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| 1 | Esophagectomy for locally advanced esophageal cancer, followed by chemoradiotherapy and adjuvant chemotherapy显示文摘AIM: To compare the efficacy and toxicity of a three-step combination therapy with post-operative radiation alone for locally advanced esophageal cancer.METHODS: Patients with T3-4 and N0-1 esophageal carcinoma from a number of institutions were non-randomly,prospectively enrolled in the study. All patients underwent single-stage curative en bloc esophagectomy. The patients were then assigned into one of two treatment groups based on treatment consisting of either post-operative concurrent chemoradiotherapy (CCRT) with weekly cisplatin 30 mg/m2 followed by systemic adjuvant chemotherapy (four monthly cycles of cisplatin 20 mg/m2 and 5-fiuorouracil 1 000 mg/m2 for five consecutive days),or, post-operative radiation alone. The radiotherapy dose was 55-60 Gy for all patients. Primary end-point of this study was to assess the per-protocol patients' improvement of overall survival benefit. Secondary end-point was designed to evaluate both the per-protocol and intent-to-treat patients' outcome of survival.RESULTS: A total of 60 patients (n = 30 per group) were enrolled in this study. The two groups were generally comparable for demographic characteristics and hematological and non-hematological toxicities. The CCRT with weekly cisplatin was well tolerated, with significantly better overall survival (30.9 mo vs 20.7 mo; 95% CI,27.5-36.4 vs15.2-26.1) and 3-year survival (70.0% vs 33.7%; P = 0.003). Low histological grade of tumor (P<0.001) was associated with favorable survival in these locally advanced patients.CONCLUSION: For locally advanced esophageal cancer,the combination of esophagectomy, post-operative CCRT with weekly cisplatin and systemic adjuvant chemotherapy is well tolerated and effective. A large-scale, prospective randomized trial of this regimen is in progress. | Hung-Chang Liu Shih-Kai Hung Cham-Jer Huang Chung-Chu Chen Ming-Jen Chen Chun-Chao Chang Cheng-Jeng Tai Chi-Yuan Tzen Li-Hua Lu Yu-Jen Chen | 2005 | World Journal of Gastroenterology2005，11，34： | 25 |
| 2 | Current status in the treatment options for esophageal achalasia显示文摘Recent advances in the treatment of achalasia include the use of high-resolution manometry to predict the outcome of patients and the introduction of peroral endoscopic myotomy(POEM).The first multicenter randomized,controlled,2-year follow-up study conducted by the European Achalasia Trial group indicated that laparoscopic Heller myotomy(LHM)was not superior to pneumatic dilations(PD).Publications on the long-term success of laparoscopic surgery continue to emerge.In addition,laparoscopic single-site surgery is applicable to advanced laparoscopic operations such as LHM and anterior fundoplication.The optimal treatment option is an ongoing matter of debate.In this review,we provide an update of the current progress in the treatment of esophageal achalasia.Unless new conclusive data prove otherwise,LHM is considered the most durable treatment for achalasia at the expense of increased reflux-associated complications.However,PD is the first choice for non-surgical treatment and is more costeffective.Repeated PD according to an'on-demand'strategy based on symptom recurrence can achieve long-term remission.Decision making should be based on clinical evidence that identifies a subcategory of patients who would benefit from specific treatment options.POEM has shown promise but its long-term efficacy and safety need to be assessed further. | Seng-Kee Chuah Chien-Hua Chiu Wei-Chen Tai Jyong-Hong Lee Hung-I Lu Chi-Sin Changchien Ping-Huei Tseng Keng-Liang Wu | 2013 | World Journal of Gastroenterology2013，19，33： | 15 |
