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| 1 | Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?显示文摘Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumors. The majority of these data are derived from surgical specimens and malignant cell series, rendering their clinical application questionable, due to subjectivity factors and post-treatment quantification. In an effort to overcome these drawbacks, an alternative method of immunodetection of the circulating levels of these molecules has been used in studies on gastric, esophageal and colorectal cancer. Their results denotethat quantification of VEGF-C and VEGF-D in blood samples could serve as lymph node metastasis predictive biomarkers and contribute to preoperative staging of gastrointestinal malignancies. | Theodore D Tsirlis George Papastratis Kyriaki Masselou Christos Tsigris Antonis Papachristodoulou Alkiviadis Kostakis Nikolaos I Nikiteas | 2008 | World Journal of Gastroenterology2008，14，17： | 12 |
| 2 | Propranolol for the prevention of postoperative arrhythmias in general thoracic surgery显示文摘 | Charles D Bayliff David R Massel Richard I Inculet Richard A Malthaner Susan D Quinton Frank S Powell Renee S Kennedy | 1999 | The Annals of Thoracic Surgery1999，，1： | 2 |
| 3 | Diagnosing acute myocardial infarction in the setting of left bundle branch block : prevalence and observer variability from a large communituy study 显示文摘 | Gula LJ Dick A Massel D | 2003 | Coron Artery Dis2003，14，5： | 1 |
| 4 | Clot-bound thrombin is protected from inhibition by heparin-antithrombin Ⅲ but is susceptible to inactivation by antithrombin Ⅲ-independent inhibitors显示文摘 | Weitz JI Hudoba M Massel D | 1990 | J Clin Invest1990，86，： | 1 |
| 5 | Reducing bedrest following arterial puncture for coronary interventional procedures-impact on vascular complication:the BAC Trial显示文摘 | Vlasic W Almond D Massel D | 2001 | J Invasive Cardiol2001，13，12： | 1 |
| 6 | Anaphylactoid reaction during an infu- sion of recombinant tissue-type plasminogen activator for acute myo- cardial infhrction 显示文摘 | Massel D Gill JB Cairns JA | 1991 | Can J Cardiot1991，7，： | 1 |
| 7 | Mediastinal irradiation: a risk factor for atherosclerosis of the internal thoracic arteries 显示文摘 | RENNER S M MASSEL D MOON B C | 1999 | Can J Cardiol1999，15，5： | 1 |
| 8 | Clot-bound Thrombin is Protected from Inhibition by Heparin-antithrombin- Ⅲ but Its Susceptible to Inactivation by Antithrombin Ⅲ - independent Inhibitiors 显示文摘 | WEITZ J I HUDOBA M MASSEL D | 1990 | Clin Invest1990，86，： | 1 |
| 9 | Diagnosing acute myocardial infarction in the setting of left bundle branch block:prevalence and observer variability from a large comunity study显示文摘 | Gula LJ Dick A Massel D | 2003 | Coron Artery Dis2003，14，： | 1 |
| 10 | Clot bound thrombin is protected from inhibition by heparin-antithrombin Ⅲ but is susceptible to inactivation by antithrombin Ⅲ -independent inhibitors显示文摘 | Weitz JI Hudoba M Massel D | 1994 | J Clin Invest1994，86，： | 1 |
| 11 | How sound is the evidence that thrombolysis increases the risk of cardiac rupture?显示文摘 | MASSEL D R | 1993 | Br Heart J1993，69，： | 1 |
| 12 | Reducing Bed rest Following Arterial Puncture for Coronary interventional procedures ( BAC trial) : impact on vascular complications 显示文摘 | Vlasic W Almond D Massel D | 2001 | J Invasive Card2001，13，： | 1 |
| 13 | A prospective randomized trial of endoscopic versus conventional harvesting of the saphenous vein in coronary artery bypass surgery 显示文摘 | Kiaii B Moon B C Massel D | 2002 | J Thorac Cardiovasc Surg2002，123，2： | 1 |
| 14 | Ejection fraction velocity ratio as an indicator of aortic stenosis severity 显示文摘 | Al-Ghamdi AM Melendez LJ Massel D | 2005 | Echocardiography2005，22，3： | 1 |
| 15 | An echocardiographic study of the limitations of the Tei index in aortic stenosis 显示文摘 | Sud S Massel D | 2009 | Echoeardiography2009，26，8： | 1 |
| 16 | Risk of arrhythmia and sudden death in patients with asymptomatic preexcitation:a meta-analysis显示文摘 | OBEYESEKERE M N LEONG-SIT P MASSEL D | 2012 | Circulation2012，125，19： | 1 |
| 17 | Impact of routine transoesophageal echocardiography on safety, outcomes, and cost of pulmonary vein ablation: inferences drawn from a decision analysis model 显示文摘 | Gula LJ Massel D Redfearn DP | 2010 | Europace2010，12，11： | 1 |
| 18 | Diagnosing of acute myo- cardial infarction in the setting of left bundle branch block: prevalence and observer variability from a large community study 显示文摘 | Gula LJ Dick A Massel D | 2003 | Coron Artery Dis2003，14，5： | 1 |
| 19 | Clot-bound thrombin is protected from inhibition by heparin-antithrombin Ⅲ but is susceptible to inactivation by antithrombin Ⅲ -independent inhibitors显示文摘 | Hudoba M Massel D | 1990 | J Clin Invest1990，86，： | 1 |
| 20 | Clot-bound thrombin is protected from inhibition by heparin-antithrombin Ⅲ but is susceptible to inactivation by antithrombin Ⅲ-independent inhibitors显示文摘 | Weitz J I Hudoba M Massel D | 1990 | J Clin Invest1990，86，： | 1 |
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