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| 1 | Importance of fatigue and its measurement in chronic liver disease显示文摘The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. Metabolic contributors to fatigue, beginning with the uptake of substrate from the gut, the passage through the portal system to hepatic storage and release of energy to target organs (muscle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflammation either causing or resulting from chronic liver disease contributes to fatigue, although inflammation has not been demonstrated to be causal. It is this unique combination of factors, the nexus of metabolic abnormality and the inflammatory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. Many use the terms central and peripheral fatigue. Central fatigue is characterized by a lack of self-motivation and can manifest both in physical and mental activities. Peripheral fatigue is classically manifested by neuromuscular dysfunction and muscle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to measuring fatigue include the use of objective measures as well as patient reported outcomes. These measures have improved the precision with which we are able to describe fatigue. The measures of fatigue severity and its impact on usual daily routines in this population have also been improved, and they are more generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatment have relied of biosignatures associated with fatigue. These have been used singly or in combination and include: physical performance measures, cognitive performance measures, mood/behavioral measures, brain imaging and serological measures. Treatment with non-pharmacological agents have been shown to be effective in symptom reduction, whereas pharmacological agents have not been shown effective. | Lynn H Gerber Ali A Weinstein Rohini Mehta Zobair M Younossi | 2019 | World Journal of Gastroenterology2019，25，28： | 7 |
| 2 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 3 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 4 | Risk factors associated with major cerebrovascular complications after intracranial stenting显示文摘 | F Nahab M J. Lynn S E. Kasner M J. Alexander R Klucznik O O. Zaidat J Chaloupka H Lutsep S Barnwell M Mawad B Lane M I. Chimowitz | 2009 | Neurology2009，，23： | 2 |
| 5 | Efficient algorithms for pairing-based cryptosystems 显示文摘 | BARRETO P S L M KIM H Y LYNN B | 2002 | Lecture Notes in Computer Science2002，2442，： | 1 |
| 6 | Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis显示文摘 | Chimowitz M I Lynn M J Howlett-Smith H | 2005 | N Engl J Med2005，352，13： | 1 |
| 7 | Azimuthal anisotropy in P-wave 3D multiazimuth data显示文摘 | Lynn H B Simon K M | 1996 | The Leading Edge1996，15，8： | 1 |
| 8 | Risk of cerebral angiogra- phy in patients with symptomatic intracranial atherosclerotic st- enosis显示文摘 | Cloft H J Lynn M J Feldmann E | 2011 | Cerebrovasc Dis2011，31，6： | 1 |
| 9 | Nontraumatic osteoaeemsis of the femoral head: ten years later 显示文摘 | MICHAEL M LYNNE J DAVID H | 2006 | J Bone Joint Surg Am2006，88，5： | 1 |
| 10 | Correlation between P-wave AVOA and S-wave traveltime anisotropy in naturally fractured gas reservoir显示文摘 | Lynn H B Simon K M Bates C R | 1996 | The Leading Edge1996，15，8： | 1 |
| 11 | Risk of Breast Cancer With Oral Contraceptive 显示文摘 | Dawn M Grabrick M P H Lynn C | 2001 | Use in Women With a Family History of Breast Cancer2001，20，3： | 1 |
| 12 | Mapping maize microsatellites and polymerase chain reaction confirmation of the targeted repeats using a CT primer显示文摘 | Senior Lynn M Manfred H | 1993 | Genome1993，36，： | 1 |
| 13 | Phylogeny of trichostome ciliates (Ciliophora, Litostomatea) endosymbiotic in the Yakut horse (Equus caballus) 显示文摘 | Striider-Kypke M C Kornilova O A Lynn D H | 2007 | European Journal of Protistology2007，43，： | 1 |
| 14 | 显示文摘 | Wang C L Weber M H Lynn K G | 2002 | Appl Phys Lett2002，81，23： | 1 |
| 15 | 显示文摘 | Petkov M P Weber M H Lynn K G | 1999 | J Appl Phys1999，86，6： | 1 |
| 16 | Com- parison of warfarin and aspirin for symptomatic intracranial arterial stenosis 显示文摘 | Chimowitz MI Lynn M J Howlett-Smith H | 2005 | N Engl J Med2005，352，13： | 1 |
| 17 | A two-layer architecture for economically optimal Process control and operation显示文摘 | Lynn W Ralf H Wolfgang M | 2011 | Journal of Process Control2011，21，3： | 1 |
| 18 | Review:cyclodextrins and their interaction with amylolytic enzymes显示文摘 | Lynn M H Catherine T K William M F 2000 | 2000 | Enzyme and Microbial Technology2000，26，： | 1 |
| 19 | Postoperative ketorolac tromethamine use in infants aged 6 - 18 months: the effect on morphine usage, safety assessment, and stereo - specific pharmaeokineties 显示文摘 | Lynn A M Bradford H Kantor E D | 2007 | Anesth Analg2007，104，5： | 1 |
| 20 | Compari- son of warfarin and aspirin for symptomatic intracranial arterial stenosis 显示文摘 | Chimowittz MI Lynn M J Howlett-Smith H | 2005 | N Engl J Med2005，352，： | 1 |
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