|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 2 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | Determination of Tryptophan by High-performance Liquid Chromatography of Alkaline Hydrolysates With Spectrophotometric Detection 显示文摘 | Maria M Y Justo P Julio G C etal | 2004 | Food Chemistry(S0308-8146)2004，85，2： | 1 |
| 5 | Isolation of helicobacter pylori from sheep—implications for transmission to humans显示文摘 | Maria P Dore Antonia R Sepulveda Hala El-Zimaity Yoshio Yamaoka Michael S Osato Kato Mototsugu Antonio M Nieddu Giuseppe Realdi David Y Graham | 2001 | The American Journal of Gastroenterology2001，，5： | 1 |
| 6 | Trace Analysis of Seven Neonicotinoid Insecticides in Bee Pollen by Solid-liquid Extraction and Liquid Chromatography Coupled to Electrospray Ionization Mass Spectrometry显示文摘 | KAREN P Y MARIA T M JOSE L B | 2014 | Food Analytical Methods2014，7，2： | 1 |
| 7 | Isotherm studies for determination of removal capacity of bi-metal (Ni and Cr) ions by Aspergillus niger显示文摘 | KIRAN M MARIA Y NOREEN Z | | 0，，01： | 1 |
| 8 | Production and characterizationof casein hydrolysates with a high amino acid Fischer*s ratio using im-mobilized proteases显示文摘 | JustoP Maria M Y Hassane L | 2004 | International Dairy Journal2004，，14： | 1 |
| 9 | Effects of Ca(OH)2 treatments (overliming) on the composition and toxicity of bagasse hemicellulose hydrolysates显示文摘 | ALFREDO M MARIA E R SEAN W Y | 2000 | Biotechnology and Bioengineering2000，69，5： | 1 |
| 10 | Neolignans, styrylpyrones and flavonoids from an Aniba species 显示文摘 | Maria H R Massayoshi Y Jose G S M | 1997 | Phytochemistry1997，45，6： | 1 |
| 11 | Effect of UV-B Radiation on the Activity and Isoforms of Enzymes with Peroxidase Activity in Sunflower Cotyledons显示文摘 | Gustavo G Y Susana M G Maria L T | | Envb''omnental and Experimental Botany0，56，2： | 1 |
| 12 | Cadinane sesquiterpenoids of Phomopsis cassiae, an endophytic fungus associated with Cassia spectabilis ( Leguminosae ) 显示文摘 | Geraldo H S Helder L T Maria C M Y | 2006 | Phytachemistry2006，67，： | 1 |
| 13 | Cadinane sesquiterpenoids of Phornopsis cassiae,an endophytic fungus associated with Cassia spectabilis(Leguminosae)显示文摘 | GERALDO H S HELDER L T MARIA C M Y | 2006 | Phytochemistry2006，67，： | 1 |
| 14 | Production of ace inhibitory peptides by digestion of chickpea legumin with alcalase显示文摘 | MARIA M Y JUSTO P JULIO G C | 2003 | Food Chem2003，81，： | 1 |
| 15 | Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells显示文摘 | Slomiany M G Grass G D Robertson A D Yang X Y Maria B L Beeson C | 2009 | Cancer Res2009，69，： | 1 |
| 16 | Quantitative detection of Citrus tristeza virus in citrus and aphids by real-time reverse transcription-PCR (TaqMan) 显示文摘 | Maria S Keremane M Raymond K Y | 2008 | Journal of Virological Methods2008，147，： | 1 |
| 17 | The adaptive MSINR algorithm to improve error rate for channel equalization显示文摘 | JAN W M BERGMANS MARIA Y L | 2005 | Signal Processing2005，85，7： | 1 |
| 18 | Fracture behaviour of polypropylene films at different temperatures:Fractography and deformation mechanisms studied by SEM显示文摘 | DIDAC F B MARIA L M MAI Y W | | 0，，10： | 1 |
| 19 | Morphological and molecular characterization of Cladosporium tenuissimum (Deuteromycotina: Hyphomycetes) on mango tree panicles: symptom, pathogenicity and severity of the fungus显示文摘 | Dagoberto G S Maria J Y M Daniel T O | 2007 | Fruits2007，62，： | 1 |
| 20 | A dual-mode molecular switch based on a chiral binaphthol- coumarin compound 显示文摘 | MARIA M B WANG Z Y | 2000 | Tetrahedron Letters2000，41，21： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员