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| 1 | Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells显示文摘橡黄素是自然地发生之一饮食的黄酮醇混合物。它在植物富有地是在场的并且有 chemopreventive 和 anticancer 效果。调查它的 anticancer 机制,我们对尖锐白血病房间线检验了橡黄素的活动, HL-60。我们的结果证明橡黄素禁止了房间增长并且在一个时间依赖者和剂量依赖者举止导致了 apoptosis。而且,橡黄素下面调整 anti-apoptosis 蛋白质 Bcl-2 的表示并且起来调整 pro-apoptosis 蛋白质 Bax 的表示。Caspase-3 被橡黄素也激活,它开始了一条 caspase-3-depended mitochodrial 小径导致 apoptosis。橡黄素禁止了 cycloocygenase-2 (Cox-2 ) 的表示,这也被发现 mRNA 和 Cox-2 蛋白质。一起拿,这些调查结果建议橡黄素由禁止 Cox-2 表示在一条 caspase-3-dependent 小径导致 apoptosis 并且调整下游的 apoptotic 部件的表示,包括 Bcl-2 和 Bax。橡黄素能是可能安全地在白血病治疗被使用的一个有势力和有希望的药。 | Guomin Niu Songmei Yin Shuangfeng Xie Yiqing Li Danian Nie Liping Ma Xiuju Wang Yudan Wu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 28 |
| 2 | SKP2 siRNA inhibits the degradation of P27^kip1 and down-regulates the expression of MRP in HL-60/A cells显示文摘S 阶段联系 kinase 的蛋白质 2 (SKP2 ) 基因是肿瘤 suppressor 基因,并且涉及 P27kip1 的调停 ubiquitin 的降级。SKP2 和 P27kip1 影响通过调整白血病房间的增长, apoptosis 和区别继续和白血病的预后。在这研究,我们探索了通过 SKP2 下面规定 HL-60/A 药抵抗逆行的机制。HL-60/A 房间是由有 SKP2 siRNA 的 Amaxa Nucleofector 系统的 nucleofected。Skp2, P27kip1,和多药抵抗的基因和蛋白质表示层次联系了蛋白质(MRP ) 被反向的抄写聚合酶链反应和西方的污点分析分别地决定。房间周期被流动 cytometry 分析。50% 禁止的集中价值在 chemotherapeutics 的不同集中下面根据这些二种房间的死亡率用细胞毒素的分析被计算比较房间的敏感。HL-60/A 房间显示出由抗力移转特征的多药抵抗显型到 adriamycin, daunorubicin,和 arabinosylcytosine,由于 MRP 的表示。我们发现 SKP2 的表示比在 HL-60 房间在 HL-60/A 房间是更高的,但是 P27kip1 的表示更低。而 P27kip1 的蛋白质水平是起来调整的,在由 SKP2 siRNA 的 HL-60/A 房间 nucleofected 的 SKP2 的表示是下面调整的。与在控制组(由控制 siRNA 的 nucleofected ) 的 MRP 表达式水平相比, mRNA 和蛋白质表达式由 SKP2 siRNA 在 HL-60/A 房间 nucleofected MRP 铺平更低,并且后者房间对 adriamycin, daunorubicin,和 arabinosylcytosine 更敏感。下面调整在 G0/G1 阶段的 SKP2 表示和逮捕房间与下面调整的 MRP 改进白血病房间的药敏感表示。 | Jie Xiao Songmei Yin Yiqing Li Shuangfeng Xie Danian Nie Liping Ma Xiuju Wang Yudan Wu Jianhong Feng | 2009 | Acta Biochimica et Biophysica Sinica2009，41，8： | 7 |
| 3 | Evaluation of the four potential Cretaceous-Paleogene (K-Pg) boundaries in the Nanxiong Basin based on evidences from volcanic activity and paleoclimatic evolution显示文摘Determining the location of the Cretaceous-Paleogene(K-Pg) boundary in terrestrial strata is highly significant for studying the evolution of terrestrial ecosystems at the end of the Cretaceous(especially the extinction of non-avian dinosaurs). At present, research on terrestrial K-Pg boundaries worldwide is concentrated in the middle and high latitudes, such as North America and Northeast China. Although many studies have also been carried out in the Nanxiong Basin, located at low latitudes(which has become the standard for dividing and comparing the continental K-Pg stratigraphy in China), many researchers have proposed four possible boundaries from different perspectives. Therefore, the exact location remains to be determined. In this study, the total mercury(Hg) content, environmental magnetism, geochemistry, and other parameters for the samples collected near the four boundaries were determined and compared with existing records. Results indicated that: 1) The total Hg content significantly increased in the upper part of the Zhenshui Formation and Pingling part of the Shanghu Formation with sharp fluctuations. As per latest dating results of Deccan Traps, the significantly high Hg value was attributed to the Deccan Traps eruption. Boundary 1 was located in the middle of the Hg anomaly interval, which was consistent with the relationship between the global K-Pg boundary and time of volcanic eruption. 2) The reconstructed paleoclimate evolution curve revealed that the red sediments in the basin recorded the late Maastrichtian warming event(66.2 Ma). Regarding the relationship between the four boundaries and this warming event, only boundary 1 was found to be closest to the real K-Pg boundary of the Nanxiong Basin. | Mengting ZHAO Mingming MA Mei HE Yudan QIU Xiuming LIU | 2021 | Science China Earth Sciences2021，64，4： | 4 |
| 4 | Effects of the Molecular Weight of PLGA on Degradation and Drug Release In vitro from an mPEG-PLGA Nanocarrier显示文摘 | LIU Rui WANG Yan MA Yudan WU Yi GUO Yi XU Li | 2016 | Chemical Research in Chinese Universities2016，32，5： | 2 |
