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| 1 | XS0601 REDUCES THE INCIDENCE OF RESTENOSIS: A PROSPECTIVE STUDY OF 335 PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION IN CHINA显示文摘Background XS0601, consisting of active ingredients (Chuangxiongol and paeoniflorin), has been shown to inhibit arterial neointimal hyperplasia in animal models and in preliminary human studies. The objective of this study was to evaluate the safety and efficacy of XS0601 in preventing restenosis following percutaneous coronary intervention (PCI). Methods A multi-center, randomized, double-blind, placebo-controlled trial was conducted. A total of 335 patients were randomized into treatment with the oral administration of XS0601, or a placebo for 6 months after successful PCI. Angiographic follow-up was scheduled at 6 months, and clinical follow-ups performed at 1, 3 and 6 months after PCI. The primary end point was angiographic restenosis. The secondary end points were the combined incidence of death, target lesion nonfatal myocardial infarction, repeat angioplasty, and coronary artery bypass graft surgery. Results A total of 308 patients (91.9%) completed the study and 145 cases (47.1%) received angiographic follow-up. The restenosis rates were significantly reduced in the XS0601 group as compared with the placebo group (26.0% vs. 47.2%, P < 0.05), and the minimum lumen diameter (MLD) was greater [(2.08 ± 0.89) mm for XS0601 vs. (1.73 ± 0.94) mm for placebo, P < 0.05]. XS0601 also significantly reduced the combined incidence of major adverse cardiac event (10.4% in the XS0601 group vs. 22.7% in the placebo group, P < 0.05). The incidence of recurrent angina at 3 and 6 months after PCI was also significantly reduced in XS0601 group (7.1% and 11.0%) as compared with those in placebo group (19.5% and 42.9%) (P < 0.05). No significant side effects occurred within the 6-month follow-up period in the XS0601 group. Conclusion Administration of XS0601 for 6 months is demonstrated to be safe and effective in reducing restenosis in post-PCI patients. | CHEN Ke-ji SHI Da-zhuo XU Hao LUE Shu-zheng LI Tian-chang KE Yuan-nan ZHANG Min-zhou LU Xiao-yan SUN Rui-yuan YOU Shi-jie | 2006 | Chinese Medical Journal2006，，1： | 83 |
| 2 | EFFECT OF ASPIRIN PLUS CLOPIDOGREL ON INFLAMMATORY MARKERS IN PATIENTS WITH NON-ST-SEGMENT ELEVATION ACUTE CORONARY SYNDROME显示文摘Background Aspirin can inhibit inflammatory reactions and platelet aggregation, but little is known about the effects of the combination of aspirin plus clopidogrel, a new antiplatelet agent, on inflammation. The purpose of this study was to determine whether aspirin plus clopidogrel can further suppress inflammation in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Methods One hundred and fifteen patients with NSTEACS were randomized into two groups: group A (aspirin alone, n=58) and group B (aspirin plus clopidogrel, n=57). Patients in group A received a loading dose of 300 mg aspirin, then 100 mg per day. The patients in group B received a loading dose of 300 mg aspirin and 300 mg clopidogrel, then 100 mg aspirin and 75 mg clopidogrel per day. Serum high sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α(TNF-α) were measured in all patients at baseline prior to any drug treatment after admission, and at 7 and 30 days after beginning drug treatment. Thirty healthy volunteers on no medications were enrolled as controls (group C). Results Baseline levels of hs-CRP and TNF-αin group A and group B were significantly higher than those in