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| 1 | Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy显示文摘Treatment strategies,whether as follow-up or'total incisional biopsy'for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic treatment.Based on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive tumors.Therefore,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during follow-up.Recent advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade neoplasms.Future studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness. | Tsutomu Nishida Shusaku Tsutsui Motohiko Kato Takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 18 |
| 2 | Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘AIM:To examine the significance of branched-chain amino acid (BCAA) treatment before transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).METHODS:This study included 99 patients who underwent TACE therapy for HCC at our hospital and were followed up without treatment for at least 6 mo between January 2004 and January 2010.They were divided into 2 groups:those receiving BCAA granules (n=40) or regular diet (n=59,control).Data obtained were retrospectively analyzed (prior to TACE,and 1 wk,1,3,and 6 mo after TACE) in terms of nutritional condition and clinical laboratory parameters (serum albumin level and Child-Pugh score),both of which are determinants of hepatic functional reserve.RESULTS:The BCAA group comprised 27 males and 13 females with a mean age of 69.9 ± 8.8 years.The patients of the BCAA group were classified as follows:Child-Pugh A/B/C in 22/15/3 patients,and Stage Ⅱ/Ⅲ /ⅣA HCC in 12/23/5 patients,respectively.The controlgroup comprised 32 males and 27 females with a mean age of 73.2 ± 10.1 years.In the control group,9 patients had chronic hepatitis,Child-Pugh A/B/C in 39/10/1 patients,and StageⅠ/Ⅱ/Ⅲ/ⅣA HCC in 1/11/35/12 patients,respectively.Overall,both serum albumin level and Child-Pugh score improved significantly in the BCAA group as compared with the control 3 and 6 mo after TACE (P < 0.05).Further analysis was performed by the following categorization:(1) child-Pugh classification;(2) liver cirrhosis subgroup with a serum albumin level > 3.5 g/dL;and (3) epirubicin dose.A similar trend indicating a significant improvement of all variables in the BCAA group was noted (P < 0.05).CONCLUSION:Treatment with BCAA granules in patients who have undergone TACE for HCC is considered useful to maintain their hepatic functional reserve. | Hiroki Nishikawa Yukio Osaki Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Shinichiro Henmi Azusa Sakamoto Tetsuro Ishikawa Sumio Saito Ryuichi Kita Toru Kimura | 2012 | World Journal of Gastroenterology2012，18，12： | 16 |
| 3 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 4 | Prevention of esophageal strictures after endoscopic submucosal dissection显示文摘Endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD) have recently been accepted as less invasive methods for treating patients with early esophageal cancers such as squamous cell carcinoma and dysplasia of Barrett's esophagus.However,the large defects in the esophageal mucosa often cause severe esophageal strictures,which dramatically reduce the patient's quality of life.Although preventive endoscopic balloon dilatation can reduce dysphagia and the frequency of dilatation,other approaches are necessary to prevent esophageal strictures after ESD.This review describes several strategies for preventing esophageal strictures after ESD,with a particular focus on anti-inflammatory and tissue engineering approaches.The local injection of triamcinolone acetonide and other systemic steroid therapies are frequently used to prevent esophageal strictures after ESD.Tissue engineering approaches for preventing esophageal strictures have recently been applied in basic research studies.Scaffolds with temporary stents have been applied in five cases,and this technique has been shown to be safe and is anticipated to prevent esophageal strictures.Fabricated autologous oral mucosal epithelial cell sheets to cover the defective mucosa similarly to how commercially available skin products fabricated from epidermal cells are used for skin defects or in cases of intractable ulcers.Fabricated autologous oralmucosal-epithelial cell sheets have already been shown to be safe. | Shinichiro Kobayashi Nobuo Kanai Takeshi Ohki Ryo Takagi Naoyuki Yamaguchi Hajime Isomoto Yoshiyuki Kasai Takahiro Hosoi Kazuhiko Nakao Susumu Eguchi Masakazu Yamamoto Masayuki Yamato Teruo Okano | 2014 | World Journal of Gastroenterology2014，20，41： | 12 |
