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| 1 | Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery?显示文摘AIM To clarify which factors may influence pathological tumor response and affect clinical outcomes in patients with locally advanced rectal carcinoma treated with neo-adjuvant chemoradiotherapy and surgery.METHODS Tumor regression grade(TRG) according to the Dworak system and yT NM stage were assessed and correlated with pre-treatment clinico-pathological variables in 215 clinically locally advanced(c TNM stage Ⅱ and Ⅲ) rectal carcinomas. Prognostic value of all pathological and clinical factors on disease free survival(DFS) and cancer specific survival(CSS) was analyzed by Kaplan Meier and Cox-regression analyses.RESULTS cN + status, mucinous histotype or poor differentiation in the pre-treatment biopsy were significantly associated with lower pathological response(low Dworak grade and TNM remaining unchanged/upstaging). Cases showing acellular mucin pools in surgical specimens all had unremarkable clinical courses with no deaths or recurrences during follow-up. Dworak grade had prognostic significance for DFS and CSS. However, compared to the 5-tiered system, a simplified twotiered grading system, in which grades 0, 1 and 2 were grouped as absent/partial regression and grades 3 and 4 were grouped as total/subtotal regression, was more reproducible and prognostically informative. The twotiered Dworak system, yN stage, craniocaudal extension of the tumor and radial margin status were significant independent prognostic variables. CONCLUSION Our data suggest that caution should be applied in using a conservative approach in rectal carcinomas with c N+ status, extensive/lower involvement of the rectum and mucinous histotype or poor differentiation. Although Dworak TRG is prognostically significant, a simplified two-tiered system could be preferable. Finally, cases with acellular mucin pools should be carefully evaluated to definitely exclude residual mucinous carcinoma. | Luca Reggiani Bonetti Simona Lionti Federica Domati Valeria Barresi | 2017 | World Journal of Gastroenterology2017，23，8： | 7 |
| 2 | Measurement of Spleen Stiffness to Evaluate Portal Hypertension and the Presence of Esophageal Varices in Patients With HCV-Related Cirrhosis显示文摘 | Antonio Colecchia Lucia Montrone Eleonora Scaioli Maria Letizia Bacchi–Reggiani Agostino Colli Giovanni Casazza Ramona Schiumerini Laura Turco Anna Rita Di Biase Giuseppe Mazzella Luca Marzi Umberto Arena Massimo Pinzani Davide Festi | 2012 | Gastroenterology2012，，3： | 3 |
| 3 | Heavily calcified gastrointestinal stromal tumors:Pathophysiology and implications of a rare clinicopathologic entity显示文摘Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, and are characterized by a broad spectrum of clinical, histological and molecular features at presentation. Although focal and scattered calcifications are not uncommon within the primary tumor mass, heavy calcification within a GIST is rarely described in the literature and the clinical-biological meaning of this feature remains unclear. Cases with such an atypical presentation are challenging and may be associated with diagnostic pitfalls. Herein, we report a gastric GIST with the unusual presentation of prominent calcifications that was identified incidentally on imaging during a post-trauma diagnostic work-up. The patient underwent laparoscopic surgery with a radical resection of the mass, which was subsequently characterized by histological analysis as spindle-shaped tumor cells, positive for CD117/c-KIT, CD34 and DOG1, and with calcified areas. Given the intermediate risk of recurrence, no adjuvant therapy was recommended andthe patient underwent regular follow-up for 22 mo, with no evidence of relapse. Our case can be considered of interest because of the rarity of clinical presentation and the uniquely large size of the GIST at diagnosis(longest diameter exceeding 9 cm). In closing, we discuss the pathophysiology and clinical implications of calcifications in GISTs by reviewing the most up-to-date relevant literature. | Massimiliano Salati Giulia Orsi Luca Reggiani Bonetti Fabrizio Di Benedetto Giuseppe Longo Stefano Cascinu | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 2 |
| 4 | Clinical outcome of low- and high-risk malignant colorectal polyps: results of a population-based study and meta-analysis of the available literature显示文摘 | Carmela Di Gregorio Luca Reggiani Bonetti Carmela Gaetani Monica Pedroni Shaniko Kaleci Maurizio Ponz de Leon | 2014 | Internal and Emergency Medicine2014，，2： | 2 |
