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| 1 | Crustal velocity structure in the Emeishan large igneous province and evidence of the Permian mantle plume activity显示文摘The Emeishan large igneous province(ELIP) in SW China is interpreted to be associated with an ancient mantle plume. Most of the constraints on the role of mantle plume in the generation of the Emeishan flood basalts were provided by geological and geochemical methods, but the geophysical investigation is very limited. In order to better understand the deep structure and features of ELIP, we have studied the crustal velocity structure using the data acquired from the Lijiang-Panzhihua-Qingzhen wide-angle seismic profile. This profile crosses the three sub-zones of the ELIP(the inner, intermediate, and outer zones), divided based on the differential erosion and uplift of the Maokou limestone. The results provided by the active source seismic experiment demonstrate:(1) The average depth of the crystalline basement along the profile is about 2 km.(2) The middle crust in the Inner Zone is characterized by high-velocity anomalies, with the average velocity of 6.2-6.6 km/s, which is about 0.1– 0.2 km/s higher than the normal one. The velocity of the lower crust in the inner zone is 6.9-7.2 km/s, higher than those observed in the intermediate and outer zones(6.7-7.0 km/s). Relatively low velocity anomalies appear in the upper, middle and lower crusts near the junction of the inner zone and intermediate zone, probably due to the effect of the Xiaojiang fault(XJF).(3) The average velocity of the crust is comparatively low on both sides of XJF, especially on the east side, and the average velocity of the consolidated continental crust is also low there. This may suggest that the XJF extends at least down to 40 km deep, even beyond through the crust.(4) The depth to the Moho discontinuity decrease gradually from 47-53 km in the inner zone, via 42-50 km in the intermediate zone to 38-42 km in the outer zone. In the inner zone, the Moho uplifts locally and the(consolidated) crust is characterized by high-velocity anomalies, which are likely related to intensive magma intrusion and underplating associated with melting of plume head. Overall the crustal velocity structure in the study area recorded the imprint left by the Permian Emeishan mantle plume. | XU Tao ZHANG ZhongJie LIU BaoFeng CHEN Yun ZHANG MingHui TIAN XiaoBo XU YiGang TENG JiWen | 2015 | Science China Earth Sciences2015，58，7： | 36 |
| 2 | Functionalization of small black phosphorus nanoparticles for targeted imaging and photothermal therapy of cancer显示文摘Black phosphorus(BP) nanomaterials have attracted extensive attention due to their unique physical,chemical, and biological properties. In this study, small BP nanoparticles were synthesized and modified with dextran and poly(ethyleneimine) for functionalization with folic acid and cyanine 7. The functionalized BP nanoparticles exhibit excellent biocompatibility, stability, and near infrared optical properties for targeted imaging of tumors through photoacoustic imaging and near-infrared fluorescence imaging.They also display high photothermal conversion efficiency for photothermal therapy of cancer. This work demonstrates the potential of functionalized small BP nanoparticles as an emerging nanotheranostic agent for the diagnosis and treatment of cancer. | Lijuan Deng Yifan Xu Caixia Sun Baofeng Yun Qiao Sun Chongjun Zhao Zhen Li | 2018 | Science Bulletin2018，63，14： | 12 |
| 3 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 4 | Construction of plasmid vector pAFP-HSVtk-IRES2-EGFP and its effect on the cytotoxicity of ganciclovir to hepatocellular carcinoma显示文摘 | Lai Zhiyong Qin Qin Yu Baofeng Xie Jun Gao Ranpeng Zhang Tiantian Li Chunfeng Niu Kai Xu Jun | 2014 | Chinese Medical Journal2014，，12： | 6 |