| 5 | Antibody markers in the diagnosis of inflammatory boweldisease显示文摘Inflammatory bowel disease(IBD), including Crohn's disease and ulcerative colitis, is a chronic intestinal inflammation of unknown etiology. The diagnosis of IBD is based on endoscopic, radiologic and histopathologic criteria. Recently, the search for a noninvasive marker that could augment or replace part of this diagnostic process has become a focus of IBD research. In this review, antibody markers, including microbial antibodies, autoantibodies and peptide antibodies, will be described, focusing on their common features. At present, no single marker with qualities that are satisfactory for the diagnosis and treatment of IBD has been identified, although panels of some antibodies are being evaluated with keen interest. The discovery of novel IBD-specific and sensitive markers is anticipated. Such markers could minimize the use of endoscopic and radiologic examinations and could enable clinicians to implement individualized treatment plans designed to improve the long-term prognosis of patients with IBD. | Keiichi Mitsuyama Mikio Niwa Hidetoshi Takedatsu Hiroshi Yamasaki Kotaro Kuwaki Shinichiro Yoshioka Ryosuke Yamauchi Shuhei Fukunaga Takuji Torimura | 2016 | World Journal of Gastroenterology2016，22，3： | 12 |
| 6 | study to determine guidelines for pediatric colonoscopy显示文摘AIM To investigated characteristics, diagnosis, bowelcleansing preparation, sedation, and colonoscope length and diameter in Japanese pediatric patients receiving total colonoscopy.METHODS The present study evaluated consecutive patients aged ≤ 15 years who had undergone their first colonoscopy in Kurume University between January 2007 and February 2015. Data were retrospectively analyzed. We identified 110 pediatric patients who had undergone colonoscopy that had reached the cecum, allowing the observation of the total colon.RESULTS Hematochezia, abdominal pain, and diarrhea were the most common symptoms. For bowel-cleansing preparation, pediatric patients aged ≤ 12 years were treated with magnesium citrate, and patients aged 13-15 years were treated with polyethylene glycol 4000. For sedation, thiamylal with pentazocine, which has an analgesic effect, was used in patients aged ≤ 6 years, and midazolam with pentazocine was used in patients aged ≥ 7 years. Regarding the choice of endoscope, short and thin endoscopes were selected for younger patients, particularly patients aged ≤ 3 years. Positive diagnoses were made in 78 patients(70.9%). Inflammatory bowel disease(n = 49, 44.5%), including ulcerative colitis(n = 37, 33.6%) and Crohn's disease(n = 12, 10.9%), was the most common diagnosis. CONCLUSION Colonoscopy offers a high diagnostic capability for pediatric patients with gastrointestinal symptoms. The selection of appropriate management the performance of colonoscopy is important in pediatric patients. | Shinichiro Yoshioka Hidetoshi Takedatsu Shuhei Fukunaga Kotaro Kuwaki Hiroshi Yamasaki RyosukeYamauchi Atsushi Mori Hiroshi Kawano Tadahiro Yanagi Tatsuki Mizuochi Kosuke Ushijima Keiichi Mitsuyama Osamu Tsuruta Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，31： | 10 |
| 7 | Anisotropic optical and electronic properties of two- dimensional layered germanium sulfide显示文摘二维(2D ) 分层的材料,转变金属 dichalcogenides,和黑磷从基本物理和设备应用的观点吸引了可观的兴趣。在各向异性的分层的 2D 材料的新功能的建立是挑战性却令人满意的边疆,由于为新设备的这些材料和他们的前景的显著光性质。此处,我们报导各向异性并且厚度依赖者 2D 的光性质金者硫化物(GeS ) 的分层的 monochalcogenide。相应于 B 3g, 的三座散布 Raman 山峰 g 1 ,和 有强壮的极化依赖的 g 2 模式在 GeS 薄片被表明,它为识别各向异性的分层的 GeS 的水晶取向作为一个有效方法验证极化的拉曼光谱学。光致发光(PL ) 在 ~ 与一座山峰被观察在房间温度在 GeS 从直接光的转变发源的 1.66 eV。PL 的极化依赖者特征,第一次被揭示,在 GeS 的乐队边附近显示明显的各向异性的光转变,它被密度支持功能的理论计算。显著地,厚度依赖者 PL 被观察并且讨论。这各向异性的分层的 GeS 为新物理现象和愿望的发现介绍机会发现利用它的各向异性的性质的应用,例如极化敏感的光电探测器。 | Dezhi Tan Hong En Lim Feijiu Wang Nur Baizura Mohamed Shinichiro Mouri Wenjin Zhang Yuhei Miyauchi Mari Ohfuchi Kazunari Matsuda | 2017 | Nano Research2017，10，2： | 7 |