group C. Seven days after administration, the levels of hs-CRP in both group A and group B decreased significantly [Group A: (6.15 ± 1.39) mg/L vs (9.18 ± 1.62) mg/L, P <0.01; Group B:(4.99 ± 1.62) mg/L vs (10.29 ± 1.47) mg/L, P<0.01]. Similarly, levels of TNF-αin both groups decreased at 7 days compared to baseline [Group A: (90.99 ± 28.91) pg/ml vs (117.20 ± 37.13) pg/ml, P <0.01; Group B: (74.32± 21.83) pg/ml vs (115.27 ± 32.11) pg/ml, P <0.01]. Thirty days after administration, the levels of hs-CRP in both group A and group B decreased further to (3.49 ± 1.53) mg/L, and (2.40 ± 1.17) mg/L respectively (P <0.01 for both comparisons). Levels of TNF-αin groups A and B also decreased significantly between 7 and 30 days, to 63.28 ± 29.01 pg/ml (group A) and (43.95 ± 17.10) pg/ml (group B; P <0.01 for both comparisons). Significantly lower levels of hs-CRP and TNF-αwere observed in group B compared to Group A at thirty days after initiating drug treatment (P <0.05). Conclusions Aspirin plus clopidogrel treatment reduced levels of serum hs-CRP and TNF-α in patients with NSTEACS significantly more than aspirin alone. Because both aspirin and clopidogrel produce important anti-inflammatory effects, these results suggest the possibility that long-term treatment with aspirin plus clopidogrel may produce greater clinical benefits compared to treatment with aspirin alone. | CHEN Yu-guo XU Feng ZHANG Yun JI Qiu-shang SUN Yi LUE Rui-juan LI Rui-jian | 2006 | Chinese Medical Journal2006，，1： | 25 |
| 3 | Clay mineral composition and their sources for the fluvial sediments of Taiwan Residents rivers显示文摘Located at the collision boundary between the Philippine Sea Plate and the Eurasian Continental Plate,the island of Taiwan is generally recognized as an important example in the MARGINS Program Science Plan and 'source-to-sink' research because of its high tectonic activity,heavy rainfall and unique geography.Large suspended sediment loads are transported to the adjacent ocean by Taiwan Residents rivers every year,making Taiwan an important source of sediments into the adjacent seas and a natural laboratory for studying the systemic movement of fluvial sediments from source to sink.A detailed study on the clay mineral composition of surface sediments collected from the drainage basins of 12 Taiwan Residents rivers using X-ray diffraction methods was conducted.Our results indicated that the clay mineral assemblages consisted dominantly of illite(approximately 73%) and chlorite(approximately 24%),with lesser abundances of kaolinite(approximately 3%) and even lower levels of smectite from the Danshuei River sediments in northwestern Taiwan.The Jhuoshuei River sediments from western Taiwan contained clay mineral assemblages that consisted of illite(approximately 75%) and chlorite(approximately 25%),but they lacked kaolinite and smectite.In southwestern Taiwan,the clay mineral assemblages were dominated by illite(approximately 75%) and chlorite(approximately 23%),but had a low abundance of kaolinite(generally < 2%) and no smectite.The clay mineral assemblages in eastern Taiwan are obviously different from those in western parts of the island.The most noticeable difference is that the average abundance of chlorite in the Hualien River from eastern Taiwan was the highest(approximately 48%) of all the Taiwan Residents rivers.We concluded that,in general,the clay mineral assemblages in Taiwan Residents rivers were mainly composed of illite and chlorite with kaolinite and smectite being scarce,and these