|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNAs in tomato plants显示文摘MicroRNAs (miRNAs) are a specialized class of small silencing RNAs that regulate gene expression in eukaryotes.In plants,miRNAs negatively regulate target mRNAs containing a highly complementary sequence by either mRNA cleavage or translational repression.As a model plant to study fleshy fruit ripening,miRNA studies in tomato have made great progress recently.MiRNAs were predicted to be involved in nearly all biological processes in tomato,particularly development,differentiation,and biotic and abiotic stress responses.Surprisingly,several miRNAs were verified to be involved in tomato fruit ripening and senescence.Recent studies suggest that miRNAs are related to host-virus interactions,which raises the possibility that miRNAs can be used as diagnostic markers for response to virus infection in tomato plants.In this review,we summarize our current knowledge systematically and advance future directions for miRNA research in tomato. | ZUO JinHua WANG YunXiang LIU HaiPing MA YuanZheng JU Zheng ZHAI BaiQiang FU DaQi ZHU Yi LUO YunBo ZHU BenZhong | 2011 | Science China(Life Sciences)2011，54，7： | 13 |
| 2 | CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys显示文摘Dear Editor,PINK1 mutations cause autosomal recessive and early-onset Parkinson’s disease(PD)with selective neurodegeneration.Unfortunately,current PINK1 knockout(KO)mouse1,2 and pig models3,4 are unable to recapitulate the selective and overt neurodegeneration seen in PD patients.Furthermore,endogenous Pink1 in the mouse brain is expressed at very low levels and can only be detected via immunoprecipitation,5 meaning that PINK1’s function in the mammalian brain needs to be assessed using larger animals that are closer to humans.We previously used CRISPR/Cas9 to target the monkey gene in one-cell stage embryos.6 Using the same approach,we designed two gRNAs to target exon 2(T1)and exon 4(T2),which encode a kinase domain in the PINK1 gene of rhesus monkeys(Fig.1a).CRISPR/Cas9 and PINK1 gRNAs were injected into one-cell stage rhesus monkey embryos.A T7E1 assay and sequencing of PCR products from the injected embryos showed high efficiency(61.5%)in targeting PINK1(Fig.1b and Supplementary information,Fig.S1).Transfer of 87 embryos to 28 surrogate rhesus monkeys resulted in 11 pregnancies(39.2%)(Fig.1b).Eleven fetuses developed to term and were born naturally.Of these live monkeys,eight carried PINK1 mutations(M),and three were wild type(WT).However,three mutant monkeys(M1,M3 and M4)were newborn triplets that struggled to survive and died 3-4 days after birth.One WT newborn monkey also died after a difficult labor.Another mutant monkey(M2)died 7 days after birth without noticeable warning signs or symptoms.The other three mutant monkeys(M6,M7 and M8)have lived for three years;M5,however,reduced its food intake and showed weakness at the age of 1.5 years,and died 30 days after anesthesia for MRI examination. | Weili Yang Yunbo Liu Zhuchi Tu Chong Xiao Sen Yan Xishan Ma Xiangyu Guo Xiusheng Chen Peng Yin Zhengyi Yang Su Yang Tianzi Jiang Shihua Li Chuan Qin Xiao-Jiang Li | 2019 | Cell Research2019，29，4： | 12 |
| 3 | Bipartite Consensus of Discrete-Time Double-Integrator Multi-Agent Systems with Measurement Noise显示文摘The effects of measurement noise are investigated in the context of bipartite consensus of multi-agent systems. In the system setting, discrete-time double-integrator dynamics are assumed for the agent, and measurement noise is present for the agent receiving the state information from its neighbors. Time-varying stochastic bipartite consensus protocols are designed in order to lessen the harmful effects of the noise. Consequently, the state transition matrix of the closed-loop system is analyzed, and sufficient and necessary conditions for the proposed protocol to be a mean square bipartite consensus protocol are given with the help of linear transformation and algebraic graph theory. It is proven that the signed digraph to be structurally balanced and having a spanning tree are the weakest communication assumptions for ensuring bipartite consensus. In particular, the proposed protocol is a mean square bipartite average consensus one if the signed digraph is also weight balanced. | MA Cuiqin ZHAO Weiwei ZHAO Yunbo | 2018 | Journal of Systems Science & Complexity2018，31，6： | 4 |