| 5 | Functional assembly of root-associated microbial consortia improves nutrient efficiency and yield in soybean显示文摘Root-associated microbes are critical for plant growth and nutrient acquisition. However, scant information exists on optimizing communities of beneficial root-associated microbes or the mechanisms underlying their interactions with host plants. In this report, we demonstrate that rootassociated microbes are critical influencers of host plant growth and nutrient acquisition. Three synthetic communities(SynComs) were constructed based on functional screening of 1,893 microbial strains isolated from root-associated compartments of soybean plants. Functional assemblage of SynComs promoted significant plant growth and nutrient acquisition under both N/P nutrient deficiency and sufficiency conditions.Field trials further revealed that application of SynComs stably and significantly promoted plant growth, facilitated N and P acquisition, and subsequently increased soybean yield. Among the tested communities, SynCom1 exhibited the greatest promotion effect, with yield increases of up to 36.1% observed in two field sites. Further RNA-seq implied that SynCom application systemically regulates N and P signaling networks at the transcriptional level, which leads to increased representation of important growth pathways, especially those related to auxin responses. Overall,this study details a promising strategy for constructing SynComs based on functional screening,which are capable of enhancing nutrient acquisition and crop yield through the activities of beneficial root-associated microbes. | Cunhu Wang Yanjun Li Mingjia Li Kefei Zhang Wenjing Ma Lei Zheng Hanyu Xu Baofeng Cui Ran Liu Yongqing Yang Yongjia Zhong Hong Liao | 2021 | Journal of Integrative Plant Biology2021，63，6： | 5 |
| 6 | Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics显示文摘Limited knowledge of cellular and molecular mechanisms underlying hematopoietic stem cell and multipotent progenitor(HSC/MPP)expansion within their native niche has impeded the application of stem cell-based therapies for hematological malignancies.Here,we constructed a spatiotemporal transcriptome map of mouse fetal liver(FL)as a platform for hypothesis generation and subsequent experimental validation of novel regulatory mechanisms.Single-cell transcriptomics revealed three transcriptionally heterogeneous HSC/MPP subsets,among which a CD93-enriched subset exhibited enhanced stem cell properties.Moreover,by employing integrative analysis of single-cell and spatial transcriptomics,we identified novel HSC/MPP‘pocket-like’units(HSC PLUS),composed of niche cells(hepatoblasts,stromal cells,endothelial cells,and macrophages)and enriched with growth factors.Unexpectedly,macrophages showed an 11-fold enrichment in the HSC PLUS.Functionally,macrophage-HSC/MPP co-culture assay and candidate molecule testing,respectively,validated the supportive role of macrophages and growth factors(MDK,PTN,and IGFBP5)in HSC/MPP expansion.Finally,cross-species analysis and functional validation showed conserved cell-cell interactions and expansion mechanisms but divergent transcriptome signatures between mouse and human FL HSCs/MPPs.Taken together,these results provide an essential resource for understanding HSC/MPP development in FL,and novel insight into functional HSC/MPP expansion ex vivo. | Suwei Gao Qiang Shi Yifan Zhang Guixian Liang Zhixin Kang Baofeng Huang Dongyuan Ma Lu Wang Jianwei Jiao Xiangdong Fang Cheng-Ran Xu Longqi Liu Xun Xu Berthold Gottgens Cheng Li Feng Liu | 2022 | Cell Research2022，32，1： | 4 |
| 7 | Genomic profiling and the impact of MUC19 mutation in hepatoid adenocarcinoma of the stomach显示文摘Dear Editor,Hepatoid adenocarcinoma(HAC)is a rare pathological subtype of extrahepatic tumor,featured by hepatoid differentiation andα-fetoprotein(AFP)-production[1,2].Hepatoid adenocarcinoma of the stomach(HAS),accounting for 0.3%to 1.0%of all gastric cancers(GCs),has attracted increasing attention due to its high degree of malignancy[3].Compared with classic GC,HAS showed a higher rate of vascular invasion,lymph node metastasis,and liver metastasis,with only 9.0%survival rate at 5 years[4].Currently,there is no effective treatment for HAS,and little is known about its pathogenesis.Herein,we investigated the molecular features of HAS and identified potential therapeutic targets for HAS. | Mengxuan Zhu Erbao Chen Shan Yu Chen Xu Yiyi Yu Xin Cao Wei Li Pengfei Zhang Yan Wang Baofeng Lian Shuirong Zhang Yueting Qu Lujia Huang Weiwei Shi Yuehong Cui Li Qian Tianshu Liu | 2022 | Cancer Communications2022，42，10： | 3 |