trends are different from those in China's mainland rivers.The clay mineral composition shown in this study was primarily determined by the properties of the bedrock,and the differential weathering intensities of the drainage area.The surface sediments in Taiwan's rivers showed a greater abundance of illite and chlorite because the outcropped rocks were mainly composed of Tertiary sedimentary rocks,especially sandstone,shale and slate,and show strong physical weathering.The relatively high relief and more abundant rainfall also caused the clay minerals in the fluvial sediments to be transported to the estuaries down rivers from the mountains and then delivered to the adjacent seas by currents and waves over a shorter time scale. | LI ChuanShun SHI XueFa KAO ShuhJi CHEN MinTe LIU YanGuang FANG XiSheng LUE HuaHua ZOU JianJun LIU ShengFa QIAO ShuQing | 2012 | Chinese Science Bulletin2012，57，6： | 23 |
| 4 | Ozone mini-hole occurring over the Tibetan Plateau in December 2003显示文摘By analyzing the total ozone data from TOMS and ground-based observations, it is found that a large area with extremely low ozone occurred over the Tibetan Plateau during December 14-17, 2003. After correcting the bias in TOMS data, the area with the total ozone < 220 DU is found to be over 2500000 km2, and the minimum value is only 190 DU. It is the first time that an ozone mini-hole or an extremely low ozone event is found to occur over the Tibetan Plateau. | BIAN Jianchun WANG Gengchen CHEN Hongbin QI Donglin LUE Daren ZHOU Xiuji | 2006 | Chinese Science Bulletin2006，51，7： | 19 |
| 5 | Response of Stream Pollution Characteristics to Catchment Land Cover in Cao-E River Basin, China显示文摘This study addressed the relationship of river water pollution characteristics to land covers and human activities in the catchments in a complete river system named Cao-E River in eastern China.Based on the hydrogeochemical data collected monthly over a period of 3 years,cluster analysis(CA) and principal component analysis(PCA) were adopted to categorize the river reaches and reveal their pollution characteristics.According to the differences of water quality in the river reaches and land use patterns and average population densities in their catchments,the whole river system could be categorized into three groups of river reaches,i.e.,non-point sources pollution reaches(NPSPR),urban reaches(UR) and mixed sources pollution reaches(MSPR).In UR and MSPR,the water quality was mainly impacted by nutrient and organic pollution,while in NPSPR nutrient pollution was the main cause.The nitrate was the main nitrogen form in NPSPR and particulate phosphorus was the main phosphorus form in MSPR.There were no apparent trends for the variations of pollutant concentrations with increasing river flows in NPSPR and MSPR,while in UR the pollutant concentrations decreased with increasing river flows.Thus dry season was the critical period for water pollution control in UR.Therefore,catchment land covers and human activities had significant impact on river reach water pollution type,nutrient forms and water quality responses to hydrological conditions,which might be crucial for developing strategies to combat water pollution in watershed scale. | SHEN Ye-Na LUE Jun CHEN Ding-Jiang SHI Yi-Ming | 2011 | Pedosphere2011，21，1： | 13 |
| 6 | PROGNOSIS OF UNPROTECTED LEFT MAIN CORONARY ARTERY STENTING AND THE FACTORS AFFECTING THE OUTCOMES IN CHINESE显示文摘 | GAO Run-lin XU Bo CHEN Ji-lin HAN Ya-ling LI Zhan-quan LUE Shu-zheng QI Xiao-yong HUO Yong WANG Le-feng CHEN Jun-zhu SHEN Wei-feng FANG Wei-yi JIA San-qing | 2006 | Chinese Medical Journal2006，，1： | 10 |
