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| 1 | Bacteremia in hemodialysis patients显示文摘Infection is a common complication and is the second leading cause of death in hemodialysis patients. The risk of bacteremia in hemodialysis patients is 26-fold higher than in the general population, and 1/2-3/4 of the causative organisms of bacteremia in hemodialysis patients are Gram-positive bacteria. The ratio of resistant bacteria in hemodialysis patients compared to the general population is unclear. Several reports have indicated that hemodialysis patients have a higher risk of methicillin-resistant Staphylococcus aureus infection. The most common site of infection causing bacteremia is internal prostheses; the use of a hemodialysis catheter is the most important risk factor for bacteremia. Although antibiotic lock of hemodialysis catheters and topical antibiotic ointment can reduce catheter-related blood stream infection(CRBSI), their use should be limited to necessary cases because of the emergence of resistant organisms. Systemic antibiotic administration and catheter removal is recommended for treating CRBSI, although a study indicated the advantages of antibiotic lock and guidewire exchange of catheters over systemic antibiotic therapy. An infection control bundle recommended by the Center for Disease Control and Prevention succeeded in reducing bacteremia in hemodialysis patients with either a catheter or arteriovenous fistula. Appropriate infection control can reduce bacteremia in hemodialysis patients. | Masashi Suzuki Nobuhiko Satoh Motonobu Nakamura Shoko Horita George Seki Kyoji Moriya | 2016 | World Journal of Nephrology2016，5，6： | 14 |
| 2 | Inhibitory effect of angiotensinⅡreceptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis显示文摘AIM: To investigate the efficacy of angiotensinⅡreceptor antagonist on hepatic stellate cells (HSCs) activation in the patients with non-alcoholic steatohepatitis (NASH). METHODS: Seven patients with NASH were prescribed losartan, a selective angiotensinⅡtype 1 receptor antagonist (50 mg/d) for 48 wk. Liver biopsies were performed both at the entry and end of the study in all patients. Quiescent and activated HSCs were identified by double immunostaining using anti-p75 andα-smooth muscle actin antibodies, and the number of each phenotype was counted. Similarly, the liver specimens obtained from the eight patients with non-alcoholic fatty liver (NAFL) were also examined as controls. RESULTS: In NASH hepatic tissues, activated HSCs were dominantly distributed as compared with those in NAFL. The 48-wk losartan treatment induced a remarkable decrease in activated HSCs and a mild increase in quiescent phenotypes. CONCLUSION: Our data suggest the crucial involvement of HSCs in anti-fibrotic effect of angiotensinⅡreceptor antagonist on patients with NASH. | Shiro Yokohama Yoshihiko Tokusashi Kimihide Nakamura Yosui Tamaki Satoshi Okamoto Mituyoshi Okada Kazunobu Aso Takenao Hasegawa Masaru Aoshima Naoyuki Miyokawa Masakazu Haneda Masashi Yoneda | 2006 | World Journal of Gastroenterology2006，12，2： | 10 |
| 3 | Irsogladine maleate and rabeprazole in non-erosive reflux disease: A double-blind, placebo-controlled study显示文摘AIM:To evaluate the efficacy of adding irsogladine maleate(IM) to proton-pump inhibitor(PPI) therapy in non-erosive reflux disease(NERD) treatment.METHODS:One hundred patients with NERD were recruited and randomized to receive rabeprazole plus IM(group I) or rabeprazole plus placebo(group P).The efficacy of the treatment was assessed using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease(FSSG) and the short form(SF)-36 quality of life questionnaires after four weeks of treatment.We also assessed whether patients with NERD with minimal changes(grade M) had different responses to the therapies compared with patients who did not have minimal changes(grade N).RESULTS:Group I and group P showed significant improvements in their FSSG scores after the treatment(from 17.9 ± 7.9 to 9.0 ± 7.6, and from 17.7 ± 7.3 to 11.2 ± 7.9, respectively, P = 0.0001), but there was no statistically significant difference between the FSSG scores in group I and those in group P.Subgroup analysis showed that significant improvements in the FSSG scores occurred in the patients in group I who had NERD grade N(modified Los Angeles classification)(7.8 ± 7.4 vs 12.5 ± 9.8, P = 0.041).The SF-36 scores for patients with NERD grade N who had received IM and rabeprazole were significantly improved in relation to their vitality and mental health scores.CONCLUSION:The addition of IM to rabeprazole significantly improves gastroesophageal reflux diseasesymptoms and the quality of the lives of patients with NERD grade N. | Takayoshi Suzuki Masashi Matsushima Aya Masui Shingo Tsuda Jin Imai Jun Nakamura Yoko Tsukune Tetsufumi Uchida Hiroki Yuhara Muneki Igarashi Jun Koike Tetsuya Mine | 2015 | World Journal of Gastroenterology2015，21，16： | 8 |