| 5 | The role of AMP-activated protein kinase in quercetin-induced apoptosis of HL-60 cells显示文摘我们的以前的研究证明了橡黄素禁止 Cox-2 和 Bcl-2 表情,并且导致人的白血病 HL-60 cellapoptosis。以便在 HL-60cells 的导致橡黄素的 apoptosis 上调查激活安培的蛋白质 kinase (AMPK ) 的角色,我们使用了流动 cytometry 检测房间 apoptosis。LKB1, phosphorylated AMPK (p-AMPK ) ,和 Cox-2 proteinwere 的表情由西方的污点在 HL-60 房间和正常的外部血 mononuclear 房间(PBMC ) 检测了。LKB1, p-AMPK,和 Cox-2 的表情与橡黄素在文化以后在 HL-60 房间被检测。p-AMPK 的表情与 AMPK 禁止者混合物 C 在文化以后在 HL-60cells 被检测。然后, LKB1, p-AMPK,和 Cox-2 的表情与独自一个的橡黄素或橡黄素 + 混合物 C 在文化以后在 HL-60cells 被检测。在 PBMC 和 HL-60 之间没有重要 differencein LKB1,这被发现。在 PBMC 的 p-AMPK 在 HL-60 比那高,当 Cox-2 更低时。在 HL-60with 橡黄素的文化以后, p-AMPK 被增加, Cox-2 被减少,但是 LKB1 仍然保持未改变。在有 CompoundC 的 HL-60 的文化以后, p-AMPK 被减少。在 LKB1 在之间没有重要差别橡黄素独自一个并且橡黄素 + CompoundC 组。p-AMPK 更显著地减少了,当 Cox-2 在橡黄素 + 混合物 C groupsthan 更显著地增加了时那些在橡黄素独自一个的组。一起拿,这些调查结果建议橡黄素激活独立于 LKB1 激活的 AMPK expressionin HL-60 房间,由激活 AMPK 禁止 Cox-2 表示,并且进一步调整施加它的反白血病效果的 apoptosis 的 Bcl-2-dependentpathways。 | Jie Xiao Guomin Niu Songmei Yin Shuangfeng Xie Yiqing Li Danian Nie Liping Ma Xiuju Wang Yudan Wu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 2 |
| 6 | Involvement of levels of Toll like receptor-4 in monocytes, CD4+ T-lymphocyte subsets, and cytokines in patients with immune thrombocytopenic purpura显示文摘 | Hongyun Liu Xianfeng Ouyang Yiqing Li Hua Zeng Xiuju Wang Shuangfeng Xie Danian Nie Jie Xiao Jing Wei Yudan Wu Songmei Yin Liping Ma | 2013 | Thrombosis Research2013，，： | 2 |
| 7 | Survey on Immunization Services for Children with Medical Conditions-China, 2022显示文摘Summary What is already known about this topic?Children with medical conditions frequently experience under-immunization.Ensuring high-quality immunization services is crucial for enhancing vaccination coverage levels;nevertheless,the state of immunization service provision for children with medical conditions in China remains unclear.What is added by this report?Immunization support for children with medical conditions in China demonstrates considerable variability and may be inadequate.Primary obstacles to the provision of immunization services include an absence of comprehensive vaccination recommendations and assessment guidelines for specific medical conditions,as well as inconsistencies among vaccine recommendations,package inserts,and expert consensus statements pertaining to the vaccination of children with medical conditions.What are the implications for public health practice?The examination of provincial practices in providing immunization services for children with medical conditions,as well as understanding the barriers faced by National Immunization Program providers in administering vaccinations,can contribute to the improvement of immunization services for this population in China. | Yong Huang Yudan Song Junhong Li Yamin Wang Xiang Zeng Chao Ma Zundong Yin | 2023 | China CDC weekly2023，5，19： | 0 |
| 8 | Novel Chemical Strategy for the Synthesis of RGDCySS Tetrapeptide显示文摘 | XU Baofeng YANG Sen ZHU Jinming MA Yudan ZHAO Gang GUO Yi XU Li | 2014 | Chemical Research in Chinese Universities2014，30，1： | 0 |
| 9 | Observation of Collimated Atoms by Light Pressure Force in Absorption Cell显示文摘Experimental observation of laser cooling and collimation of moving atoms in an absorption cell by light pressure force of an intense standing light wave field is reported.The hyper fine structure of atomic sodium has been observed due to the cooled and collimated atoms.The mechanism of laser cooling and collimation of atoms is discussed. | WANG Yuzhu YE Chao WU Yongsheng WANG Xiaojuan ZHOU Shanyu CHENG Yudan MA Longsheng DING Liangen | 1993 | Chinese Physics Letters1993，10，4： | 0 |
| 10 | An Outbreak of Serogroup Y Meningococcal Meningitis in a Private Secondary Vocational School-Guangzhou City,Guangdong Province,China,2023显示文摘Summary What is already known about this topic?The inclusion of meningococcal vaccines in the National Immunization Program(NIP)over several years has significantly reduced the incidence of meningococcal meningitis in China to historic lows.Worldwide,there has been a diversification of meningococcal serogroups,leading to a shift in dominant serogroups in China from serogroup A to serogroups C and B,accompanied by a rise in reports of serogroups Y and W. | Xiang Zeng Qing He Yilan Li Yong Zhou Xiaoping Shao Pei Hu Jian Liang Yudan Song Chao Ma Lijie Zhang Limei Sun Lei Luo | 2024 | China CDC weekly2024，6，12： | 0 |
