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| 1 | Prognostic evaluation of postoperative adjuvant therapy for operable cervical cancer:10 years'experience of National Cancer Center in China显示文摘Objective: The aim of this study was to investigate the prognostic factors and to evaluate the impact of adjuvant therapy on clinical outcome for early-stage cervical cancer.Methods: The clinical-pathological data of all 1,335 patients with the International Federation of Gynecology and Obstetrics(FIGO) Ib–IIa cervical cancer treated with primary radical surgery at the Chinese National Cancer Center between May 2007 and Dec 2013 were retrospectively reviewed.The median follow-up was 70 months.Results: Of all the patients,61.6% of the cases received adjuvant therapy,with 5-year disease-free survival(DFS)of 92.1% and 5-year overall survival(OS) of 95.0%.In multivariate analysis,differentiation of G3(P<0.05),lymph node metastasis(LNM,P<0.05) and lymphovascular space invasion(LVSI,P<0.05) were independent predictors for OS,while LNM(P<0.05),deep stroma invasion(DSI,P<0.05) and LVSI(P<0.05) were independent factors for DFS.The samples were stratified by histologic type,and cervical squamous cell carcinoma(SCC) was found to share the same independent factors except for differentiation of OS.As to patients with cervical adenocarcinoma/adenosquamous carcinoma(AC/ASC),differentiation was the independent predictor of OS(P<0.05); and LVSI of DFS(P<0.05).Of 236 patients with high-risk factors,there was no significant difference in survival between concurrent chemoradiotherapy(CCRT,n=195),radiotherapy(RT,n=24),and chemotherapy(CT,n=17).Among the 190 patients with LNM who underwent CCRT,124 cases showed improved DFS after sequential CT(P=0.118),with a recurrence rate decrease of 14%,though the difference was not statistically significant.Patients with single intermediate-risk factors like DSI or LVSI were found to partially benefit from adjuvant therapy,but the difference was not statistically significant.Conclusions: LNM,LVSI,DSI and differentiation were found to be independent prognostic factors for operable cervical cancer.Aggressive postoperative adjuvant therapy based on single risk factors in Chinese National Cancer Center could benefit survival.CCRT+CT outperformed CCRT in high-risk patients.For patients with single non-high-risk factor,the role of adjuvant therapy needs to be further discussed. | Tong Shu Dan Zhao Bin Li Yating Wang Shuanghuan Liu Pingping Li Jing Zuo Ping Ba i RongZhang Lingying Wu | 2017 | Chinese Journal of Cancer Research2017，29，6： | 12 |
| 2 | The study on the safety and efficacy of amnion graft for preventing the recurrence of moderate to severe intrauterine adhesions显示文摘Transcervical resection of adhesion(TCRA)is the standard treatment for the intrauterine adhesions,but the recurrence of adhesions is a tough problem for the gynecologist.In addition,the therapeutic strategy after TCRA about prevention of recurrence remains controversial especially for the patients with moderate to severe intrauterine adhesions(IUAs).Hence,we designed this study to explore the safety and efficacy of fresh amnion grafts for preventing the recurrence after TCRA for patients with moderate to severe IUAs.One hundred patients with moderate to severe IUAs who presented with a history of hypomenorrhea,amenorrhea and infertility were included in the study from January 2015 to December 2017.Patients were divided into amnion group(52 patients)and chitosan group(48 patients).Fresh amnion grafts or intrauterine injections of chitosan were administered after TCRA.Transvaginal ultrasonography(TVUS)and hysteroscopy were performed at the first and third month after the operation.The surgical procedures for all patients were completed successfully without relevant complications.In amnion group,8 patients exhibited relapse in the first month and 2 patients in three months after surgery;in chitosan group,23 women exhibited relapse in the first month and 18 patients in three months after surgery.Statistical analysis revealed that the recurrence rate of adhesion in amnion group was significantly lower than those of chitosan group in the first and three months after surgery(P1=0.000,P2=0.000).After TCRA,fresh amnion graft plays a significant role in preventing further adhesions than injections of chitosan. | Changjiang Li Aiqi Cai Congcong Sun Benyuan Wu Xinpei Chen Yanhua Mao Yingfeng Zhang Yating Gou Jie Yu Yuhan Wang Huanhuan Yu Jia Wang | 2020 | Genes & Diseases2020，7，2： | 11 |
