|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatic resection can provide long-term survival of patients with non–early-stage hepatocellular carcinoma: Extending the Indication for resection?显示文摘 | Wen-Tsan Chang Wei-Yu Kao Gar-Yang Chau Chien-Wei Su Hao-Jan Lei Jaw-Ching Wu Cheng-Yuan Hsia Wing-Yiu Lui Kuang-Liang King Shou-Dong Lee | 2012 | Surgery2012，，5： | 6 |
| 2 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 3 | Blood hibernation: a novel strategy to inhibit systemic inflammation and coagulation induced by cardiopulmonary bypass显示文摘背景发炎和凝结亲密地是二大多数的 cross-linked 防卫机制,如果并非所有有机体到损害。在期间心肺绕过(CPB ) ,这二过程被激活并且通过几条普通小径与对方一起交往,它可以导致随后的机关机能障碍。在现在的学习,我们假设了氮的氧化物,前列腺素 E1 (PGE1 ) ,和到全身的发行量的 aprotinin 的增加,在此把冬眠叫作血,将稀释 CPB 导致的发炎和凝结。三十条成年杂种狗同等地被划分成五个组,的方法 anesthetized 并且放了在低体温的 CPB (32 C ) 上。每个组分别地接受了下列处理:(1 ) 40 ppm 的吸入氮的氧化物;(2 ) 20 ng 的静脉内的注入 ????? ??? ???? ￣ ???????? 倠 ???‵?? | ZHOU Jing WU Xiao-dong LIN Ke Raphael C. Lui AN Qi TAO Kai-yu DU Lei LIU Jin | 2010 | Chinese Medical Journal2010，，13： | 5 |
| 4 | Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy显示文摘BK polyomavirus-associated nephropathy(BKPyVAN)is a common cause of allograft failure.However,differentiation between BKPyVAN and type I T cell-mediated rejection(TCMR)is challenging when simian virus 40(SV40)staining is negative,because of the similarities in histopathology.This study investigated whether donor-derived cell-free DNA(ddcfDNA)can be used to differentiate BKPyVAN.Target region capture sequencing was applied to detect the ddcfDNAs of 12 recipients with stable graft function,22 with type I TCMR,21 with proven BKPy VAN,and 5 with possible Py VAN.We found that urinary ddcfDNA levels were upregulated in recipients with graft injury,whereas plasma ddcfDNA levels were comparable for all groups.The median urinary concentrations and fractions of ddcfDNA in proven BKPyVAN recipients were significantly higher than those in type I TCMR recipients(10.4 vs.6.1 ng/mL,P<0.001 and 68.4%vs.55.3%,P=0.013,respectively).Urinary ddcfDNA fractions(not concentrations)were higher in the BKPyVAN-pure subgroup than in the BKPyVAN-rejection-like subgroup(81.30%vs.56.64%,P=0.025).With a cut-off value of 7.81 ng/m L,urinary ddcf DNA concentrations distinguished proven BKPyVAN from type I TCMR(area under the curve(AUC)=0.848,95%confidence interval(95%CI):0.734 to 0.963).These findings suggest that urinary ddcf DNA is a non-invasive biomarker which can reliably differentiate BKPy VAN from type I TCMR. | Jia SHEN Luying GUO Wenhua LEI Shuaihui LIU Pengpeng YAN Haitao LIU Jingyi ZHOU Qin ZHOU Feng LIU Tingya JIANG Huiping WANG Jianyong WU Jianghua CHEN Rending WANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 4 |
| 5 | Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma显示文摘Glioblastoma(GBM),one of the most common primary intracranial malignant tumours,is very difficult to be completely excised by surgery due to its irregular shape.Here,we use an MRI/NIR fluorescence dual-modal imaging nanoprobe that includes superparamagnetic iron oxide nanoparticles(SPIONs)modified with indocyanine(Cy7)molecules and peptides(ANG orDANG)to locate malignant gliomas and guide accurate excision.Both peptides/Cy7-SPIONs probes displayed excellent tumour-homing properties and barrier penetrating abilities in vitro. | Ruoxi Xie Zijun Wu Fanxin Zeng Huawei Cai Dan Wang Lei Gu Hongyan Zhu Su Lui Gang Guo Bin Song Jinxing Li Min Wu Qiyong Gong | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 3 |
| 6 | Estimating reference evapotranspiration with the FAO Penman–Monteith equation using daily weather forecast messages显示文摘 | Jiabing Cai Yu Liu Tingwu Lei Luis Santos Pereira | 2007 | Agricultural and Forest Meteorology2007，，1： | 2 |