| 8 | The characteristics of shear wave splitting in the source region of the April 20,2013 Lushan earthquake显示文摘Using seismic data of the aftershocks sequence of the April 20,2013 Lushan earthquake recorded by seismic temporary and permanent stations in the source region,with the visual inspection of particle motion diagrams,this paper preliminarily contains the polarization directions of fast shear wave and the time-delays of split shear waves at every station,and analyzes the crustal anisotropic characteristics in the source region.In the study area,the polarization directions at stations BAX,TQU,L132,L133,L134,and L135 are northeast,which is consistent with the strike of Dachuan–Shuangshi fault.There are two polarization directions at MDS and L131,which are northeast and southeast.The scatter of polarization directions suggests the complex stress field around these two stations where two faults intersect.For the normalized time-delays at every station,the range is1.02–8.64 ms/km.The largest time-delay is from L134which is closest to the mainshock,and the smallest one is from L133.The variations in time-delays show the decreasing at stations BAX,L134,and L135 because of the stress–relaxation after earthquake. | Sha Liu Jiansi Yang Baofeng Tian Yu Zheng Xudong Jiang Zhiqiang Xu | 2013 | Earthquake Science2013，26，3： | 2 |
| 9 | Transsphenoidal microsurgical treatment of infradiaphragmatic craniopharyngioma显示文摘Objective Typically,the transcranial approach has been used for the treatment of craniopharyngiomas with suprasellar extension,whereas the transsphenoidal approach has been used mostly for infradiaphragmatic craniopharyngioma.Total resection of craniopharyngioma can reduce the recurrence rate,especially in young children,but it may lead to severe complications.Therefore,any benefit of the degree of resection must be weighed against the risk of complications by the surgeons.The purpose of this study was to explore the therapeutic outcome after transsphenoidal microsurgical treatment of infradiaphragmatic craniopharyngioma and share our experiences.Methods Between January 2003 and June 2013,30 patients with infradiaphragmatic craniopharyngioma underwent transsphenoidal microsurgical resection in our hospital.The neurological,visual,and endocrine functions,and extent of resection were analyzed retrospectively.Recurrence or growth of residual tumor tissue during follow-up was assessed using magnetic resonance imaging(MRI).Results Total resection was achieved in 25 patients(83.3%),subtotal resection was achieved in 4 patients(13.3%),and partial resection was achieved in 1 patient(3.4%).There were no perioperative deaths.Cerebrospinal fluid(CSF) leakage occurred in 6 patients,and among them,2 required surgical repair of the sella.New-onset postoperative diabetes insipidus(DI) developed in 8 patients.Vision and visual fields were improved at different levels in 13 out of 16 patients who had sight impediments before treatment.Tumor recurrence and regrowth was observed in 2 patients;1 patient underwent transsphenoidal reoperation,the condition of the other patient who had undergone several craniotomies grew worse over the 6-month follow-up period.Conclusion Transsphenoidal surgery is an ideal choice in treating infradiaphragmatic craniopharyngioma.The transsphenoidal approach,which preserves pituitary function and avoids damage to the hypothalamic structures and optic nerve,is associated with fewer complications than the transcranial approach and a low mortality rate. | Ting Lei Baofeng Wang Juan Chen Yu Xu Kai Shu Wei Sun Shaozheng Liu Xiaopeng Li | 2016 | Oncology and Translational Medicine2016，2，5： | 2 |
| 10 | Dasatinib inhibits proliferation of liver cancer cells,but activation of Akt/mTOR compromises dasatinib as a cancer drug显示文摘Dasatinib is a multi-target protein tyrosine kinase inhibitor.Due to its potent inhibition of Src,Abl,the platelet-derived growth factor receptor(PDGFR)family kinases,and other oncogenic kinases,it has been investigated as a targeted therapy for a broad spectrum of cancer types.However,its efficacy has not been significantly extended beyond leukemia.The mechanism of resistance to dasatinib in a wide array of cancers is not clear.In the present study,we investigated the effect of dasatinib on hepatocellular carcinoma cell growth and explored the underlying mechanisms.Our results showed that dasatinib potently inhibited the proliferation of