| 3 | Bilayer dissolving microneedle array containing 5-fluorouracil and triamcinolone with biphasic release profile for hypertrophic scar therapy显示文摘Hypertrophic scar(HS)is an undesirable skin abnormality following deep burns or operations.Although intralesional multi-injection with the suspension of triamcinolone acetonide(TA)and 5-fluorouracil(5-Fu)has exhibited great promise to HS treatment in clinical,the difference of metabolic behavior between TA and 5-Fu remarkably compromised the treatment efficacy.Besides,the traditional injection with great pain is highly dependent on the skill of the experts,which results in poor compliance.Herein,a bilayer dissolving microneedle(BMN)containing TA and 5-Fu(TA-5-Fu-BMN)with biphasic release profile was designed for HS therapy.Equipped with several micro-scale needle tips,the BMN could be self-pressed into the HS with uniform drug distribution and less pain.Both in vitro permeation and in vivo HS retention tests revealed that TA and 5-Fu could coexist in the scar tissue for a sufficient time period due to the well-designed biphasic release property.Subsequently,the rabbit ear HS model was established to assess therapeutic efficacy.The histological analysis showed that TA-5-Fu-BMN could significantly reduce abnormal fibroblast proliferation and collagen fiber deposition.It was also found that the value of scar elevation index was ameliorated to a basal level,together with the downregulation of mRNA and protein expression of Collagen I(Col I)and transforming growth factor-β1(TGF-β1)after application of TA-5-Fu-BMN.In conclusion,the BMN with biphasic release profiles could serve as a potential strategy for HS treatment providing both convenient administrations as well as controlled drug release behavior. | Beibei Yang Yating Dong Yifeng Shen Ailin Hou Guilan Quan Xin Pan Chuanbin Wu | 2021 | Bioactive Materials2021，6，8： | 8 |
| 4 | Routing valley exciton emission of a WS_(2) monolayer via delocalized Bloch modes of in-plane inversion-symmetry-broken photonic crystal slabs显示文摘The valleys of two-dimensional transition metal dichalcogenides(TMDCs)offer a new degree of freedom for information processing.To take advantage of this valley degree of freedom,on the one hand,it is feasible to control valleys by utilizing different external stimuli,such as optical and electric fields.On the other hand,nanostructures are also used to separate the valleys by near-field coupling.However,for both of the above methods,either the required low-temperature environment or low degree of coherence properties limit their further applications.Here,we demonstrate that all-dielectric photonic crystal(PhC)slabs without in-plane inversion symmetry(C_(2) symmetry)can separate and route valley exciton emission of a WS2 monolayer at room temperature.Coupling with circularly polarized photonic Bloch modes of such PhC slabs,valley photons emitted by a WS_(2) monolayer are routed directionally and are efficiently separated in the far field.In addition,far-field emissions are directionally enhanced and have long-distance spatial coherence properties. | Jiajun Wang Han Li Yating Ma Maoxiong Zhao Wenzhe Liu Bo Wang Shiwei Wu Xiaohan Liu Lei Shi Tian Jiang Jian Zi | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 5 | Circular dichroism-like response of terahertz wave caused by phase manipulation via all-silicon metasurface显示文摘Chiral metasurfaces based on asymmetric meta-atoms have achieved artificial circular dichroism(CD),spin-dependent wavefront control,near-field imaging,and other spin-related electromagnetic control.In this paper,we propose and experimentally verify a scheme for achieving high-efficiency chiral response similar to CD of terahertz(THz)wave via phase manipulation.By introducing the geometric phase and dynamic phase in an all-silicon metasurface,the spin-decoupled terahertz transmission is obtained.The giant circular dichroism-like effect in the transmission spectrum is observed by using a random phase distribution for one of the circular polarization components.More importantly,the effect can be adjusted when we change the area of the metasurface illuminated by an incident terahertz beam.In addition,we also demonstrate the spin-dependent arbitrary wavefront control of the transmitted terahertz wave,in which one of the circularly polarized components is scattered,while the other forms a focused vortex beam.Simulated and experimental results show that this method provides a new idea for spin selective control of THz waves. | Jie Li Chenglong Zheng Guocui Wang Jitao Li Hongliang Zhao Yue Yang Zhang Zhang Maosheng Yang Liang Wu Jining Li Yating Zhang Yan Zhang Jianquan Yao | 2021 | Photonics Research2021，9，4： | 3 |