| 7 | Relationship between intravascular ultrasound imaging features of coronary plaques and soluble CD105 level in patients with coronary heart disease显示文摘Plaque rupture with subsequent thrombus formation isthe common pathophysiological substrate of acutecoronary syndrome (ACS). Moreno et al reported thatneovascularization as manifested by the localizedappearance of microvessels is increased in rupturedplaques in the human aorta. Microvessel density is alsoincreased in inflammatory lesions, with intraplaquehemorrhage and in thin-cap fibroatheromas. Microvesselsat the base of the plaque are independently | CUI Song LUe Shu-zheng CHEN Yun-dai HE Guo-xiang LIU Jian-ping SONG Zhi-yuan SHU Mao-qin HU Hou-yuan RAN Bo-li JING Tao | 2007 | Chinese Medical Journal2007，，7： | 7 |
| 8 | Intracoronary adenosine improves myocardial perfusion in late reperfused myocardial infarction显示文摘背景:有临床的症候群和预后的心肌的灌注伙伴。腺苷能在 6 个小时以内改进尖锐心肌的梗塞的心肌的灌注,但是很少数据在心肌的梗塞(MI ) 的迟了的灌注上是可得到的。这研究瞄准了评估与心肌的对比回响心动描记法(MCE ) 在晚重新酒的 MI 改进心肌的灌注的 intracoronary 腺苷的价值的份量上。方法:有前面的墙梗塞的 26 个病人随机被划分成 2 个组:腺苷组(n = 12 ) 并且生理盐水组(n = 14 ) 。他们心肌的梗塞的历史是大约 3 - 12 个星期。当指导电线通过经皮的冠的干预(一种总线标准) 穿过损害时,腺苷或生理盐水被给,然后,汽球被扩大并且斯滕特氏印模膏(密码 / 密码精选) 在损害被植入。有经由冠的线路的 Sonovue 对比的对比脉搏定序 MCE 在一种总线标准以后在一种总线标准和 30 分钟前被做。录像测密度术和对比充满空白的区域用 CUSQ 离线的软件被计算。心功能和心脏的事件被跟随在上面在 30 天以内。结果:在在腺苷组的犯罪闭塞的冠的动脉的片断的灌注在盐的组比那好(5.71 +/- 0.29 对 4.95 +/- 1.22, P <
0.05 ) 。局部缺血的心肌的片断在一种总线标准以后显著地是 deminished,但是改善区域比在盐的组在腺苷组是更大的((1.56 +/- 0.60 ) 厘米(2 ) 对(1.02 +/- 0.56 ) 厘米(2 ) , P <
0.05 ) 。在批评片断的录像测密度术也在腺苷组显著地被改进(5.53 +/- 0.36 对 5.26 +/- 0.35, P <
0.05 ) 。左室的喷射部分(LVEF ) 在一种总线标准以后在所有病人被改进,但是 EF 不在二个组之间是重要的((67 +/- 6 )% 对(62 +/- 7 )% , P >
0.05 ) 。在腺苷组没有在里面医院或 30 天的主要不利心脏的事件(向) ,但是在 saline 的 3 向在一种总线标准以后在 30 组织天。结论:腺苷能在相关动脉(在 AMI 以后的 3 ~ 12 个星期) 和在后续时期的临床的结果,和心肌的微脉管的灌注是的堵塞梗塞的迟了的再开改进心肌的微脉管的灌注临床的事件的一个强大的预言者。 | TIAN Feng CHEN Yun-dai LUE Shu-zheng SONG Xian-tao YUAN Fei FANG Fang LI Zhi-an | 2008 | Chinese Medical Journal2008，，3： | 5 |
| 9 | ^(226)Ra evidence for the ecosystem shift over the past 40 years in the North Pacific Subtropical Gyre显示文摘Surface seawater was collected for ^(226)Ra measurement in the North Pacific Subtropical Gyre from July to October, 1999 and October to December, 2003. Combined with the historical data reported for this sea area, a declined trend of surface ^(226)Ra concentrations was observed since 1960s, indicating the ecosystem shift in response to global warming. On one side, the enhanced stratification of the upper water column resulting from global warming reduced the ^(226)Ra input from the depth, on the other, the temporal increase of biological production resulting from the climate-related ecosystem structure change strengthened the ^(226)Ra removal from the surface ocean. Both the physical and biological processes resulted in the decrease of surface ^(226)Ra concentrations in the North Pacific Subtropical Gyre. The temporal trend of surface ^(226)Ra concentrations was consistent with the trends of chlorophyll a, silicate, phosphate and primary production previously reported. This study provided ^(226)Ra evidence for the ecosystem shift under global change. | YANG JunHong CHEN Min QIU YuSheng LI YanPing MA Qiang LUE E ZHANG Run HUANG YiPu | 2007 | Chinese Science Bulletin2007，52，6： | 5 |
