|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Microsatellite analysis of genetic diversity and population structure of Chinese mitten crab (Eriocheir sinensis)显示文摘中国露指手套螃蟹(Eriocheir sinensis ) 在中国比 Eriocheir 的任何另外的种类作为食物来源有更高商业的价值。为了评估细菌原生质资源并且在不同的水系统,二张股票和二张耕作人口描绘基因差异和螃蟹的人口结构,与在公共场合可得到的 25 多态的 microsallite loci 被估计 GenBank。基本统计证明一般水准观察了杂合现象(惊讶) 在人口之中从 0.5789 ~ 0.6824 。然而,使近交的显著存在和异质接合体缺乏被观察。到分析人口结构,配对系数从露指手套螃蟹人口的分向仅仅 10.3% 可变性解释了的明智的 FST,留下的可变性在潜水艇人口以内源自分。尽管四张人口有细微区别,不同突变而产生之遗传的频率导致了不同人口结构。二张股票和股票耕作人口一起被聚类到 Yangtze 螃蟹的种系发生的分支,与 95% 的一个近似会员。而,另一张耕作人口单身地被聚类到 Liaohe 螃蟹的种系发生的分支,与 97.1% 的一个会员。为单个混合的测试证明那只 Yangtze 螃蟹可能从另外的水系统与个人一起被污染了。在人口之间的基因关系也支持了尽管有一样的种类的起源,那只 Yangtze 螃蟹和 Liaohe 螃蟹有不同基因库的结论。 | Yumei Chang Liqun Liang Haitao Ma Jianguo He Xiaowen Sun | 2008 | Journal of Genetics and Genomics2008，35，3： | 29 |
| 2 | GDNF-Enhanced Axonal Regeneration and Myelination Following Spinal Cord Injury is Mediated by Primary Effects on Neurons显示文摘我们先前研究表明胶质细胞源性神经营养因子(GDNF)联合施万细胞移植能促进脊髓损伤后轴突再生和髓鞘形成。然而,GDNF介导这一过程的细胞靶点尚不清楚。在此,我们报道了GDNF可增加在体再生轴突的数目和直径,并促进体外背根神经节神经元的轴突向外生长,提示GDNF对神经元有直接作用。在施万细胞-背根神经节神经元共培养下,GDNF显著增加施万细胞生成的髓鞘数目;GDNF处理对孤立培养的施万细胞增殖无作用,但可促进已与神经轴突有突触联系的施万细胞增殖;GDNF可增加孤立施万细胞中分子量为140kDa的神经细胞黏附分子(NCAM)的表达,但对黏附分子L1表达或神经营养因子NGF、NT3及BDNF分泌没有影响。总之,这些结果支持假设:GDNF提高轴突再生和施万细胞髓鞘形成主要是通过GDNF对神经元的直接作用介导的,并且提示GDNF联合施万细胞移植可能是促进脊髓损伤后轴突再生和髓鞘形成的有效策略之一。 | LIQUN ZHANG ZHENGWEN MA GEORGE M. SMITH XUEJUN WEN YELENA PRESSMAN PATRICK M. WOOD AND XIAO-MING XU | 2009 | 神经损伤与功能重建2009，4，4： | 25 |
| 3 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 4 | Recanalization of extracranial internal carotid artery occlusion A 12-year retrospective study显示文摘This study aimed to summarize therapy experience of carotid endarterectomy, carotid endarterec-tomy combined with Fogarty catheter embolectomy, and hybrid surgery for the treatment of extrac-ranial internal carotid artery occlusion. The study included 65 patients with extracranial internal ca-rotid artery occlusion who underwent carotid endarterectomy, carotid endarterectomy combined with Fogarty catheter embolectomy, or hybrid surgery in the Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, China between January 2006 and December 2012. Prior to surgery, all patients underwent perfusion CT or xenon CT to evaluate the occlusion. The procedure for each patient was chosen according to digital subtraction angiography data. The carotid artery was successfully recanalized in 46 of 51 patients who underwent carotid endarterectomy, 9 of 10 patients who underwent carotid endarterectomy combined with Fogarty catheter embolectomy, and 3 of 4 patients who underwent hybrid surgery. In patients with symptomatic carotid artery occlusion, the carotid artery can be recanalized by choosing a treatment procedure based on imaging ex-amination findings. | Liqun Jiao Gang Song Yang Hua Yan Ma Yanfei Chen Yabing Wang Feng Ling | 2013 | Neural Regeneration Research2013，8，23： | 19 |
| 5 | TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice显示文摘 | Zhidan Luo Liqun Ma Zhigang Zhao Hongbo He Dachun Yang Xiaoli Feng Shuangtao Ma Xiaoping Chen Tianqi Zhu Tingbing Cao Daoyan Liu Bernd Nilius Yu Huang Zhencheng Yan Zhiming Zhu | 2012 | Cell Research2012，22，3： | 18 |
| 6 | Genotypic variations in the accumulation of Cd exhibited by different vegetables显示文摘It is an important approach to use the Cd-contaminated soils properly by growing low accumulator or excluder plants for Cd to produce safe foods. To find the suitable vegetable species for growing in Cd-contaminated soils, in the present study the variations in the Cd accumulation for twenty eight vegetable species and several cultivars of five common vegetables (cowpea, kidney pea, bitter gourd, cucumber and squash) were investigated in two soil Cd levels (1 and 2 mg/kg Cd). Experimental results showed that highly significant differences in Cd concentration were evident among 28 vegetables. For example, spinach Cd concentrations were 110-fold and 175-fold higher than that of sweet pea under the 1 and 