SNU-449 cells,but not that of other cell lines,such as SK-Hep-1,even though it inhibited the phosphorylation of Src on both negative and positive regulation sites in all these cells.Dasatinib activated the phosphoinositide-dependent protein kinase1(PDK1)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)signaling pathway in SK-Hep-1 cells,but not in SNU-449 cells.Blocking the Akt/mTOR signaling pathway strongly promoted the efficacy of dasatinib in SK-Hep-1 cells.In SNU-449 cells,dasatinib promoted apoptosis and the cleavage of caspase-3 and caspase-7,induced cell cycle arrest in the G1 phase,and inhibited the expression of Cyclin-dependent kinase(CDK4)/6/CyclinD1 complex.These findings demonstrate that dasatinib exerts its anti-proliferative effect on hepatocellular cell proliferation by blocking the Src family kinases;however,it causes Akt activation,which compromises dasatinib as an anti-cancer drug. | Chang Liu Xiaoxia Zhu Yuqi Jia Fenqing Chi Keru Qin Jinhong Pei Chan Zhang Xiuli Mu Hongwei Zhang Xiushan Dong Jun Xu Baofeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 2 |
| 11 | Optimization of Texture Determination of ‘Yali' by Texture Analyzer显示文摘[Objectives] This study was carried out to determine texture parameters for texture profile analysis( TPA),and optimize the texture determination of‘Yali'by texture analyzer. [Methods]The traditional varieties of‘Yali'were taken as the materials,and texture parameters were determined at different compression rates and deformations at target. [Results]In the process of the TPA,the deformation at target had an extremely significant influence on 8 TPA texture parameters,namely,the hardness,cohesiveness,springiness,adhesiveness,gumminess,resilience,fracturability,and chewiness( P≤0. 01),while the compression rate had significant influence on the hardness and gumminess( P≤0. 05),had an extremely significant influence on fracturability( P≤0. 01),and had no significant influence on other 5 TPA parameters. [Conclusions]Taking the compression rate of 1 mm/s and 20% deformation at target as the experimental conditions for TPA could avoid the impact load of high speed on the tissue and objectively reflect the textural characteristics of‘Yali'pulp tissue. | Jintao XU Lijuan GAO Longfei LI Hai'e ZHANG Wenquan LE Baofeng HAO | 2018 | Agricultural Biotechnology2018，7，4： | 2 |
| 12 | Investigation of plateau basin crustal structures and thickening mechanisms in the northeastern margin of the Tibetan plateau显示文摘This paper uses deep seismic sounding (DSS) data to contrast and analyze the crustal structures of three plateau basins (Songpan-Garze, Qaidam, Longzhong) in the northeastern margin of the Qinghai-Xizang (Tibetan) plateau, as well as two stable cratonic basins (Ordos, Sichuan) in its peripheral areas. Plateau basin crustal structures, lithological variations and crustal thickening mechanisms were investigated. The results show that, compared to the peripheral stable cratonic basins, the crystalline crusts of plateau basins in the northeastern margin are up to 10-15 km thicker, and the relative medium velocity difference is about 5% less. The medium velocity change in crustal layers of plateau basin indicates that the upper crust undergoes brittle deformation, whereas the lower crust deforms plastically with low velocity. The middle crust shows a brittle-to-plastic transition zone in this region. Thickening in the lower crust (about 5-10 km), and rheological characteristics that show low- medium velocity (relatively reduced by 7%), suggest that crustal thickening mainly takes place in lower crust in the northeastern margin of the Tibetan plateau. The crust along the northeastern margin shows evidence of wholesale block movement, and crustal shortening and thickening seem to be the main deformation features of this region. The GPS data show that the block motion modes and crustal thickening in the Tibetan plateau is closely related to the peripheral tectonic stress field and motion direction of the Indian plate. The Mani-Yushu- Xianshuihe fold belt along the boundary between the Qiangtang block and the Bayan Har block divides the different plateau thickening tectonic environments into the middle-western plateau, the northeastern margin and the southeastern plateau. | Shixu Jia Zhaofan Xu Zhi Liu Jianshi Zhang Baofeng Liu Jiyan Lin Wenbin Guo | 2012 | Earthquake Science2012，25，5： | 1 |