| 7 | The Safety, Tolerability, and Efficacy of Once-Daily Memantine (28 mg): A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial in Patients with Moderate-to-Severe Alzheimer’s Disease Taking Cholinesterase Inhibitors显示文摘 | George T. Grossberg Facundo Manes Ricardo F. Allegri Luis Miguel Gutiérrez-Robledo Sergio Gloger Lei Xie X. Daniel Jia Vojislav Pejovi? Michael L. Miller James L. Perhach Stephen M. Graham | 2013 | CNS Drugs2013，，6： | 1 |
| 8 | Elemene display anti-cancer ability on laryngeal cancer cells in vitro and in vivo显示文摘 | Lei Tao Liang Zhou Luying Zheng | 2006 | Cancer Chemother Pharmacol2006，，58： | 1 |
| 9 | Prognostic value and clinical relevance of the 6th Edition 2002 American Joint Committee on Cancer staging system in patient with resectable hepatocellular carcinoma显示文摘 | Lei HJ Chau GY Lui WY | 2006 | J Am Coll Surg2006，203，4： | 1 |
| 10 | Recent advanced development of stabilizing sodium metal anodes显示文摘As the application of next-generation energy storage systems continues to expand,rechargeable secondary batteries with enhanced energy density and safety are imperative for energy iteration.Sodium-ion batteries(SIBs)have attracted extensive attention and are recognized as ideal candidates for large-scale energy storage due to the abundant sodium resources and low cost.Sodium metal anodes(SMAs)have been considered as one of the most attractive anode materials for SIBs owing to their high specific capacity(1166 mAh g^(-1)),low redox potential,and abundant natural resources.However,the uncontrollable dendrite growth and inevitable side reactions on SMA lead to the continuous deterioration of the electrochemical performance,causing serious safety concerns and limiting their practical application in the future.Therefore,the construction of stable dendrite-free SMAs is a pressing problem for advanced sodium metal batteries(SMBs).In this review,we comprehensively summarize the research progress in suppressing the formation of sodium dendrite,including artificial solid electrolyte interphase(SEI),liquid electrolyte modification,three-dimensional(3D)host materials,and solid-state electrolyte.Additionally,key aspects and prospects of future research directions for SMAs are highlighted.We hope that this timely review can provide an overall picture of sodium protection strategies and stimulate more research in the future. | Liyu Zhu Yucheng Li Jingyang Zhao Jing Liu Luying Wang Jiandu Lei | 2023 | Green Energy & Environment2023，8，5： | 1 |
| 11 | Tracking transplanted ceils in live animal using upconversion fluorescent nanoparticles 显示文摘 | Idris Niagara Muhammad Li Zhengquan Ye Lei Sim Eugene Kwang Wei Mahendran Ratha Ho Paul Chi Lui Zhang Yong | 2009 | Biomaterials2009，30，28： | 1 |
| 12 | Serum levels of the novel adipokine isthmin-1 are associated with obesity in pubertal boys显示文摘Objectives To evaluate whether there is an association between the serum levels of the novel insulin-like adipokine isthmin-1(ISM1)and obesity-related phenotypes in a population of Spanish children and to investigate the plausible molecular alterations behind the alteration of the serum levels of this protein in children with obesity.Methods The study population is a sub-cohort of the PUBMEP research project,consisting of a cross-sectional population of 119 pubertal children with overweight(17 boys,19 girls),obesity(20 boys,25 girls),and normal weight(17 boys,21 girls).All subjects were classified into experimental groups according to their sex,obesity,and insulin resistance(IR)status.They were counted anthropometry,glucose and lipid metabolism,inflammation and cardiovascular biomarkers as well as isthmin-1(ISM1)serum levels.This population was intended as a discovery