2 mg/kg Cd exposures, respectively. For Cd accumulation, the order of vegetable species was: leafy vegetables > solanaceous vegetables > kale vegetables > root vegetables > allimus > melon vegetables > legumes. Distinctive differences were also identified when comparing different cultivars of the five common vegetables with an average range of 0.003–0.094 mg/kg Cd. Our results indicated that a large genotypic variation existed among vegetable species or cultivars when subjected to Cd exposure. Therefore, it is important and feasible to elect/breed vegetable species/cultivars with low accumulation of Cd, especially in mildly Cd-contaminated soils. | Junxing Yang Haitao Guo Yibing Ma Liqun Wang Dongpu Wei Luo Hua | 2010 | Journal of Environmental Sciences2010，22，8： | 16 |
| 7 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 8 | Exosome-encapsulated miR-505 from ox-LDL-treated vascular endothelial cells aggravates atherosclerosis by inducing NET formation显示文摘Neutrophil extracellular traps(NETs)play an important role in the pathological process of atherosclerosis(AS).This study aims to evaluate whether exosomes from oxidized low-density lipoprotein(ox-LDL)-treated vascular endothelial cells(VECs)aggravate AS by inducing NET formation.Exosomes from the peripheral blood of healthy donors and AS patients(namely NC-EXO and AS-EXO,respectively)and exosomes from human umbilical vein endothelial cells(HUVECs)treated without or with ox-LDL(namely normal EXO and ox-LDL-EXO,respectively)were isolated,identified,and co-cultured with neutrophils from peripheral blood of healthy donors.NET formation was evaluated by immunofluorescence staining and determining the content of cell-free DNA and myeloperoxidase-DNA complex.Dual-luciferase reporter assay,chromatin immunoprecipitation assay,quantitative reverse transcription polymerase chain reaction,and western blot analysis were performed to explore the underlying mechanisms.We found that AS-EXO and ox-LDLEXO in duced NET release from n eutrophils.Meeh a nistically,ox-LDL treatment in HUVECs might activate the NF-κB pathway,which transcriptionally activates miR-505,and then the exosome-encapsulated high miR-505 expression targeted and inhibited SIRT3 in neutrophils,thereby inducing reactive oxygen species(ROS)level increase and NET release by neutrophils.Further in vivo experiments showed that ox-LDLEXO accelerated AS progression in AS mice.In summary,exosome-encapsulated miR-505 from ox-LDLtreated VECs aggravates AS by inducing NET formation. | Li Chen Liqun Hu Qing Li Jian Ma Hongqi Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，12： | 11 |
| 9 | Experimental investigation on control of vortex shedding mode of a circular cylinder using synthetic jets placed at stagnation points显示文摘Control of flow around a circular cylinder by synthetic jets has been experimentally investigated in a water tunnel with particle image velocimetry(PIV) technique.The synthetic jets are positioned at both the front and rear stagnation points.With power spectrum analysis,proper orthogonal decomposition(POD) method and other techniques for data processing,particular attention is paid to the control of vortical structures around the circular cylinder,in which the excitation frequency f e is one to three times of the natural frequency f0 and the cylinder Reynolds number and the excitation amplitude are fixed.The influenced-scope of the synthetic jet enlarges as the excitation frequency increases,and thus the synthetic jet dominates the global flow field gradually.For the natural case and the control case at fe/f0=1,the distributions of the first two POD modes and the power spectra for their POD coefficients all exhibit the characteristics of the natural shedding with antisymmetric mode.For fe/f0=2 and fe/f0=3,the variations in the third and fourth POD modes and the corresponding power spectra indicate that the wake vortex shedding mode changes and the dominant frequency becomes the excitation frequency.For fe/f0=2,the wake vortex sheds downstream with either the antisymmetric or the symmetric mode;for fe/f0=3,the synthetic jet vortex pair interacts with the near wake shear layers from both sides to induce a pair of the symmetric wake vortices,which is gradually converted into an antisymmetric mode when shedding downstream. | MA LiQun FENG LiHao | 2013 | Science China(Technological Sciences)2013，56，1： | 11 |