| 4 | Endoscopic papillary large balloon dilation for removal of bile duct stones显示文摘AIM:To investigate the efficacy and outcomes of endoscopic papillary large balloon dilation(EPLBD)for bile duct stones in a multicenter prospective study.METHODS:Lithotomy by EPLBD was conducted in 124patients with bile duct stones≥13 mm in size or with three or more bile duct stones≥10 mm.After endoscopic sphincterotomy,the papilla was dilated using balloons 12-20 mm in diameter fitting the bile duct diameter.RESULTS:The success rate of first-time lithotomy was 86.3%(107/124)and the final lithotomy success rate was 100%(124/124).Lithotripsy was needed in10 of the 124(13.6%)patients.Adverse events due to the treatment procedure occurred in 6(4.8%)patients,all of which were mild.Performing large balloon dilation after endoscopic sphincterotomy in patients with large stones or multiple stones in the bile duct is considered to ensure the safety of treatment and to reduce the need for lithotripsy.CONCLUSION:It is suggested that treatment by EPLBD for large bile duct stones may be safe and useful. | Yuji Sakai Toshio Tsuyuguchi Yoshiaki Kawaguchi Nobuto Hirata So Nakaji Katsuya Kitamura Shigeru Mikami Tatsuya Fujimoto Masashi Ijima Eishin Kurihara Shuhei Oana Takayoshi Nishino Ryo Tamura Dai Sakamoto Masato Nakamura Takao Nishikawa Harutoshi Sugiyama Hitoshi Yoshida Tetsuya Mine Osamu Yokosuka | 2014 | World Journal of Gastroenterology2014，20，45： | 6 |
| 5 | Autoimmune pancreatitis with IgG4-positive plasma cell infiltration in salivary glands and biliary tract显示文摘A 62-year-old male was referred to our hospital because of liver dysfunction, diffuse pancreatic swelling, and trachelophyma. At admission, the patient was free of pain.Physical examination showed enlarged and palpable bilateral submandibular masses, but no palpable mass or organomegaly in the abdomen. Laboratory findings were as follows: total protein 90 g/L with γ-globulin of 37.3% (33 g/L), total bilirubin 4 mg/L, aspartate aminotransferase 39 IU/L, alanine aminotransferase 67 IU/L, γ-glutamyl transpeptidase 1 647 IU/L, and amylase 135 IU/L. Autoantibodies were negative, and tumor markers were within the normal range. Serum IgG4 level was markedly elevated (18 900 mg/L). Computed tomography (CT) showed diffuse swelling of the pancreas and dilatation of both common and intra-hepatic bile ducts. Endoscopic retrograde pancreatography (ERP) revealed diffuse irregular and narrow main pancreatic duct and stenosis of the lower common bile duct. Biopsy specimens from the pancreas, salivary gland and liver showed marked periductal IgG4-positive plasma cell infiltration with fibrosis. We considered this patient to be autoimmune pancreatitis (AIP) with fibrosclerosis of the salivary gland and biliary tract, prescribed prednisolone at an initial dose of 40 mg/d. Three months later, the laboratory data improved almost to normal. Abdominal CT reflected prominent improvement in the pancreatic lesion. Swelling of the salivary gland also improved. At present, the patient is on 10 mg/d of prednisolone without recurrence of the pancreatitis. We present here a case of AIP with fibrosclerosis of salivary gland and biliary tract. | Masashi Taguchi Gentaro Aridome Shintaro Abe Keiichiro Kume Mitsuo Tashiro Mitsuyoshi Yamamoto Yasuyuki Kihara Hayato Nakamura Makoto Otsuki | 2005 | World Journal of Gastroenterology2005，11，35： | 5 |