| 4 | The Observation of Ice-Nucleating Particles Active at Temperatures above –15℃ and Its Implication on Ice Formation in Clouds显示文摘A series of measurements of ice-nucleating particles(INPs) were performed at two sites in Beijing. At the Beijing Meteorological Service(BMS) site, which was an urban site, no INPs were found to be active above –15℃.However, at the Yanjiaping(YJP) site, which was a rural site, the concentration of INPs active at temperatures above–15℃ was found to be as high as 1.73 g^(–1). Two parameterizations were constructed by respectively fitting the data obtained at BMS site and YJP site. The two parameterizations, as well as another parameterization from the literature,were implemented into a parcel model to investigate the effect of INPs active above –15℃ on phase partitioning in mixed-phase clouds. At a vertical velocity of 0.01 m s^(–1), which is typical for stratiform clouds associated with frontal systems, the INPs active above –15℃ nucleate ice crystals at low levels. The growth of these ice crystals remarkably reduces both the maximum liquid water mixing ratio and the altitude where the maximum liquid water mixing ratio is reached. When the vertical velocity of the parcel is increased to 0.1 m s^(–1) or an even higher value, the evolution of liquid water mixing ratio is not controlled by the INPs active above –15℃ but those active below –15℃. | Kai BI Xincheng MA Yunbo CHEN Shizuo FU Huiwen XUE | 2018 | Journal of Meteorological Research2018，32，5： | 3 |
| 5 | Effect of rich R-TiO2 on the rate and cycle properties of Li4Ti5O12 as anode for lithium ion batteries显示文摘Li4Ti5012 (LTO) with rich R-TiO2 (17.06, 23.69, and 34.42 wt%), namely, R-TiO2@Li4Ti5O12 composites, were synthesized using the hydrothermal method and tetrabutyl titanate (TBT) as the precursor. Rietveld refinement of X-ray diffraction (XRD) results show that the proportion of Li occupying 16d sites is extraordinary low and the lattice constants of LTO and R-TiO2 change with the ritanium dioxide content. EIS measurements showed that with in creasing R-TiO2 content, both its charge transfer impedance (Rct) and lithium ion diffusion coefficient (DLi) decreased. The changes of Rct and DLi caused by the increase of titanium dioxide content have synergic-antagonistic effects on the rate and cycle properties of Li4Ti5012. The rate performance is positively related to DLi, while the cycle property is negatively correlated with Rct, indicati ng that the rate performs nee is mainly related to DLi, while Rct more significantly affects the cycle performance. LTO-RT-17.06% exhibited excellent rate properties, especially under a high current density (5.0 C, 132.5 mAh/g) and LTO-RT-34.42% showed superior long-term cycle performance (0.012% capacity loss per cycle) compared to that of LTO-RT-17.06% and LTO-RT-23.69%. | Delai Qian Yijie Gu Shuainan Guo Hongquan Liu Yunbo Chen Juan Wang Guoxuan Ma Chuan Wu | 2019 | Journal of Energy Chemistry2019，28，5： | 3 |
| 6 | Design and dynamic analysis of single-axis integrated inertia measurement device显示文摘The structure and measurement theory of a single-axis integrated inertia measurement device are discussed in this paper.The acceleration and angle velocity can be detected by the proposed sensor at the same time.The ki- netic model of the device is also established.In addition,the signal generation of the single-axis integrated inertia measurement device is analyzed and simulated.The results of the model are consistent with simulation result. | Ma Zongmin Shi Yunbo Meng Meiyu Liu Jun | 2007 | 仪器仪表学报2007，28，9： | 2 |
| 7 | Research on gears' dynamic performance influenced by gear backlash based on fractal theory显示文摘 | CHEN Qi MA Yunbo HUANG Shouwu | 2014 | Applied Surface Science2014，313，： | 1 |