| 10 | Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer显示文摘5-methylcytosine (5mC ) 和它的氧化形式 5-hydroxymethylcytosine (5hmC ) 被建议了涉及 tumorigenesis。因为印射方法的广泛地使用的 5mC 的读出,定序的重亚硫酸盐(BS-seq ) ,是 5mC 的和, 5hmC 层次, 5mC/5hmC 模式和这二修正的关系仍然保持糟糕理解。由介绍真实 5mC (BS-seq 由帮助 Tet 的 BS-seq 改正了, TAB-seq ) 并且 5hmC (TAB-seq ) 在单个核苷酸的分辨率同时铺平,我们这里证明与匹配的正常纸巾相比没有在肾肿瘤的 5mC 的全球损失。相反地, 5hmC 全球性被失去在几乎所有肾肿瘤纸巾。在肿瘤纸巾的 5hmC 水平是为肾癌症的一个独立预示的标记,与与更短的全面幸存联系的 5hmC 的底层。而且,我们证明 5hmC 的损失与匹配的正常纸巾相比在肿瘤被连接到 hypermethylation,特别地在基因身体区域。惊人地,基因身体 hypermethylation 显著地与肿瘤相关的基因的 silencing 被联系。IDH1 的 Downregulation 作为在肾癌症位于 5hmC 损失下面的机制被识别。恢复 5hmC 层次稀释了肿瘤房间的侵略能力并且在一个异种皮移植模型压制了肿瘤生长。一起,我们的结果证明 5hmC 的损失在由改变 DNA methylation 模式的肾癌症是一个预示的标记和一个 oncogenic 事件。 | Ke Chen Jing Zhang Zhongqiang Guo Qin Ma Zhengzheng Xu Yuanyuan Zhou Ziying Xu Zhongwu Li Xiongjun- Ye Xuesong Li Bifeng Yuan Yuwen Ke Chuan He Liqun Zhou Jiang Liu WeiminCi | 2016 | Cell Research2016，26，1： | 10 |
| 11 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 12 | The ex vivo and in vivo biological performances of graphene oxide and the impact of surfactant on graphene oxide's biocompatibility显示文摘Graphene oxide(GO)displays promising properties for biomedical applications including drug delivery and cancer therapeutics.However,GO exposure also raises safety concerns such as potential side effects on health.Here,the biological effects of GO suspended in phosphate buffered saline(PBS)with or without 1% nonionic surfactant Tween 80 were investigated.Based on the ex vivo experiments,Tween 80 significantly affected the interaction between GO and peripheral blood from mice.GO suspension in PBS tended to provoke the aggregation of diluted blood cells,which could be prevented by the addition of Tween 80.After intravenous administration,GO suspension with or without 1% Tween 80 was quickly eliminated by the mononuclear phagocyte system.Nevertheless,GO suspension without Tween 80 showed greater accumulation in lungs than that containing 1% Tween 80.In contrast,less GO was found in livers for GO suspension compared to Tween 80 assisted GO suspension.Organs including hearts,livers,lungs,spleens,kidneys,brains,and testes did not reveal histological alterations.The indexes of peripheral blood showed no change upon GO exposure.Our results together demonstrated that Tween 80 could greatly alter GO's biological performance and determine the pattern of its biodistribution in mice. | Guangbo Qu Xiaoyan Wang Qian Liu Rui Liu Nuoya Yin Juan Ma Liqun Chen Jiuyang He Sijin Liu Guibin Jiang | 2013 | Journal of Environmental Sciences2013，25，5： | 7 |
| 13 | Mesenchymal stem cell-derived exosomal miR-21a-5p promotes M2 macrophage polarization and reduces macrophage infiltration to attenuate atherosclerosis显示文摘Atherosclerosis(AS)is the main pathological basis for ischemic cardiovascular and cerebrovascular diseases.Mesenchymal stem cell(MSC)-derived exosomes have the potential to alleviate AS,while the underlying mechanism remains unclear.Here,we aimed to investigate the mechanism of MSC-derived exosomes in AS.The AS mouse model was prepared by feeding ApoE–/–mice with high-fat diet.AS mice were administered with MSC-derived exosomes,and the atherosclerotic plaque area was analyzed by Oil Red O staining.Mouse RAW264.7 macrophages were incubated with MSC-derived exosomes.The macrophage infiltration,macrophage proportion,and cell migration were estimated by immunohistochemistry,flow cytometry,or Transwell assay.The relationship between miR-21a-5p and kruppel-like factor 6(KLF6)or extracellular signal-regulated protein kinases 2(ERK2)was verified by luciferase reporter assay.We found that