| 6 | Laparoscopic partial resection for hemangioma in the third portion of the duodenum显示文摘Benign duodenal tumors are rare and less commonthan malignant tumors.Furthermore,vascular lesionsof the duodenum,including hemangiomas,are rarecauses of gastrointestinal bleeding.This report describes a case with bleeding hemangiomas in the thirdportion of the duodenum and jejunum and their successful treatment using a laparoscopic approach.Thereis no report of totally laparoscopic resection for tumorin the third portion of duodenum.After performinga laparoscopic Kocher maneuver,the location of theduodenal hemangioma was confirmed by endoscopicand laparoscopic observation.The lesion was excisedusing ultrasonic coagulating shears and the defect inthe duodenal wall was sutured laparoscopically.Thehemangioma of the jejunum was treated extracorporeally through a 3.0 cm umbilical incision.The operatingtime was 241 min and blood loss was negligible.Thepostoperative course was uneventful.For benign duodenal tumors in the third portion,if endoscopic resection is not adapted,this less invasive technique may be a standard treatment. | Shingo Kanaji Tetsu Nakamura Masayasu Nishi Masashi Yamamoto Kiyonori Kanemitu Kimihiro Yamashiita Tatsuya Imanishi Yasuo Sumi Satoshi Suzuki Kenichi Tanaka Yoshihiro Kakeji | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 7 | Myocardial perfusion and fatty acid metabolism in patients with tako-tsubo-like left ventricular dysfunction显示文摘 | Satoshi Kurisu Ichiro Inoue Takuji Kawagoe Masaharu Ishihara Yuji Shimatani Kenji Nishioka Takashi Umemura Suji Nakamura Masashi Yoshida Hikaru Sato | 2003 | Journal of the American College of Cardiology2003，，： | 2 |
| 8 | Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia显示文摘 | Masashi Ikeda Yoshio Yamanouchi Yoko Kinoshita Tsuyoshi Kitajima Reiji Yoshimura Shuji Hashimoto Michael C O&rsquor Donovan Jun Nakamura Norio Ozaki Nakao Iwata | 2008 | Pharmacogenomics2008，，10： | 1 |
| 9 | Idiopathic Mesenteric Phlebosclerosis Occurring in a Wife and Her Husband显示文摘 | Masashi Miyazaki Shotaro Nakamura Takayuki Matsumoto | 2009 | Clinical Gastroenterology and Hepatology2009，，6： | 1 |
| 10 | Upper-Airway Obstruction After Short Posterior Occipitocervical Fusion in a Flexed Position显示文摘 | Makoto Yoshida Masashi Neo Shunsuke Fujibayashi Takashi Nakamura | 2007 | Spine2007，，8： | 1 |
| 11 | Structure effects of electrochemical oxidation of formic acid on single crystal electrodes of palladium显示文摘 | Nagalliro Hoshi Kaori Kida Masashi Nakamura | 2006 | J Phys Chem2006，110，12： | 1 |
| 12 | Takotsubo cardiomyopathy associated with pulmonary resections after induction chemoradiotherapy for non-small cell lung cancer显示文摘 | Shinichi Toyooka Satoshi Akagi Masashi Furukawa Kazufumi Nakamura Junichi Soh Masaomi Yamane Takahiro Oto Shinichiro Miyoshi | 2012 | General Thoracic and Cardiovascular Surgery2012，，9： | 1 |
| 13 | Association of anastomotic leakage with long-term oncologic outcomes of patients with esophagogastric junction cancer显示文摘BACKGROUND Despite improvements in surgical procedures and peri-operative patients management,the postoperative complications in esophagogastric junction(EGJ)cancer remain high because of technical aspects.Several studies have indicated the negative influence of postoperative infectious complications on long-term survival after gastrointestinal surgery.However,no study has shown the association between postoperative complications and long-term survival of patients with EGJ cancer.AIM To elucidate influence of postoperative complications on the long-term outcomes of patients with EGJ cancer.METHODS A total of 122 patients who underwent surgery for EGJ cancer at the Keio University were included in this study.We examined the association between complications and long-term oncologic outcomes.RESULTS In all patients,the 3-year overall survival(OS)rate was 71.9%,and the recurrencefree survival(RFS)rate was 67.5%.Compared with patients without anastomotic leakage,those with anastomotic leakage had poor median OS(8 mo vs not reached,P=0.028)and median RFS(5 mo vs not reached,P=0.055).Among patients with cervical anastomosis,there were not significant differences between patients with and without anastomotic leakage.However,among patients who underwent intrathoracic anastomosis,patients with anastomotic leakage had significantly worse OS(P=0.002)and RFS(P=0.005).CONCLUSION Anastomotic leakage was significantly associated with long-term oncologic outcomes of patients with EGJ cancer,especially those who underwent intrathoracic anastomosis.Cervical anastomosis with subtotal esophagectomy may be an option for the patients who are at high risk for anastomotic leakage. | Masashi Takeuchi Hirofumi Kawakubo Satoru Matsuda Shuhei Mayanagi Tomoyuki Irino Jun Okui Kazumasa Fukuda Rieko Nakamura Norihito Wada Hiroya Takeuchi Yuko Kitagawa | 2022 | World Journal of Gastrointestinal Surgery2022，14，1： | 1 |
