Environmental Sciences2021，34，2： | 6 |
| 2 | Expression pattern of neural synaptic plasticity marker-Arc in different brain regions induced by conditioned drug withdrawal from acute morphine-dependent rats显示文摘 | Mu LI Yuan-yuan HOU Bin LU Jie CHEN Zhi-qiang CHI Jing-gen LIU | 2009 | Acta Pharmacologica Sinica2009，30，3： | 5 |
| 3 | Expression changes of hippocampal energy metabolism enzymes contribute to behavioural abnormalities during chronic morphine treatment显示文摘学习和记忆的依赖和缺陷是象 opioids 那样的滥用的药引起的二 well-establishedfeatures。马头鱼尾的怪兽是与两药依赖联系的一个重要区域并且学习并且记忆。然而,在到象 opioids 那样的滥用的药的马头鱼尾的怪兽追随者暴露的分子的事件很好没被理解。这里,我们由 proteomic 分析在海马趾的蛋白质表示上检验了长期的吗啡处理的效果。 Wefound 到为 10 天的吗啡的老鼠的那长期的暴露生产了柔韧的吗啡退却跳和记忆缺陷,并且也导致了三新陈代谢的酶的海马趾的蛋白质层次的一条重要down 规定包括 Fe-S 蛋白质 1 NADH 脱氢酶, pyruvate 建筑群和乳酸脱氢酶的 dihydrolipoamide acetyltransferase 或 E2 部件 2 。进一步即时的量的 PCR 分析证实相应 mRNAs 的层次显著地也被减少。与这些调查结果,更低的 ATP 层次和把葡萄糖变换成 ATP 的一个损害能力一致也在长期地对待的老鼠的马头鱼尾的怪兽被观察。显著地与吗啡附随地管理的 Opioid 对手 naltrexone 压制了吗啡退却跳并且颠倒了这些蛋白质的 down 规定。到吗啡的尖锐暴露也生产了跳的柔韧的吗啡退却和重要存储器缺陷,但是在吗啡管理显著地提高了 ATPlevels 并且压制了吗啡退却不在长期的对待吗啡的鼠标在尖锐 morphine-treatedbut 跳和存储器缺陷以前,没有通过 D 葡萄糖的这三 proteins.Intrahippocampal 注射的表达式到减少。D 葡萄糖的高剂量的 Intraperitoneal 注射在作为中央处理跳的导致吗啡的退却上显示出类似的效果。总起来说,我们的结果建议在由于长期的吗啡处理的马头鱼尾的怪兽的三新陈代谢的酶的那减少的表情贡献象吗啡退却跳和记忆缺陷那样的导致药的症状的发展。 | Xiao-Lan Chen Gang Lu Ying-Xia Gong Liang-Cai Zhao Jie Chen Zhi-Qiang Chi Yi-Ming Yang Zhong Chen Qing-lin Li Jing-Gen Liu | 2007 | Cell Research2007，17，8： | 2 |
| 4 | Credit scoring using the hybrid neural discriminant technique显示文摘 | Lee Tian Shyug Chiu Chih Chou Lu Chi Jie Chen I Fei | 2002 | Expert Systems with Applications2002，，3： | 1 |
| 5 | Comparison of Ca/P mineralization on the surfaces of poly (ε-caprolactone) composites filled with silane-modified nano-apatite显示文摘 | Chi Deng Nin Yao Xiong Lu Shuxin Qu Bo Feng Jie Weng Xiaobing Yang | 2009 | Journal of Materials Science2009，，16： | 1 |
| 6 | Characteristics of plankton Hg bioaccumulations based on a global data set and the implications for aquatic systems with aggravating nutrient imbalance显示文摘The bioaccumulation of mercury(Hg)in aquatic ecosystem poses a potential health risk to human being and aquatic organism.Bioaccumulations by plankton represent a crucial process of Hg transfer from water to aquatic food chain.However,the current understanding of major factors affecting Hg accumulation by plankton is inadequate.In this study,a data set of 89 aquatic ecosystems worldwide,including inland water,nearshore water and open sea,was established.Key factors influencing plankton Hg bioaccumulation(i.e.,plankton species,cell sizes and biomasses)were discussed.The results indicated that total Hg(THg)and methylmercury(MeHg)concentrations in plankton in inland waters were significantly higher than those in nearshore waters and open seas.Bioaccumulation factors for the logarithm of THg and MeHg of phytoplankton were 2.4–6.0 and 2.6–6.7 L/kg,respectively,in all aquatic ecosystems.They could be further biomagnified by a factor of 2.1–15.1 and 5.3–28.2 from phytoplankton to zooplankton.Higher MeHg concentrations were observed with the increases of cell size for both phyto-and zooplankton.A contrasting trend was observed between the plankton biomasses and BAF_(MeHg),with a positive relationship for zooplankton and a negative relationship for phytoplankton.Plankton physiologic traits impose constraints on the rates of nutrients and contaminants obtaining process from water.Nowadays,many aquatic ecosystems are facing rapid shifts in nutrient compositions.We suggested that these potential influences on the growth and composition of plankton should be incorporated in future aquatic Hg modeling and ecological risk assessments. | Zhike Li Jie Chi Zhenyu Wu Yiyan Zhang Yiran Liu Lanlan Huang Yiren Lu Minhaz Uddin Wei Zhang Xuejun Wang Yan Lin Yindong Tong | 2022 | Frontiers of Environmental Science & Engineering2022，16，3： | 1 |