| 8 | Safety assessment of dehydration-responsive element-binding (DREB) 4 protein expressed in E. coli显示文摘 | Bo Cao Xiaoyun He Yunbo Luo Lina Ma Pengfei Liu Sishuo Cao Yaozheng Liu Shiying Zou Wentao Xu Kunlun Huang | 2012 | Food and Chemical Toxicology2012，，11： | 1 |
| 9 | Efficient large fragment deletion in plants:double pairs of sgRNAs are better than dual sgRNAs显示文摘Dear Editor,Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)is a powerful and versatile gene editing system that has been extensively utilized in various animals and plants,which holds enormous potential and value for scientific research and breeding.However,single-targeted CRISPR can only induce a few base deletions,insertions,or substitution.Ideally,thesemutations result in premature termination of the protein encoded by the target gene,leading to a loss of function[1]. | Guoning Zhu Lingling Zhang Liqun Ma Qing Liu Kejian Wang Jinyan Li Guiqin Qu Benzhong Zhu Daqi Fu Yunbo Luo Hongliang Zhu | 2023 | Horticulture Research2023，10，10： | 1 |
| 10 | Postoperative Radiotherapy and N2 Non-small Cell Lung Cancer Prognosis: A Retrospective Study Based on Surveillance, Epidemiology, and End Results Database显示文摘The purpose of this study is to clarify the significance of postoperative radiotherapy for N2 lung cancer.This study aimed to investigate the effect of postoperative radiotherapy on the survival and prognosis of patients with N2 lung cancer.Data from 12,000 patients with N2 lung cancer were extracted from the Surveillance,Epidemiology,and End Results database(2004-2012).Age at disease onset and 5-year survival rates were calculated.Survival curves were plotted using the Kaplan-Meier method.The univariate log-rank test was performed.Multivariate Cox regression were used to examine factors affecting survival.Patients’median age was 67 years(mean 66.46±10.03).The 5-year survival rate was 12.55%.Univariate analysis revealed age,sex,pathology,and treatment regimen as factors affecting prognosis.In multivariate analysis,when compared to postoperative chemotherapy,postoperative chemoradiotherapy was better associated with survival benefits(hazard ratio[HR]=0.85,95%confidence interval[CI]:0.813-0.898,P<0.001).Propensity score matching revealed that patients who had received postoperative chemoradiotherapy had a better prognosis than did patients who had received postoperative chemotherapy(HR=0.869,95%CI:0.817-0.925,P<0.001).Female patients and patients aged<65 years had a better prognosis than did their counterparts.Patients with adenocarcinoma had a better prognosis than did patients with squamous cell carcinoma.Moreover,prognosis worsened with increasing disease T stage.Patients who had received postoperative chemoradiotherapy had a better prognosis than did patients who had received postoperative chemotherapy.Postoperative radiotherapy was an independent prognostic factor in this patient group. | Yunbo Zhang Liping Zheng Junqi Liu Jinqiu Li Jianguang Zhang Jingjing Ma Yuxiu Song | 2021 | Journal of Oncology Research2021，3，2： | 0 |
| 11 | Strong Localization Effect of Oxygen Deficiency on Carriersin T1 Based Superconductors显示文摘Investigation on the effect of Fe-doped T1-1223 superconductors has been carried out by the simultaneousmeasurements of the spectra of positron annihilation lifetime and Doppler broadening of position annihilation,together with the measurement of Hall coefficient. The results of samples with different doping level show that theoccupation of Fe atoms on Cu sites results in a linear decrement of superconducting transition temperature. The electron concentration in Cu-O layer has been enhanced by Fe doping. The difference in valence between Fe3+ andCu+ induces extra oxygen into the lattice and forms the extra oxygen defects. This Fe dopant leads to a stronglocalization of the electrons in the Cu-O layer. So the decrement of the concentration of the itinerant electronsresults in a decline of the superconducting transition temperature. | MA Qingzhu WANG Yunbo LI Yang CAO Guohui(Department of Physics, USTB, Beijing 100083, China Department of Materials Physics, USTB)(Laboratory of Nuclear Analysis Techniques Academia Sinica National Laboratory of Superconduchvity, Academia Sinica) | 1997 | International Journal of Minerals,Metallurgy and Materials1997，11，1： | 0 |
