4篇
您的检索式：作者名="SHINGO DAN"
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| 1 | Chromoendoscopy with indigo carmine dye added to acetic acid in the diagnosis of gastric neoplasia: a prospective comparative study显示文摘 | Yuzo Sakai Reiko Eto Junji Kasanuki Fukuo Kondo Kazuki Kato Makoto Arai Takuto Suzuki Michiko Kobayashi Tomoaki Matsumura Dan Bekku Kenichi Ito Shingo Nakamoto Takeshi Tanaka Osamu Yokosuka | 2008 | Gastrointestinal Endoscopy2008，，4： | 1 |
| 2 | Surgical Management of Pouch-Vaginal Fistula after Restorative Proctocolectomy显示文摘 | Shingo Tsujinaka Dan Ruiz Steven D. Wexner Mirza K. Baig Dana R. Sands Eric G. Weiss Juan J. Nogueras Jonathan E. Efron Anthony M. Vernava | 2006 | Journal of the American College of Surgeons2006，，6： | 1 |
| 3 | Pyridine-Fused Azacorannulene:Fine-Tuning of the Structure and Properties of Nitrogen-Embedded Buckybowls显示文摘Heteroatom-embedded buckybowl molecules provide a fundamental molecular framework that has potential applications in various research fields.However,selective introduction of heteroatoms into buckybowls is challenging,and thus,studies investigating the effect of introduced heteroatoms have been limited.Here,we report the synthesis of pyridine-fused azacorannulene molecules.The influence of nitrogen atoms introduced into the peripheral positions on the structural,electronic,and optical properties is discussed. | Kimihiro Nakamura Kotaro Ochiai Ayaka Yubuta Dan He Daigo Miyajima Shingo Ito | 2023 | Precision Chemistry2023，1，1： | 0 |
| 4 | Identification of a dihydroorotate dehydrogenase inhibitor thatinhibits cancer cell growth by proteomic profiling显示文摘Dihydroorotate dehydrogenase(DHODH)is a central enzyme of the de novo pyrimidine biosynthesis pathway and is a promising drug target for the treatment of cancer and autoimmune diseases.This study presents the identification of a potent DHODH inhibitor by proteomic profiling.Cell-based screening revealed that NPD723,which is reduced to H-006 in cells,strongly induces myeloid differentiation and inhibits cell growth in HL-60 cells.H-006 also suppressed the growth of various cancer cells.Proteomic profiling of NPD723-treated cells in ChemProteoBase showed that NPD723 was clustered with DHODH inhibitors.H-006 potently inhibited human DHODH activity in vitro,whereas NPD723 was approximately 400 times less active than H-006.H-006-induced cell death was rescued by the addition of the DHODH product orotic acid.Moreover,metabolome analysis revealed that H-006 treatment promotes marked accumulation of the DHODH substrate dihydroorotic acid.These results suggest that NPD723 is reduced in cells to its active metabolite H-006,which then targets DHODH and suppresses cancer cell growth.Thus,H-006-related drugs represent a potentially powerful treatment for cancer and other diseases. | MAKOTO KAWATANI HARUMI AONO SAYOKO HIRANUMA TAKESHI SHIMIZU MAKOTO MUROI TOSHIHIKO NOGAWA TOMOKAZU OHISHI SHUN-ICHI OHBA MANABU KAWADA KANAMI YAMAZAKI SHINGO DAN NAOSHI DOHMAE HIROYUKI OSADA | 2023 | Oncology Research2023，31，6： | 0 |
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