| 3 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 4 | Chronic angiotensin (1-7) injection accelerates STZ-induced diabetic renal injury显示文摘瞄准:高血压蛋白原酶血管收缩素系统(地岬) 在血压控制和身体液体和电解质动态平衡起一个关键作用。在过去几年里,血管收缩素(Ang )(1-7 ) 被报导了抵抗 Ang II 的效果并且甚至在地岬被看作一个新 therapeutical 目标。现在的学习试图在本地地岬上在一个糖尿病的动物模型和调整上调查 Ang (1-7 ) 管理的效果。方法:Streptozotocin (STZ ) 导致注射的糖尿病的老鼠在实验被使用。动物被划分成 3 个组:(1 ) 控制;(2 )导致 STZ 的糖尿病;并且(3 ) 有长期的 Ang (1-7 ) 处理的导致 STZ 的糖尿病[D+Ang (1-7 )] 。在 D+Ang (l-7 ) 组, 25 μ g · k g~ 的剂量(Ang (1-7 ) 的 -1) · h^(-1) 被嵌入微型渗透的泵 6 个星期不断地通过颈部的静脉注射。血浆葡萄糖,到体重的肾的比率,和 24 h 尿蛋白质和浆液肌酸酐被常规测量监视。血浆和肾的 Ang II 层次被放射性免疫测定测量。Ang-con-verting 酶(王牌) , ACE2, Ang II 打 1 (AT1 ) 受体, Ang II 打 2 (AT2 ) 受体, Ang (1-7 ) 妈受体,和 TGF-β 1 niRNA 层次被实时 PCR 测量;王牌, ACE2,和 TGF-β 1 蛋白质层次被西方的弄污分析。结果:当时,糖尿病的老鼠的肾的函数显著地被倒退与控制老鼠的相比。在由为 6 个星期的经常的 Ang (1-7 ) 静脉注射的处理以后,肾的功能被发现平比糖尿病的老鼠,和两 TGF-β 1 更坏 mRNA 和蛋白质层次与糖尿病的老鼠相比在 D+Ang (l-7 ) 组被提高。即时 PCR 结果也在 D+Ang (1-7 ) 组在 ACE2 mRNA 水平在王牌 mRNA 表示和减少看了增加是否与糖尿病的老鼠相比。受体在 Ang (1-7 ) 增加了的 ATI 的数字注射了组,当 AT2 和妈受体的数字减少了时。结论:外长的 Ang (1-7 ) 注射没改善导致 STZ 的糖尿病的老鼠肾损伤;相反,它加速了进步糖尿病的 nephropathies。 | Ying SHAO Ming HE Li ZHOU Tai YAO Yu HUANG Li-min LU | 2008 | Acta Pharmacologica Sinica2008，29，7： | 12 |
| 5 | Modified FOLFIRINOX for unresectable locally advanced or metastatic gallbladder cancer,a comparison with GEMOX regimen显示文摘Background:The first-line chemotherapy regimen for advanced gallbladder cancer(GBC)is gemcitabine plus platinum(GP),despite its efficacy is limited.The current investigation is a retrospective study to compare the safety and efficacy between the modified FOLFIRINOX(mFOLFIRINOX)and gemcitabine plus oxaliplatin(GEMOX)as the first-line chemotherapy for unresectable locally advanced or metastatic GBC.Methods:The data of patients with unresectable locally advanced or metastatic GBC,who were treated with mFOLFIRINOX or GEMOX as the first-line therapy between April 2014 and April 2018 at Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,were retrieved.This retrospective study evaluated the clinical characteristics,survival outcomes and adverse events.Results:A total of 44 patients(n=25 in mFOLFIRINOX,n=19 in GEMOX)were included.There were no significant differences between groups in baseline characteristics.The median progression free survival(mPFS)was 5.0 months in the mFOLFIRINOX group and 2.5 months in the GEMOX group[P=0.021;hazard ratio(HR),0.499;95%CI,0.266 to 0.937].The median overall survival(mOS)was 9.5 months in the mFOLFIRINOX group and 7.0 months in the GEMOX group(P=0.019;HR,0.471;95%CI,0.239 to 0.929).Disease control rate(DCR)was 76.0%in the mFOLFIRINOX group and 47.4%in the GEMOX group(P=0.051).The rate of grade 3-4 adverse events was 48%in the mFOLFIRINOX group and 36.8%in the GEMOX group(P=0.459).The incidence of grade 3-4 neutropenia and diarrhea were more common in the mFOLFIRINOX