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| 1 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 2 | Fatigue and fracture behavior of nickel-based superalloy Inconel 718 up to the very high cycle regime显示文摘The fatigue and fracture behavior of nickel-based superalloy Inconel 718 was investigated up to the very high cycle regime under rotary bending tests at room temperature. It was found that this superalloy can still fracture after exceeding 107 cycles. Fractographic analysis revealed that there was a transition from fatigue crack initiation at multi-sites to single initiation with decreasing stress levels. The fracture surface can be divided into four areas according to the appearance, associated with fracture mechanics analysis of the corresponding stress intensity factors. The fracture mechanism dominant in each area was disclosed by scanning electron microscope examination and analyzed in comparison with those obtained from the crack growth tests. Subsequently, life prediction modeling was proposed by estimating the crack initiation and propagation stage respectively. It was found that Chan (2003)'s model for initiation life and the Paris law for growth life can provide comparable predictions against the experimental life. | Xian-feng MA Zheng DUAN Hui-ji SHI Ryosuke MURAI Eiichi YANAGISAWA | 2010 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2010，11，10： | 9 |
| 3 | Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers显示文摘 | Takuji Gotoda Akio Yanagisawa Mitsuru Sasako Hiroyuki Ono Yukihiro Nakanishi Tadakazu Shimoda Yo Kato | 2000 | Gastric Cancer2000，，4： | 8 |
| 4 | 胆道肿瘤临床实践指南(英文第三版)显示文摘日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确定推荐意见、推荐强度以及推荐说明。根据证据推荐分级的评估、制订与评价(GRADE)系统,推荐强度被分为1级(强)或者2级(弱)。英文第三版胆道肿瘤临床实践指南中提出的31个临床问题涵盖:(1)预防性治疗;(2)诊断;(3)胆道引流;(4)外科治疗;(5)化疗;(6)放疗。31个临床问题中,14个问题给予推荐强度为强的推荐意见,14个问题给予推荐强度为弱的推荐意见,剩余的3个问题未给予推荐意见。每条推荐意见都进行推荐强度说明。最新版指南基于循证医学证据,为临床提供了重要建议。未来与癌症登记数据库协作将是评估指南和建立新证据的关键。 | Masato Nagino Satoshi Hirano Hideyuki Yoshitomi Taku Aoki Katsuhiko Uesaka Michiaki Unno Tomoki Ebata Masaru Konishi Keiji Sano Kazuaki Shimada Hiroaki Shimizu Ryota Higuchi Toshifumi Wakai Hiroyuki Isayama Takuji Okusaka Toshio Tsuyuguchi Yoshiki Hirooka Junji Furuse Hiroyuki Maguchi Kojiro Suzuki Hideya Yamazaki Hiroshi Kijima Akio Yanagisawa Masahiro Yoshida Yukihiro Yokoyama Takashi Mizuno Itaru Endo 杨翼飞(译) 仇毓东(译) 赵梦珂(译) 伏旭(译) 蔡正华(译) 毛凉(审校) | 2021 | 中华消化外科杂志2021，20，4： | 7 |
| 5 | Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers显示文摘 | Takuji Gotoda Akio Yanagisawa Mitsuru Sasako Hiroyuki Ono Yukihiro Nakanishi Tadakazu Shimoda Yo Kato | 2000 | Gastric Cancer2000，，4： | 7 |
| 6 | Post-polypectomy bleeding and thromboembolism risks associated with warfarin vs direct oral anticoagulants显示文摘AIM To verify the validity of the endoscopy guidelines for patients taking warfarin or direct oral anticoagulants(DOAC).METHODS We collected data from 218 patients receiving oral anticoagulants(73 DOAC users, 145 warfarin users) and 218 patients not receiving any antithrombotics(age-and sexmatched controls) who underwent polypectomy.(1) We evaluated post-polypectomy bleeding(PPB) risk in patients receiving warfarin or DOAC compared with controls;(2) we assessed the risks of PPB and thromboembolism between three AC management methods: Discontinuing AC with heparin bridge(HPB)(endoscopy guideline recommendation), continuing AC, and discontinuing AC without HPB.RESULTS PPB rate was significantly higher in warfarin users and DOAC users compared with controls(13.7% and 13.7% vs 0.9%, P < 0.001), but was not significantly different between rivaroxaban(13.2%), dabigatran(11.1%), and apixaban(13.3%) users. Two thromboembolic events occurred in warfarin users, but none in DOAC users. Compared with the continuing anticoagulant group, the discontinuing anticoagulant with HPB group(guideline recommendation) had a higher PPB rate(10.8% vs 19.6%, P = 0.087). These findings were significantly evident in warfarin but not DOAC users. One thrombotic event occurred in the discontinuing anticoagulant with HPB group and the discontinuing anticoagulant without HPB group; none occurred in the continuing anticoagulant group.CONCLUSION PPB risk was similar between patients taking warfarin and DOAC. Thromboembolism was observed in warfarin users only. The guideline recommendations for HPB should be re-considered. | Naohiro Yanagisawa Naoyoshi Nagata Kazuhiro Watanabe Tatsuhiro Iida Mariko Hamada Sakurako Kobayashi Takuro Shimbo Junichi Akiyama Naomi Uemura | 2018 | World Journal of Gastroenterology2018，24，14： | 6 |