MSC-derived exosomes promoted M2 polarization of macrophages and reduced plaque area and macrophage infiltration in AS mice.miR-21a-5p overexpression caused an increase of M2 macrophages in RAW264.7 cells and led to a decrease in migration of RAW264.7 cells.Moreover,both KLF6 and ERK2 are the targets of miR-21a-5p.MSC-derived exosomes containing miR-21a-5p promoted M2 polarization of RAW264.7 cells by suppressing KLF6 expression.MSC-derived exosomes containing miR-21a-5p inhibited migration of RAW264.7 cells through inhibiting the ERK1/2 signaling pathway.In conclusion,MSC-derived exosomes containing miR-21a-5p promote macrophage polarization and reduce macrophage infiltration by targeting KLF6 and ERK1/2 signaling pathways,thereby attenuating the development of AS.Thus,MSC-derived exosomes may be a promising treatment for AS. | Jian Ma Li Chen Xiang Zhu Qing Li Liqun Hu Hongqi Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 7 |
| 14 | Fourier mode decomposition of PIV data.显示文摘The modal decomposition technique is one of the most effective methods for studying the flow dynamics in a complex flow. By rejuvenating the discrete Fourier transform(DFT), this paper proposes a Fourier mode decomposition(FMD) method for the time series of particle image velocimetry(PIV) data from the fluid field. An experimental case concerning the control of the flow around a circular cylinder by a synthetic jet positioned at the rear stagnation point is used to demonstrate the use of the FMD method. In the three different regimes where the natural shedding frequency and actuation frequency dominate respectively or simultaneously, it is found that the FMD method is capable of extracting the dynamic mode along with its amplitude and phase according to the selected characteristic frequency based on the global power spectrum. For the quasiperiodic flow phenomena presented in this particular case, the FMD method can reconstruct the original flow field using the zero-th mode and the selected mode corresponding to the characteristic frequency. Similarities and differences between the FMD method and the dynamical mode decomposition(DMD) and proper orthogonal decomposition(POD) methods are also discussed. | MA LiQun FENG LiHao PAN Chong GAO Qi WANG JinJun | 2015 | Science China(Technological Sciences)2015，58，11： | 6 |
| 15 | Quasi-phase-matching-division multiplexing holography in a three-dimensional nonlinear photonic crystal显示文摘Nonlinear holography has recently emerged as a novel tool to reconstruct the encoded information at a new wavelength,which has important applications in optical display and optical encryption.However,this scheme still struggles with low conversion efficiency and ineffective multiplexing.In this work,we demonstrate a quasi-phasematching(QPM)-division multiplexing holography in a three-dimensional(3D)nonlinear photonic crystal(NPC).3D NPC works as a nonlinear hologram,in which multiple images are distributed into different Ewald spheres in reciprocal space.The reciprocal vectors locating in a given Ewald sphere are capable of fulfilling the complete QPM conditions for the high-efficiency reconstruction of the target image at the second-harmonic(SH)wave.One can easily switch the reconstructed SH images by changing the QPM condition.The multiplexing capacity is scalable with the period number of 3D NPC.Our work provides a promising strategy to achieve highly efficient nonlinear multiplexing holography for high-security and high-density storage of optical information. | Pengcheng Chen Chaowei Wang Dunzhao Wei Yanlei Hu Xiaoyi Xu Jiawen Li Dong Wu Jianan Ma Shengyun Ji Leran Zhang Liqun Xu Tianxin Wang Chuan Xu Jiaru Chu Shining Zhu Min Xiao Yong Zhang | 2021 | Light(Science & Applications)2021，10，8： | 5 |
