|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers显示文摘 | Marc L. Mendillo Sandro Santagata Martina Koeva George W. Bell Rong Hu Rulla M. Tamimi Ernest Fraenkel Tan A. Ince Luke Whitesell Susan Lindquist | 2012 | Cell2012,,3: | 1 |
| 2 | Influ- ence detection between blog posts through blog features, content analy- sis, and conmaunity identity 显示文摘 | Tan Luke Kien - Weng Na Jin - Cheon Theng Yin - Leng | 2011 | Online infomlation review2011,35,3: | 1 |
| 3 | Complications of foreign bodies in the esophagus显示文摘 | Kwok Seng Loh Luke Kim Siang Tan James D. Smith Kian Hian Yeoh Fang Dong | 2000 | Otolaryngology - Head and Neck Surgery2000,,5: | 1 |
| 4 | The genomic and bulked segregant analysis of Curcuma alismatifolia revealed its diverse bract pigmentation显示文摘Compared with most flowers where the showy part comprises specialized leaves(petals)directly subtending the reproductive structures,most Zingiberaceae species produce showy“flowers”through modifications of leaves(bracts)subtending the true flowers throughout an inflorescence.Curcuma alismatifolia,belonging to the Zingiberaceae family,a plant species originating from Southeast Asia,has become increasingly popular in the flower market worldwide because of its varied and esthetically pleasing bracts produced in different cultivars.Here,we present the chromosome-scale genome assembly of C.alismatifolia“Chiang Mai Pink”and explore the underlying mechanisms of bract pigmentation.Comparative genomic analysis revealed C.alismatifolia contains a residual signal of whole-genome duplication.Duplicated genes,including pigment-related genes,exhibit functional and structural differentiation resulting in diverse bract colors among C.alismatifolia cultivars.In addition,we identified the key genes that produce different colored bracts in C.alismatifolia,such as F3′5'H,DFR,ANS and several transcription factors for anthocyanin synthesis,as well as chlH and CAO in the chlorophyll synthesis pathway by conducting transcriptomic analysis,bulked segregant analysis using both DNA and RNA data,and population genomic analysis.This work provides data for understanding the mechanism of bract pigmentation and will accelerate breeding in developing novel cultivars with richly colored bracts in C.alismatifolia and related species.It is also important to understand the variation in the evolution of the Zingiberaceae family. | Xuezhu Liao Yuanjun Ye Xiaoni Zhang Dan Peng Mengmeng Hou Gaofei Fu Jianjun Tan Jianli Zhao Rihong Jiang Yechun Xu Jinmei Liu Jinliang Yang Wusheng Liu Luke RTembrock Genfa Zhu Zhiqiang Wu | 2022 | aBIOTECH2022,3,3: | 1 |
| 5 | Influence detection between blog posts through blog features, content analysis, and community identity显示文摘 | Luke Kien-Weng Tan | 2011 | Online Information Re- view2011,35,3: | 1 |
| 6 | EPISTAXIS显示文摘 | Luke K.S. Tan Karen H. Calhoun | 1999 | Medical Clinics of North America1999,,1: | 1 |
| 7 | HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers显示文摘 | Marc L. Mendillo Sandro Santagata Martina Koeva George W. Bell Rong Hu Rulla M. Tamimi Ernest Fraenkel Tan A. Ince Luke Whitesell Susan Lindquist | 2012 | Cell2012,,: | 1 |
| 8 | Role of presynaptic phosphoprotein synapsin Ⅱ in schizophrenia显示文摘Synapsin Ⅱ is a member of the neuronal phosphoprotein family. These phosphoproteins are evolutionarily conserved across many organisms and are important in a variety of synaptic functions, including synaptogenesis and the regulation of neurotransmitter release. A number of genome-wide scans, meta-analyses, and genetic susceptibility studies have implicated the synapsin II gene(3p25) in the etiology of schizophrenia(SZ) and other psychiatric disorders. Further studies have found a reduction of synapsin II m RNA and protein in the prefrontal cortex in post-mortem samples from schizophrenic patients. Disruptions in the expression of this gene may cause synaptic dysfunction, which can result in neurotransmitter imbalances, likely contributing to the pathogenesis of SZ. SZ is a costly, debilitating psychiatric illness affecting approximately 1.1% of the world's population, amounting to 51 million people today. The disorder is characterized by positive(hallucinations, paranoia), negative(social withdrawal, lack of motivation), and cognitive(memory impairments, attention deficits) symptoms. This review provides a comprehensive summary of the structure, function, and involvement of the synapsin family, specifically synapsin II, in the pathophysiology of SZ and possible target for therapeutic intervention/implications. | Luke Molinaro Patricia Hui Mattea Tan Ram K Mishra | 2015 | World Journal of Psychiatry2015,5,3: | 0 |
| 9 | 伊普西隆别墅显示文摘Ypsilon别墅位于伯罗奔尼撒半岛南部的橄榄树林中,是一处避暑别墅。该项目将设计与身体和感官触发结合在一起,采用旨在民主化定制建筑的建筑实践方法。Villa Ypsilon采用绿色屋顶外壳,既是地形的无障碍延伸,也是内外部场地最重要的景观。 | Theo Sarantoglou Lalis Dora Sweijd Kasper Ax Yousef Al-Mehdari Theo Grousopoulos Thomas Jensen Valeria Garcia Nikolaos Klimentidis Greg Spaw Luke Tan Yu Zheng 无 | 2021 | 世界建筑导报2021,36,5: | 0 |