| 14 | Preoperative sonographic evaluation is a useful method of detecting contralateral patent processus vaginalis in pediatric patients with unilateral inguinal hernia显示文摘 | Shinsuke Hata Yuji Takahashi Takanari Nakamura Rei Suzuki Masashi Kitada Takashi Shimano | 2004 | Journal of Pediatric Surgery2004，，： | 1 |
| 15 | Functional coupling of V-ATPase and CLC-5显示文摘Dent's disease is an X-linked renal tubulopathy characterized by low molecular weight proteinuria,hypercalciuria and progressive renal failure. Disease aetiology is associated with mutations in the CLCN5 gene coding for the electrogenic 2Cl^-/H^+ antiporter chloride channel 5(CLC-5),which is expressed in the apical endosomes of renal proximal tubules with the vacuolar type H^+-ATPase(V-ATPase). Initially identified as a member of the CLC family of Cl- channels,CLC-5 was presumed to provide Cl- shunt into the endosomal lumen to dissipate H^+ accumulation by V-ATPase,thereby facilitating efficient endosomal acidification. However,recent findings showing that CLC-5 is in fact not a Cl-channel but a 2Cl^-/H^+ antiporter challenged this classical shunt model,leading to a renewed and intense debate on its physiological roles. Cl- accumulation via CLC-5 is predicted to play a critical role in endocytosis,as illustrated in mice carrying an artificial Cl- channel mutation E211 A that developed defective endocytosis but normal endosomal acidification. Conversely,a recent functional analysis of a newly identified disease-causing Cl^- channel mutation E211 Q in a patient with typical Dent's disease confirmed the functional coupling between V-ATPase and CLC-5 in endosomal acidification,lending support to the classical shunt model. In this editorial,we will address the current recognition of the physiological role of CLC-5 with a specific focus on the functional coupling of V-ATPase and CLC-5. | Nobuhiko Satoh Masashi Suzuki Motonobu Nakamura Atsushi Suzuki Shoko Horita George Seki Kyoji Moriya | 2017 | World Journal of Nephrology2017，6，1： | 1 |
| 16 | Comprehensive Histologic Analysis of ALK-Rearranged Lung Carcinomas显示文摘 | Akihiko Yoshida Koji Tsuta Harumi Nakamura Takashi Kohno Fumiaki Takahashi Hisao Asamura Ikuo Sekine Masashi Fukayama Tatsuhiro Shibata Koh Furuta Hitoshi Tsuda | 2011 | The American Journal of Surgical Pathology2011，，8： | 1 |
| 17 | Two-dimensional self-assembly of melem and melemium cations at pH-controlled aqueous solution-Au(111) interfaces under electrochemical control显示文摘二维在控制 pH 的水的 solution-Au (111 ) 的 melem 自己组装接口被电气化学的扫描调查了通道显微镜学。在有 pH 的答案 > pK melem,二订的自我装配的结构(蜂房和拥挤不堪的结构) 和一混乱纤丝状的结构的 b1 作为电极潜力控制的 melem 的表面范围的功能被观察。相反,在有 pH 的酸的解决方案 < pK melem 的 b1 ,仅仅自我装配的蜂房网络由于 monoprotonated melem 阳离子的存在可能在一个相对宽的潜在的范围被观察。归因于 counteranions 的点经常在蜂房网络的毛孔被观察。在低 pH 的拥挤不堪、纤丝状的结构的缺乏(< pK b1 ) 被归因于 melemium 阳离子的离子的排斥。 | Shinobu Uemura Kenki Sakata Masashi Aono Yusuke Nakamura Masashi Kunitake | 2016 | Frontiers of Chemical Science and Engineering2016，10，2： | 1 |
| 18 | Linkage of Familial Moyamoya Disease (Spontaneous Occlusion of the Circle of Willis) to Chromosome 17q25显示文摘 | Tohru Yamauchi Mitsuhiro Tada Kiyohiro Houkin Toshihiro Tanaka Yusuke Nakamura Satoshi Kuroda Hiroshi Abe Takuya Inoue Kiyonobu Ikezaki Toshio Matsushima Masashi Fukui | 2000 | Stroke: Journal of the American Heart Association2000，，： | 1 |
| 19 | Hepatic ISG Expression Is Associated With Genetic Variation in Interleukin 28B and the Outcome of IFN Therapy for Chronic Hepatitis C显示文摘 | Masao Honda Akito Sakai Tatsuya Yamashita Yasunari Nakamoto Eishiro Mizukoshi Yoshio Sakai Taro Yamashita Mikiko Nakamura Takayoshi Shirasaki Katsuhisa Horimoto Yasuhito Tanaka Katsushi Tokunaga Masashi Mizokami Shuichi Kaneko | 2010 | Gastroenterology2010，，2： | 1 |
| 20 | Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system 1 1 Published on the World Wide Web on 27 June 2000.显示文摘 | Toshiaki Nakamura Kazuhide Uramura Tadahiro Nambu Toshihiko Yada Katsutoshi Goto Masashi Yanagisawa Takeshi Sakurai | 2000 | Brain Research2000，，1： | 1 |
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