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| 1 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 2 | Preclinical models of idiosyncratic drug-induced liver injury(iDILI):Moving towards prediction显示文摘Idiosyncratic drug-induced liver injury(iDILI) encompasses the unexpected harms that prescription and non-prescription drugs,herbal and dietary supplements can cause to the liver.iDILI remains a major public health problem and a major cause of drug attrition.Given the lack of biomarkers for iDILI prediction,diagnosis and prognosis,searching new models to predict and study mechanisms of iDILI is necessary.One of the major limitations of iDILI preclinical assessment has been the lack of correlation between the markers of hepatotoxicity in animal toxicological studies and clinically significant iDILI.Thus,major advances in the understanding of iDILI susceptibility and pathogenesis have come from the study of well-phenotyped iDILI patients.However,there are many gaps for explaining all the complexity of iDILI susceptibility and mechanisms.Therefore,there is a need to optimize preclinical human in vitro models to reduce the risk of iDILI during drug development.Here,the current experimental models and the future directions in iDILI modelling are thoroughly discussed,focusing on the human cellular models available to study the pathophysiological mechanisms of the disease and the most used in vivo animal iDILI models.We also comment about in silico approaches and the increasing relevance of patient-derived cellular models. | Antonio Segovia-Zafra Daniel E.Di Zeo-Sanchez Carlos Lopez-Gomez Zeus Perez-Valdes Eduardo Garcıa-Fuentes Raul J.Andrade M.Isabel Lucena Marina Villanueva-Paz | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 3 |
| 3 | Tourism image, evaluation variables and after purchase behaviour: inter-relationship显示文摘 | J.Enrique Bigné M.Isabel Sánchez Javier Sánchez | 2001 | Tourism Management2001，，6： | 2 |
| 4 | Sequential extractions for determination of cadmium distribution in coal fly ash, soil and sediment samples显示文摘 | M.Dolores Petit M.Isabel Rucandio | 1999 | Analytica Chimica Acta1999，，1： | 1 |
| 5 | A global consistent positive effect of urban green area size on bird richness显示文摘Background: Although the species-urban green area relationship (SARu) has been analyzed worldwide, the global consistency of its parameters, such as the fit and the slope of models, remains unexplored. Moreover,the SARu can be explained by 20 different models. Therefore, our objective was to evaluate which models provide a better explanation of SARus and, focusing on the power model,to evaluate the global heterogeneity in its fit and slope. Methods: We tested the performance of multiple statistical models in accounting for the way in which species richness increases with area, and examined whether variability in model form was associated with various methodological and environmental factors. Focusing on the power model, we analyzed the global heterogeneity in the fit and slope of the models through a meta-analysis. Results: Among 20 analyzed models, the linear model provided the best fit to the most datasets, was the top ranked model according to our efficiency criterion, and was the top overall ranked model.The Kobayashi and power models were the second and third overall ranked models, respectively.The number of green areas and the minimum number of species within a green area were the only significant variables explaining the variation in model form and performance, accounting for less than 10% of the variation. Based on the power model,there was a consistent overall fit (r2=0.50) and positive slope of 0.20 for the species richness increase with area worldwide.Conclusions:The good fit of the linear model to our SARu datasets contrasts with the non-linear SAR frequently found in true and non-urban habitat island systems;however, this finding may be a result of the small sample size of many SARu datasets. The overall power model slope of 0.20 suggests low levels of isolation among urban green patches, or alternatively that habitat specialist and area sensitive species have already been extirpated from urban green areas. | Lucas M.Leveau Adriana Ruggiero Thomas J.Matthews M.Isabel Bellocq | 2019 | Avian Research2019，10，3： | 1 |