| 8 | 用重组 rK39抗原试纸条快速诊断内脏利什曼病(英文)显示文摘[目的 ]评价以恰氏利氏曼原虫类 kinesin基因中编码 39个氨基酸的基因片段 (r K39)为重组抗原 ,用于血清学诊断内脏利什曼病的价值。 [方法 ]在新疆喀什地区对 13例经脾检和骨髓穿刺阳性的内脏利什曼病患者 ,取一滴病人全血或血清滴在 r K39抗原试纸条底部的吸收垫上 ,血清中蛋白随缓冲液向试纸条上部移动 ,其中相应特异抗体可与 r K39抗原带结合 ,而产生阳性条带。同时 ,本文亦用相同阳性血清作了关于 r K 39抗原的 Western印迹分析对照。 [结果 ]EL ISA分析显示病人血清抗体滴度在 10 - 2~ 10 - 4 ,与所见到的 r K39试纸条上的反应强度符合。Western印迹分析亦显示阳性血清可识别 r K39蛋白条带。[结论 ]与传统诊断内脏利什曼病方法相比较 ,r K39试纸条更快速 ,特异 ,灵敏和低损伤性 。 | 瞿靖琦 管立人 依马木苏里单 左新平 柴君杰 陈生邦 Shinichiro Kawazu KenKatakura YoshigeruMatsumoto S.G.Reed K.-P.Chang | 2000 | 中国寄生虫学与寄生虫病杂志2000，18，3： | 6 |
| 9 | Choroidal and cutaneous metastasis from gastric adenocarcinoma显示文摘Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of men, and cutaneous metastasis occurs in 0.8% of all gastric cancers. We report a patient with gastric adenocarcinoma who presented with visual disorder in his left eye and skin pain on his head as his initial symptoms. These symptoms were diagnosed to be caused by choroidal and cutaneous metastasis of gastric adenocarcinoma. Two cycles of chemotherapy consisted of oral S-1 and intravenous cisplatin (SPIRITS regimen); this was markedly effective to reduce the primary gastric lesion and almost all the metastatic lesions. | Shoichiro Kawai Tsutomu Nishida Yoshito Hayashi Hisao Ezaki Takuya Yamada Shinichiro Shinzaki Masanori Miyazaki Kei Nakai Takayuki Yakushijin Kenji Watabe Hideki Iijima Masahiko Tsujii Kohji Nishida Tetsuo Takehara | 2013 | World Journal of Gastroenterology2013，19，9： | 6 |
| 10 | 东日本铁路公司的环保措施显示文摘介绍了东日本铁路公司生态委员会自成立以来所制定的环保目标和具体的行动计划以及已取得的一些成就。 | Shinichiro Kanata Toshiki Saito 郑陵 | 1998 | 中国铁路1998，，6： | 6 |
| 11 | Improving Ambient Wind Environments of a Cross-flow Wind Turbine near a Structure by using an Inlet Guide Structure and a Flow Deflector显示文摘A cross-flow wind turbine near a structure was tested for the performance. The results showed that the performance of a cross-flow wind turbine near a structure was up to 30% higher than the one without a structure. In addition, we tried to get higher performance of a cross-flow wind turbine by using an Inlet Guide Structure and a Flow Deflector. An Inlet Guide Structure was placed on the edge of a structure and a Flow Deflector was set near a cross-flow wind turbine and can improve ambient wind environments of the wind turbine, the maximum power coefficients were about 15 to 40% higher and the tip speed ratio range showing the high power coefficient was wide and the positive gradients were steep apparently. | Tadakazu TANINO Shinichiro NAKAO Genki UEBAYASHI | 2005 | Journal of Thermal Science2005，14，3： | 5 |
| 12 | Immunological milieu in the peritoneal cavity at laparotomy for gastric cancer显示文摘AIM:To investigate the immunological repertoire in the peritoneal cavity of gastric cancer patients.METHODS:The peritoneal cavity is a compartment in which immunological host-tumor interactions can occur.However,the role of lymphocytes in the peritoneal cavity of gastric cancer patients is unclear.We observed 64 patients who underwent gastrectomy for gastric cancer and 11 patients who underwent laparoscopic cholecystectomy for gallstones and acted as controls.Lymphocytes isolated from both peripheral blood and peritoneal lavage were analyzed for surface markers of lymphocytes and their cytokine production by flow cytometry.CD4+CD25high T cells isolated from the patient's peripheral blood were co-cultivated for 4 d with the intra-peritoneal lymphocytes,and a cytokine assay was performed.RESULTS:At gastrectomy,CCR7 -CD45RA-CD8+ef-fector memory T cells were observed in the peritoneal cavity.The frequency of CD4+CD25 high T cells in both the peripheral blood and peritoneal cavity was elevated in patients at advanced stage[control vs stage Ⅳin the peripheral blood:6.89(3.39-10.4)vs 15.34(11.37-19.31),P<0.05,control vs stageⅣin the peritoneal cavity:8.65(5.28-12.0)vs 19.56(14.81-24.32),P<0.05].On the other hand,the suppression was restored with CD4+CD25high T cells from their own peripheral blood.This study is the first to analyze lymphocyte and cytokine production in the peritoneal cavity in patients with gastric cancer.Immune regulation at advanced stage is reversible at the point of gastrectomy.CONCLUSION:The immunological milieu in the peritoneal cavity of patients with advanced gastric cancer elicited a Th2 response even at gastrectomy,but this response was reversible. | Akira Yoneda Shinichiro Ito Seiya Susumu Mitsutoshi Matsuo Ken Taniguchi Yoshitsugu Tajima Susumu Eguchi Takashi Kanematsu Yasuhiro Nagata | 2012 | World Journal of Gastroenterology2012，18，13： | 5 |