| 7 | 在早 colorectal 癌症的内视镜的切除术的组织学的评估的重要性显示文摘 The diagnostic criteria for colonic intraepithelial tumors vary from country to country.While intramucosal adenocarcinoma is recognized in Japan,in Western countries adenocarcinoma is diagnosed only if the tumor invades to the submucosa and accesses the muscularis mucosae.However,endoscopic therapy,including endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD),is used worldwide to treat adenoma and early colorectal cancer.Precise histopathological evaluation is important for the curativeness of these therapies as inappropriate endoscopic therapy causes local recurrence of the tumor that may develop into fatal metastasis.Therefore,colorectal ESD and EMR are not indicated for cancers with massive submucosal invasion.However,diagnosis of cancer with massive submucosal invasion by endoscopy is limited,even when magnifying endoscopy for pit pattern and narrow band imaging and flexible spectral imaging color of enhancement are performed.Therefore,occasional cancers with massive submucosal invasion will be treated by ESD and EMR.Precise histopathological evaluation of these lesions should be performed in order to determine the necessity of additional therapy,including surgical resection. | Naohisa Yoshida Yuji Naito Nobuaki Yagi Akio Yanagisawa | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，2： | 5 |
| 8 | Epidemiology,clinical characteristics,and management of chronic kidney disease in human immunodeficiency virusinfected patients显示文摘Antiretroviral therapy has markedly reduced acquired immune deficiency syndrome-related deaths and opportunistic infectious diseases.This has resulted in prolonged survival of individuals infected with the human immunodeficiency virus(HIV).However,this improvement in survival has been accompanied by an increase in the incidence of chronic kidney disease(CKD) and end-stage renal disease.CKD is now epidemic among HIV-infected populations in both Western and Eastern countries.Risk factors associated with CKD in HIV-infected populations include aging,hypertension,diabetes mellitus,co-infection with hepatitis C virus,a low CD4 cell count,and a high HIV viral load.Clinical experience has shown that HIVinfected individuals often have one or more concurrent risk factors for CKD.The cumulative effect of multiple risk factors on the development of CKD should be noted in this population.Glomerular disease directly related to HIV infection,so-called HIV-associated nephropathy,remains an important cause of CKD among a limited HIV population of African descent,but is less likely to be common among other urban HIV populations.The impact of exposure to nephrotoxic antiretroviral agents on the development of kidney disease is both an old and a new concern.In particular,the association of tenofovir with kidney tubular injury has been an area of great interest.The findings regarding tenofovir's adverse effect on long-term kidney function vary among studies.The early identification and treatment of CKD is recommended for reducing the burden of patients requiring dialysis in HIV-infected populations.Periodic monitoring of urinary concentrations of albumin,protein,and tubular injury markers such as low-molecular-weight proteins may be useful for the early diagnosis of patients at risk for incident CKD.This review focuses on recent epidemiology,clinical characteristics,and management of CKD in a contemporary HIV-infected population. | Minoru Ando Naoki Yanagisawa | 2015 | World Journal of Nephrology2015，4，3： | 5 |
| 9 | Soluble ST2 protein inhibits LPS stimulation on monocyte-derived dendritic cells显示文摘ST2 蛋白质是 ST2L 蛋白质的可溶的拼接变体,它是为 interleukin-33 (IL-33 ) 的受体。以前,我们报导可溶的 ST2 在 monocytic 房间压制了 lipopolysaccharide (LPS ) 和 cytokine 生产的信号 transduction。到调查这禁止的效果是否发生在树枝状的房间,它是在天生、适应的免疫的关键播放器,人的导出单核白血球的树枝状的房间在 LPS 刺激前与可溶的 ST2 蛋白质被预先对待。尽管可溶的 ST2 没稀释树枝状的房间的导致 LPS 的成熟,有可溶的 ST2 的预告的处理压制了 cytokine 生产并且禁止了 LPS 发信号。而且,天真的 T 房间的增长被可溶的 ST2 显著地禁止预告的处理。IL-33 在不成熟的导出单核白血球的树枝状的房间的 cytokine 生产上有小效果。而且,可溶的 ST2 蛋白质被使内在化进树枝状的房间,建议那可溶的 ST2 蛋白质由除 IL-33 的隐遁以外的不在经典中的机制行动。 | Akihisa Nagata Naoki Takezako Hiroyuki Tamemoto Hiromi Ohto-Ozaki SatoshiOhta Shin-ichi Tominaga Ken Yanagisawa | 2012 | Cellular & Molecular Immunology2012，9，5： | 4 |