| 7 | High‑accuracy measurement of Compton scattering in germanium for dark matter searches显示文摘Compton scattering with bound electrons contributes to a significant atomic effect in low-momentum transfer,yielding background structures in direct light dark matter searches as well as low-energy rare event experiments.We report the measurement of Compton scattering in low-momentum transfer by implementing a 10-g germanium detector bombarded by a^(137)Cs source with a radioactivity of 8.7 mCi and a scatter photon captured by a cylindrical NaI(Tl)detector.A fully relativistic impulse approximation combined with multi-configuration Dirac–Fock wavefunctions was evaluated,and the scattering function of Geant4 software was replaced by our calculation results.Our measurements show that the Livermore model with the modified scattering function in Geant4 is in good agreement with the experimental data.It is also revealed that atomic many-body effects significantly influence Compton scattering for low-momentum transfer(sub-keV energy transfer). | Hai‑Tao Jia Shin‑Ted Lin Shu‑Kui Liu Hsin‑Chang Chi Muhammed Deniz Chang‑Hao Fang Peng Gu Xi Jiang Yi‑Ke Shu Qian‑Yun Li Yu Liu Ren‑Ming‑Jie Li Chen‑Kai Qiao Chang‑Jian Tang Henry Tsz‑King Wong Hao‑Yang Xing Li‑Tao Yang Qian Yue Yu‑Lu Yan Kang‑Kang Zhao Jing‑Jun Zhu | 2022 | Nuclear Science and Techniques2022，33，12： | 1 |
| 8 | MicroRNA ‐30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS , PIK3CD and BCL2显示文摘 | Wen‐Ting Liao Ya‐Ping Ye Nian‐Jie Zhang Ting‐Ting Li Shu‐Yang Wang Yan‐Mei Cui Lu Qi Ping Wu Hong‐Li Jiao Yi‐Jun Xie Chi Zhang Jun‐Xian Wang Yan‐Qing Ding | 2014 | J. Pathol2014，，4： | 1 |
| 9 | Initial experience of heroin use under a two-chained operant schedule influences drug-seeking behavior after one month of abstinence显示文摘 | Bin LU Mu LI Yuan-yuan HOU Jie CHEN Zhi-qiang CHI Jing-gen LIU | 2010 | Acta Pharmacologica Sinica2010，31，4： | 1 |
| 10 | Combining nonlinear independent component analysis and neural network for the predic- tion of Asian stock market indexes显示文摘 | Dai Wensheng Wu Jui - Yu Lu Chi - Jie | 2012 | Expert Systems with Appli- cations2012，，39： | 1 |
| 11 | Baseline radiologic features as predictors of efficacy in patients with pancreatic neuroendocrine tumors with liver metastases receiving surufatinib显示文摘Objective:Currently,pre-treatment prediction of patients with pancreatic neuroendocrine tumors with liver metastases(PNELM)receiving surufatinib treatment was unsatisfying.Our objective was to examine the association between radiological characteristics and efficacy/prognosis.Methods:We enrolled patients with liver metastases in the phase III,SANET-p trial(NCT02589821)and obtained contrast-enhanced computed tomography(CECT)images.Qualitative and quantitative parameters including hepatic tumor margins,lesion volumes,enhancement pattern,localization types,and enhancement ratios were evaluated.The progression-free survival(PFS)and hazard ratio(HR)were calculated using Cox’s proportional hazard model.Efficacy was analyzed by logistic-regression models.Results:Among 152 patients who had baseline CECT assessments and were included in this analysis,the surufatinib group showed statistically superior efficacy in terms of median PFS compared to placebo across various qualitative and quantitative parameters.In the multivariable analysis of patients receiving surufatinib(N=100),those with higher arterial phase standardized enhancement ratio-peri-lesion(ASER-peri)exhibited longer PFS[HR=0.039;95%confidence interval(95%CI):0.003−0.483;P=0.012].Furthermore,patients with a high enhancement pattern experienced an improvement in the objective response ratio[31.3%vs.14.7%,odds ratio(OR)=3.488;95%CI:1.024−11.875;P=0.046],and