| 13 | Immediate detection of endoscopic retrograde cholangiopancreatographyrelated periampullary perforation: Fluoroscopy or endoscopy?显示文摘AIM:To investigate the causes and intraoperative detection of endoscopic retrograde cholangiopancreatography(ERCP)-related perforations to support immediate or early diagnosis.METHODS:Consecutive patients who underwent ERCP procedures at our hospital between January2008 and June 2013 were retrospectively enrolled in the study(n=2674).All procedures had been carried out using digital fluoroscopic assistance with the patient under conscious sedation.For patients showing alterations in the gastrointestinal anatomy,a short-type double balloon enteroscope had been applied.Cases of perforation had been identified by the presence of air in or leakage of contrast medium into the retroperitonealspace,or upon endoscopic detection of an abdominal cavity related to the perforated lumen.For patients with ERCP-related perforations,the data on medical history,endoscopic findings,radiologic findings,diagnostic methods,management,and clinical outcomes were used for descriptive analysis.RESULTS:Of the 2674 ERCP procedures performed during the 71-mo study period,only six(0.22%)resulted in perforations(male/female,2/4;median age:84 years;age range:57-97 years).The cases included an endoscope-related duodenal perforation,two periampullary perforations related to endoscopic sphincterotomy,two periampullary perforations related to endoscopic papillary balloon dilation,and a periampullary or bile duct perforation secondary to endoscopic instrument trauma.No cases of guidewire-related perforation occurred.The video endoscope system employed in all procedures was only able to immediately detect the endoscope-related perforation;the other five perforation cases were all detected by subsequent digital fluoroscope applied intraoperatively(at a median post-ERCP intervention time of 15 min).Three out of the six total perforation cases,including the single case of endoscope-related duodenal injury,were surgically treated;the remaining three cases were treated with conservative management,including trans-arterial embolization to control the bleeding in one of the cases.All patients recovered without further incident.CONCLUSION:ERCP-related perforations may be difficult to diagnose by video endoscope and digital fluoroscope detection of retroperitoneal free air or contrast medium leakage can facilitate diagnosis. | Yasuaki Motomura Kazuya Akahoshi Junya Gibo Kenji Kanayama Shinichiro Fukuda Shouhei Hamada Yoshihiro Otsuka Masaru Kubokawa Kiyoshi Kajiyama Kazuhiko Nakamura | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 14 | Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3显示文摘 | Takumi Kawaguchi Takafumi Yoshida Masaru Harada Takao Hisamoto Yumiko Nagao Tatsuya Ide Eitaro Taniguchi Hiroto Kumemura Shinichiro Hanada Michiko Maeyama Shinji Baba Hironori Koga Ryukichi Kumashiro Takato Ueno Hisanobu Ogata Akihiko Yoshimura Michio Sat | 2004 | The American Journal of Pathology2004，，5： | 5 |
| 15 | Serum type Ⅳ collagen level is predictive for esophageal varices in patients with severe alcoholic disease显示文摘AIM: To determine factors predictive for esophageal varices in severe alcoholic disease (SAD). METHODS: Abdominal ultrasonography (US) was performed on 444 patients suffering from alcoholism. Forty-four patients found to have splenomegaly and/ or withering of the right liver lobe were defined as those with SAD. SAD patients were examined by upper gastrointestinal (UGI) endoscopy for the presence of esophageal varices. The existence of esophageal varices was then related to clinical variables. RESULTS: Twenty-five patients (56.8%) had esophageal varices. A univariate analysis revealed a significant