| 5 | SSJD14101300034250显示文摘 | Federica Domati Stefania Maffei Shaniko Kaleci Carmela Gregorio Monica Pedroni Luca Roncucci Piero Benatti Giulia Magnani Luigi Marcheselli Luca Reggiani Bonetti Francesco Mariani Antonio Maria Alberti Valerio Rossi Maurizio Ponz de Leon | 2014 | Internal and Emergency Medicine2014，，6： | 1 |
| 6 | Liver transplantation for hepatocellular carcinoma in a patient with a novel telomerase mutation and steatosis显示文摘 | Luca Valenti Paola Dongiovanni Marco Maggioni Benedetta Maria Motta Raffaela Rametta Marta Milano Silvia Fargion Paolo Reggiani Anna Ludovica Fracanzani | 2012 | Journal of Hepatology2012，，： | 1 |
| 7 | Immunohistochemical Assessment of Lymphovascular Invasion in Stage I Colorectal Carcinoma: Prognostic Relevance and Correlation With Nodal Micrometastases显示文摘 | Valeria Barresi Luca Reggiani Bonetti Enrica Vitarelli Carmela Di Gregorio Maurizio Ponz de Leon Gaetano Barresi | 2012 | The American Journal of Surgical Pathology2012，，1： | 1 |
| 8 | Adaping the ranging algorithm to the positioning tech- nique in UWB sensor networks显示文摘 | Mats Rydstrom Luca Reggiani Erik G Strom | 2008 | Wireless pers com- mun2008，47，1： | 1 |
| 9 | Pseudo-Chaotic Time Hopping for UWB Impulse Radio显示文摘 | Gian Mario Maggio Nikolai Rulkov Luca Reggiani | 2001 | IEEE Transactions on Circuits and Systems2001，48，12： | 1 |
| 10 | Common bile duct lesions-how cholangioscopy helps rule out intraductal papillary neoplasms of the bile duct:A case report显示文摘BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a rare variant of bile duct tumors,characterized by an exophytic growth exhibiting a papillary mass within the bile duct lumen and it can be localized anywhere along the biliary tree,with morphological variations and occasional invasion.CASE SUMMARY We present a patient with obstructive jaundice who was diagnosed with IPNB using cholangioscopy during endoscopic retrograde cholangio-pancreatography.Using the SpyGlass DS Ⅱ technology,we were able to define tumor extension and obtain targeted Spy-byte biopsies.After multidisciplinary evaluation,the patient was scheduled for surgical resection of the tumor,which was radically removed.CONCLUSION Cholangioscopy appears to be crucial for the rapid and clear diagnosis of lesions in the bile duct to achieve radical surgical resection. | Helga BertaniEndoscopy Unit Silvia Cocca Giuseppe Grande Luca Reggiani Bonetti Paolo Magistri Stefano Di Sandro Fabrizio DiBenedetto Rita Conigliaro Helga Bertani | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，12： | 0 |
| 11 | 直肠癌放疗损伤会阴肌肉显示文摘The interesting contribution of Qin et al.[1]about radiation injury on the rectum deserves to be integrated with observations regarding the equivalent damage to the perineal striated muscles.In approaching this topic,not yet extensively studied,we were interested at first in delineating its basic pathology by histological methods,as already proposed[2,3].For this,we selected from our anatomopathological archive 20 surgical specimens of abdominoperineal resections.In the first group,we enclosed 10 surgical specimens of lower rectal cancers operated on 5-6 weeks after a neoadjuvant radiochemotherapy,consisting of 50 Gy,fractioned in 5 weeks,and associated with a FOLFOX pharmacological treatment.In the second group,we included 5 cases of the same pathology,at a lower stage,and submitted for surgery 10 days after a‘short-term’neoadjuvant radiotherapy of 25 Gy in 5 fractions over 1 week.A third group encompassed 5 surgical specimens of abdominoperineal resection,performed for recurrent anal cancer 1 year after the same radiation treatment of 50 Gy as applied in the first group.From our study,we excluded cases with neoplastic infiltration of the perineal muscles,previous perineal surgery,radiation or trauma,systemic diseases such as diabetes,vasculitis,connective-tissue or musculoskeletal disorders,manifest atherosclerosis,morbid obesity,and poor nutrition.Clearly,the second and third groups were implemented for dose-and timerelated controls,in comparison to the first group.The perineal striated muscles found in the specimens were extensively studied with serial histological sections of 4mm and different staining techniques(Haematoxylin-Eosin,Trichrome Masson,and Mallory Azan). | Luca Reggiani Bonetti Antonio Manenti Graziana Gallo Federica Domati | 2020 | Gastroenterology Report2020，8，4： | 0 |
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