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| 1 | Intraoperative laparoscopic complications for urological cancer procedures显示文摘AIM: To structure the rate of intraoperative complications that requires an intraoperative or perioperative resolution. METHODS: We perform a literature review of Medline database. The research was focused on intraoperative laparoscopic procedures inside the field of urological oncology. General rate of perioperative complications in laparoscopic urologic surgery is described to be around 12.4%. Most of the manuscripts published do not make differences between pure intraoperative, intraoperative with postoperative consequences and postoperative complications. RESULTS: We expose a narrative statement of complications, possible solutions and possible preventions for most frequent retroperitoneal and pelvic laparoscopic surgery. We expose the results with the following order: retroperitoneal laparoscopic surgery(radical nephrectomy, partial nephrectomy, nephroureterectomy and adrenalectomy) and pelvic laparoscopic surgery(radical prostatectomy and radical cystectomy).CONCLUSION: Intraoperative complications vary from different series. More scheduled reports should be done in order to better understand the real rates of complications. | Sergio Fernández-Pello Montes Ivan Gonzalez Rodríguez Rodrigo Gil Ugarteburu Luis Rodríguez Villamil Begoa Diaz Mendez Patricio Suarez Gil Javier Mosquera Madera | 2015 | World Journal of Clinical Cases2015，3，5： | 4 |
| 2 | Capsule endoscopy capture rate: Has 4 frames-per-second any impact over 2frames-per-second?显示文摘AIM: To compare the current capsule and a new prototype at 2 and 4 frames-per-second, respectively, in terms of clinical and therapeutic impact. METHODS: One hundred patients with an indication for capsule endoscopy were included in the study. All procedures were performed with the new device(SB24). After an exhaustive evaluation of the SB24 videos, they were then converted to 'SB2-like' videos for their evaluation. Findings, frames per finding, and clinical and therapeutic impact derived from video visualization were analyzed. Kappa index for interobserver agreement and χ2 and Student's t tests for qualitative/quantitative variables, respectively, were used. Values of P under 0.05 were considered statistically significant.RESULTS: Eighty-nine out of 100 cases included in the study were ultimately included in the analysis. The SB24 videos detected the anatomical landmarks(Zline and duodenal papilla) and lesions in more patients than the 'SB2-like' videos. On the other hand, the SB24 videos detected more frames per landmark/lesion than the 'SB2-like' videos. However, these differences were not statistically significant(P > 0.05). Both clinical and therapeutic impacts were similar between SB24 and 'SB2-like' videos(K = 0.954). The time spent by readers was significantly higher for SB24 videos visualization(P < 0.05) than for 'SB2-like' videos when all images captured by the capsule were considered. However, these differences become non-significant if we only take into account small bowel images(P > 0.05).CONCLUSION: More frames-per-second detect more landmarks, lesions, and frames per landmark/lesion, but is time consuming and has a very low impact on clinical and therapeutic management. | Ignacio Fernandez-Urien Cristina Carretero Erika Borobio Ana Borda Emilio Estevez Sara Galter Begoa Gonzalez-Suarez Benito Gonzalez Marisol Lujan Jose Luis Martinez Vanessa Martínez Pedro Menchén Javier Navajas Vicente Pons Cesar Prieto Julio Valle | 2014 | World Journal of Gastroenterology2014，20，39： | 2 |
| 3 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 4 | Iron Activation of Natural Aluminosilicates to Remove Arsenic from Groundwater显示文摘 | Irma Lia Botto Maria Jose Gonzalez Delia Gazzolli Edgardo Luis Soto | 2013 | Journal of Environmental Science and Engineering(A)2013，2，12： | 2 |
