4篇
您的检索式：作者名="MAKOTO KAWATANI"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transmembrane domain of Bcl -2 is required for hlhibition of ceramide synthesis, but not cytochrome release in the pathway nf inostamycin - induced apoptosis显示文摘 | Makoto Kawatani Madoka Uchi Siro Simizu | 2003 | Experimental Cell Research2003，286，1： | 1 |
| 2 | Reveromycin A,an agent for osteaporosis,inhibits bone resorption by inducing apoptosis specifically in osteoclasts显示文摘 | Je-Tae Woo Makoto Kawatani Masanori Kato | 2006 | PNAS Mar2006，103，： | 1 |
| 3 | Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis 显示文摘 | Makoto Kawatani Madoka Uchi Siro Simizu | 2003 | Exp Cell Res2003，286，1： | 1 |
| 4 | Identification of a dihydroorotate dehydrogenase inhibitor thatinhibits cancer cell growth by proteomic profiling显示文摘Dihydroorotate dehydrogenase(DHODH)is a central enzyme of the de novo pyrimidine biosynthesis pathway and is a promising drug target for the treatment of cancer and autoimmune diseases.This study presents the identification of a potent DHODH inhibitor by proteomic profiling.Cell-based screening revealed that NPD723,which is reduced to H-006 in cells,strongly induces myeloid differentiation and inhibits cell growth in HL-60 cells.H-006 also suppressed the growth of various cancer cells.Proteomic profiling of NPD723-treated cells in ChemProteoBase showed that NPD723 was clustered with DHODH inhibitors.H-006 potently inhibited human DHODH activity in vitro,whereas NPD723 was approximately 400 times less active than H-006.H-006-induced cell death was rescued by the addition of the DHODH product orotic acid.Moreover,metabolome analysis revealed that H-006 treatment promotes marked accumulation of the DHODH substrate dihydroorotic acid.These results suggest that NPD723 is reduced in cells to its active metabolite H-006,which then targets DHODH and suppresses cancer cell growth.Thus,H-006-related drugs represent a potentially powerful treatment for cancer and other diseases. | MAKOTO KAWATANI HARUMI AONO SAYOKO HIRANUMA TAKESHI SHIMIZU MAKOTO MUROI TOSHIHIKO NOGAWA TOMOKAZU OHISHI SHUN-ICHI OHBA MANABU KAWADA KANAMI YAMAZAKI SHINGO DAN NAOSHI DOHMAE HIROYUKI OSADA | 2023 | Oncology Research2023，31，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员