| 6 | Functional Recovery of Paraplegic Rats and Motor Axon Regeneration in Their Spinal Cords by Olfactory Ensheathing Glia显示文摘 | Almudena Ramón-Cueto M.Isabel Cordero Fernando F. Santos-Benito Jesús Avila | 2000 | Neuron2000，，2： | 1 |
| 7 | Functional Recovery of Paraplegic Rats and Motor Axon Regeneration in Their Spinal Cords by Olfactory Ensheathing Glia显示文摘 | Almudena Ramón-Cueto M.Isabel Cordero Fernando F. Santos-Benito Jesús Avila | 2000 | Neuron2000，，2： | 1 |
| 8 | Analyzing knowledge transfer channels between universities and industry:To what degree do sectors also matter显示文摘 | R.Bekkers M.Isabel F.Bodas | | 0，，10： | 1 |
| 9 | Prevalence of hospital malnutrition in Latin America:显示文摘 | M.Isabel T.D Correia Antonio Carlos L Campos | 2003 | Nutrition2003，，10： | 1 |
| 10 | Electrochemical noise and impedance study of aluminium in weakly acid chloride solution显示文摘 | Carla Gouveia-Caridade M.Isabel S. Pereira Christopher M.A. Brett | 2003 | Electrochimica Acta2003，，5： | 1 |
| 11 | Hospital malnutrition: the Brazilian national survey (IBRANUTRI): a study of 4000 patients显示文摘 | Dan L Waitzberg Waleska T Caiaffa M.Isabel T.D Correia | 2001 | Nutrition2001，，7： | 1 |
| 12 | Integrated physiological and molecular approaches to improvement of abiotic stress tolerance in two pulse crops of the semi-arid tropics显示文摘Chickpea(Cicer arietinum L.) and pigeonpea [Cajanus cajan L.(Millsp.)] play an important role in mitigating protein malnutrition for millions of poor vegetarians living in regions of the semi-arid tropics. Abiotic stresses such as excess and limited soil moisture(water-logging and drought), heat and chilling(high and low temperature stresses), soil salinity, and acidity are major yield constraints, as these two crops are grown mostly under rainfed conditions in risk-prone marginal and degraded lands with few or no inputs. Losses due to such stresses vary from 30% to 100% depending on their severity. The literature abounds in basic information concerning screening techniques, physiological mechanisms, and genetics of traits associated with resistance/tolerance to abiotic stresses in these two crops. However, the final outcome in terms of resistant/tolerant varieties has been far from satisfactory. This situation calls for improving selection efficiency through precise phenotyping and genotyping under high-throughput controlled conditions using modern tools of genomics. In this review, we suggest that an integrated approach combining advances from genetics, physiology, and biotechnology needs to be used for higher precision and efficiency of breeding programs aimed at improving abiotic stress tolerance in both chickpea and pigeonpea. | arbind k.choudhary rafat sultana m.isabel vales kul bhushan saxena ravi ranjan kumar pasala ratnakumar | 2018 | The Crop Journal2018，6，2： | 0 |
| 13 | Response of saproxylic insect communities to logging history, tree species, stage of decay, and wood posture in the central Nearctic boreal forest显示文摘Saproxylic insect assemblages are essential functional components of forest ecosystems that can be affected by forest management.We used a split-plot ANOVA design to analyze differences in selected saproxylic insects(all arthropod orders and dipteran and parasitic hymenopteran families) emerging from dead wood of sites with different logging histories(horse-logged,mechanically-logged and unlogged),tree species(Populus and Picea),stage of decay(early-and late-decay stages) and posture(standing and downed logs) in the boreal forest of central Canada.No clear effects of logging history were seen for the studied taxa; however,interaction between logging history and other dead wood features was apparent.Cecidomyiidae consistently emerged more from Populus than from Picea dead wood.Most of the studied saproxylic families were more abundant in late-decay than in early-decay wood.Dipterans of the Cecidomyiidae,Ceratopogonidae,Empididae,Mycetophilidae and Sciaridae families,and hymenopterans of the Diapriidae and Ichneumonidae families were significantly more abundant in downed than in standing dead wood.In contrast,Mymaridae was most abundant in standing dead wood.Our study provides evidence that some insects at high taxonomic levels respond differently to dead wood quality,and this could inform future management strategies in the boreal forest for the conservation of saproxylic fauna and their ecological functions. | R.W.James Dennis Jay R.Malcolm Sandy M.Smith M.Isabel Bellocq | 2018 | Journal of Forestry Research2018，29，5： | 0 |