population to elucidate the relationship between obesity and ISM1 levels in children.Furthermore,the study population had blood whole-genome DNA methylation examined,allowing deepening into the obesity–ISM1 molecular relationship.Results Higher serum ISM1 levels were observed in boys with obesity than in normal weight(P=0.004)and overweight(P=0.007)boys.ISM1 serum levels were positively associated with body mass index(BMI)Z-score(P=0.005)and fat mass(P=0.058)and negatively associated with myeloperoxidase(MPO)(P=0.043)in boys.Although we did not find associations between ISM1 serum levels and metabolic outcomes in girls,which may indicate a putative sexual dimorphism,fat mass was positively associated in all children,including boys and girls(P=0.011).DNA methylation levels in two-enhancer-related CpG sites of ISM1(cg03304641 and cg14269097)were associated with serum levels of ISM1 in children.Conclusions ISM1 is associated with obesity in boys at the pubertal stage,elucidating how this protein might be of special relevance as a new biomarker of obesity in children.Further studies including a longitudinal design during puberty are needed. | Francisco Javier Ruiz‑Ojeda Augusto Anguita‑Ruiz Maria C.Rico Rosaura Leis Gloria Bueno Luis A.Moreno Mercedes Gil‑Campos Ángel Gil Concepción M.Aguilera | 2023 | World Journal of Pediatrics2023，19，9： | 1 |
| 13 | Elemene displays anti-cancer ability on laryngeal cancer cells in vitro and in vivo 显示文摘 | Tao Lei Zhou Liang Zheng Luying | 2006 | Cancer Chemother Pharmacol2006，58，1： | 1 |
| 14 | A better option for patients with TGA/VSD and severe pulmonary hypertension undergoingpalliative arterial switch operation显示文摘 | Lui RC Zhuang J Lei BF | 2012 | Ann Thorac Surg2012，93，2： | 1 |
| 15 | The expression of proto-oncogene eIF4E in laryngeal squamous cell carcinoma显示文摘 | LIANG Z LEI T LUYING Z | 2003 | Laryngoscope2003，113，7： | 1 |
| 16 | Scientific objectives of the Hot Universe Baryon Surveyor(HUBS) mission显示文摘The Hot Universe Baryon Surveyor(HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view,the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, difuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope. | Joel Bregman Renyue Cen Yang Chen Wei Cui Taotao Fang Fulai Guo Edmund Hodges-Kluck Rui Huang Luis C.Ho Li Ji Suoqing Ji Xi Kang Xiaoyu Lai Hui Li Jiangtao Li Miao Li Xiangdong Li Yuan Li Zhaosheng Li Guiyun Liang Helei Liu Wenhao Liu Fangjun Lu Junjie Mao Gabriele Ponti Zhijie Qu Chenxi Shan Lijing Shao Fangzheng Shi Xinwen Shu Lei Sun Mouyuan Sun Hao Tong Junfeng Wang Junxian Wang Q.Daniel Wang Song Wang Tinggui Wang Weiyang Wang Zhongxiang Wang Dandan Xu Haiguang Xu Heng Xu Renxin Xu Xiaojie Xu Yongquan Xue Hang Yang Feng Yuan Shuinai Zhang Yuning Zhang Zhongli Zhang Yuanyuan Zhao Enping Zhou Ping Zhou | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 1 |
| 17 | Analysis of parametric histogram from dynamic contrast‐enhanced MRI: application in evaluating brain tumor response to radiotherapy显示文摘 | Shin‐Lei Peng Chih‐Feng Chen Ho‐Ling Liu Chun‐Chung Lui Yu‐Jie Huang Tsung‐Han Lee Chiung‐Chih Chang Fu‐Nien Wang | 2012 | NMR Biomed2012，，4： | 1 |
| 18 | Artificial neural network modeling of plating rate and phosphorus content in the coatings of electroless nickel plating 显示文摘 | Wu Yating Shen Bin Lui Lei | 2008 | Journal of Materials Processing Technology2008，，205： | 1 |
| 19 | The expression of proto-oncogene eIF4E in laryngeal squamous cell carcinoma显示文摘 | HANG Z LEI T LUYING Z | 2003 | Laryngoscope2003，113，7： | 1 |
| 20 | The expression of proto-oncogene eIF4E in laryngeal squamous cell carcinoma显示文摘 | Liang Z Lei T LuYing Z | 2003 | Laryngoscope2003，113，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员