group,while the incidence of grade 3-4 thrombocytopenia and peripheral neuropathy were more common in the GEMOX group.Conclusions:mFOLFIRINOX might improve the poor prognosis of unresectable locally advanced or metastatic GBC,and the results need to be further verified by prospective clinical studies. | Xu-Ya Cui Xue-Chuan Li Jiu-Jie Cui Xiang-Song Wu Lu Zou Xiao-Ling Song Tai Ren Yi-Di Zhu Huai-Feng Li Yang Yang Ke Liu Xu-Sheng Han Zi-Yao Jia Wen-Guang Wu Xu-An Wang Wei Gong Li-Wei Wang Mao-Lan Li Ying-Bin Liu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 10 |
| 6 | All-trans retinoic acid inhibited angiotensin Ⅱ-induced increase in cell growth and collagen secretion of neonatal cardiac fibroblasts显示文摘瞄准:为了决定 all-trans retinoic 酸(atRA ) 是否行动调制血管收缩素, II (Ang II ) 导致了心脏的成纤维细胞房间生长和骨胶原分泌物。方法:有教养的新生的老鼠心脏的成纤维细胞(CF ) 在实验被使用。A 3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyl tetrazolium 溴化物(MTT ) 试金被用来检测 CF 的细胞生长;并且免疫细胞化学并且西方的弄污被用来测量骨胶原的生产和由 CF 转变生长 factor-beta1 (TGF-beta1 ) 的表示。结果:atRA (10 (到 10 的 -7)(-5) mol/L ) 禁止了 Ang CF (P<0.05 ) 的房间生长的导致 II 的增加。Ang II 刺激了骨胶原类型的分泌物我和由 CF 的 III。这效果被堵住由在(1 ) 受体对手 losartan (10 (-6) mol/L ) ,然而并非由 AT2 受体对手 PD123319 (多达 10 (-6) mol/L ) 。到 atRA 的 CF 的暴露((-5) mol/L ) 10 稀释了骨胶原的分泌物的导致 II 的增加打的 Ang 我和 III (P<0.05 ) 。atRA ((-5) mol/L ) 10 也堵住了 Ang TGF-beta1 的表示的导致 II 的增加。结论:atRA 禁止 Ang 细胞生长和新生的老鼠 CF 的骨胶原分泌物的导致 II 的增加。atRA 的效果被降低 TGF-beta1 水平可能调停。这些观察支持 atRA 是心脏的改变的预防和治疗的一个潜在的候选人的观点。 | Yan HE Ying HUANG Li ZHOU Li-min LU Yi-chun ZHU Tai YAO | 2006 | Acta Pharmacologica Sinica2006，27，4： | 8 |
| 7 | Effect of adrenotensin on cell proliferation is mediated by angiotensin II in cultured rat mesangial cells显示文摘 | Hong XUE Ping YUAN Li ZHOU Tai YAO Yu HUANG Li-min LU | 2009 | Acta Pharmacologica Sinica2009，30，8： | 7 |
| 8 | A novel synthetic route for LiFePO_4/C cathode materials by addition of starch for lithium-ion batteries显示文摘LiFePO4/Carbon composite cathode material was prepared using starch as carbon source by spray-pelleting and subsequent pyrolysis in N2. The samples were characterized by XRD, SEM, Raman, and their electrochemical performance was investigated in terms of cycling behavior. There has a special micro-morphology via the process, which is favorable to electrochemical properties. The discharge capacity of the LiFePO4.C composite was 170 mAh g-1, equal to the theoretical specific capacity at 0.1 C rate. At 4 C current density, the specific capacity was about 80 mAh g-1, which can satisfy for transportation applications if having a more flat discharge flat. | Shao Hua Luo, Zi Long Tang, Jun Biao Lu, Zhong Tai Zhang State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China | 2007 | Chinese Chemical Letters2007，18，2： | 5 |
| 9 | Complete disassociation of adult pancreas into viable single cells through cold trypsin-EDTA digestion显示文摘The in vitro isolation and analysis of pancreatic stem/progenitor cells are necessary for understanding their properties and function; however, the preparation of high-quality single-cell suspensions from adult pancreas is prerequisite. In this study, we applied a cold trypsin-ethylenediaminetetraacetic acid (EDTA) digestion method to disassociate adult mouse pancreata into single cells. The yield of single cells and the viability of the harvested cells were much