| 14 | 局部麻醉剂引起的眼压改变(英文)显示文摘目的:确定局麻药,年龄和角膜中央厚度对非接触眼压计眼压测量值的影响。方法:记录47例93眼滴局麻药前后角膜中央厚度和非接触眼压计眼压测量值。结果:在47例中女31例,男16例;平均年龄66.4岁(标准差16,范围34~88岁);平均基础眼压16.0mmHg(标准差4.0,范围8.5~26.1mmHg)。滴局麻药后1min平均眼压16.0mmHg(标准差3.8,范围7.7~26.7mmHg),5min平均眼压14.9mmHg(标准差3.9,范围7.6~26.3)。0~1min(P=0.0007)和0~5min(P=0.0003)的数值差异有统计学意义,1~5min(P=0.27)的数值差异无统计学意义(配对资料t检验)。滴局麻药前的平均角膜中央厚度为565.4μm。直线回归分析认为年龄和眼压之间以及角膜中央厚度和眼压之间无直线关系。结论:我们的研究证实,滴局麻药后前5min内引起的眼压降低是进行性的,降低值与角膜中央厚度和年龄无关。 | Javier A Montero Jose M Ruiz-Moreno Marta Fernandez-Munoz M.Isabel Rodriguez-Palacios | 2006 | 国际眼科杂志2006，6，6： | 0 |
| 15 | Using meshes to change the characteristics of simulated rainfall produced by spray nozzles显示文摘Rainfall simulators have been used for many years contributing to the understanding of soil and water conservation processes.Nevertheless,rainfall simulators’design and operation might be rather demanding for achieving specific rainfall intensity distributions and drop characteristics and are still open for improvement.This study explores the potential of combining spray nozzle simulators with meshes to change rainfall characteristics,namely drop properties(drop diameters and fall speeds).A rainfall simulator laboratory set-up was prepared that enabled the incorporation of different wire meshes beneath the spray nozzles.The tests conducted in this exploratory work included different types of spray nozzles,mesh materials(plastic and steel),square apertures and wire thicknesses,and positions of the meshes in relation to the nozzles.Rainfall intensity and drop size distribution and fall speed were analysed.Results showed that the meshes combined with nozzles increased the mean rainfall intensity on the 1 m^(2) control plot below the nozzle and altered the rain drops’properties,by increasing the mass-weighted mean drop diameter,for example. | Sílvia C.P.Carvalho João L.M.P.de Lima M.Isabel P.de Lima | 2014 | International Soil and Water Conservation Research2014，2，2： | 0 |
| 16 | Synthesis and Structure of Novel Cyclohistidinopeptide Box显示文摘 A novel tetra-histidine cyclopeptide was prepared through multi-step reactions from histidine and naphthalene diamine (Scheme 1). All new compounds were characterized by 1H, 13C, 1H-15N and 1H-13C HETCOR spectra.…… | ZHOU,Cheng-He WU,Jun YUAN,Yong BAI,Xue Juan F.Miravet M.Isabel Burguete Santiago V.Luis | 2004 | 有机化学2004，24，z1： | 0 |
| 17 | Structural Determination of Bis-histidinopeptide Zinc Complexes by 15N NMR (HMBC) Spectra显示文摘 Polynitrogen receptors such as bis-histidine peptides possess strong ability to bind metals, which play much important roles in medicinal, bioinorganic, bioorganic, biomimetic and supramolecular chemistry. In order to investigate the interaction of these hosts with a variety of neutral, cationic and anionic guests, several techniques, for example, NMR,potentiometric tirations and monocrystal X-ray diffraction have been employed. Among them NMR is a powerful technique for unraveling the structure of polynitrogen receptors as long as they are in solution where the rapid tumbling of molecules averages out the anisotropies such as chemical shift and dipole-dipole interactions. General 1H NMR approach has been widely used for the study of host-guest interaction, but it is difficult for the accurate measurement in complexes structures, particularly metal complexes structures in which how the polynitrogen receptors bind metal, and which nitrogen binds metal and so on.…… | ZHOU,Cheng-He Juan F.Miravet M.Isabel Burguete Santiago V.Luis BAI,Xue YUAN,Yong | 2004 | 有机化学2004，24，z1： | 0 |
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