difference in age and type Ⅳ collagen levels between patients with and without esophageal varices. A logistic regression analysis identified type Ⅳ collagen as the only independent variable predictive for esophageal varices (P = 0.017). The area under the curve (AUC) for type Ⅳ collagen as determined by the receiver operating characteristic (ROC) for predicting esophageal varices was 0.78. CONCLUSION: This study suggests that the level of type Ⅳ collagen has a high diagnostic accuracy for the detection of esophageal varices in SAD. | Satoshi Mamori Yasuyuki Searashi Masato Matsushima Kenichi Hashimoto Shinichiro Uetake Hiroshi Matsudaira Shuji Ito Hisato Nakajima Hisao Tajiri | 2008 | World Journal of Gastroenterology2008，14，13： | 4 |
| 16 | Esophageal early basaloid squamous carcinoma with unusual narrowband imaging magnified endoscopy findings显示文摘Basaloid squamous carcinoma(BSC)is a rare variant of esophageal cancer.There are very few reports of'early'BSC.Here we report a case of early BSC with unusual findings by narrowband imaging magnified endoscopy(NBI-ME).A 70-year-old man with a middle thoracic esophageal tumor was referred to our hospital.White-light endoscopy revealed a reddish depressed lesion 5 mm in diameter having a subepithelial tumor-like prominence with a gentle rising slope.NBI-ME revealed irregular loop-shaped microvessels coexistent with thick irregularly branched non-looped vessels.Iodine staining revealed a pale brown lesion.We performed endoscopic submucosal dissection for diagnostic treatment.Histologic examination showed the proliferation of basal cell-like hyperchromatic tumor cells in the lamina propria and with slight invasion into the submucosa at a depth of 320μm.The tumor cells formed solid nests and microcystic structures,containing an Alcian blue-positive mucoid matrix.The surface was covered with squamous epithelium without cellular atypia.Thin vessels were observed in the intra-epithelial papilla and thick vessels were observed around the solid nests beneath the epithelium.Based on these findings together,we diagnosed the lesion as BSC.In this case,the NBI-ME findings differed from those of typical squamous cell carcinoma in that both non-invasive cancer-like irregular loop-shaped microvessels coexisted with massively invasive cancerlike thick non-looped vessels.We speculate that the looped and non-looped vessels observed by NBI-ME histologically corresponded to thin vessels in the intraepithelial papilla and thick vessels around the tumor nests,respectively.These NBI-ME findings might be a feature of early esophageal BSC. | Yugo Kai Motohiko Kato Yoshito Hayashi Tomofumi Akasaka Shinichiro Shinzaki Tsutomu Nishida Masahiko Tsujii Eiichi Morii Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，35： | 4 |
| 17 | Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3显示文摘 | Takumi Kawaguchi Takafumi Yoshida Masaru Harada Takao Hisamoto Yumiko Nagao Tatsuya Ide Eitaro Taniguchi Hiroto Kumemura Shinichiro Hanada Michiko Maeyama Shinji Baba Hironori Koga Ryukichi Kumashiro Takato Ueno Hisanobu Ogata Akihiko Yoshimura Michio Sat | 2004 | The American Journal of Pathology2004，，5： | 4 |
| 18 | Prediction of colorectal tumor grade and invasion depth through narrow-band imaging scoring显示文摘AIM To determine the usefulness of assigning narrow-band imaging(NBI) scores for predicting tumor grade and invasion depth in colorectal tumors.METHODS A total of 161 colorectal lesions were analyzed from138 patients who underwent endoscopic or surgical resection after conventional colonoscopy and magnifying endoscopy with NBI. The relationships between the surface and vascular patterns of the lesions, as visualized with NBI, and the tumor grade and depth of submucosa(SM) invasion were determined histopathologically.Scores were assigned to distinct features of the surface microstructures of tubular and papillary-type lesions.Using a multivariate analysis, a model was developed for predicting the tumor grade and depth of invasion based on NBI-finding scores.RESULTS NBI findings that correlated with a high tumor grade were associated with the 'regular/irregular'(P < 0.0001)surface patterns and the 'avascular area' pattern(P =0.0600). The