| 12 | A Fast and Effective Surgical Method for a Painful Skin Lesion显示文摘Background Eccrineangiomatoushamartoma(EAH)is a rare benign disease that comprises vascular and eccrine malformations.Pain is one of the most common symptoms and surgical resection is generally required.Objective To report a novel surgical technique that can alleviate severe pain caused by a large lesion in an EAH patient.Methods On magnetic resonance imaging(MRI),a subcutaneous abnormal signal was detected in the right hip and groin area of an 18-year-old male.The lesion was carefully elevated from the normal tissue above the plane of the deep fascia and was sutured in situ.Additionally,a small sample of the central lesion tissue was collected for histological examination.Results The visual analog scale score of pain decreased from 9 points to 2 points at 1week and to 0 points at 2 weeks after the surgery.The only complication observed was local numbness,which recovered spontaneously.No recurrence of pain was observed after 1 year of surgery.Histological findings demonstrated that the numbers of eccrine sweat glands and abnormal vessels decreased post-surgery.Conclusion The surgical procedure used in our case may represent a novel,easy,safe,and effective option for the treatment of a large,severely painful EAH. | Li HU Hui CHEN Xi YANG Yunbo JIN Gang MA Wei LI Xiaoxi LIN | 2020 | Chinese Journal Of Plastic and Reconstructive Surgery2020，2，1： | 0 |
| 13 | Systemic Hemodynamic Changes in Low-Dose Ethanol Embolotherapy for Soft-Tissue Arteriovenous Malformations显示文摘Background Ethanol embolotherapy is considered an optimal choice for the treatment of arteriovenous malformations(AVMs);however,there are some complications associated with this treatment.This study aimed to prospectively investigate systemic hemodynamic changes in high-flow AVMs using ethanol embolotherapy.Methods From September 2012 to September 2014,34 male patients and 26 female patients with AVMs who underwent embolotherapy(100 sessions in total)with absolute ethanol were included in this study.Invasive systolic blood pressure(SBP)and heart rate(HR)were recorded before and after each injection and throughout the procedure.Differences between the initial and highest SBP(ΔmaxSP)and HR values(ΔmaxHR),as well as the initial and final SBP(ΔSP)and HR(ΔHR)values,were analyzed.We aimed to explore the potential association between these values and the amount of ethanol that was used.Results The total ethanol used was variable(0.01–0.40 mL/kg;mean,0.20 mL/kg).SBP and HR increased after ethanol injection in most sessions(91 in 100 sessions).SBP decreased in 9 sessions(9 in 100 sessions),while HR,oxygen saturation,and end-tidal CO2 decreased in one of the 9 sessions.ΔmaxSP andΔmaxHR averaged 38.4 mmHg and 27.8 bpm,respectively(both P<0.05),whileΔSP andΔHR averaged 3.4 mmHg and 4.0 bpm,respectively(both P<0.05).ΔmaxSP andΔmaxHR were positively correlated with the total dose of ethanol injected.Conclusions Elevations in SBP and HR during ethanol embolotherapy are common,temporary,and most likely pain-mediated;these increases tend to be positively correlated with ethanol dose.Hypotension may be regarded as an acute complication of ethanol embolotherapy.Hypotension combined with bradycardia,oxygen desaturation,and decreased end-tidal CO2 may be a potential predictor of cardiovascular collapse. | Xi YANG Chen HUA Hui CHEN Lan LUO Gang MA Xiaojie HU YaJing QIU Wenxin YU Lei CHANG Yunbo JIN Xiaoxi LIN | 2021 | Chinese Journal Of Plastic and Reconstructive Surgery2021，3，1： | 0 |
| 14 | Study on Radiochemical Sensor of 99Tc显示文摘99Tc is one of important monitored radionuclides in environment.The traditional analysis procedure for 99Tc contains sampling,separation,measurement,etc,which is time-consuming and cannot determine the concentration in real-time,so fail to meet the rapidly | SONG Zhijun DING Youqian MA Peng DANG Yunbo WANG Xiufeng | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员