| 10 | Mechanism of local scour around submarine pipelines based on numerical simulation of turbulence model显示文摘The mechanism of local scour around submarine pipelines is studied numerically based on a renormalized group (RNG) turbulence model. To validate the numerical model, the equilibrium profiles of local scour for two cases are simulated and compared with the experimental data. It shows that the RNG turbulence model can give an appropriate prediction for the configuration of equilibrium scour hole, and it is applicable to this situation. The local scour mechanism around submarine pipelines including the flow structure, shear stress distribution and pressure field is then analyzed and compared with experiments. For further comparison and validation, especially for the flow structure, a numerical calculation employing the large eddy simulation (LES) is also conducted. The numerical results of RNG demonstrate that the critical factor governing the equilibrium profile is the seabed shear stress distribution in the case of bed load sediment transport, and the two-equation RNG turbulence model coupled with the law of wall is capable of giving a satisfying estimation for the bed shear stress. Moreover, the piping phenomena due to the great difference of pressure between the upstream and downstream parts of pipelines and the vortex structure around submarine pipelines are also simulated successfully, which are believed to be the important factor that lead to the onset of local scour. | LUE Lin LI Yucheng CHEN Bing | 2006 | Acta Oceanologica Sinica2006，25，2： | 5 |
| 11 | Influence of particle composition on thorium scavenging in the marginal China seas显示文摘Thorium-234 and particle composition (organic matter, biogenic silica, carbonate and lithogenic component) were examined in the East China Sea (ECS) and the northern South China Sea (NSCS) in order to constrain the particle types scavenging thorium isotopes. Good positive correlations be-tween particulate organic matter (POM) or carbonate and thorium-234 in suspended particulate matter (SPM) indicates that POM and carbonate are efficient to scavenge thorium-234. No relation-ship between biogenic silica and thorium-234 suggests that geochemical behavior of thorium-234 may be not influenced by biogenic silica. A simple model was used to evaluate the affinity of thorium-234 to different particle components. The results show that POM is the most efficient scavenger for thorium-234 in the ECS and the NSCS, followed by carbonate. The authors’ re-sults lend support to the utility of thorium-234 as a proxy of POC and carbonate in the upper layer. However, the strong dependence of thorium scavenging on particle composition challenges thorium-230 as a constant flux proxy. | YANG Weifeng CHEN Min CAO Jianping QIU Yusheng ZHANG Run MA Qiang TONG Jinlu YANG Junhong YANG Zhi LUE E | 2009 | Acta Oceanologica Sinica2009，28，2： | 4 |
| 12 | Advances in Researches on the Middle and Upper Atmosphere in 2008-2010显示文摘This paper summarizes the results of the researches on the middle and upper atmosphere obtained by Chinese scientists in 2008-2010.The focuses are specifically placed on the researches being associated with ground-based observation capability development,dynamical processes,the property of atmospheric circulation and the chemistry-climate coupling of the middle atmospheric layers. | Chen Zeyu Chen Hongbin Lue Daren Xu Jiyao Chen Wen Tian Wenshou Ren Rongcai Hu Yongyun Huang Kaiming | 2010 | 空间科学学报2010，30，5： | 2 |