well-defined tumor margins were associated with a higher disease control rate(DCR)(89.3%vs.68.2%,OR=4.535;95%CI:1.285−16.011;P=0.019)compared to poorlydefined margins.Conclusions:These pre-treatment radiological features,namely high ASER-peri,high enhancement pattern,and well-defined tumor margins,have the potential to serve as predictive markers of efficacy in patients with PNELM receiving surufatinib. | Jianwei Zhang Haibin Zhu Lin Shen Jie Li Xiaoyan Zhang Chunmei Bai Zhiwei Zhou Xianrui Yu Zhiping Li Enxiao Li Xianglin Yuan Wenhui Lou Yihebali Chi Nong Xu Yongmei Yin Yuxian Bai Tao Zhang Dianrong Xiu Jia Chen Shukui Qin Xiuwen Wang Yujie Yang Haoyun Shi Xian Luo Songhua Fan Weiguo Su Ming Lu Jianming Xu | 2023 | Chinese Journal of Cancer Research2023，35，5： | 0 |
| 12 | Modulation of dynamic aggregation in fluorogenic SNAP-tag probes for long-term super-resolution imaging显示文摘The combination of super-resolution microscopy and synthetic fluorescence probes has emerged as a universal tool to monitor dynamic biological events at the nanometer scale.However,the limited site-specificity and fluorogenicity of synthetic fluorescent probes make it still difficult to realize long-term super-resolution imaging.Herein,we introduce a dynamic aggregation mediated SNAP-tag fluorogenic probe,BGAN-Aze,which can specifically bind to various SNAP-tag fusion proteins with 41-fold fluorescence enhancement.The equilibrium between the non-fluorescent aggregate/dimer(A–D)and the fluorescent monomer(M)of BGAN-Aze acts as an effective method to reduce the fluorescence background and endow BGAN-Aze with the capability of conducting washing-free super-resolution imaging of various intracellular and extracellular proteins.Using this probe,we monitored multiple dynamic biological events,such as MMC,mitophagy,the fusion of nucleolus,and the growth and contact of filopodia.We expect that BGAN-Aze will become a widely used SNAP-tag for super-resolution imaging of dynamic biological events and the A-D-M equilibrium can be a general strategy for designing fluorogenic probes. | Qinglong Qiao Wenjuan Liu Weijie Chi Jie Chen Wei Zhou Ning Xu Jin Li Xiangning Fang Yi Tao Yinchan Zhang Yingzhu Chen Lu Miao Xiaogang Liu Zhaochao Xu | 2023 | Aggregate2023，4，2： | 0 |
| 13 | Influence of SAM Quality on the Organic Semiconductor Thin Film Gas Sensors显示文摘Gas sensors based on organic semiconductors receive tremendous attentions owing to their advantages on high selectivity and room temperature operation. However, until now, most organic semiconductor based sensors still suffered from problems, such as low sensitivity, slow response/recovery speed and poor stability. In addition, a clear correlation between the sensing performance and the film property is still absent. Herein, we report the investigation on sensing performance of a series of organic films with various morphologies. By simply adjusting the quality of self-assembled monolayer(SAM) on the silicon wafer surface, we obtain organic semiconductor 6,13-bis(triisopropylsilylethynyl)pentacene (TIPS-pentacene) films with varied morphologies and different charge transport abilities. The film with a small grain size and a continuous morphology presents the highest sensing performance to NO2, with a sensitivity up to 730%/ppm(ppm=parts per million, vo-lume ratio). We thus reveal that the high sensitivity of the organic film is evident related with the charge transport ability and initial conductivity of the films, as well as the morphologies of both modification layer and the active films. | ZHU Lunan WANG Zi LU Jie ZHOU Xu ZENG Zhoufang HUANG Lizhen CHI Lifeng | 2022 | Chemical Research in Chinese Universities2022，38，2： | 0 |