| 16 | Highway constructions on the Qinghai-Tibet Plateau:Challenge,research and practice显示文摘Highway constructions on the Qinghai-Tibet Plateau(QTP)face great challenges induced by the unique local environmental,geological,and engineering conditions.The large area of permafrost,great temperature variability,strong UV rays,and complex geological conditions are the major factors that adversely influence the longterm performance of pavement systems.Since 1960s,Chinese engineers and researchers have started conducting research on the QTP to enhance the performance and durability of pavement systems.The present paper provide a comprehensive review of challenge,research and practice of highway constructions on the QTP including the special environmental and geological conditions,history of highway constructions on the QTP,major challenges and the state-of-the-art technology of subgrade constructions on permafrost,developments of the pavement structures and materials,performance prediction and maintenance methods of pavement surfaces,and applications of the research achievements on the first expressway on the QTP(i.e.,Gongyu Expressway).Based on the comprehensive literature review,it can be found that(1)frost heave and thaw weakening induced subgrade disease and longitudinal cracks on the pavement surface are complex coupled water-thermal-load problems.Engineering solutions are focusing on active cooling and thermal insulation methods,which can help to reduce temperature variations in the subgrade and thus improving its stability,(2)the harsh environmental and construction conditions may reduce the early strength and induce premature damage of cement-treated base materials.Some field validations showed that geocell-reinforced or asphalt-treated flexible base materials can provide better long-term performance,(3)the large temperature variability and strong UV rays can significantly accelerate aging of asphalt binders and greatly reduce the service life of asphalt mixtures.Various binder modification methods were developed for improving their viscoelasticity and enhance the low-temperature cracking resistance of pavement surface materials but are still lack of field validation data and comparisons of their life cycle costs.Therefore,it is recommended that a demonstration research project build test sections to examine a range of pavement structures and materials,and compare their long-term performance and life cycle costs,which can serve as important reference for future highway constructions on the QTP. | Aimin Sha Biao Ma Hainian Wang Liqun Hu Xuesong Mao Xilan Zhi Huaxin Chen Yu Liu Feng Ma Zhuangzhuang Liu Rui He Wei Si Xuhao Wang Cheng Li | 2022 | Journal of Road Engineering2022，2，1： | 4 |
| 17 | Engineering self-healing adhesive hydrogels with antioxidant properties for intrauterine adhesion prevention显示文摘Intrauterine adhesion (IUA) is the fibrosis within the uterine cavity. It is the second most common cause of female infertility, significantly affecting women’s physical and mental health. Current treatment strategies fail to provide a satisfactory therapeutic outcome for IUA patients, leaving an enormous challenge for reproductive science. A self-healing adhesive hydrogel with antioxidant properties will be highly helpful in IUA prevention. In this work, we prepare a series of self-healing hydrogels (P10G15, P10G20, and P10G25) with antioxidant and adhesive properties. Those hydrogels exhibit good self-healing properties and can adapt themselves to different structures. They possess good injectability and fit the shape of the human uterus. Moreover, the hydrogels exhibit good tissue adhesiveness, which is desirable for stable retention and therapeutic efficacy. The in vitro experiments using P10G20 show that the adhesive effectively scavenges ABTS+, DPPH, and hydroxyl radicals, rescuing cells from oxidative stress. In addition, P10G20 offers good hemocompatibility and in vitro and in vivo biocompatibility. Furthermore, P10G20 lowers down the in vivo oxidative stress and prevents IUA with less fibrotic tissue and better endometrial regeneration in the animal model. It can effectively downregulate fibrosis-related transforming growth factor beta 1 (TGF-β1) and vascular endothelial growth factor (VEGF). Altogether, these adhesives may be a good alternative for the clinical treatment of intrauterine adhesion. | Luyao Feng Liqun Wang Yao Ma Wanglin Duan Sergio Martin-Saldana Ye Zhu Xianpeng Zhang Bin Zhu Chaowei Li Shibo Hu Mingjie Bao Ting Wang Yuan Zhu Fei Yang Yazhong Bu | 2023 | Bioactive Materials2023，，9： | 3 |
