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| 1 | Anti-anginal Effect of Fasudil, a Rho-Kinase Inhibitor, in Patients With Stable Effort Angina: A Multicenter Study显示文摘 | Hiroaki Shimokawa Katsuhiko Hiramori Hiroyuki Iinuma Saichi Hosoda Hiroshi Kishida Hirofumi Osada Takashi Katagiri Kazunobu Yamauchi Yoshiki Yui Takazo Minamino Mitsuyoshi Nakashima Kazuzo Kato | 2002 | Journal of Cardiovascular Pharmacology2002，，5： | 2 |
| 2 | Development of wire harness modules 显示文摘 | Osada Yasufumi Nakano Hiroyuki | 1999 | Furukawa Review1999，18，： | 1 |
| 3 | Welding characteristics and temperature rise of high frequency and complex vibration ultrasonic wire bonding显示文摘 | Jiromaru Tsujino Hiroyuki Yoshihara Kazuyoshi Kamimoto and Yoshiaki Osada | 1998 | Ultrasonics Volume 36 Issues 1 - 51998，1998，： | 1 |
| 4 | Development of wire harness modules显示文摘 | Osada Yasufumi Nakano Hiroyuki | 1999 | Furukawa Review1999，18，： | 1 |
| 5 | Ventriculomegaly after decompressive craniectomy with hematoma evacuation for large hemispheric hypertensive intracerebral hemorrhage显示文摘 | Satoru Takeuchi Hiroshi Nawashiro Kojiro Wada Yoshio Takasato Hiroyuki Masaoka Takanori Hayakawa Kimihiro Nagatani Naoki Otani Hideo Osada Katsuji Shima | 2012 | Clinical Neurology and Neurosurgery2012，，： | 1 |
| 6 | Developmentof Wire Harness Modules显示文摘 | Osada Yasufumi Nakano Hiroyuki | 1999 | Furukawa Review1999，，18： | 1 |
| 7 | Inhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated fromSorbus commixta显示文摘 | Minkyun Na Bo Yeon Kim Hiroyuki Osada | 2009 | Journal of Enzyme Inhibition and Medicinal Chemistry2009，24，4： | 1 |
| 8 | High concentration of vitamin K1 proved in the seaweeds and sweet potato leaves显示文摘 | Sumi Hiroyuki Osada | 2003 | 日本食品科學工學會志2003，50，2： | 1 |
| 9 | Development of wire hamess modules 显示文摘 | Osada Yasufumi Nakano Hiroyuki | 1999 | Furukawa Review1999，18，： | 1 |
| 10 | Isolation and characterization ofβ-transducin repeat-containing protein ligands screened using a high-throughput screening system显示文摘β-transducin repeat-containing protein(β-TrCP)is an F-box protein subunit of the E3 Skp1-Cullin-F box(SCF)type ubiquitin-ligase complex,and provides the substrate specificity for the ligase.To find potent ligands ofβ-TrCP useful for the proteolysis targeting chimera(PROTAC)system usingβ-TrCP in the future,we developed a high-throughput screening system for small moleculeβ-TrCP ligands.We screened the chemical library utilizing the system and obtained several hit compounds.The effects of the hit compounds on in vitro ubiquitination activity of SCFβ-TrCP1 and on downstream signaling pathways were examined.Hit compounds NPD5943,NPL62020-01,and NPL42040-01 inhibited the TNFα-induced degradation of IκBαand its phosphorylated form.Hence,they inhibited the activation of the transcription activity of NF-κB,indicating the effective inhibition ofβ-TrCP by the hit compounds in cells.Next,we performed an in silico analysis of the hit compounds to determine the important moieties of the hit compounds.Carboxyl groups of NPL62020-01 and NPL42040-01 and hydroxyl groups of NPD5943 created hydrogen bonds withβ-TrCP similar to those created by intrinsic target phosphopeptides ofβ-TrCP.Our findings enhance our knowledge of useful small molecule ligands ofβ-TrCP and the importance of residues that can be ligands ofβ-TrCP. | XINTONG LIU EMIKO SANADA JIANG LI XIAOMENG LI HIROYUKI OSADA NOBUMOTO WATANABE | 2023 | Oncology Research2023，31，5： | 0 |
| 11 | Identification of microbial metabolites that accelerate the ubiquitindependent degradation of c-Myc显示文摘Myc belongs to a family of proto-oncogenes that encode transcription factors.The overexpression of c-Myc causes many types of cancers.Recently,we established a system for screening c-Myc inhibitors and identified antimycin A by screening the RIKEN NPDepo chemical library.The specific mechanism of promoting tumor cell metastasis by high c-Myc expression remains to be explained.In this study,we screened approximately 5,600 microbial extracts using this system and identified a broth prepared from Streptomyces sp.RK19-A0402 strongly inhibits c-Myc transcriptional activity.After purification of the hit broth,we identified compounds closely related to the aglycone of cytovaricin and had a structure similar to that of oligomycin A.Similar to oligomycin A,the hit compounds inhibited mitochondrial complex V.The mitochondria dysfunction caused by the compounds induced the production of reactive oxygen species(ROS),and the ROS activated GSK3α/βthat phosphorylated c-Myc for ubiquitination.This study provides a successful screening strategy for identifying natural products as potential c-Myc inhibitors as potential anticancer agents. | ZIYU LIU AKIKO OKANO EMIKO SANADA YUSHI FUTAMURA TOSHIHIKO NOGAWA KOSUKE ISHIKAWA KENTARO SEMBA JIANG LI XIAOMENG LI HIROYUKI OSADA NOBUMOTO WATANABE | 2023 | Oncology Research2023，31，5： | 0 |
| 12 | Identification of a dihydroorotate dehydrogenase inhibitor thatinhibits cancer cell growth by proteomic profiling显示文摘Dihydroorotate dehydrogenase(DHODH)is a central enzyme of the de novo pyrimidine biosynthesis pathway and is a promising drug target for the treatment of cancer and autoimmune diseases.This study presents the identification of a potent DHODH inhibitor by proteomic profiling.Cell-based screening revealed that NPD723,which is reduced to H-006 in cells,strongly induces myeloid differentiation and inhibits cell growth in HL-60 cells.H-006 also suppressed the growth of various cancer cells.Proteomic profiling of NPD723-treated cells in ChemProteoBase showed that NPD723 was clustered with DHODH inhibitors.H-006 potently inhibited human DHODH activity in vitro,whereas NPD723 was approximately 400 times less active than H-006.H-006-induced cell death was rescued by the addition of the DHODH product orotic acid.Moreover,metabolome analysis revealed that H-006 treatment promotes marked accumulation of the DHODH substrate dihydroorotic acid.These results suggest that NPD723 is reduced in cells to its active metabolite H-006,which then targets DHODH and suppresses cancer cell growth.Thus,H-006-related drugs represent a potentially powerful treatment for cancer and other diseases. | MAKOTO KAWATANI HARUMI AONO SAYOKO HIRANUMA TAKESHI SHIMIZU MAKOTO MUROI TOSHIHIKO NOGAWA TOMOKAZU OHISHI SHUN-ICHI OHBA MANABU KAWADA KANAMI YAMAZAKI SHINGO DAN NAOSHI DOHMAE HIROYUKI OSADA | 2023 | Oncology Research2023，31，6： | 0 |
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