| 13 | The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes显示文摘 | Chaoqian Xu Yanjie Lu Zhenwei Pan Wenfeng Chu Xiaobin Luo Huixian Lin Jiening Xiao Hongli Shan Zhiguo Wang and Baofeng Yang | | Journal of Cell Science0，120，17： | 1 |
| 14 | Isothermal crystallization kinetics, morphology, and thermal conductivity of graphene nanoplatelets/polyphenylene sulfide composites显示文摘 | Deng Shuling Lin Zhidan Xu Baofeng et a l | 2014 | Journal of Thermal Analysis and Calorimetry2014，118，1： | 1 |
| 15 | Study on the Changes of the Major Nutrient Elements During Simple Composting Process of Dry Chicken Manure显示文摘[Objectives]This study was conducted to provide a theoretical basis for production and application of chicken manure compost.[Methods]With dry manure as a material,the variations of the major nutrients during simple composting process of dry chicken manure were studied,in order to get the best fermentation method.[Results]Chicken manure should not be preserved wet,but should be preserved after air-drying and fermented before use.Necessary moisture,simple sealing treatment and a certain amount of N element were conducive to simple fermentation of chicken manure.The treatments in which the chicken manure was wrapped around and compacted,added with an appropriate amount of water(50%-60%)and naturally fermented,or was wrapped around and compacted and added with an appropriate amount of water(50%-60%)and 0.2%of urea,were more appropriate for the production directly.[Conclusions]This study provides a theoretical basis for the actual production and application of chicken manure compost. | Jintao XU Longfei LI Lijuan GAO Yong GUO Hai'e ZHANG Minghui JI Baofeng HAO | 2020 | Agricultural Biotechnology2020，9，6： | 1 |
| 16 | The functions of CD4 T-helper lymphocytes in chronic obstructive pulmonary disease显示文摘Chronic obstructive pulmonary disease(COPD)has been increasingly accounted for global morbidity and mortality worldwide.Although it is partially reversible,the obstructive ventilatory schema of COPD often causes chronic inflammation that primarily affects peripheral airways,pulmonary parenchyma,and the development of lung lymphoid follicles.Among various T-helper(Th)cell types associated with COPD,Th1,Th2 and Th17 cell numbers are increased in COPD patients,whereas Treg cell number is reduced.Here,we reviewed recent advance in understanding the roles of Th1/Th2 and Th17/Treg in the pathogenesis of COPD and discussed the potential underlying mechanism. | Keru Qin Baixue Xu Min Pang Hailong Wang Baofeng Yu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，2： | 1 |
| 17 | CoP x synthesis and lithiation by ball-milling for anode materials of lithium ion cells显示文摘 | Zongshuang Zhang Jun Yang Yanna Nuli Baofeng Wang Jinqiang Xu | 2004 | Solid State Ionics2004，，7： | 1 |
| 18 | Control Effects of Different Fungicides on Pear Scab显示文摘[Objective] The paper was to select different fungicides for field efficacy test against pear scab in summer.[Method] Five treatments were designed in the test,including 10% difenoconazole WDG 6 000 times dilution,50% captan WP 600 times dilution,30% pyraclostrobin SC 2 000 times dilution,430 g/L tebuconazole 4 000 times dilution,and water(control).[Result] 10% Difenoconazole WDG 6 000 times dilution,50% captan WP 600 times dilution,30% pyraclostrobin SC 2 000 times dilution,430 g/L tebuconazole SC 4 000 times dilution had good control effects against pear scab,and the efficacies were 89.13%-93.51%.[Conclusion] The results will provide the theoretical basis for field control of pear scab in summer. | Geo Lijuan Zhang Hai'e Xu Jintao Li Longfei Ji Minghui Hao Baofeng | 2020 | Plant Diseases and Pests2020，11，4： | 1 |
| 19 | The protective efficacy of chimeric SO7/IL-2 DNA vaccine against coccidiosis in chickens显示文摘 | Hongyan Song Baofeng Qiu Ruofeng Yan Lixin Xu Xiaokai Song Xiangrui Li | 2012 | Research in Veterinary Science2012，，： | 1 |
| 20 | Photoelectrocatalytic oxidation of Cu- 11 -EDTA at TiO2 electrode and simultaneous reco- very ofCu- by electrodeposition 显示文摘 | Zhao Xu Guo Libao Zhang Baofeng | 2013 | Environmental Science and Technology2013，47，9： | 1 |
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