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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Alcohol consumption on pancreatic diseases显示文摘Although the association between alcohol and pancreatic diseases has been recognized for a long time,the impact of alcohol consumption on pancreatitis and pancreatic cancer(PC)remains poorly defined.Nowadays there is not consensus about the epidemiology and the beverage type,dose and duration of alcohol consumption causing these diseases.The objective of this study was to review the epidemiology described in the literature for pancreatic diseases as a consequence of alcoholic behavior trying to understand the association between dose,type and frequency of alcohol consumption and risk of pancreatitis and PC.The majority of the studies conclude that high alcohol intake was associated with a higher risk of pancreatitis(around 2.5%-3% between heavy drinkers and 1.3%between non drinkers).About 70%of pancreatitis are due to chronic heavy alcohol consumption.Although this incidence rate differs between countries,it is clear that the risk of developing pancreatitis increases with increasing doses of alcohol and the average of alcohol consumption vary since 80 to 150 g/d for 10-15 years.With regard to PC, the role of alcohol consumption remains less clear,and low to moderate alcohol consumption do not appear to be associated with PC risk,and only chronic heavy drinking increase the risk compared with lightly drinkers.In a population of 10%-15%of heavy drinkers, 2%-5%of all PC cases could be attributed to alcohol consumption.However,as only a minority(less than 10%for pancreatitis and 5%for PC)of heavily drinkers develops these pancreatic diseases,there are other predisposing factors besides alcohol involved.Genetic variability and environmental exposures such as smoking and diet modify the risk and should be considered for further investigations. | Marta Herreros-Villanueva Elizabeth Hijona Jesus Maria Baales Angel Cosme Luis Bujanda | 2013 | World Journal of Gastroenterology2013，19，5： | 3 |
| 3 | Long-termfunctional and morphological assessment of a stand-ardized rat sciatic nerve crush injury with a non-ser-rated clamp显示文摘 | Luis AL Amado S Geuna S | 2007 | Neurosci Methods2007，163，1： | 1 |
| 4 | Cartilage regeneration using principles of tissue engineering显示文摘 | LUIS A SOLCHAGA P D VICTOR M et al | 2001 | Clin Orthop Res2001，，： | 1 |
| 5 | How does fish metamorphosis affect aromatic amino acid metabolism?显示文摘 | Wilson Pinto Luis Figueira Maria Teresa Dinis ct al | 2009 | Amino Acids2009，36，： | 1 |
| 6 | The management and outcome oflateral process fracture of the talus显示文摘 | Perera A Baker JF Lui DF ei al | 2010 | Foot Ankle Surg2010，1，： | 1 |
| 7 | Effect oftemperature on chilling in jury, decay and quality of hami melon during storage显示文摘 | Bi Y Tian S Lui H ct al | 2003 | Post harvest Bio)ogy and Technology2003，29，22： | 1 |
| 8 | Relation of C-Reactive Protein to Coronary Collaterals in Patients With Stable Angina Pectoris and Coronary Artery Disease 显示文摘 | Arthur Kemer MD Luis Gruberg MD Alexander Goldberg MD et al | 2007 | Amer J Cardio2007，99，： | 1 |
| 9 | Stereo-Based All-Terrain Obstacle Detection Using Visual Saliency显示文摘 | Pedro S Magno G Luis C el al | 2011 | Journal of Field Robotics2011，28，2： | 1 |
| 10 | Cellwall-degrading isoenzyme profiles of Trichoderma biocontrol strains show correlation with tDNA taxonomic species显示文摘 | Luis Sanz ManuelMontero lsabel Grondona et al | 2004 | Curr Genet2004，46，： | 1 |
| 11 | Antifibrotic therapy for the treatment of pulmonary fibrosis显示文摘 | Luis AO | 2001 | Am J Med Sci2001，322，7： | 1 |
| 12 | Relation of Trp64Arg Polymorphism of Beta 3-Adrenergic Receptor Gene to Adipocytokines and Fat Distribution in Obese Patients 显示文摘 | DE LUIS D A ALLER R IZAOLA O el al | 2008 | Ann Nutr Metab2008，52，4： | 1 |
| 13 | Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer 显示文摘 | Zhang Q Bhola NE Lui VW ct al | 2007 | Mol Cancer Ther2007，，4： | 1 |
| 14 | Low prevalence of autoimmune diabetes markers in a mixed ethnic population of Singaporean diabetics显示文摘 | Todd AL~ Ng 'vVYj Lui KF~ | 2004 | Intern MedJ2004，34，12： | 1 |
| 15 | Influence of insulin resistance and adipokines in the grade of steatosis of nonalcoholic fatty liver disease显示文摘 | Aller R de Luis DA Fernandez L el al | 2008 | Dig Dis Sci2008，53，4： | 1 |
| 16 | MHC class II sequences of susceptibility and protection in Mexicans with autoimmune hepatitis显示文摘 | Miriam Nohemí Vázquez-García Carmen Aláez Angélica Olivo Héctor Debaz Elva Pérez-Luque Ana Burguete Silvia Cano Gabriela de la Rosa Norma Bautista Arturo Hernández José Bandera Luis Fernando Torres David Kershenobich Fernando Alvarez Clara Gorodezky | 1998 | Journal of Hepatology1998，，6： | 1 |
| 17 | Correlation between genetic variations in Hox clusters and Hirschsprung's disease显示文摘 | Garcia - Barcelo MM Miao X Lui VC et al | 2007 | Ann Hum Genet2007，71，4： | 1 |
| 18 | Association study of PHOX2B as a candidate gene for Hirschsprung's disease 显示文摘 | Garcia- Barcelo M Sham MH Lui VC et al | 2003 | Gut2003，52，4： | 1 |
| 19 | Cystic nephroma: a histologic and immunohistochemical study of 10 cases显示文摘 | MUKHOPADHYAY S VALENTE AL LUIS A | 2004 | Arch Path Lab Med2004，128，： | 1 |
| 20 | Association of gamma- glutamyltransferase,metabolic syndrome and cardiovascular risk显示文摘 | Maria Carmo Martins Luis Lima Faleiro Beatriz Afonso et al | 2010 | Acta Med Port2010，23，4： | 1 |
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