| 10 | 血管内皮细胞产生一种新的强效血管收缩肽显示文摘一种内皮细胞产生的21个氨基酸残基的血管收缩肽——内皮素(endothelin)经分离已获得。实验证明,内皮索是迄今为止所知的最强的血管收缩物质之一,内皮素原前体的互补DNA的克隆和序列表明,具活性的内皮素经一不寻常的蛋白水解过程产生,是一组神经毒素的部分类似物。 | Yanagisawa M 李茜 | 1989 | 国外医学(分子生物学分册)1989，11，3： | 4 |
| 11 | Efficient hemostatic method for endoscopic submucosal dissection of colorectal tumors显示文摘AIM:To evaluate a new hemostatic method using hemostatic forceps to prevent perforation and perioperative hemorrhage during colonic endoscopic submucosal dissection(ESD).METHODS:We studied 250 cases,in which ESD for colorectal tumors was performed at the Kyoto Prefectural University of Medicine or Nara City Hospital between 2005 and 2010.We developed a new hemostatic method using hemostatic forceps in December 2008 for the efficient treatment of submucosal thick vessels.ESD was performed on 126 cases after adoption of the new method(the adopted group)and the new method was performed on 102 of these cases.ESD was performed on 124 cases before the adoption of the new method (the unadopted group).The details of the new method are as follows:firstly,a vessel was coagulated using the hemostatic forceps in the soft coagulation mode according to the standard procedure,and the coagulated vessel was removed using the forceps in the'endocut' mode without perioperative hemorrhage.Secondly,the partial surrounding submucosa was dissected using the forceps in the endocut mode.In the current study,we evaluated the efficacy of this method.RESULTS:Coagulated vessels were successfully removed using the hemostatic forceps in all 102 cases without severe perioperative hemorrhage.Moderate perioperative hemorrhage occurred in five cases(4.9%);however,it was stopped by immediately reuse of the hemostatic forceps.The partial surrounding submucosa was dissected using the forceps in all 102 cases.In the adopted group,the median operation time was 105 min.The proportion of endoscopic en bloc resection was 92.8%(P<0.01)compared to 80.6%in the unadopted group.The postoperative hemorrhage and perforation rates were 2.3%and 2.3%.The rate of perforation was significantly lower than that in the unadopted group (9.6%,P<0.01).We evaluated the ease of use of this method by allowing our three trainees to performed ESD on 46 cases,which were accomplished without any severe hemorrhage.CONCLUSION:The new method effectively treated submucosal thick vessels and shows promise for the prevention of perforation and perioperative hemorrhage in colonic ESD. | Naohisa Yoshida Yuji Naito Munehiro Kugai Ken Inoue Naoki Wakabayashi Nobuaki Yagi Akio Yanagisawa Toshikazu Yoshikawa | 2010 | World Journal of Gastroenterology2010，16，33： | 4 |
| 12 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells显示文摘 | Yanagisawa M Kurihara H Kimura S | | 0，，6163： | 3 |
| 13 | Image-enhanced endoscopy for diagnosis of colorectal tumors in view of endoscopic treatment显示文摘Recently,image-enhanced endoscopy(IEE) has been used to diagnose gastrointestinal tumors.This method is a change from conventional white-light(WL) endoscopy without dyeing solution,requiring only the push of a button.In IEE,there are many advantages in diagnosis of neoplastic tumors,evaluation of invasion depth for cancerous lesions,and detection of neoplastic lesions.In narrow band imaging(NBI) systems(Olympus Medical Co.,Tokyo,Japan),optical filters that allow narrow-band light to pass at wavelengths of 415 and 540 nm are used.Mucosal surface blood vessels are seen most clearly at 415 nm,which is the wavelength that corresponds to the hemoglobin absorption band,while vessels in the deep layer of the mucosa can be detected at 540 nm.Thus,NBI also can detect pit-like structures named surface pattern.The flexible spectral imaging color enhancement(FICE) system(Fujifilm Medical Co.,Tokyo,Japan) is also an IEE but different to NBI.FICE depends on the use of spectral-estimation technology to reconstruct images at different wavelengths based on WL images.FICE can enhance vascular and surface patterns.The autofluorescence imaging(AFI) video endoscope system(Olympus Medical Co.,Tokyo,Japan) is a new illumination method that uses the difference in intensity of autofluorescence between the normal area and neoplastic lesions.AFI light comprises a blue light for emitting and a green light for hemoglobin absorption.The aim of this review is to highlight the efficacy of IEE for diagnosis of colorectal tumors for endoscopic treatment. | Naohisa Yoshida Nobuaki Yagi Akio Yanagisawa Yuji Naito | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，12： | 3 |
