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| 1 | Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord显示文摘The aim of this work was to study effects of ketotifen fumarate(KF)on prevention of tissue damage in testes of rats with experimental autoimmune orchitis(EAO)and on the contralateral testis in a model of prolonged testicular cord torsion(TCT).Rats with EAO or TCT were injected intraperitoneally once daily with KF or saline solution(vehicle group).Incidence and severity of testicular damage were evaluated by histopathology using an EAO score or a Johnsen score.Mast cells(MC)were identified by histochemistry and quantified.In EAO model,KF significantly reduced severity of histopathological testicular damage compared to rats in the vehicle group.KF also reduced the number of testicular MC compared to vehicle group.Similarly,in TCT model,multifocal damage of the contralateral testis was observed 30 days after testicular torsion characterized by sloughing of the germinal epithelium,seminiferous tubule atrophy,and interstitial edema.Focal signs of inflammation and fibrosis of seminiferous tubular walls were also observed.In contrast,sections of contralateral testis of rats injected with KF and killed 30 days after surgery showed normal histological features.A significant decrease in the number of MC was observed in rats treated with KF compared to untreated animals.In conclusion,we demonstrated that treatment with KF reduced testicular inflammatory process and MC infiltrates in both EAO and TCT models.The results suggest a promising treatment for infertile male patients with testicular pathologies associated with inflammation and germ cell loss. | Diego Moreno Cristian M Sobarzo Livia Lustig Marcelo G Rodriguez Pena Vanesa Anabella Guazzone | 2020 | Asian Journal of Andrology2020，22，1： | 3 |
| 2 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 3 | High- er-order predictor-corrector interlor-polnt methodswith applications to quadratic objectives 显示文摘 | Carpenter T J Lustig I J Mulvey J M etal | 1993 | SIAM Journal on Optimization1993，3，4： | 1 |
| 4 | Sparse MRI:the application of compressed sensing for rapid MR imaging显示文摘 | Lustig M Donoho D Pauly JM | 2007 | Magn Reson Med2007，58，6： | 1 |
| 5 | Compressed sensing MRI显示文摘 | LUSTIG M DONOHO D L SANTOS J M | 2008 | IEEE Signal Processing Magazine2008，25，2： | 1 |
| 6 | An Integrated UASB-sludge Digester System for Raw Domestic Wastewater Treatment in Temperate Climates 显示文摘 | Lew B Lustig I Beliavski M | 2011 | Bioresource Technology2011，102，7： | 1 |
| 7 | Toward a unifying hypothesis of metabolic syndrome显示文摘 | Bremer AA Mietus-Snyder M Lustig RH | 2012 | Pediatrics2012，129，3： | 1 |
| 8 | Sparse MRI: The Application of Compressed Sensing for Rapid MR Imaging显示文摘 | LUSTIG M DONOHO D PAULY J M | 2007 | Magnetic Resonance in Medicine2007，58，6： | 1 |
| 9 | An interior-point method for large-scale /1-regularized Least Squares显示文摘 | Kim S J Koh K Lustig M | 2007 | IEEE Journal of Selected Topics in Signal Process2007，1，4： | 1 |
| 10 | Compressed sensing MRI 显示文摘 | Lustig M Donoho D L Santos J M | 2008 | IEEE Signal Processing Magazine2008，25，2： | 1 |
| 11 | Sparse MRI:The application of compressive sensing for rapid MR imaging显示文摘 | Lustig M Donoho D Pauly J M | | 0，，06： | 1 |
| 12 | Compressed sensing MRI 显示文摘 | LUSTIG M DONOHO D SANTOS J | 2008 | IEEE Signal Processing Magazine2008，3，： | 1 |
| 13 | An interior-point method for large-scale 11 regularized least squares显示文摘 | KIM S KOH K LUSTIG M | 2007 | IEEE Journal of Selected Topics in Signal Processing2007，1，4： | 1 |
| 14 | An interior - point method forlarge - scale €1 - regularized leastsquares 显示文摘 | Kim S Koh K Lustig M | 2007 | IEEE Journalof Selected Topics in Signal Processing2007，，1： | 1 |
| 15 | Balint Groups-Australian Perspective显示文摘 | Lustig M | 2003 | Australian Family Physician2003，35，： | 1 |
| 16 | Compressed Sensing MRI 显示文摘 | Lustig M Donoho D Santos J | 2008 | IEEE Signal Processing Magazine2008，25，2： | 1 |
| 17 | SparseMRI: the application of compressed sensing for rapid MR imaging显示文摘 | Lustig M Donoho D Pauly J M | 2007 | Magnetic Resonance in Medicine2007，58，6： | 1 |
| 18 | Sparse MRI: The appli- cation of compressed sensing for rapid MR imaging 显示文摘 | Lustig M Donoho D Pauly J M | 2007 | Magnetic Resonance in Medicine2007，58，6： | 1 |
| 19 | Sparse MRI: The application of compressed sensing for rapid MR imaging显示文摘 | Lustig M Donoho D Panly JM | 2007 | Magn Resort Med2007，58，6： | 1 |
| 20 | Compressed sensing MRI 显示文摘 | Lustig M Donoho D L Santos J M | 2008 | Signal Processing Magazine IEEE2008，25，2： | 1 |
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