| 5 | Antioxidant and immunomodulatory effects of Viusid in patients with chronic hepatitis C显示文摘AIM:To investigate the efficacy of Viusid,a nutritional supplement,as an antioxidant and an immunomodulator in patients with chronic hepatitis C.METHODS:Sixty patients with chronic hepatitis C who were non-responders to standard antiviral treatment were randomly assigned to receive Viusid(3 sachets daily,n=30) or placebo(n=30) for 24 wk.The primary outcome was the change in serum malondialdehyde and 4-hydroxyalkenals(lipid peroxidation products).Secondary outcomes were changes in serum tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ) and interleukin-10(IL-10).RESULTS:Statistically significant reductions in serum 4-hydroxyalkenals and malondialdehyde levels were observed in both groups in comparison with pretreatment values,but the patients who received Viusid showed a more marked reduction as compared with the control group(P=0.001).TNF-α levels significantly increased from 6.9 to 16.2 pg/mL(P< 0.01) in the patients who received placebo in comparison with almost unchanged levels,from 6.6 to 7.1 pg/mL(P=0.26),in the patients treated with Viusid(P=0.001).In addition,IL-10 levels were markedly increased in the patients treated with Viusid(from 2.6 to 8.3 pg/mL,P=0.04) in contrast to the patients assigned to placebo(from 2.8 to 4.1 pg/mL,P=0.09)(P=0.01).Likewise,the administration of Viusid markedly increased mean IFN-γ levels from 1.92 to 2.89 pg/mL(P< 0.001) in comparison with a reduction in mean levels from 1.80 to 1.68 pg/mL(P=0.70) in the placebo group(P< 0.0001).Viusid administration was well tolerated.CONCLUSION:Our results indicate that treatment with Viusid leads to a notable improvement of oxidative stress and immunological parameters in patients with chronic hepatitis C. | Eduardo Vilar Gomez Yadina Martinez Perez Hector Vega Sanchez Gretel Riveron Forment Enrique Arus Soler Luis Calzadilla Bertot Ali Yasells Garcia Maria del Rosario Abreu Vazquez Licet Gonzalez Fabian | 2010 | World Journal of Gastroenterology2010，16，21： | 2 |
| 6 | A procedure to assess the spatial variability in the importance of abiotic factors affecting distributions: the case of world freshwater fishes显示文摘 | Ana M. MANJARRES-HERNANDEZ Castor GUISANDE Emilio GARCiA-ROSELLO Patricia PELAYO-VILLAMIL Jacinto GONZALEZ-DAcOSTA Juirgen HEINE Luis GONZALEZ VILAS Carlos GRANADO-LORENClO Santiago R. DUQUE Jorge M. LOBO | 2018 | Current Zoology2018，64，5： | 2 |
| 7 | 在经历 transcatheter 的病人的 atrial 纤维性颤动的临床、预示的含意大动脉的阀门培植显示文摘 AIM: To study a cohort of consecutive patients under-going transcatheter aortic valve implantation (TAVI) and compare the outcomes of atrial fibrillation (AF) patients vs patients in sinus rhythm (SR). METHODS: All consecutive patients undergoing TAVI in our hospital were included. The AF group comprised patients in AF at the time of TAVI or with history of AF, and were compared with the SR group. Procedural, echocardiographic and follow-up variables were compared. Likewise, the CHA 2 DS 2-VASC stroke risk score and HAS-BLED bleeding risk score and antithrombotic treatment at discharge in AF patients were compared with that in SR patients. RESULTS: From a total of 34 patients undergoing TAVI, 17 (50%) were allocated to the AF group, of whom 15 (88%) were under chronic oral anticoagulation. Patients in the AF group were similar to those in the SR group except for a trend (P = 0.07) for a higher logistic EuroSCORE (28% vs 19%), and a higher prevalence of hypertension (82% vs 53%) and chronic renal failure (17% vs 0%). Risk of both stroke and bleeding was high in the AF group (mean CHA 2 DS 2-VASC 4.3, mean HAS-BLED 2.9). In the AF group, treatment at discharge included chronic oral anticoagulation in all except one case, and in association with an antiplatelet drug in 57% of patients. During a mean follow-up of 11 mo (maximum 32), there were only two strokes, none of them during the