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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 3 | Determination of Tryptophan by High-performance Liquid Chromatography of Alkaline Hydrolysates With Spectrophotometric Detection 显示文摘 | Maria M Y Justo P Julio G C etal | 2004 | Food Chemistry(S0308-8146)2004，85，2： | 1 |
| 4 | Modeling changes of sensory attributes for individual and mixed fresh-cut leafy vegetables显示文摘 | Andrea M P Julio C M Daniel R G | 2005 | Postharvest Biology and Technology2005，，3： | 1 |
| 5 | Processing of spent platinum-based catalysts via fusion with potassium hydrogenosulfate显示文摘 | Sebastiao G Batista J Julio C A | 2010 | Journal of Hazardous Materials2010，184，13： | 1 |
| 6 | A convenient method to prepare emulsified polyacrylate nanoparticles from for drug delivery applications显示文摘 | Julio C G J Edward T | 2011 | Bioorganic&Medicinal Chemistry Letters2011，21，15： | 1 |
| 7 | Use and application of stem cells in toxicology 显示文摘 | JULIO C GABRIELA G | 2004 | Toxicol Sci2004，79，2： | 1 |
| 8 | Determination of partition and diffusion coefficients of components of two rubber adhesives in different multilayer materials显示文摘 | Nerin C Julio G Paula V | | 0，，： | 1 |
| 9 | Integrated Nonlinear Optimization of Bioprocesses via Linear Programming 显示文摘 | Vera Julio Torres N V Moles C G Banga Julio | 2003 | AIChE Journal2003，49，12： | 1 |
| 10 | Risk of fracture in celiac disease:Gender,dietary compliance,or both?显示文摘AIM:To determine the incidence of peripheral fractures in patients with celiac disease (CD) and the effect of treatment on fracture risk.METHODS:We compared the incidence and risk of peripheral fractures before and after diagnosis between a cohort of 265 patients who had been diagnosed with CD at least 5 years before study entry and a cohort of 530 age-and sex-matched controls who had been diagnosed with functional gastrointestinal disorders.Data were collected through in-person interviews with an investigator.The overall assessment window for patients was 9843 patient-years (2815 patient-years after diagnosis).RESULTS:Compared with the control group,the CD cohort showed significantly higher incidence rate and risk of first peripheral fracture before diagnosis [adjusted hazard ratio (HR):1.78,95% CI:1.23-2.56,P < 0.002] and in men (HR:2.67,95% CI:1.37-5.22,P < 0.004).Fracture risk was significantly associated with the classic CD presentation with gastrointestinal symptoms (P < 0.003).In the time period after diagnosis,the risk of fractures was comparable between the CD cohort and controls in both sexes (HR:1.08,95% CI:0.55-2.10 for women;HR:1.57,95% CI:0.57-4.26 for men).CONCLUSION:CD patients have higher prevalence of fractures in the peripheral skeleton before diagnosis.This is associated with male sex and classic clinical presentation.The fracture risk was reduced after the treatment. | María Inés Pinto Sánchez Adriana Mohaidle Andrea Baistrocchi Dolores Matoso Horacio Vázquez Andrea González Roberto Mazure Evangelina Maffei Guillermina Ferrari Edgardo Smecuol Adriana Crivelli Juan Andrés de Paula Juan C Gómez Silvia Pedreira Eduardo Maurio Julio César Bai | 2011 | World Journal of Gastroenterology2011，17，25： | 1 |
| 11 | Solving design equation system for animal cell cultures by two step sedimentation显示文摘 | Marya I C Julio A L Ricardo J G | 2001 | Journal of Biotechnology2001，84，： | 1 |
| 12 | Organic contanminants in sediments from San Quintin Bay, Baja California, Mexico显示文摘 | EFRAIN A G G JULIO A V C GILBERTO F M | 1996 | Marine Pollution Bulletin1996，32，4： | 1 |
| 13 | Use and Application of Stem Cells in Toxicology显示文摘 | Julio C Davila Gabriela G Cezar Mark Thiede | 2004 | Toxicological Sciences2004，79，： | 1 |
| 14 | Leptospiral proteins recognized during the humoral immune response to leptospirosis in humans 显示文摘 | Hygia G Julio C Brendan F | 2001 | Infect lmmun2001，69，8： | 1 |
| 15 | Integrated Nonlinear Optimization of Bioprocesses via Linear Programming显示文摘 | Vera Julio Torres N V Moles C G Banga Julio | 2003 | AIChE Journal2003，49，12： | 1 |
| 16 | The protein HC chromnphore is linked to the eysteine residue at position 34 of the polypeptide chain by a reduction-resistant bond and causes the charge heterogeneity of protein HC 显示文摘 | Julio E Anders G Miguel C | 1991 | The Journal of Biological Chemistry1991，266，15： | 1 |
| 17 | Tobacco and male infertility: a retrospective study in infertile couples 显示文摘 | Coelho C Julio C Silva G | 2009 | Acta Med Port2009，22，6： | 1 |
| 18 | Production of ace inhibitory peptides by digestion of chickpea legumin with alcalase显示文摘 | MARIA M Y JUSTO P JULIO G C | 2003 | Food Chem2003，81，： | 1 |
| 19 | A Traceability Information Model for CNC Manufacturing显示文摘 | Julio G C Martin H | 2006 | Computer-aided Design2006，38，： | 1 |
| 20 | Solving design equations for a hollow fiber bioreactor with arbitrary kinetics显示文摘 | Julio A L Ricardo J G | 2001 | Chemical Engineering Journal2001，，84： | 1 |
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