| 11 | La_(2)O_(3)-promoted Ni/H-ZSM-5 catalyzed aqueous-phase guaiacol hydrodeoxygenation to cyclohexanol显示文摘Hydrodeoxygenation(HDO)of renewable lignin-derived biomass in aqueous-phase to produce high value-added products is of great significance.However,developing new catalysts with high activity and excellent stability in an aqueous phase faces considerable challenges.Rare earth doping can effectively regulate the water exchange rate constant(WERC)value of the catalyst and play an important role in promoting the hydrolysis of ether bonds.Therefore,in this paper the bimetallic supported catalyst Ni-La_(2)O_(3)/H-ZSM-5 doped with rare earth metal La_(2)O_(3)was prepared,and used to catalyze the conversion of the lignin model co mpound guaiacol to cyclohexanol in the aqueous phase.The co nversion of guaiacol catalyzed by 10Ni-3La_(2)O_(3)/H-ZSM-5 reaches 100%,and the selectivity of the product cyclohexanol is 85%.A series of characterizations illustrate that the doping of La_(2)O_(3)causes the electron transfer between La_(2)O_(3)-Ni and changes the distribution of Ni,and a strong metal carrier interaction occurs between the bimetallic Ni-La_(2)O_(3)and H-ZSM-5.This can effectively promote the hydrolysis of the C-O ether bond in guaiacol and significantly improve the activity of the catalyst.The possible catalytic reaction mechanism of Ni-La_(2)O_(3)/H-ZSM-5 catalytic conversion of guaiacol was proposed. | Feng Lin Yudan Zhong Yulong Ma Yonggang Sun Xiuqin Men Yingbo Zhu | 2023 | Journal of Rare Earths2023，41，2： | 0 |
| 12 | Calcium ion channel and epilepsy显示文摘OBJECTIVE: To review the relationship between calcium ion channel and epilepsy for well investigating the pathogenesis of epilepsy and probing into the new therapeutic pathway of epilepsy. DATA SOURCES: A computer-based online research Calcium ion channel and epilepsy related articles published between January 1994 and December 2006 in the CKNI and Wanfang database with the key words of 'calcium influxion, epilepsy, calcium-channel blocker'. The language was limited to Chinese. At the same time, related articles published between January 1993 and December 2006 in Pubmed were searched for on online with the key words of 'calcium influxion, epilepsy' in English. STUDY SELECTION: The materials were selected firstly. Inclusive criteria: ① Studies related to calcium ion channel and the pathogenesis of epilepsy. ② Studies on the application of calcium ion channel blocker in the treatment of epilepsy. Exclusive criteria: repetitive or irrelated studies. DATA EXTRACTION: According to the criteria, 123 articles were retrieved and 93 were excluded due to repetitive or irrelated studies. Altogether 30 articles met the inclusive criteria, 11 of them were about the structure and characters of calcium ion channel, 10 about calcium ion channel and the pathogenesis of epilepsy and 9 about calcium blocker and the treatment of epilepsy. DATA SYNTHESIS: Calcium ion channels mainly consist of voltage dependent calcium channel and receptor operated calcium channel. Depolarization caused by voltage gating channel-induced influxion is the pathological basis of epileptic attack, and it is found in many studies that many anti-epileptic drugs have potential and direct effect to rivalizing voltage-dependent calcium ion channel. CONCLUSION: Calcium influxion plays an important role in the seizure of epilepsy. Some calcium antagonists seen commonly are being tried in the clinical therapy of epilepsy that is being explored, not applied in clinical practice. If there are enough evidences to justify its effect in epilepsy, there will be considerable clinical significance. | Yudan Lue Weihong Lin Dihui Ma | 2006 | Neural Regeneration Research2006，1，3： | 0 |