peri-procedural period: one in the AF group at 30 mo and one in the SR group at 3 mo. There were no statistical differences in procedural success, and clinical outcome (survival at 1 year 81% vs 74% in AF and SR groups, respectively, P = NS). CONCLUSION: Patients in AF undergoing TAVI show a trend to a higher surgical risk. However, in our cohort, patients in AF did not have a higher stroke rate compared to the SR group, and the prognosis was similar in both groups. | Pablo Salinas Raúl Moreno Luis Calvo Santiago Jiménez-Valero Guillermo Galeote Angel Sánchez-Recalde Teresa López-Fernández Sergio Garcia-Blas Diego Iglesias Luis Riera Isidro Moreno-Gómez Jose María Mesa Ignacio Plaza Rocio Ayala Rosa Gonzalez José-Luis López-Sendón | 2012 | World Journal of Cardiology2012，4，1： | 2 |
| 8 | HLA B27 as Predisposition Factor to Suffer Age Related Macular Degeneration显示文摘研究是否特定的等位基因 HLA 一级(HLA -- A 和 HLA-B ) 并且班 II (HLA 医生) 是风险因素因为年龄的 exudative 类型的发展联系了有斑点的退化(ARMD ) , HLA 抗原与 ARMD 在正常、影响的眼睛两个都被表示。我们设计了未来的控制盒子的研究。我们与主要经典或秘密的 choroidal neovascularization 招募了 75 个病人,对 ARMD 第二等,并且与光力学的治疗对待。超过 55 岁的 250 个病人,没有 ophthalmologic 病理,为分析平淡的检查去了医院的人,被用作控制。数据的分析显示出二个组之间的重要差别。等位基因 HLA-B27 与 ARMD 断然相关(p < 0.0113 ) 。然而,我们没发现等位基因否定地联系了。因此 HLA-B27 是等位基因预先安排承受 ARMD。 | Enrique Villegas Becerril Rafael Gonzalez Fernandez Luis Perula Torres Manuel Santos Lacomba Jose Maria Gallardo Galera | 2009 | Cellular & Molecular Immunology2009，6，4： | 2 |
| 9 | N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects. | Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 10 | Relation of resistin levels with cardiovascular risk factors and insulin resistance in non - diabetes obese patients 显示文摘 | Luis DA Gonzalez Sagrado M Conde R | 2009 | Diabetes Res Clin Pract2009，84，2： | 1 |
| 11 | The market ori- entation concept in the private nonprofit organisation domain显示文摘 | LUIS 1GNACIO ALVAREZ GONZALEZ Maria LETIC1A SANTOS VIJANDE RODOLFO VAZQUEZ CASIELLES | 2002 | lnternational Journal of Nonprofit and Voluntary Sector Marketing2002，，7： | 1 |
| 12 | Electronic nose based on metal oxide semiconductor sensors and pattern recognition techniques: haracterization of vegetable oils显示文摘 | Yolanda Gonzalez Martin Concepcion Cerrato Oliveros M Jose Luis Perez Pavon | 2001 | Analytica Chimica Acta2001，449，： | 1 |
| 13 | The natural history of compensated HCV-related cirrhosis: A prospective long-term study显示文摘 | Eduardo Vilar Gomez Yoan Sanchez Rodriguez Luis Calzadilla Bertot Ana Torres Gonzalez Yadina Martinez Perez Enrique Arus Soler Ali Yasells Garcia Luis Perez Blanco | 2012 | Journal of Hepatology2012，，： | 1 |
| 14 | Contrast neuro- toxicity following percutaneous revascularization 显示文摘 | Gonzalez IA Tapia C Herndndez - Luis C | 2008 | Rev Esp Cardiol2008，61，8： | 1 |
| 15 | Complete nucleotide sequence of the penicillin acylase gene from Kluyvera citrophila显示文摘 | Jose Luis Barbero Jose Maria Buesa Gonzalo Gonzalez de Buitrago | 1986 | Gene1986，49，： | 1 |
| 16 | Effect of a hypocaloric diet on serum visfatin in obese non-diabetic patients显示文摘 | Luis DA Gonzalez SM Conde R | | 0，，06： | 1 |
| 17 | Fusion of Multispectral and Panchromatic Images Using Improved IHS and PCA Mergers Based on Wavelet Decomposition 显示文摘 | Maria Gonzalez -Audtcana Jose Luis Salem | 2004 | IEEE Transactions on Geoscience and Remote Sensing2004，42，6： | 1 |
| 18 | Magnesium silicate filler in rubber tread compounds显示文摘 | Luis Gonzalez Hemandez Luis Ma Ibarra Celia Chamomoa Anton | 1989 | Rubber Chemistry and Technolgy1989，60，： | 1 |
| 19 | Flavonoids from Salvia texana显示文摘 | Gonzalez AG Agular ZE Luis JG | | 0，，10： | 1 |
| 20 | Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype显示文摘 | Jose M. Garcia Jose M. Silva Gemma Dominguez Rocio Gonzalez Antonia Navarro Luis Carretero Mariano Provencio Pilar Espa?a Felix Bonilla | 1999 | Breast Cancer Research and Treatment1999，，3： | 1 |
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