higher than those obtained via the two commonly used warm digestion methods. Flow cytometric analysis showed that the ratio of ductal or BCRP1-positive cells in cell suspensions prepared through cold digestion was consistent with that found in vivo. Cell culture tests showed that pancreatic epithelial cells prepared by cold digestion maintained proliferative capacity comparable to those derived from warm collagenase digestion. These results indicate that cold trypsin-EDTA digestion can effectively disassociate an adult mouse pancreas into viable single cells with minimal cell loss, and can be used for the isolation and analysis of pancreatic stem/progenitor cells. | Dan LI Shi-yun PENG Zhen-wu ZHANG Rui-cheng FENG Lu LI Jie LIANG Sheng TAI Chun-bo TENG | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，7： | 5 |
| 10 | Keggin type heteropolyacids-catalyzed synthesis of quinoxaline derivatives in water显示文摘Keggin 类型 heteropolyacids 被发现是为从有在水里的优秀收益的 1,2-dicarbonyl 混合物的 1,2 肼的冷凝作用的生物学上活跃的 quinoxaline 衍生物的合成的有效、可重用的催化剂。这个方法以催化剂,底层的一个宽范围,和简单病情的检查过程的小数量提供一个新、有效的协议。 | Tai Kun Huang Lin Shi Rui Wang Xing Zhou Guo Xiao Xia Lu | 2009 | Chinese Chemical Letters2009，20，2： | 4 |
| 11 | ISORHYNCHOPHYLLIC ACID,A NEW AIKALOID FROM UNCARIA SINENSIS显示文摘From the hook of Uncaria sinensis, a new alkaloid, isorhynchophyllicacid was isolated and its structure was elucidated by spectral data and chemicalreaction. | Hong Mei LIU Xiao Zhang FENG Yang LU Qi Tai ZHENG Institetu of Materia Medica, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050 | 1992 | Chinese Chemical Letters1992，3，6： | 4 |
| 12 | Increase of ambient formaldehyde in Beijing and its implication for VOC reactivity显示文摘影响大气哦激进的预算和 tropospheric 臭氧生产,周围的甲醛(HCHO ) 是关键氧化不稳定的有机化合物(OVOC ) 之一。我们在场在在北京的夏日的甲醛列密度上的变化从臭氧监视检索了在 2005 和 2011 之间的仪器(OMI ) 。尽管有一些显著差别, HCHO 的卫星列与可得到的基于地面的大小相关很好。直角的距离回归(ODR ) 方法被用来估计在卫星列和地面级的集中之间的比率,而平常的最少的广场(OLS ) 方法被用来适合周围的甲醛的趋势。从列在 712 ppbv 并且稳定地的范围的 HCHO 导出的甲醛集中以 0.64 ppbv/yr 的近似的率增加了(7.8% 在 2005 水平) 与 51% 的无常。VOC 反应确定了借助于哦损失率出现了从甲醛和乙醛增加贡献,在 2010 在 2005 ~ 40% 从 35% 升起,并且减少从人为的 VOC 的贡献,在 2010 在 2005 ~ 40% 从 49% 落下。更多的注意应该对理解增加甲醛到臭氧形成潜力的网反馈被给予。 | Qian Zhang Min Shao Yang Li Si Hua Lu Bin Yuan Wen Tai Chen | 2012 | Chinese Chemical Letters2012，23，9： | 3 |
| 13 | 2D materials for conducting holes from grain boundaries in perovskite solar cells显示文摘Grain boundaries in organic-inorganic halide perovskite solar cells(PSCs)have been found to be detrimental to the photovoltaic performance of devices.Here,we develop a unique approach to overcome this problem by modifying the edges of perovskite grain boundaries with flakes of high-mobility two-dimensional(2D)materials via a convenient solution process.A synergistic effect between the 2D flakes and perovskite grain boundaries is observed for the first time,which can significantly enhance the performance of PSCs.We find that the 2D flakes can conduct holes from the grain boundaries to the hole transport layers in PSCs,thereby making hole channels in the grain boundaries of the devices.Hence,2D flakes with high carrier mobilities and short distances to grain boundaries can induce a more pronounced performance enhancement of the devices.This work presents a cost-effective strategy for improving the performance of PSCs by using high-mobility 2D materials. | Peng You Guanqi Tang Jiupeng Cao Dong Shen Tsz-Wai Ng Zafer Hawash Naixiang Wang Chun-Ki Liu Wei Lu Qidong Tai Yabing Qi Chun-Sing Lee Feng Yan | 2021 | Light(Science & Applications)2021，10，4： | 3 |