| 18 | Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity显示文摘Brown adipose tissue(BAT)is an energy-expending organ that produces heat.Expansion or activation of BAT prevents obesity and diabetes.Chronic cold exposure enhances thermogenesis in BAT through uncoupling protein 1(UCP1)activation triggered via a b-adrenergic pathway.Here,we report that the cold-sensing transient receptor potential melastatin 8(TRPM8)is functionally present in mouse BAT.Challenging brown adipocytes with menthol,a TRPM8 agonist,up-regulates UCP1 expression and requires protein kinase A activation.Upon mimicking long-term cold exposure with chronic dietary menthol application,menthol significantly increased the core temperatures and locomotor activity in wild-type mice;these effects were absent in both TRPM82/2 and UCP12/2 mice.Dietary obesity and glucose abnormalities were also prevented by menthol treatment.Our results reveal a previously unrecognized role for TRPM8,suggesting that stimulation of this channel mediates BAT thermogenesis,which could constitute a promising way to treat obesity. | Shuangtao Ma Hao Yu Zhigang Zhao Zhidan Luo Jing Chen Yinxing Ni Rongbing Jin Liqun Ma Peijian Wang Zhenyu Zhu Li Li Jian Zhong Daoyan Liu Bernd Nilius Zhiming Zhu | 2012 | Journal of Molecular Cell Biology2012，4，2： | 2 |
| 19 | Passivating buried interface with multifunctional novel ionic liquid containing simultaneously fluorinated anion and cation yielding stable perovskite solar cells over 23% efficiency显示文摘Interfacial defects and energy barrier would result in serious interfacial non-radiative recombination losses.In addition,the quality of perovskite films is highly dependent on deposition substrates.Consequently,there is an urgent desire to develop multifunctional interface modulators to manage the interface between electron transport layer and perovskite layer.Here,we report a multifunctional buried interface modulation strategy that 4-fluoro-phenylammonium tetrafluoroborate (FBABF_(4)) consisting of simultaneously fluorinated anion and cation is inserted between SnO_(2)layer and perovskite layer.It is uncovered by time-of-flight secondary ion mass spectroscopy that the anion and cation in modifier are mainly located at this interface,which is put down to coordination bond of the fluorine atom on BF_(4)^(-) with SnO_(2),and the hydrogen bond of the fluorine atom on FBA^(+) with formamidinium.This suggests that simultaneous fluorination of anion and cation in the ionic liquid molecule is of crucial importance to ameliorate interfacial contact through chemical linker.The interface modification approach enables the realization of interfacial defect passivation,interfacial energy band alignment modulation,and perovskite crystallization manipulation,which are translated into enhanced efficiency and stability as well as significantly suppressed hysteresis.The multiple functions of FBABF_(4) endow the modified solar cells excellent photovoltaic performance with an efficiency exceeding 23%along with appealing long-term stability.This work highlights the critical role of fluorination strategy in engineering multifunctional organic salt modulators for improving interfacial contact. | Deyu Gao Liqun Yang Xiaohui Ma Xueni Shang Chen Wang Mengjia Li Xinmeng Zhuang Boxue Zhang Hongwei Song Jiangzhao Chen Cong Chen | 2022 | Journal of Energy Chemistry2022，31，6： | 2 |
| 20 | Electrochemical properties of MmNi 3.8 Co 0.75 Mn 0.4 Al 0.2 hydrogen storage alloy modified with nanocrystalline nickel显示文摘 | Xiangyu Zhao Yi Ding Liqun Ma Linying Wang Meng Yang Xiaodong Shen | 2008 | International Journal of Hydrogen Energy2008，，22： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员