| 13 | Hybrid Dirac semimetal-based photodetector with efficient low-energy photon harvesting显示文摘Despite the considerable effort,fast and highly sensitive photodetection is not widely available at the low-photon-energy range(~meV)of the electromagnetic spectrum,owing to the challenging light funneling into small active areas with efficient conversion into an electrical signal.Here,we provide an alternative strategy by efficiently integrating and manipulating at the nanoscale the optoelectronic properties of topological Dirac semimetal PtSe_(2)and its van der Waals heterostructures.Explicitly,we realize strong plasmonic antenna coupling to semimetal states near the skin-depth regime(λ/10^(4)),featuring colossal photoresponse by in-plane symmetry breaking.The observed spontaneous and polarization-sensitive photocurrent are correlated to strong coupling with the nonequilibrium states in PtSe_(2)Dirac semimetal,yielding efficient light absorption in the photon range below 1.24 meV with responsivity exceeding∼0.2 A/W and noise-equivalent power(NEP)less than~38 pW/Hz^(0.5),as well as superb ambient stability.Present results pave the way to efficient engineering of a topological semimetal for high-speed and low-energy photon harvesting in areas such as biomedical imaging,remote sensing or security applications. | Lin Wang Li Han Wanlong Guo Libo Zhang Chenyu Yao Zhiqingzi Chen Yulu Chen Cheng Guo Kaixuan Zhang Chia-Nung Kuo Chin Shan Lue Antonio Politano Huaizhong Xing Mengjie Jiang Xianbin Yu Xiaoshuang Chen Wei Lu | 2022 | Light(Science & Applications)2022，11，3： | 2 |
| 14 | Relationship between MDR1 polymorphism and blood concentration of cyclosporine A显示文摘 | WANG Wei ZHANG Xiao-dong GUAN De-lin LUE Yue-ping MA Lin-lin HU Xiao-peng ZHANG Peng WANG Yong CHEN Xiao | 2005 | Chinese Medical Journal2005，，24： | 2 |
| 15 | Taxonomic status of the Taiwanese Gekko,with comments on the synonymy of Luperosaurus amissus Taylor显示文摘 | Ota H Lue K Y Chen S H | 1989 | Journal of Herpetology1989，23，1： | 1 |
| 16 | Effects of elevated CO2 on the foraging behavior of cotton bollworm, Helicoverpa armigera显示文摘Huebner 在在成年的春小麦的似牛奶的谷物上饲养了的棉花 bollwormHelicoverpa 有佩带徽章权利的人的 foraging 行为上的提高的 CO_2 的效果周围,在开顶的房间(OTC ) 的 550 μ L /L and750 μ L /L CO_2 集中气氛被学习。结果显示了那:(ⅰ) 提高了显著地影响的 CO_2 吃的食物的类型和数量 byH。有佩带徽章权利的人一在周围的 CO_2-grown 小麦的似牛奶的谷物上高耸了比为幼虫在在 550 和 750 μ L /L CO_2 气氛种的小麦谷物上饲养了的一种蛾的幼虫的那些高重要;(ⅱ)当一种蛾的幼虫幼虫从不同 CO_2-grown 小麦( food-choicecondition )在混合似牛奶的谷物上被饲养时,幼虫的持续时间显著地增加了-蛹体重,成年长寿,和肥沃显著地减少了,与那些作比较在周围的 CO_2-grown 小麦的似牛奶的谷物上高耸了, 550 μL /L CO_2-grown 小麦和 750 μL /L CO_2-grown 小麦分别地;(ⅲ) 在 fructose 和总蛋白质和葡萄糖的内容的重要增加(GP ) 的内容的重要减少,直链淀粉,全部的糖类(TSC ) , TSC:在有 CO_2 升起的小麦谷物的 GP 比率,游离氨基酸和可溶性蛋白质;(ⅳ) 和精选牧草的 amount/food-choice 棉花一种蛾的幼虫 H 索引。有佩带徽章权利的人一是显著地积极的与 fructose 的内容和小麦谷物的 GP 相关,但是他们与葡萄糖,直链淀粉, TSC 和 TSC 的内容有显著地否定的关系:小麦谷物的 GP 比率。 | FA-JUN CHEN GANG WU JUN LUE FENG GE | 2005 | Insect Science2005，12，5： | 1 |
| 17 | Early use of cyclic TPN prevents further deterioration of liver functions for the TPN patients with impaired liver function显示文摘 | Hwang TL Lue MC Chen LL | 2000 | Hepatogastroenterology2000，47，35： | 1 |
| 18 | Health,financial stresses,and life satis- faction affecting late-life depression among older adults:a nation- wide, longitudinal survey in Taiwan 显示文摘 | Lue BH Chen LJ Wu SC | 2010 | Arch Gerontol Geriatr2010，50，1： | 1 |
| 19 | Social support and family functioning on psychological symptoms in elderly Chinese显示文摘 | LEUNG K K CHEN C Y LUE B H | 2006 | Arch Gerontol Geriatr2006，44，2： | 1 |
| 20 | Fabrication an field mission property studies of multiwall carbon nanotubes 显示文摘 | Chen S Y Miao H Y Lue J T | 2004 | J Phys D: Appl Phys2004，37，： | 1 |
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