| 13 | Drought-triggered repression of miR166 promotes drought tolerance in soybean显示文摘Drought stress limits agricultural productivity worldwide.Identifying and characterizing genetic components of drought stress-tolerance networks may improve crop resistance to drought stress.We show that the regulatory module formed by miR166 and its target gene,ATHB14-LIKE,functions in the regulation of drought tolerance in soybean(Glycine max).Drought stress represses the accumulation of miR166,leading to upregulation of its target genes.Optimal knockdown of miR166 in the stable transgenic line GmSTTM166 conferred drought tolerance without affecting yield.Expression of ABA signaling pathway genes was regulated by the miR166-mediated regulatory pathway,and ATHB14-LIKE directly activates some of these genes.There is a feedback regulation between ATHB14-LIKE and MIR166 genes,and ATHB14-LIKE inhibits MIR166 expression.These findings reveal that drought-triggered regulation of the miR166-mediated regulatory pathway increases plants drought resistance,providing new insights into drought stress regulatory network in soybean. | Chen Zhao Jingjing Ma Chen Yan Yu Jiang Yaohua Zhang Yudan Lu Ye Zhang Suxin Yang Xianzhong Feng Jun Yan | 2024 | The Crop Journal2024，12，1： | 0 |
| 14 | Observations on the Effectiveness of Internet+ Nursing Practice in Promoting Exclusive Breastfeeding显示文摘Objective:To analyze the effect of Internet+nursing practice to promote exclusive breastfeeding.Methods:60 new mothers were selected from our hospital between February 2021 and February 2022,randomly divided into two groups,the control group and the observation group.Conventional care was given to the control group and the Internet+care was given to the observation group.The healing of perineal wounds,breastfeeding rate as well as the nursing satisfaction of both groups were compared with each other.Results:The perineal wound healing rate was 100.00%in the observation group and 83.33%in the control group,the healing rate was higher in the observation group(P<0.05).80.00%,with higher nursing satisfaction in the observation group(P<0.05).Conclusion:Internet+nursing guidance during the perinatal care of mothers can improve the success rate of breastfeeding and achieve higher nursing satisfaction. | Duomei Ren Pei Zhang Lei Han Yudan Ma Chunrong Yang | 2022 | Journal of Clinical and Nursing Research2022，6，5： | 0 |
| 15 | A developed ant colony algorithm for cancer molecular subtype classification to reveal the predictive biomarker in the renal cell carcinoma显示文摘Background:Recently,researchers have been attracted in identifying the crucial genes related to cancer,which plays important role in cancer diagnosis and treatment.However,in performing the cancer molecular subtype classification task from cancer gene expression data,it is challenging to obtain those significant genes due to the high dimensionality and high noise of data.Moreover,the existing methods always suffer from some issues such as premature convergence.Methods:To address those problems,we propose a new ant colony optimization(ACO)algorithm called DACO to classify the cancer gene expression datasets,identifying the essential genes of different diseases.In DACO,first,we propose the initial pheromone concentration based on the weight ranking vector to accelerate the convergence speed;then,a dynamic pheromone volatility factor is designed to prevent the algorithm from getting stuck in the local optimal solution;finally,the pheromone update rule in the Ant Colony System is employed to update the pheromone globally and locally.To demonstrate the performance of the proposed algorithm in classification,different existing approaches are compared with the proposed algorithm on eight high-dimensional cancer gene expression datasets.Results:The experiment results show that the proposed algorithm performs better than other effective methods in terms of classification accuracy and the number of feature sets.It can be used to address the classification problem effectively.Moreover,a renal cell carcinoma dataset is employed to reveal the biological significance of the proposed algorithm from a number of biological analyses.Conclusion:The results demonstrate that CAPS may play a crucial role in the occurrence and development of renal clear cell carcinoma. | ZEKUN XIN YUDAN MA WEIQIANG SONG HAO GAO LIJUN DONG BAO ZHANG ZHILONG REN | 2023 | BIOCELL2023，47，3： | 0 |
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