| 14 | High-performance organic electrochemical transistors gated with 3D-printed graphene oxide electrodes显示文摘Organic electrochemical transistors(OECTs)have garnered significant interest due to their ability to facilitate both ionic and electronic transport.A large proportion of research efforts thus far have focused on investigating high-performance materials that can serve as mixed ion doping and charge transport layers.However,relatively less attention has been given to the gateelectrode materials,which play a critical role in controlling operational voltage,redox processes,and stability,especially in the context of semiconductor-based OECTs working in accumulation mode.Moreover,the demand for planarity and flexibility in modern bioelectronic devices presents significant challenges for the commonly used Ag/AgCl electrodes in OECTs.Herein,we report the construction of high-performance accumulation-mode OECTs by utilizing a gate electrode made of three-dimensional(3D)-printed graphene oxide.The 3D-printed graphene oxide electrode incorporating one-dimensional(1D)carbon nanotubes,is directly printed using an aqueous-based ink and showcases exceptional mechanical flexibility and porosity properties,enabling high-throughput preparation for both top gates and integrated planar architecture,as well as fast ion/charge transport.OECTs with high performance comparable to that of Ag/AgCl-gated OECTs are thus achieved and present promising feasibility for electrocardiograph(ECG)signal recording.This provides a promising choice for the application of flexible bioelectronics in medical care and neurological recording. | Xingyu Jiang Zhiqiang Liang Miao Wu Jie Lu Cheng Shi Qi Wang Zi Wang Zhen Jin Lin Jiang Lizhen Huang Lifeng Chi | 2023 | Nano Research2023，16，11： | 0 |
| 15 | Construction of a High-Quality Organic-Inorganic Hybrid Heterostructure and Its Photo-response Performance显示文摘The combination of metal oxide and organic semiconductor for constructing organic-inorganic hybrid heterostructure is promising to offer unique optoelectronic properties.However,the distinct difference in electron structure and processing technology of the two types of materials makes it usually difficult to fully deliver their complementary advantages.Herein,we report the construction of a high quality organic/In_(2)O_(3) hybrid heterostructure presenting a good ambipolar transport with average electron mobility>1 cm^(2)V^(-1)·s^(-1) and hole mobility up to 0.4 cm^(2)·V^(-1)·s^(-1),respectively,together with a high-gain inverter.In addition,the incorporation with organic film on top of In_(2)O_(3) remarkably reduces the dark current,enabling the realization of high photoconductivity response with photo-sensitivity of two magnitudes higher than that of pure In2O3.The photoconductor and phototransistor of the hybrid structure demonstrate high photoresponsivity>10^(3) AW^(-1) and detectivity up to 10^(14) Jones,demonstrating the promising functionality of such a high quality hybrid heterostructure. | Yadan Zhang Guanghua Yu Di Xue Jie Lu Xing Meng Yao Yin Qi Wang Zi Wang Lizhen Huang Lifeng Chi | 2023 | Chinese Journal of Chemistry2023，41，1： | 0 |
| 16 | Growth Behavior of Rubrene Thin Films on Hexagonal Boron Nitride in the Early Stage显示文摘Two-dimensional materials,with an in-plane ordered and dangling-bonding-free surface,are ideal substrates for fabricating high-quality crystalline thin films.Here,we show a systematic study on the growth of a benchmark organic semiconductor,rubrene,on hexagonal boron nitride(h-BN)substrate via physical vapor deposition from the initial amorphous phase to the final crystalline phase;the role of temperature in such transition and the epitaxy relationship between rubrene and h-BN are revealed.With the increase of substrate temperature,the critical thickness of amorphous-crystalline-transition decreases and the morphology of crystalline phase also