| 14 | Cardiac-specific knockout of ET_(A)receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction显示文摘Cold exposure is associated with oxidative stress and cardiac dysfunction.The endothelin(ET)system,which plays a key role in myocardial homeostasis,may participate in cold exposure-induced cardiovascular dysfunction.This study was designed to examine the role of ET-1 in cold stress-induced cardiac geometric and contractile responses.Wild-type(WT)and ETA receptor knockout(ETAKO)mice were assigned to normal or cold exposure(48C)environment for 2 and 5 weeks prior to evaluation of cardiac geometry,contractile,and intracellular Ca21 properties.Levels of the temperature sensor transient receptor potential vanilloid(TRPV1),mitochondrial proteins for biogenesis and oxidative phosphorylation,including UCP2,HSP90,and PGC1a were evaluated.Cold stress triggered cardiac hypertrophy,depressed myocardial contractile capacity,including fractional shortening,peak shortening,and maximal velocity of shortening/relengthening,reduced intracellular Ca21 release,prolonged intracellular Ca21 decay and relengthening duration,generation of ROS and superoxide,as well as apoptosis,the effects of which were blunted by ETAKO.Western blotting revealed downregulated TRPV1 and PGC1a as well as upregulated UCP2 and activation of GSK3b,GATA4,and CREB in cold-stressed WT mouse hearts,which were obliterated by ETAKO.Levels of HSP90,an essential regulator for thermotolerance,were unchanged.The TRPV1 agonist SA13353 attenuated whereas TRPV1 antagonist capsazepine mimicked cold stress-or ET-1-induced cardiac anomalies.The GSK3b inhibitor SB216763 ablated cold stress-induced cardiac contractile(but not remodeling)changes and ET-1-induced TRPV1 downregulation.These data suggest that ETAKO protects against cold exposure-induced cardiac remodeling and dysfunction mediated through TRPV1 and mitochondrial function. | Yingmei Zhang Linlin Li Yinan Hua Jennifer M.Nunn Feng Dong Masashi Yanagisawa Jun Ren | 2012 | Journal of Molecular Cell Biology2012，4，2： | 2 |
| 15 | Possible involvement of a chloride- bicarbonate exchanger in apoptosis of endothelial cells and cardiomyocytes显示文摘 | Fujita H Ishizaki Y Yanagisawa A | 1999 | Cell Biol Int1999，23，4： | 2 |
| 16 | Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English version显示文摘 | Toshirou Nishida Seiichi Hirota Akio Yanagisawa Yoshinori Sugino Manabu Minami Yoshitaka Yamamura Yoshihide Otani Yasuhiro Shimada Fumiaki Takahashi Tetsuro Kubota | 2008 | International Journal of Clinical Oncology2008，，5： | 2 |
| 17 | Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization显示文摘 | Norihiro Kokudo Keiichiro Tada Makoto Seki Hirotoshi Ohta Kaoru Azekura Masashi Ueno Keiichiro Ohta Toshiharu Yamaguchi Toshiki Matsubara Takashi Takahashi Toshifusa Nakajima Tetsuichiro Muto Takaaki Ikari Akio Yanagisawa Yo Kato | 2001 | Hepatology2001，，2： | 2 |
| 18 | Molecular basis of cleft palates in mice显示文摘Cleft palate, including complete or incomplete cleft palates, soft palate clefts, and submucosal cleft palates, is the most frequent congenital craniofacial anomaly in humans. Multifactorial conditions, including genetic and environmental factors, induce the formation of cleft palates. The process of palatogenesis is temporospatially regulated by transcription factors, growth factors, extracellular matrix proteins, and membranous molecules; a single ablation of these molecules can result in a cleft palate in vivo. Studies on knockout mice were reviewed in order to identify genetic errors that lead to cleft palates. In this review, we systematically describe these mutant mice and discuss the molecular mechanisms of palatogenesis. | Noriko Funato Masataka Nakamura Hiromi Yanagisawa | 2015 | World Journal of Biological Chemistry2015，6，3： | 2 |
| 19 | Angiogenesis in pancreatic carcinoma: thymidine phosphorylase expression in stromal cells and intratumoral microvessel density as independent predictors of overall and relapse-free survival显示文摘 | Fujioka S Yoshida K Yanagisawa S | 2001 | Cancer2001，92，7： | 2 |
| 20 | Common Variants in the Complement Factor H Gene Confer Genetic Susceptibility to Central Serous Chorioretinopathy显示文摘 | Akiko Miki Naoshi Kondo Suiho Yanagisawa Hiroaki Bessho Shigeru Honda Akira Negi | 2013 | Ophthalmology2013，，： | 2 |
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