vascular patterns of 'disrupted vessels'(P = 0.0714) and 'thick vessels'(P = 0.0133) but none of the surface patterns were associated with a depth of invasion of ≥ 1000 μm. In our model, a total NBIfinding score ≥ 1 was indicative of a high tumor grade(sensitivity: 0.97; specificity: 0.24), and a total NBIfinding score ≥ 9(sensitivity: 0.56; specificity: 1.0) was predictive of a SM invasion depth ≥ 1000 μm. Scores less than these cutoff values signified adenomas and a SM invasion depth < 1000 μm, respectively. Associations were also noted between selected NBI findings and tumor tissue architecture and histopathology.CONCLUSION Our multivariate statistical model for predicting tumor grades and invasion depths from NBI-finding scores may help standardize the diagnosis of colorectal lesions and inform therapeutic strategies. | Yasuhiko Maeyama Keiichi Mitsuyama Tetsuhiro Noda Shiuchiro Nagata Tsutomu Nagata Shinichiro Yoshioka Hikaru Yoshida Michita Mukasa Hiroaki Sumie Hiroshi Kawano Jun Akiba Yuko Araki Tatsuyuki Kakuma Osamu Tsuruta Takuji Torimura | 2018 | World Journal of Gastroenterology2018，24，42： | 4 |
| 19 | Effect of digital elevation models on monitoring slope displacements in open-pit mine by differential interferometry synthetic aperture radar显示文摘Displacement monitoring in open-pit mines is one of the important tasks for safe management of mining processes.Differential interferometric synthetic aperture radar(DInSAR),mounted on an artificial satellite,has the potential to be a cost-effective method for monitoring surface displacements over extensive areas,such as open-pit mines.DInSAR requires the ground surface elevation data in the process of its analysis as a digital elevation model(DEM).However,since the topography of the ground surface in open-pit mines changes largely due to excavations,measurement errors can occur due to insufficient information on the elevation of mining areas.In this paper,effect of different elevation models on the accuracy of the displacement monitoring results by DInSAR is investigated at a limestone quarry.In addition,validity of the DInSAR results using an appropriate DEM is examined by comparing them with the results obtained by global positioning system(GPS)monitoring conducted for three years at the same limestone quarry.It is found that the uncertainty of DEMs induces large errors in the displacement monitoring results if the baseline length of the satellites between the master and the slave data is longer than a few hundred meters.Comparing the monitoring results of DInSAR and GPS,the root mean square error(RMSE)of the discrepancy between the two sets of results is less than 10 mm if an appropriate DEM,considering the excavation processes,is used.It is proven that DInSAR can be applied for monitoring the displacements of mine slopes with centimeter-level accuracy. | I Nyoman Sudi Parwata Shinichiro Nakashima Norikazu Shimizu Takahiro Osawa | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，5： | 4 |
| 20 | Delayed esophageal perforation occurring with endoscopic submucosal dissection:A report of two cases显示文摘We report two cases of delayed esophageal perforation occurring with endoscopic submucosal dissection. Our cases involved delayed perforation after 10 d in case 1 and after 6 d in case 2. Both cases were related to solid food. We performed subtotal esophagectomy with gastric tube reconstruction of the esophagus via the subcutaneous route anterior to the thoracic wall without conservative treatment because both cases involved chest pain and major leakage of food into the mediastinum. Postoperative complications were a local factor(including suture failure and esophageal stricture) in case 1, and we performed endoscopic balloon dilatation five times for esophageal stricture. There was no intrathoracic and mediastinal infection in either case. Surgical treatment for delayed esophageal perforation can be performed safely and surely if diagnosis and assessment are not delayed. | Yasuhiro Matsuda Naoki Kataoka Tomoyuki Yamaguchi Masafumi Tomita Kazuki Sakamoto Shinichiro Makimoto | 2015 | World Journal of Gastrointestinal Surgery2015，7，7： | 4 |
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