| 14 | Five-year sequential changes in secondary antibiotic resistance of Helicobacter pylori in Taiwan显示文摘AIM: To determine changes in the antibiotic resistance of Helicobacter pylori(H. pylori) in southern Taiwan after failure of first-line standard triple therapy.METHODS: We analyzed 137 H. pylori-infected isolates from patients who experienced eradication failure after standard first-line triple therapy from January2010 to December 2014. The H. pylori strains were tested for susceptibility to amoxicillin, clarithromycin,levofloxacin, metronidazole and tetracycline using the E-test method. The minimal inhibitory concentration(MIC) was determined by the agar dilution test.MIC values of ≥ 0.5, ≥ 1, ≥ 1, ≥ 4 and ≥ 8 mg/L were considered to be the resistance breakpoints for amoxicillin, clarithromycin, levofloxacin, tetracycline and metronidazole, respectively.RESULTS: A high resistance rate was found for clarithromycin(65%-75%) and metronidazole(30%-40%)among patients who failed first-line standard therapy.The resistance levels to amoxicillin and tetracycline remained very low; however, levofloxacin resistance was as high as 37.5% in 2010 but did not increase any further during the past 5 years. The rates of resistance to these antibiotics did not show a statistically significant upward or downward trend.CONCLUSION: Antibiotic resistance of H. pylori remains a problem for the effective eradication of this pathogen and its associated diseases in Taiwan. High clarithromycin resistance indicated that this antibiotic should not be prescribed as a second-line H. pylori eradication therapy. Moreover, levofloxacin-based second-line therapy should be used cautiously, and the local resistance rates should be carefully monitored. | I-Ting Wu Seng-Kee Chuah Chen-Hsiang Lee Chih-Ming Liang Lung-Sheng Lu Yuan-Hung Kuo Yi-Hao Yen Ming-Luen Hu Yeh-Pin Chou Shih-Cheng Yang Chung-Mou Kuo Chung-Huang Kuo Chun-Chih Chien Yu-Shao Chiang Shue-Shian Chiou Tsung-Hui Hu Wei-Chen Tai | 2015 | World Journal of Gastroenterology2015，21，37： | 3 |
| 15 | One-bath synthesis of hydrophilic molecularly imprinted quantum dots for selective recognition of chlorophenol显示文摘简单一个洗澡策略被开发了综合新奇 CdTe@SiO2@MIP (分子地印了并且 silica-functionalized CdTe 量点, MISFQD ),在哪个硅石壳在 CdTe 量点( CdTe@SiO2 QD )的表面上是涂的然后为 4-chlorophenol ( 4-CP )的选择识别的聚合物作为 stabilizer 用 mercaptoacetic 酸在 CdTe@SiO2 QD 的表面上被构造, 3-aminopropyl-trimethoxysilane ( APTES )同样功能的单体和 tetraethoxysilane ( TEOS )作为交叉连接一CdTe@SiO2@MIP 的结构被 ultravioletvisible 吸收,荧光,英尺红外光谱和粉末 X 光检查衍射分析。CdTe@SiO2@MIP 的应用程序和描述被实验调查。所有结果显示 CdTe@SiO2@MIP 罐头有选择地认出 4-chlorophenol。 | Tai Ye Shi Yan Lu Qin Qin Hu Xin Jiang Guo Fen Wei Jing Jing Wang Jian Quan Lu | 2011 | Chinese Chemical Letters2011，22，10： | 2 |
| 16 | Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer显示文摘 | Yu-Chih Chen Yi-Wei Chen Han-Shui Hsu Ling-Ming Tseng Pin-I Huang Kai-Hsi Lu Dow-Tien Chen Lung-Kuo Tai Ming-Chi Yung Shih-Ching Chang Hung-Hai Ku Shih-Hwa Chiou Wen-Liang Lo | 2009 | Biochemical and Biophysical Research Communications2009，，3： | 2 |
