5篇
您的检索式：作者名="Luo Guilian"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A rapid and efficient method to prepare exfoliated graphite by microwave irradiation显示文摘 | Tong Wei Zhuangjun Fan Guilian Luo Chao Zheng Dashou Xie | 2008 | Carbon2008，，1： | 1 |
| 2 | A rapid and efficient method to prepare exfoliated graphite by microwave irradiation 显示文摘 | Wei Tong Fan Zhuangjun Luo Guilian | 2009 | Carbon2009，47，1： | 1 |
| 3 | African swine fever virus MGF505-3R inhibits cGAS-STING-mediated IFN-βpathway activation by degrading TBK1显示文摘African swine fever virus(ASFV)is an important pathogen causing acute infectious disease in domestic pigs and wild boars that seriously endangers the global swine industry.As ASFV is structurally complex and encodes a large number of functional proteins,no effective vaccine has been developed to date.Thus,dissecting the mechanisms of immune escape induced by ASFV proteins is crucial.A previous study showed that the ASFV-encoded protein is an important factor in host immunity.In this study,we identified a negative regulator,MGF505-3R,that significantly downregulated cGAS/STING-and poly(dG:dC)-mediated IFN-βand interferon stimulation response element(ISRE)reporter activity and suppressed IFNB1 and IFIT2 mRNA levels.In addition,TBK1,IRF3 and IκBαphosphorylation levels were also inhibited.Mechanistically,MGF505-3R interacted with cGAS/TBK1/IRF3 and targeted TBK1 for degradation,thereby disrupting the cGAS-STING-mediated IFN-βsignaling pathway,which appears to be highly correlated with autophagy.Knockdown MGF505-3R expression enhanced IFN-βand IL-1βproduction.Taken together,our study revealed a negative regulatory mechanism involving the MGF505-3R-cGAS-STING axis and provided insights into an evasion strategy employed by ASFV that involves autophagy and innate signaling pathways. | Mingyang Cheng Jiawei Luo Yuetong Duan Yu Yang Chunwei Shi Yu Sun Yiyuan Lu Junhong Wang Xiaoxu Li Jianzhong Wang Nan Wang Wentao Yang Yanlong Jiang Guilian Yang Yan Zeng Chunfeng Wang Xin Cao | 2022 | Animal Diseases2022，2，3： | 1 |
| 4 | Preparation of graphene nanosheet/polymer composites using in situ reduction-extractive dispersion显示文摘 | Wei Tong Luo Guilian Fan Zhuangjun | 2009 | Carbon2009，47，9： | 1 |
| 5 | A rapid and efficient method to prepare exfoliated graphite by microwave irradiation显示文摘 | Tong Wei Zhuangjun Fan Guilian Luo Chao Zheng Dashou Xie | 2008 | Carbon2008，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员