| 6 | IntegrinαEβ7^(+)T cells direct intestinal stem cell fate decisions via adhesion signaling显示文摘Intestinal stem cell(ISC)differentiation is regulated precisely by a niche in the crypt,where lymphocytes may interact with stem and transient amplifying(TA)cells.However,whether and how lymphocyte–stem/TA cell contact affects ISC differentiation is largely unknown.Here,we uncover a novel role of T cell–stem/TA cell contact in ISC fate decisions.We show that intestinal lymphocyte depletion results in skewed ISC differentiation in mice,which can be rescued by T cell transfer.Mechanistically,integrinαEβ7 expressed on T cells binds to E-cadherin on ISCs and TA cells,triggering E-cadherin endocytosis and the consequent Wnt and Notch signaling alterations.BlockingαEβ7−E-cadherin adhesion suppresses Wnt signaling and promotes Notch signaling in ISCs and TA cells,leading to defective ISC differentiation.Thus,αEβ7^(+)T cells regulate ISC differentiation at single-cell level through cell–cell contact-mediatedαEβ7−E-cadherin adhesion signaling,highlighting a critical role of the T cell–stem/TA cell contact in maintaining intestinal homeostasis. | Shiyang Chen Yajuan Zheng Xiaojuan Ran Hui Du Hua Feng Lei Yang Yating Wen Changdong Lin Shihui Wang Mengwen Huang Zhanjun Yan Dianqing Wu Hongyan Wang Gaoxiang Ge An Zeng Yi Arial Zeng Jianfeng Chen | 2021 | Cell Research2021，31，12： | 3 |
| 7 | Quantitative climatic reconstruction of the Last Glacial Maximum in China显示文摘Quantitative paleoclimatic reconstruction is crucial for understanding the operation and evolution of the global climate system.For example,a quantitative paleoclimatic reconstruction for the Last Glacial Maximum(18±2 ka14C,LGM)is fundamental to understanding the evolution of Earth’s climate during the last glacial-interglacial cycle.Previous quantitative palaeoclimate reconstructions in China are generally based on statistical comparison of modern pollen assemblages and modern climate data.These methods are based on the premise that vegetation-climate interactions remain the same through time,and implicitly assume that the interactions are independent of changes in seasonality and atmospheric CO2concentration.However,these assumptions may not always be valid,which may affect the reconstructions.Here,we present the results of a quantitative study of the LGM climate of China based on an improved inverse vegetation model which incorporates physiological processes combined with a new China Quaternary Pollen Database.The results indicate that during the LGM,mean annual temperature(ANNT),mean temperature of the coldest month(MTCO)and mean temperature of the warmest month in China were lower by^5.6±0.8,~11.0±1.6 and^2.6±0.9°C,respectively,compared to today,and that the changes in ANNT were mainly due to the decrease of MTCO.The ANNT decrease in southern China was^5.5±0.5°C.Mean annual precipitation was lower by^46.3±17.8 mm compared to today and was especially low in northern China(~51.2±21.4 mm)due to the decrease in summer rainfall.Comparison of our results with recent outputs from paleoclimatic modelling reveals that while the latter are broadly consistent with our estimated changes in mean annual climatic parameters,there are substantial differences in the seasonal climatic parameters.Our results highlight the crucial importance of developing seasonal simulation on paleoclimatic models,as well as the need to improve the quality of paleoclimatic reconstructions based on proxy records from geological archives. | Haibin WU Qin LI Yanyan YU Aizhi SUN Yating LIN Wenqi JIANG Yunli LUO | 2019 | Science China Earth Sciences2019，62，8： | 3 |
| 8 | Forest disturbances and the attribution derived from yearly Landsat time series over 1990–2020 in the Hengduan Mountains Region of Southwest China显示文摘Background:Natural forests in the Hengduan Mountains Region(HDMR)have pivotal ecological functions and provide diverse ecosystem services.Capturing long-term forest disturbance and drivers at a regional scale is crucial for sustainable forest management and biodiversity conservation.Methods:We used 30-m resolution Landsat time series images and the LandTrendr algorithm on the Google Earth Engine cloud platform to map forest disturbances at an annual time scale between 1990 and 2020 and attributed causal agents of forest disturbance,including fire,logging,road construction and insects,using disturbance properties and spectral and topographic variables in the random forest model.Results:The conventional and area-adjusted overall accuracies(OAs)of the forest disturbance map were 92.3% and 97.70%±0.06%,respectively,and the OA of mapping disturbance agents was 85.80%.The estimated disturbed forest area totalled 3313.13 km^(2)(approximately 2.31% of the total forest area in 1990)from 1990 to 2020,with considerable interannual fluctuations and significant regional differences.The predominant disturbance agent was fire,which comprised approximately 83.33% of the forest area disturbance,followed by logging(12.2%),insects(2.4%)and road construction(2.0%).Massive forest disturbances occurred mainly before 2000,and the post-2000 annual disturbance area significantly dropped by 55% compared with the pre-2000 value.Conclusions:This study provided spatially explicit and retrospective information on annual forest disturbance and associated agents in the HDMR.The findings suggest that China’s logging bans in natural forests combined with other forest sustainability programmes have effectively curbed forest disturbances in the HDMR,which has implications for enhancing future forest management and biodiversity conservation. | Yating Li Zhenzi Wu Xiao Xu Hui Fan Xiaojia Tong Jiang Liu | 2021 | Forest Ecosystems2021，8，4： | 2 |