| 17 | Adenosine 5'-triphosphate stimulates the increase of TGF-β1 in rat mesangial cells under high-glucose conditions via reactive oxygen species and ERK1/2显示文摘 | Lin-ping QU Hong XUE Ping YUAN Li ZHOU Tai YAO Yu HUANG Li-min LU | 2009 | Acta Pharmacologica Sinica2009，30，12： | 2 |
| 18 | Accurate and generalizable quantitative scoring of liver steatosis from ultrasound images via scalable deep learning显示文摘BACKGROUND Hepatic steatosis is a major cause of chronic liver disease.Two-dimensional(2D)ultrasound is the most widely used non-invasive tool for screening and monitoring,but associated diagnoses are highly subjective.AIM To develop a scalable deep learning(DL)algorithm for quantitative scoring of liver steatosis from 2D ultrasound images.METHODS Using multi-view ultrasound data from 3310 patients,19513 studies,and 228075 images from a retrospective cohort of patients received elastography,we trained a DL algorithm to diagnose steatosis stages(healthy,mild,moderate,or severe)from clinical ultrasound diagnoses.Performance was validated on two multiscanner unblinded and blinded(initially to DL developer)histology-proven cohorts(147 and 112 patients)with histopathology fatty cell percentage diagnoses and a subset with FibroScan diagnoses.We also quantified reliability across scanners and viewpoints.Results were evaluated using Bland-Altman and receiver operating characteristic(ROC)analysis.RESULTS The DL algorithm demonstrated repeatable measurements with a moderate number of images(three for each viewpoint)and high agreement across three premium ultrasound scanners.High diagnostic performance was observed across all viewpoints:Areas under the curve of the ROC to classify mild,moderate,and severe steatosis grades were 0.85,0.91,and 0.93,respectively.The DL algorithm outperformed or performed at least comparably to FibroScan control attenuation parameter(CAP)with statistically significant improvements for all levels on the unblinded histology-proven cohort and for“=severe”steatosis on the blinded histology-proven cohort.CONCLUSION The DL algorithm provides a reliable quantitative steatosis assessment across view and scanners on two multi-scanner cohorts.Diagnostic performance was high with comparable or better performance than the CAP. | Bowen Li Dar-In Tai Ke Yan Yi-Cheng Chen Cheng-Jen Chen Shiu-Feng Huang Tse-Hwa Hsu Wan-Ting Yu Jing Xiao Lu Le Adam P Harrison | 2022 | World Journal of Gastroenterology2022，28，22： | 2 |
| 19 | Down-regulation of tumor suppressor gene PTEN, overexpression of p53,plus high proliferating cell nuclear antigen index predict poor patient outcomeof hepatocellular carcinoma after resection显示文摘 | Tsung-Hui Hu Chih-Chi Wang Chao-Cheng Huang Chao-Long Chen Chao-Hung Hung Chien-Hung Chen Jing-Houng Wang Sheng-Nan Lu Chuan-Mo Lee Chi-Sin Changchien Ming-Hong Tai | 2007 | Oncology Reports2007，，： | 2 |
| 20 | Seven-Day Nonbismuth Containing Quadruple Therapy Could Achieve a Grade “A” Success Rate for First-Line Helicobacter pylori Eradication显示文摘 | Wei-Chen Tai Chih-Ming Liang Chen-Hsiang Lee Chien-Hua Chiu Ming-Luen Hu Lung-Sheng Lu Yuan-Hung Kuo Chung-Mou Kuo Yi-Hao Yen Chung-Huang Kuo Shue-Shian Chiou Keng-Liang Wu Yi-Chun Chiu Tsung-Hui Hu Seng-Kee Chuah Khean-Lee Goh | 2015 | BioMed Research International2015，，： | 2 |
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