evolves from porous to terrace-like.When substrate temperature reaches>100℃,the critical thickness reduces to only 0.5 nm and a precise layer-by-layer growth from the very first layer is achieved,which is quite rare for rubrene growing on other substrates.The high ordering can be attributed to the fine epitaxy relationship between rubrene films and the h-BN surface lattice,and this film demonstrates good charge transport ability with a p-type field-effect mobility of>1 cm^(2)·V^(-1)·s^(-1). | Yujia Wei Di Xue Lianlian Ji Jie Lu Qi Wang Xingyu Jiang Yinghui Sun Zi Wang Lizhen Huang Lifeng Chi | 2022 | Chinese Journal of Chemistry2022，40，11： | 0 |
| 17 | Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study显示文摘Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been rare.To the best of our knowledge,no national-level study of treatment status and economic burden has been performed.This retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national level.We included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of China.Patient epidemiological and clinical features,treatment status,and total and daily costs were recorded.Trends in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression Program.The percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent surgery.Only 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 hours.The total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 hours,which is associated with improved sensorimotor recovery,increasing the awareness rate of clinical guidelines related to high-dose MPSS/MP to reduce the use of the treatment with insufficient evidence. | Hengxing Zhou Yongfu Lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng | 2024 | Neural Regeneration Research2024，19，5： | 0 |
| 18 | Stereoselective Synthesis and Bioactivities of New ω-Azolyalkenes显示文摘A series of new ω-azolylalkenes 3 were synthesized by N-alkylation of ffobromoalkenes 2 which were obtained by Witting reaction of ω-hydroxyalkylphosphonium bromide with aromatic aldehydes and subsequent bromination. The structures of products were confirmed by 1HNMR, IR,MS and elemental analysis. The preliminary bioassay indicated that some of them had high flingicidal activities. | Shui Ming LU Wen Jing XIAO Wen Fang HUANG Tian Jie WU (Departmeent of Chemistry, Central China Normal University, Wuhan, 430079)(Institute of Organic Systhesis, Central China Normal University, Wuhan, 430079)(Center of Analysis and Testing, Central Chi | 1998 | Chinese Chemical Letters1998，9，11： | 0 |
| 19 | Effects of ATPM-ET, a novel K agonist with partial μ activity, on morphine-induced physical dependence and behavior sensitization in mice显示文摘 | Jian-feng SUN Yu-hua WANG Fu-ying LI Gang LU Yi-min TAO Yun CHENG Jie CHEN Xue-jun XU Zhi-qiang CHI John L NEUMEYER Ao ZHANG Jing-gen LIU | 2010 | Acta Pharmacologica Sinica2010，31，12： | 0 |
| 20 | Four-junction AlGaAs/GaAs laser power converter显示文摘Four-junction AlGaAs/GaAs laser power converters (LPCs) with n^+-Ga As/p^+-Al_(0.37)Ga_(0.63)As hetero-structure tunnel junctions (TJs) have been designed and grown by metal-organic chemical vapor deposition(MOCVD) for converting the power of 808 nm lasers. A maximum conversion efficiency ηc of 56.9% ± 4% is obtained for cells with an aperture of 3.14 mm^2 at an input laser power of 0.2 W, while dropping to 43.3% at 1.5 W.Measured current–voltage (I–V) characteristics indicate that the performance of the LPC can be further improved by increasing the tunneling current density of TJs and optimizing the thicknesses of sub-cells to achieve current matching in LPC. | Jie Huang Yurun Sun Yongming Zhao Shuzhen Yu Jianrong Dong Jiping Xue Chi Xue Jin Wang Yunqing Lu Yanwen Ding | 2018 | Journal of Semiconductors2018，39，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员