| 9 | A full-process intelligent trial system for smart court显示文摘In constructing a smart court,to provide intelligent assistance for achieving more efficient,fair,and explainable trial proceedings,we propose a full-process intelligent trial system(FITS).In the proposed FITS,we introduce essential tasks for constructing a smart court,including information extraction,evidence classification,question generation,dialogue summarization,judgment prediction,and judgment document generation.Specifically,the preliminary work involves extracting elements from legal texts to assist the judge in identifying the gist of the case efficiently.With the extracted attributes,we can justify each piece of evidence’s validity by establishing its consistency across all evidence.During the trial process,we design an automatic questioning robot to assist the judge in presiding over the trial.It consists of a finite state machine representing procedural questioning and a deep learning model for generating factual questions by encoding the context of utterance in a court debate.Furthermore,FITS summarizes the controversy focuses that arise from a court debate in real time,constructed under a multi-task learning framework,and generates a summarized trial transcript in the dialogue inspectional summarization(DIS)module.To support the judge in making a decision,we adopt first-order logic to express legal knowledge and embed it in deep neural networks(DNNs)to predict judgments.Finally,we propose an attentional and counterfactual natural language generation(AC-NLG)to generate the court’s judgment. | Bin WEI Kun KUANG Changlong SUN Jun FENG Yating ZHANG Xinli ZHU Jianghong ZHOU Yinsheng ZHAI Fei WU | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，2： | 2 |
| 10 | Comprehensive Strategy for Keloid Treatment:Experience at Shanghai Ninth People's Hospital显示文摘Keloids are a notorious fibroproliferative disorder that may cause cosmetic concerns and life inconvenience.Various methods such as surgery,injection,and laser have been used;however,single treatments are at risk of recurrence;therefore,comprehensive therapy is the better solution.Here,we focused on the management of different medical interventions according to subjective and objective conditions of keloid patients and summarized several clinical comprehensive strategies based on our clinical experience.One original concept of laser combined with radiotherapy was also introduced as a promising method,especially for wide-based pathological scars. | Xiaoli WU Yating YANG Wei LIU Wenbo WANG Lingling XIA Xiaoqing WANG Qiong ZHAO Zhen GAO | 2020 | Chinese Journal Of Plastic and Reconstructive Surgery2020，2，2： | 2 |
| 11 | Electroless Ni–P–SiC composite coatings with superfine particles显示文摘 | Gao Jiaqiang Liu Lei Wu Yating Shen Bin Hu Wenbin | 2005 | Surface & Coatings Technology2005，，20： | 2 |
| 12 | Proteomic analysis of two functional states of the Golgi complex in mammary epithelial cells显示文摘 | Wu CC Yates JR 3rd Neville MC | | 0，，： | 1 |
| 13 | The friction and wear of electroless Ni-P matrix with PTFE and/or SiC particles composite显示文摘 | Hezhou Liu Bin Shen | 2006 | Tribol Inter2006，39，6： | 1 |
| 14 | Electroless plating of Cu - Ni - P alloy on PET fabrics and effect of plating parameters on the properties conductive fabrics 显示文摘 | Gala X Wu Yating Liu Lei | 2008 | Journal of Alloys and Compounds2008，455，： | 1 |
| 15 | The application of mass spectrometry to membrane proteomics显示文摘 | Wu C C Yates J R | 2003 | Nat Biotechnol2003，21，3： | 1 |
| 16 | Identifying tumor stem-like cells in mouse melanoma cell lines by analyzing the characteristics of side population cells显示文摘 | Jun Dou Ping Wen Weihua Hu Yating Li Yun Wu Chunsheng Liu Fengshu Zhao Kai Hu Jing Wang Chuilian Jiang Xiangfeng He Ning Gu | 2009 | Cell Biology International2009，，8： | 1 |
| 17 | The friction and wear of electroless Ni - P matrix with PTFE and/or SiC particles composite 显示文摘 | Wu Yating Liu Hezhou Shen Bin | 2006 | Tribology International2006，39，6： | 1 |
| 18 | The tribological behavior of electroless Ni-P - Gr - SiC composite 显示文摘 | Wu Yating Shen Bin Liu Lei | 2006 | Wear2006，261，2： | 1 |
| 19 | Crystallization temperature of amorphous electroless nickel–phosphorus alloys显示文摘 | Gao Jiaqiang Wu Yating Liu Lei Shen Bin Hu Wenbin | 2005 | Materials Letters2005，，13： | 1 |
| 20 | 显示文摘 | Gan Xueping Wu Yating Liu Lei | 2008 | Journal of Alloys and Compounds2008，455，： | 1 |
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